mianserin has been researched along with Disease Models, Animal in 49 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The obtained results suggest that ADs may enhance the antipsychotic-like effect of aripiprazole in the animal tests used for evaluation of some positive and cognitive symptoms of schizophrenia." | 7.88 | Combined treatment with aripiprazole and antidepressants reversed some MK-801-induced schizophrenia-like symptoms in mice. ( Lorenc-Koci, E; Rogóż, Z; Wąsik, A, 2018) |
| "The obtained results indicated that lower doses of mirtazapine enhanced the antipsychotic-like effect of risperidone in animal tests of positive symptoms of schizophrenia." | 7.78 | Effect of co-treatment with mirtazapine and risperidone in animal models of the positive symptoms of schizophrenia in mice. ( Rogóż, Z, 2012) |
| "The effects of acute systemic administration of duloxetine, amitriptyline, mirtazapine and fluoxetine were compared in experimental models of gastric ulcer in rats." | 7.78 | Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats. ( Fan, DS; Guo, L; Ji, CX; Li, W; Liang, ZL; Xu, RM; Zhang, JJ, 2012) |
| "To investigate whether the tetracyclic antidepressant mirtazapine has a pain-suppressing effect in healthy animals." | 7.77 | The acute effects of mirtazapine on pain related behavior in healthy animals. ( Baydemir, C; Dogan, AE; Erol, K; Kilic, FS, 2011) |
| " We have investigated the effects of mirtazapine on pentylenetetrazole (PTZ)- and maximal electroconvulsive shock (MES)-induced seizures in mice." | 7.74 | Mirtazapine does not affect pentylenetetrazole- and maximal electroconvulsive shock-induced seizures in mice. ( Kayir, H; Sezer, Z; Uzbay, TI; Yilmaz, I, 2007) |
| "The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain." | 7.73 | Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005) |
| " The present report deals with the effects of imipramine and mianserine on two animal models of depression, after acute or prolonged previous treatment with these antidepressants." | 7.68 | Lack of tolerance to imipramine or mianserine in two animal models of depression. ( Barros, HM; Tannhauser, M; Wainstein, M, 1990) |
| "Acute pretreatment with clinically equivalent doses of antidepressive drugs has been observed to block D,L-5-hydroxytryptophan (5-HTP) induced behavioral depression in rats working on a food-reinforced operant schedule." | 7.67 | Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. ( Aprison, MH; Hendrie, HC; Hingtgen, JN, 1984) |
| "Mirtazapine is a novel antidepressant and a potent 5-HT(2) receptor antagonistic." | 5.36 | Mirtazapine abolishes hyperthermia in an animal model of serotonin syndrome. ( Kato, S; Nisijima, K; Shioda, K; Yoshino, T, 2010) |
| " The present study was designed to explore the effects and most appropriate dosage of mirtazapine in treating neuropathic pain and its possible neuroimmune mechanisms." | 5.35 | Repeated administration of mirtazapine inhibits development of hyperalgesia/allodynia and activation of NF-kappaB in a rat model of neuropathic pain. ( Feng, X; Hu, Y; Song, J; Wei, X; Xu, J; Zhu, J, 2008) |
| "The obtained results suggest that ADs may enhance the antipsychotic-like effect of aripiprazole in the animal tests used for evaluation of some positive and cognitive symptoms of schizophrenia." | 3.88 | Combined treatment with aripiprazole and antidepressants reversed some MK-801-induced schizophrenia-like symptoms in mice. ( Lorenc-Koci, E; Rogóż, Z; Wąsik, A, 2018) |
