Page last updated: 2024-10-31

mianserin and Depression

mianserin has been researched along with Depression in 258 studies

Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
" The goal of this study was to investigate the association and causal relationship between mirtazapine treatment of patients with depression and pancreatitis."9.41Mirtazapine-induced Acute Pancreatitis in Patients With Depression: A Systematic Review. ( Janković, SM; Kostić, MJ; Milosavljević, MN; Pejčić, AV, 2023)
"To evaluate the efficacy and safety of mirtazapine in Japanese patients with fibromyalgia (FM), a parallel-group, randomized, double-blind, placebo-controlled phase IIa study was conducted at 57 sites between November 2012 and February 2014."9.22Efficacy of mirtazapine for the treatment of fibromyalgia without concomitant depression: a randomized, double-blind, placebo-controlled phase IIa study in Japan. ( Miki, K; Murakami, M; Oka, H; Onozawa, K; Osada, K; Yoshida, S, 2016)
"Mirtazapine not only alleviates symptoms associated with dyspepsia and depression linked to FD in patients with weight loss but also significantly increases body weight (mainly the visceral fat in body fat)."9.22Beneficial effects of antidepressant mirtazapine in functional dyspepsia patients with weight loss. ( Jia, L; Jiang, SM; Liu, J; Shi, MM; Xu, MZ, 2016)
" (1) The secondary analyses presented here suggest that there would be value in carrying out a placebo-controlled trial of the clinical effectiveness and cost-effectiveness of mirtazapine in the management of Behavioural and Psychological Symptoms of Dementia."9.17Study of the use of antidepressants for depression in dementia: the HTA-SADD trial--a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine. ( Baldwin, R; Ballard, C; Banerjee, S; Bentham, P; Burns, A; Dewey, M; Fox, C; Hellier, J; Holmes, C; Katona, C; Knapp, M; Lawton, C; Lindesay, J; Livingston, G; McCrae, N; Moniz-Cook, E; Murray, J; Nurock, S; O'Brien, J; Orrell, M; Poppe, M; Romeo, R; Thomas, A; Walwyn, R; Wilson, K, 2013)
"To evaluate the cost-effectiveness of sertraline and mirtazapine compared with placebo for depression in dementia."9.17Cost-effectiveness analyses for mirtazapine and sertraline in dementia: randomised controlled trial. ( Baldwin, R; Ballard, C; Banerjee, S; Bentham, P; Burns, A; Dewey, M; Fox, C; Hellier, J; Holmes, C; Katona, C; Knapp, M; Lawton, C; Lindesay, J; Livingston, G; McCrae, N; Moniz-Cook, E; Murray, J; Nurock, S; O'Brien, J; Poppe, M; Romeo, R; Thomas, A; Walwyn, R; Wilson, K, 2013)
" Eighteen patients had at least moderate depression before mirtazapine treatment and 8 patients presented mild depressive symptoms."9.11Open trial of mirtazapine in patients with fibromyalgia. ( Lezanska-Szpera, M; Rybakowski, JK; Samborski, W, 2004)
"We assessed the prevalence and associations of symptoms of insomnia in patients with acute ischemic stroke, and evaluated whether mianserin as a sedative antidepressant is beneficial in the treatment of poststroke insomnia."9.10Complaints of poststroke insomnia and its treatment with mianserin. ( Berg, A; Kaste, M; Lehtihalmes, M; Lönnqvist, J; Lönnqvist, R; Meririnne, E; Palomäki, H, 2003)
"(1) To test whether early prophylactic antidepressive treatment by mianserin is able to prevent poststroke depression, and (2) to discover whether mianserin as an antidepressant has any beneficial influence on the outcome of ischaemic stroke."9.09Prevention of poststroke depression: 1 year randomised placebo controlled double blind trial of mianserin with 6 month follow up after therapy. ( Berg, A; Hares, J; Kaste, M; Lehtihalmes, M; Lönnqvist, J; Lönnqvist, R; Palomäki, H, 1999)
"To examine the prophylactic effect of mianserin on depressive episode, 26 patients with recurrent depression were randomly allocated on a double-blind basis to treatment with either inactive placebo (PL group) or mianserin in daily dose of 20-60 mg (MIA group) for 18 months and the frequencies or durations of depressive episode during the treatment were compared between the two groups."9.07[A controlled study of the prophylactic effect of mianserin and placebo in recurrent depression]. ( Hazama, H; Kamase, H; Kishimoto, A; Kunimoto, N; Mizukawa, R; Tanaka, K, 1993)