| "Several clinical reports have postulated a beneficial effect of the addition of a low dose of risperidone to the ongoing treatment with antidepressants in treatment-resistant depression." | 3.78 | Effect of co-treatment with fluoxetine or mirtazapine and risperidone on the active behaviors and plasma corticosterone concentration in rats subjected to the forced swim test. ( Gądek-Michalska, A; Kabziński, M; Rachwalska, P; Rogóż, Z; Sadaj, W, 2012) |
| "The obtained results indicated that lower doses of mirtazapine enhanced the antipsychotic-like effect of risperidone in animal tests of positive symptoms of schizophrenia." | 3.78 | Effect of co-treatment with mirtazapine and risperidone in animal models of the positive symptoms of schizophrenia in mice. ( Rogóż, Z, 2012) |
| "The effects of acute systemic administration of duloxetine, amitriptyline, mirtazapine and fluoxetine were compared in experimental models of gastric ulcer in rats." | 3.78 | Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats. ( Fan, DS; Guo, L; Ji, CX; Li, W; Liang, ZL; Xu, RM; Zhang, JJ, 2012) |
| "To investigate whether the tetracyclic antidepressant mirtazapine has a pain-suppressing effect in healthy animals." | 3.77 | The acute effects of mirtazapine on pain related behavior in healthy animals. ( Baydemir, C; Dogan, AE; Erol, K; Kilic, FS, 2011) |
| "The purpose of this study was to elucidate the mechanism underlying the clinical efficacy of mirtazapine-perospirone combination therapy for treatment-resistant depression in a rat model." | 3.77 | Mirtazapine in combination with perospirone synergistically enhances dopamine release in the rat prefrontal cortex via 5-HT1A receptor activation. ( Morita, M; Nakayama, K, 2011) |
| " We have investigated the effects of mirtazapine on pentylenetetrazole (PTZ)- and maximal electroconvulsive shock (MES)-induced seizures in mice." | 3.74 | Mirtazapine does not affect pentylenetetrazole- and maximal electroconvulsive shock-induced seizures in mice. ( Kayir, H; Sezer, Z; Uzbay, TI; Yilmaz, I, 2007) |
| "The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain." | 3.73 | Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005) |
| " Single doses of 5-HT2 antagonists, mianserin (5mg/kg) and ritanserin (1mg/kg), effectively ameliorated withdrawal anxiety in the rat, returning behavioural function in the social interaction test and elevated plus maze to levels comparable to vehicle-treated animals." | 3.73 | Attenuation of benzodiazepine withdrawal anxiety in the rat by serotonin antagonists. ( Begg, DP; Hallam, KT; Norman, TR, 2005) |
| " The present report deals with the effects of imipramine and mianserine on two animal models of depression, after acute or prolonged previous treatment with these antidepressants." | 3.68 | Lack of tolerance to imipramine or mianserine in two animal models of depression. ( Barros, HM; Tannhauser, M; Wainstein, M, 1990) |
| "Acute pretreatment with clinically equivalent doses of antidepressive drugs has been observed to block D,L-5-hydroxytryptophan (5-HTP) induced behavioral depression in rats working on a food-reinforced operant schedule." | 3.67 | Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. ( Aprison, MH; Hendrie, HC; Hingtgen, JN, 1984) |