"Forty-two patients aged between 19 and 70 years (30 women and 12 men) suffering from primary unipolar depression were randomly selected and treated under double-blind conditions with either mianserin (Lantanon; Organon) or clomipramine (Anafranil; Ciba-Geigy) after an initial wash-out period."9.05Mianserin and clomipramine in the treatment of depression. ( Levin, A, 1982)
"A double-blind trial was carried out in 47 patients with depression to compare the effectiveness of 30 mg mianserin, 60 mg mianserin and 50 mg sustained-release amitriptyline, each given as a single dose at night over a period of 4 weeks."9.05A double-blind controlled trial of mianserin and amitriptyline in depression. ( Mehta, BM; Spear, FG; Whittington, JR, 1980)
" In a third trial, mianserin was found to be as effective as diazepam in the treatment of anxiety states in general practice."9.04Mianserin in the treatment of depressive illness and anxiety states in general practice. ( Murphy, JE, 1978)
"The aim of the present review was to assess the evidence on the efficacy and acceptability of mirtazapine compared with other antidepressive agents in the acute-phase treatment of major depression in adults."8.87Mirtazapine versus other antidepressive agents for depression. ( Barbui, C; Churchill, R; Cipriani, A; Furukawa, TA; Nakagawa, A; Omori, IM; Watanabe, N, 2011)
"Available data suggest that mirtazapine is a cost-effective alternative to amitriptyline and fluoxetine for the treatment of depression."8.80Mirtazapine. A pharmacoeconomic review of its use in depression. ( Foster, RH; Holm, KJ; Jarvis, B, 2000)
"This study evaluated the clinical efficacy of mirtazapine and its effect on serum brain-derived neurotrophic factor (BDNF) and tumor necrosis factor-α (TNF-α) levels in patients of major-depressive disorder (MDD) with severe depression."7.83Effect of Mirtazapine Treatment on Serum Levels of Brain-Derived Neurotrophic Factor and Tumor Necrosis Factor-α in Patients of Major Depressive Disorder with Severe Depression. ( Bhatia, MS; Gupta, K; Gupta, LK; Gupta, R; Tripathi, AK, 2016)
" We suspected that these symptoms were related to side effects caused by the milnacipran she was taking for depression, prior to hospitalization."7.83Probable Serotonin Syndrome and Withdrawal Symptoms Caused by Milnacipran. ( Koshiishi, T; Okuyama, K, 2016)
"We conducted a nested case-control study to evaluate the association between risk of cancer and mirtazapine use in depression patients in Taiwan."7.79Does use of tetracyclic antidepressant-mirtazapine reduce cancer risk in depression patients? ( Chang, SN; Chang, YJ; Kao, CH; Liang, JA; Lin, MC; Muo, CH; Sun, LM; Sung, FC, 2013)
" This report presents the beneficial effect of low-dose mirtazapine added onto selective serotonin reuptake inhibitors in the treatment of the symptoms of severe nausea, insomnia and loss of appetite accompanying psychiatric disorders during pregnancy, which is an important problem in clinical practice."7.79Low-dose mirtazapine added to selective serotonin reuptake inhibitors in pregnant women with major depression or panic disorder including symptoms of severe nausea, insomnia and decreased appetite: three cases. ( Uguz, F, 2013)
"We describe a patient originally suffering from a depressive syndrome who developed Stevens-Johnson syndrome after 12 days of treatment with lamotrigine."7.75Neopterin and C-reactive protein in the course of Stevens-Johnson syndrome: report of a case. ( Bertram, L; Grözinger, M; Liss, Y, 2009)
" Recent findings have shown, that adipocytokines leptin and adiponectin might play a role in both depression and MetS."7.75Leptin, adiponectin, leptin to adiponectin ratio and insulin resistance in depressive women. ( Jachymova, M; Jirak, R; Tvrzicka, E; Vecka, M; Zak, A; Zeman, M, 2009)
"Two patients, a 61-year-old man and a 79-year-old woman, developed profound hyponatremia (sodium levels, 112 and 113 mEq/L, respectively) 7 and 10 days after commencement of mirtazapine for symptoms of depression."7.74Mirtazapine associated with profound hyponatremia: two case reports. ( Cheah, CY; Fegan, PG; Ladhams, B, 2008)
"Mirtazapine is known to often provoke restless legs syndrome (RLS)."7.74Factors potentiating the risk of mirtazapine-associated restless legs syndrome. ( Kim, JM; Kim, SW; Park, KH; Shin, IS; Yoon, JS; Youn, T, 2008)