| "To further test the new hypersensitive postsynaptic serotonin (5-HT) receptor theory of depression bases on or animal model, it was necessary to demonstrate that some of the currently used antidepressive drugs can block D,L-5-hydroxytryptophan (5-HTP) induced depression acting through postsynaptic rather than presynaptic mechanisms." | 3.66 | Postsynaptic action by four antidepressive drugs in an animal model of depression. ( Aprison, MH; Hingtgen, JN; Nagayama, H, 1981) |
| " This study aimed to investigate the effects of mirtazapine (MIRT) alone and combined with alpha-lipoic acid (ALA) against corticosterone (CORT) induced behavioral and oxidative alterations." | 1.46 | Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone. ( de Oliveira, AA; de Sousa, CNS; de Sousa, LC; Honório Júnior, JER; Macedo, D; Maes, M; Medeiros, IDS; Oliveira, TQ; Patrocínio, CFV; Vasconcelos, GS; Vasconcelos, SMM, 2017) |
| " Time-course data for the dose-response effects were analyzed using two-way analysis of variance and the posthoc Tukey-Kramer multiple-comparison test." | 1.40 | Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats. ( Hashimoto, R; Hosokawa, K; Mashimo, T; Nakae, A; Nakai, K, 2014) |
| "Mirtazapine 45 mg was administered orally 90 min before the study." | 1.40 | Prokinetic effects of mirtazapine on gastrointestinal transit. ( Chen, JD; Lei, Y; Song, J; Xu, X; Yin, J, 2014) |
| "Mirtazapine was also reported to increase dopamine release in the cortical neurons with 5-HT dependent manner." | 1.40 | Mirtazapine has a therapeutic potency in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice model of Parkinson's disease. ( Fukano, T; Kadoguchi, N; Kasahara, J; Okabe, S; Shono, M; Tanabe, A; Yamamura, Y; Yokoyama, H, 2014) |
| "Mirtazapine (MTZ) is an antidepressant, which is considered to enhance noradrenergic and serotonergic neurotransmission via antagonistic action at central α2-adrenergic autoreceptors and heteroreceptors." | 1.38 | Effects of mirtazapine on sleep disturbance under neuropathic pain-like state. ( Enomoto, T; Hirayama, S; Horiuchi, H; Ikegami, D; Inada, E; Iseki, M; Nagase, H; Nakahara, K; Narita, M; Sakai, H; Suzuki, T; Torigoe, K; Yamashita, A; Yanase, M, 2012) |
| "Mirtazapine is an atypical antidepressant receiving attention for substance abuse pharmacotherapy, and its action includes alterations in monoaminergic transmission." | 1.38 | The atypical antidepressant mirtazapine attenuates expression of morphine-induced place preference and motor sensitization. ( Graves, SM; Napier, TC; Persons, AL; Riddle, JL, 2012) |
| "Mirtazapine is a novel antidepressant and a potent 5-HT(2A) receptor antagonist." | 1.37 | The effects of mirtazapine and fluoxetine on hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats. ( Iwamura, T; Kasai, M; Kato, S; Nisijima, K; Shioda, K; Yoshino, T, 2011) |
| "Mirtazapine is a novel antidepressant and a potent 5-HT(2) receptor antagonistic." | 1.36 | Mirtazapine abolishes hyperthermia in an animal model of serotonin syndrome. ( Kato, S; Nisijima, K; Shioda, K; Yoshino, T, 2010) |
| " The present study was designed to explore the effects and most appropriate dosage of mirtazapine in treating neuropathic pain and its possible neuroimmune mechanisms." | 1.35 | Repeated administration of mirtazapine inhibits development of hyperalgesia/allodynia and activation of NF-kappaB in a rat model of neuropathic pain. ( Feng, X; Hu, Y; Song, J; Wei, X; Xu, J; Zhu, J, 2008) |
| "Although acute application of mianserin may potentiate the anticonvulsant action of some antiepileptics, its chronic administration can lead to the opposite effect." | 1.34 | Acute and chronic treatment with mianserin differentially affects the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model. ( Banach, M; Borowicz, KK; Czuczwar, SJ; Lukasik, D; Luszczki, JJ; Zarczuk, R, 2007) |
| "Mirtazapine is a widely used antidepressant and the aim of this study was to further investigate its antidepressant activity in rats." | 1.33 | Study of mirtazapine antidepressant effects in rats. ( Cassanelli, A; Gambarana, C; Raone, A; Rauggi, R; Tagliamonte, A, 2005) |
| "Intensity of withdrawal symptoms was evaluated by tail-flick assay latencies and three behavioural measurements (rearing, jumping and grooming) in each group." | 1.32 | Mianserin and trazodone significantly attenuate the intensity of opioid withdrawal symptoms in mice. ( Backler, MM; Bar-Hamburger, R; Herman, I; Pick, CG; Rigai, T; Schreiber, S; Shamir, D, 2003) |
| "Depression is characterized by a lack of "motivation" rather than a lack of "physical space" to move around." | 1.32 | Open space swimming test to index antidepressant activity. ( Alkon, DL; Sun, MK, 2003) |
| "Amitriptyline was studied in greater detail and caused a dose-related (0." | 1.30 | Acute lung failure induced by tricyclic antidepressants. ( Blomgren, B; Dahlin, KL; Lâstbom, L; Ryrfeldt, A, 1997) |
| "On the average, seizures were observed at 40 mg/kg and were seen after desmethylimipramine (50 mg/kg), mianserin (30 mg/kg), amitriptyline (20 mg/kg), imipramine (40 mg/kg), maprotiline (40 mg/kg), and zimelidine (50 mg/kg)." | 1.27 | Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model. ( Bradford, D; Krijzer, F; Snelder, M, 1984) |
| " Moreover, the endocrine and behavioral deficits of bulbectomized rats are reversed by the chronic administration of drugs that reverse the symptoms of depression in people when given chronically." | 1.27 | Effects of antidepressant drugs on the behavior of olfactory bulbectomized and sham-operated rats. ( Jesberger, JA; Richardson, JS, 1986) |
| " Chronic administration of imipramine-HCl (1 and 5 mg/kg, i." | 1.27 | Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice. ( Kameyama, T; Nagasaka, M; Yamada, K, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (20.41) | 18.7374 |
| 1990's | 3 (6.12) | 18.2507 |
| 2000's | 13 (26.53) | 29.6817 |
| 2010's | 22 (44.90) | 24.3611 |
| 2020's | 1 (2.04) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Czopek, A | 1 |
| Bucki, A | 1 |
| Kołaczkowski, M | 1 |
| Zagórska, A | 1 |
| Drop, M | 1 |
| Pawłowski, M | 1 |
| Siwek, A | 1 |
| Głuch-Lutwin, M | 1 |
| Pękala, E | 1 |
| Chrzanowska, A | 1 |
| Struga, M | 1 |
| Partyka, A | 1 |
| Wesołowska, A | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 2 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Oliveira, TQ | 1 |
| de Sousa, CNS | 1 |
| Vasconcelos, GS | 1 |
| de Sousa, LC | 1 |
| de Oliveira, AA | 1 |
| Patrocínio, CFV | 1 |
| Medeiros, IDS | 1 |
| Honório Júnior, JER | 1 |
| Maes, M | 1 |
| Macedo, D | 1 |
| Vasconcelos, SMM | 1 |
| Hamadjida, A | 1 |
| Nuara, SG | 1 |
| Gourdon, JC | 1 |
| Huot, P | 1 |
| Rogóż, Z | 3 |
| Wąsik, A | 1 |
| Lorenc-Koci, E | 1 |
| Okura, T | 1 |
| Ohkawara, B | 1 |
| Takegami, Y | 1 |
| Ito, M | 1 |
| Masuda, A | 1 |
| Seki, T | 1 |
| Ishiguro, N | 1 |
| Ohno, K | 1 |
| Kabziński, M | 1 |
| Sadaj, W | 1 |