"To evaluate the safety, tolerability and efficacy of mirtazapine in patients with the primary diagnosis of chronic pain and concomitant depression in an open post-marketing surveillance study."7.73The effect of mirtazapine in patients with chronic pain and concomitant depression. ( Freynhagen, R; Lipfert, P; Muth-Selbach, U; Stevens, MF; Tölle, TR; von Giesen, HJ; Zacharowski, K, 2006)
"Shortly after initiation of mirtazapine (a noradrenergic and serotonergic antidepressant) treatment in four patients with parkinsonism, the authors observed the appearance of REM sleep behavior disorder (RBD)."7.72Mirtazapine induces REM sleep behavior disorder (RBD) in parkinsonism. ( D'Andreamatteo, G; Iacono, D; Luciano, AL; Onofrj, M; Thomas, A, 2003)
"Three patients with dementia and depression complicated by weight loss, insomnia, and anxiety were treated with mirtazapine at an outpatient memory loss clinic of a university hospital."7.71Mirtazapine for treatment of depression and comorbidities in Alzheimer disease. ( Brady, SR; Raji, MA, 2001)
"To document a case of serotonin syndrome (SS) associated with mirtazapine monotherapy, review the previously reported cases of SS associated with this tetracyclic antidepressant, and discuss the possible pathogenic mechanisms leading to this serious adverse drug reaction."7.71Severe serotonin syndrome induced by mirtazapine monotherapy. ( González-Macías, J; Hernández, JL; Infante, J; Ramos, FJ; Rebollo, M, 2002)
"This study modelled the economic impact of mirtazapine, compared to amitriptyline and fluoxetine, in the management of moderate and severe depression in the UK, as well as the costs related to discontinuation of antidepressant treatment."7.70Economic impact of using mirtazapine compared to amitriptyline and fluoxetine in the treatment of moderate and severe depression in the UK. ( Borghi, J; Guest, JF, 2000)
" To further investigate a previous postulate that increased serotonergic activity may cause depression, the effects of chronic mianserin administration on 5-HT, its metabolites, and the subtypes of 5-HT receptors were studied."7.69Effects of chronic mianserin administration on serotonin metabolism and receptors in the 5-hydroxytryptophan depression model. ( Akiyoshi, J; Kuranaga, H; Mizobe, Y; Nagayama, H; Nakamura, M; Tsuchiyama, K, 1994)
"This study was designed to validate a novel animal model of depression by testing the curative effects of the atypical antidepressant mianserin."7.69Curative effects of the atypical antidepressant mianserin in the chronic mild stress-induced anhedonia model of depression. ( Bourson, A; Jenck, F; Martin, JR; Moreau, JL; Mortas, P, 1994)
" Imipramine and mianserine potentiated amphetamine-induced anorexia both after acute administration or after prolonged previous treatment with each drug."7.68Lack of tolerance to imipramine or mianserine in two animal models of depression. ( Barros, HM; Tannhauser, M; Wainstein, M, 1990)
"Acute pretreatment with clinically equivalent doses of antidepressive drugs has been observed to block D,L-5-hydroxytryptophan (5-HTP) induced behavioral depression in rats working on a food-reinforced operant schedule."7.67Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. ( Aprison, MH; Hendrie, HC; Hingtgen, JN, 1984)
"The introduction of two tricyclic compounds (iprindole and mianserin) that are reported to have antidepressant properties but to be relatively devoid of effects on central amine neurotransmitter systems has raised questions about the amine hypothesis of depression and about the mechanism of action of tricyclics in general."7.66Novel antidepressants and the biogenic amine hypothesis of depression. The case for iprindole and mianserin. ( Goodwin, FK; Zis, AP, 1979)
"People with depression are usually managed in primary care and antidepressants are often the first-line treatment, but only one third of patients respond fully to a single antidepressant."6.82Mirtazapine added to selective serotonin reuptake inhibitors for treatment-resistant depression in primary care (MIR trial): study protocol for a randomised controlled trial. ( Anderson, IM; Campbell, J; Chew-Graham, C; Davies, S; Dickens, C; Gilbody, S; Hollingworth, W; Kessler, D; Lewis, G; Macleod, U; Peters, TJ; Tallon, D; Wiles, N, 2016)
"Depression is common in schizophrenia and worsens its course."6.76Add-on mirtazapine improves depressive symptoms in schizophrenia: a double-blind randomized placebo-controlled study with an open-label extension phase. ( Burkin, M; Joffe, G; Joffe, M; Stenberg, JH; Tchoukhine, E; Terevnikov, V; Tiihonen, J, 2011)