| Rachwalska, P | 1 |
| Gądek-Michalska, A | 1 |
| Nakai, K | 1 |
| Nakae, A | 1 |
| Hashimoto, R | 1 |
| Mashimo, T | 1 |
| Hosokawa, K | 1 |
| Yin, J | 2 |
| Song, J | 2 |
| Lei, Y | 1 |
| Xu, X | 1 |
| Chen, JD | 2 |
| Kadoguchi, N | 1 |
| Okabe, S | 1 |
| Yamamura, Y | 1 |
| Shono, M | 1 |
| Fukano, T | 1 |
| Tanabe, A | 1 |
| Yokoyama, H | 1 |
| Kasahara, J | 1 |
| Kálmán, J | 1 |
| Wang, W | 1 |
| Winston, JH | 1 |
| Zhang, R | 1 |
| Kotsovolou, O | 1 |
| Ingelman-Sundberg, M | 1 |
| Lang, MA | 1 |
| Marselos, M | 1 |
| Overstreet, DH | 1 |
| Papadopoulou-Daifoti, Z | 1 |
| Johanson, I | 1 |
| Fotopoulos, A | 1 |
| Konstandi, M | 1 |
| Shioda, K | 2 |
| Nisijima, K | 2 |
| Yoshino, T | 2 |
| Kato, S | 2 |
| Morita, M | 1 |
| Nakayama, K | 1 |
| Kasai, M | 1 |
| Iwamura, T | 1 |
| Kilic, FS | 1 |
| Dogan, AE | 1 |
| Baydemir, C | 1 |
| Erol, K | 1 |
| Enomoto, T | 1 |
| Yamashita, A | 1 |
| Torigoe, K | 1 |
| Horiuchi, H | 1 |
| Hirayama, S | 1 |
| Nakahara, K | 1 |
| Yanase, M | 1 |
| Sakai, H | 1 |
| Ikegami, D | 1 |
| Nagase, H | 1 |
| Suzuki, T | 1 |
| Iseki, M | 1 |
| Inada, E | 1 |
| Narita, M | 1 |
| Ji, CX | 1 |
| Fan, DS | 1 |
| Guo, L | 1 |
| Liang, ZL | 1 |
| Xu, RM | 1 |
| Zhang, JJ | 1 |
| Sener, MT | 1 |
| Sener, E | 1 |
| Tok, A | 1 |
| Polat, B | 1 |
| Cinar, I | 1 |
| Polat, H | 1 |
| Akcay, F | 1 |
| Suleyman, H | 1 |
| Graves, SM | 1 |
| Persons, AL | 1 |
| Riddle, JL | 1 |
| Napier, TC | 1 |
| Kreiss, DS | 1 |
| Coffman, CF | 1 |
| Fiacco, NR | 1 |
| Granger, JC | 1 |
| Helton, BM | 1 |
| Jackson, JC | 1 |
| Kim, LV | 1 |
| Mistry, RS | 1 |
| Mizer, TM | 1 |
| Palmer, LV | 1 |
| Vacca, JA | 1 |
| Winkler, SS | 1 |
| Zimmer, BA | 1 |
| Carlson, BB | 1 |
| Wisniecki, A | 1 |
| Salamone, JD | 1 |
| Schreiber, S | 1 |
| Backler, MM | 1 |
| Herman, I | 1 |
| Shamir, D | 1 |
| Rigai, T | 1 |
| Bar-Hamburger, R | 1 |
| Pick, CG | 1 |
| Sun, MK | 1 |
| Alkon, DL | 1 |
| Bomholt, SF | 1 |
| Mikkelsen, JD | 1 |
| Blackburn-Munro, G | 1 |
| Rauggi, R | 1 |
| Cassanelli, A | 1 |
| Raone, A | 1 |
| Tagliamonte, A | 1 |
| Gambarana, C | 1 |
| Begg, DP | 1 |
| Hallam, KT | 1 |
| Norman, TR | 1 |
| Freynhagen, R | 1 |
| Vogt, J | 1 |
| Lipfert, P | 1 |
| Muth-Selbach, U | 1 |
| Yilmaz, I | 1 |
| Sezer, Z | 1 |
| Kayir, H | 1 |
| Uzbay, TI | 1 |
| Borowicz, KK | 1 |
| Banach, M | 1 |
| Zarczuk, R | 1 |
| Lukasik, D | 1 |
| Luszczki, JJ | 1 |
| Czuczwar, SJ | 1 |
| Zhu, J | 1 |
| Wei, X | 1 |
| Feng, X | 1 |
| Hu, Y | 1 |
| Xu, J | 1 |
| King, GA | 1 |
| Burnham, WM | 1 |
| Leonard, BE | 1 |
| Krijzer, F | 1 |
| Snelder, M | 1 |
| Bradford, D | 1 |
| Hingtgen, JN | 2 |
| Hendrie, HC | 1 |
| Aprison, MH | 2 |
| Katz, RJ | 1 |
| Sibel, M | 1 |
| Nagayama, H | 1 |
| Leitch, IM | 1 |
| Temple, DM | 1 |
| Wei, H | 1 |
| Boura, AL | 1 |
| Dahlin, KL | 1 |
| Lâstbom, L | 1 |
| Blomgren, B | 1 |
| Ryrfeldt, A | 1 |
| Takamori, K | 1 |
| Yoshida, S | 1 |
| Okuyama, S | 1 |
| Roy, A | 1 |
| Mittal, N | 1 |
| Zhang, H | 1 |
| Pandey, SC | 1 |
| Porsolt, RD | 1 |
| Le Pichon, M | 1 |
| Jalfre, M | 1 |
| Wainstein, M | 1 |
| Tannhauser, M | 1 |
| Barros, HM | 1 |
| Bronson, ME | 1 |
| Sparber, SS | 1 |
| Jesberger, JA | 1 |
| Richardson, JS | 1 |
| Kameyama, T | 1 |
| Nagasaka, M | 1 |
| Yamada, K | 1 |
1 review available for mianserin and Disease Models, Animal
| Article | Year |
|---|---|
[Genomical and metabolomical abnormalities in Alzheimer disease and in experimental models].
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antidepressive Agents; Apolipoprotein E4 | 2008 |
48 other studies available for mianserin and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Humans; Receptors, Serotonin; St | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone.
Topics: Animals; Antidepressive Agents, Tricyclic; Antioxidants; Brain; Brain-Derived Neurotrophic Factor; C | 2017 |
The effect of mianserin on the severity of psychosis and dyskinesia in the parkinsonian marmoset.
Topics: Animals; Antidepressive Agents, Second-Generation; Callithrix; Disease Models, Animal; Dose-Response | 2018 |
Combined treatment with aripiprazole and antidepressants reversed some MK-801-induced schizophrenia-like symptoms in mice.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Aripiprazole; Citalopram; Disease Models, Anim | 2018 |
Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis.
Topics: Animals; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Female; Male; Mianserin; Osteoa | 2019 |
Effect of co-treatment with fluoxetine or mirtazapine and risperidone on the active behaviors and plasma corticosterone concentration in rats subjected to the forced swim test.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsychotic A | 2012 |
Effect of co-treatment with mirtazapine and risperidone in animal models of the positive symptoms of schizophrenia in mice.
Topics: Amphetamines; Animals; Antipsychotic Agents; Behavior, Animal; Dextroamphetamine; Disease Models, An | 2012 |
Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats.
Topics: Adrenergic alpha-Antagonists; Amines; Analgesics; Animals; Cranial Nerve Injuries; Cyclohexanecarbox | 2014 |
Prokinetic effects of mirtazapine on gastrointestinal transit.
Topics: Administration, Oral; Animals; Antidepressive Agents, Tricyclic; Colon; Disease Models, Animal; Dogs | 2014 |
Mirtazapine has a therapeutic potency in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice model of Parkinson's disease.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Disease Models, Animal; Feasibility Studies; Male; | 2014 |
Ameliorating effects of mirtazapine on visceral hypersensitivity in rats with neonatal colon sensitivity.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Colon; Disease Models, Animal; Dose | 2010 |
Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Blotting, Western; Chromatography, | 2010 |
Mirtazapine abolishes hyperthermia in an animal model of serotonin syndrome.
Topics: Animals; Body Temperature; Disease Models, Animal; Fever; Male; Mianserin; Mirtazapine; Rats; Rats, | 2010 |
Mirtazapine in combination with perospirone synergistically enhances dopamine release in the rat prefrontal cortex via 5-HT1A receptor activation.
Topics: Animals; Depression; Disease Models, Animal; Dopamine; Drug Resistance; Drug Synergism; Drug Therapy | 2011 |
The effects of mirtazapine and fluoxetine on hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Disease Models, Animal; Fever; Fluoxetine; Male; Mianseri | 2011 |
The acute effects of mirtazapine on pain related behavior in healthy animals.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Arginine; Behavior, Animal; Cyprohe | 2011 |
Effects of mirtazapine on sleep disturbance under neuropathic pain-like state.
Topics: Animals; Disease Models, Animal; Histamine H1 Antagonists; Hyperalgesia; Male; Mianserin; Mice; Mice | 2012 |
Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats.
Topics: Amitriptyline; Animals; Anti-Ulcer Agents; Antidepressive Agents; Disease Models, Animal; Duloxetine | 2012 |
Biochemical and histologic study of lethal cisplatin nephrotoxicity prevention by mirtazapine.
Topics: Animals; Antidepressive Agents, Tricyclic; Antineoplastic Agents; Antioxidants; Blood Urea Nitrogen; | 2012 |
The atypical antidepressant mirtazapine attenuates expression of morphine-induced place preference and motor sensitization.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Conditionin | 2012 |
Ritualistic chewing behavior induced by mCPP in the rat is an animal model of obsessive compulsive disorder.
Topics: Animals; Behavior, Animal; Clomipramine; Diazepam; Disease Models, Animal; Dopamine Antagonists; Flu | 2013 |
Local injections of the 5-hydroxytryptamine antagonist mianserin into substantia nigra pars reticulata block tremulous jaw movements in rats: studies with a putative model of Parkinsonian tremor.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injections; | 2003 |
Mianserin and trazodone significantly attenuate the intensity of opioid withdrawal symptoms in mice.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Anti-Anxiety Agents; Disease Models, An | 2003 |
Open space swimming test to index antidepressant activity.
Topics: Alanine; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Drug | 2003 |
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain.
Topics: Acute Disease; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Citalopra | 2005 |
Study of mirtazapine antidepressant effects in rats.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Drug Admin | 2005 |
Attenuation of benzodiazepine withdrawal anxiety in the rat by serotonin antagonists.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Interpers | 2005 |
Mirtazapine and its enantiomers differentially modulate acute thermal nociception in rats.
Topics: Afferent Pathways; Animals; Antidepressive Agents, Tricyclic; Central Nervous System; Disease Models | 2006 |
Mirtazapine does not affect pentylenetetrazole- and maximal electroconvulsive shock-induced seizures in mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Chi-Square Distribution; Depressive | 2007 |
Acute and chronic treatment with mianserin differentially affects the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model.
Topics: Analysis of Variance; Animals; Anticonvulsants; Antidepressive Agents, Second-Generation; Brain; Car | 2007 |
Repeated administration of mirtazapine inhibits development of hyperalgesia/allodynia and activation of NF-kappaB in a rat model of neuropathic pain.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Cytokines; Denervation; Disease Models, Animal; Do | 2008 |
alpha 2-adrenergic antagonists suppress epileptiform EEG activity in a petit mal seizure model.
Topics: Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Elec | 1982 |
Pharmacology of new antidepressants.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder; Disease Models, Animal; Dopamine; Humans | 1984 |
Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Dose-Response Re | 1984 |
Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Depression; Disease Models, Animal; Humans; Male; Methy | 1984 |
Animal model of depression: tests of three structurally and pharmacologically novel antidepressant compounds.
Topics: Animals; Antidepressive Agents; Bupropion; Corticosterone; Depressive Disorder; Disease Models, Anim | 1982 |
Postsynaptic action by four antidepressive drugs in an animal model of depression.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Di | 1981 |
Some anti-allergic and anti-inflammatory actions of 2-N-carboxamidinonormianserin (FCC5).
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug | 1995 |
Acute lung failure induced by tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Disease Models, Animal; Dose- | 1997 |
Availability of learned helplessness test as a model of depression compared to a forced swimming test in rats.
Topics: Amoxapine; Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Depression; Disease Model | 2001 |
Modulation of cellular expression of glucocorticoid receptor and glucocorticoid response element-DNA binding in rat brain during alcohol drinking and withdrawal.
Topics: Adaptation, Biological; Alcohol Drinking; Animals; Cerebral Cortex; Disease Models, Animal; DNA; Eth | 2002 |
Depression: a new animal model sensitive to antidepressant treatments.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Electroshock; Humans; Iprindole; | 1977 |
Lack of tolerance to imipramine or mianserine in two animal models of depression.
Topics: Amphetamine; Animals; Anorexia; Behavior, Animal; Depression; Disease Models, Animal; Dose-Response | 1990 |
Profile of opioid withdrawal in newly hatched chickens.
Topics: Animals; Arousal; Brain; Chick Embryo; Chickens; Disease Models, Animal; Dose-Response Relationship, | 1989 |
Effects of antidepressant drugs on the behavior of olfactory bulbectomized and sham-operated rats.
Topics: 11-Hydroxycorticosteroids; Amitriptyline; Animals; Antidepressive Agents; Brain Diseases; Depressive | 1986 |
Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice.
Topics: Acridines; Amitriptyline; Animals; Antidepressive Agents; Depressive Disorder; Desipramine; Diphenhy | 1985 |