" Maximum flexibility of the dosage of mirtazapine was allowed, and clinical assessments included MADRS, CGI, vital signs and spontaneous reporting of adverse events."6.72Mirtazapine naturalistic depression study (in Sweden)--MINDS(S): clinical efficacy and safety. ( Ahlner, J; Bengtsson, F; Dahl, ML; Odén, A; Prochazka, J; Sjödin, I; Wålinder, J, 2006)
"Mirtazapine is an effective treatment for major depression in perimenopausal and postmenopausal women whose depression precedes ERT use and does not respond to ERT or whose depression develops after ERT is initiated."6.70An open trial of mirtazapine in menopausal women with depression unresponsive to estrogen replacement therapy. ( Cohen, LS; Groninger, H; Joffe, H; Nonacs, R; Soares, C; Soares, CN, 2001)
"Mood depression was evaluated at 0, 4 and 8 weeks by using Zung's Self-Rating Depression Scale and Hamilton Rating Scale for Depression."6.67Chronic tension-type headache, mood depression and serotonin: therapeutic effects of fluvoxamine and mianserine. ( Bolino, F; Di Cicco, L; Manna, V, 1994)
"Mianserin was given at a dose of 30 mg for the first 7 days followed by 60 mg daily for the remaining 5 weeks."6.66The drug treatment of depression in general practice: a comparison of nocte administration of trazodone with mianserin, dothiepin and amitriptyline. ( Blacker, R; Chapman, N; Davey, A; Shanks, NJ, 1988)
"Depression is a major complication of cancer."6.66Efficacy and safety of mianserin in the treatment of depression of women with cancer. ( Costa, D; Mogos, I; Toma, T, 1985)
" The dosage for the first week was 25 mg t."6.64A comparative clinical trial of mianserin (Norval) and amitriptyline in the treatment of depression in general practice. ( Bridgman, KM; Murphy, JE, 1978)
" After one year, the dosage of mianserin was increased to 30 mg t."6.64Mianserin and lithium in the prophylaxis of depression. ( Bailey, J; Coppen, A; Ghose, K; Peet, M; Rao, R, 1978)
"Mirtazapine has demonstrated superior tolerability to the tricyclic antidepressants and trazodone, primarily on account of its relative absence of anticholinergic, adrenergic and serotonin-related adverse effects, in particular gastrointestinal adverse effects and sexual dysfunction."6.40A risk-benefit assessment of mirtazapine in the treatment of depression. ( Kasper, S; Praschak-Rieder, N; Tauscher, J; Wolf, R, 1997)
" The goal of this study was to investigate the association and causal relationship between mirtazapine treatment of patients with depression and pancreatitis."5.41Mirtazapine-induced Acute Pancreatitis in Patients With Depression: A Systematic Review. ( Janković, SM; Kostić, MJ; Milosavljević, MN; Pejčić, AV, 2023)
"Depression is a common problem in elderly patients and frequently is treated with antidepressants."5.33Recurrent hyponatremia associated with citalopram and mirtazapine. ( Akcay, A; Bavbek, N; Kargili, A; Kaya, A, 2006)
"Taurine has been known to be related to certain modifications of the immune system."5.32Taurine concentration in human blood peripheral lymphocytes: major depression and treatment with the antidepressant mirtazapine. ( Baccichet, E; Carreira, I; Lima, L; Obregón, F; Peña, S; Urbina, M, 2003)
"To evaluate the efficacy and safety of mirtazapine in Japanese patients with fibromyalgia (FM), a parallel-group, randomized, double-blind, placebo-controlled phase IIa study was conducted at 57 sites between November 2012 and February 2014."5.22Efficacy of mirtazapine for the treatment of fibromyalgia without concomitant depression: a randomized, double-blind, placebo-controlled phase IIa study in Japan. ( Miki, K; Murakami, M; Oka, H; Onozawa, K; Osada, K; Yoshida, S, 2016)
"Mirtazapine not only alleviates symptoms associated with dyspepsia and depression linked to FD in patients with weight loss but also significantly increases body weight (mainly the visceral fat in body fat)."5.22Beneficial effects of antidepressant mirtazapine in functional dyspepsia patients with weight loss. ( Jia, L; Jiang, SM; Liu, J; Shi, MM; Xu, MZ, 2016)
" (1) The secondary analyses presented here suggest that there would be value in carrying out a placebo-controlled trial of the clinical effectiveness and cost-effectiveness of mirtazapine in the management of Behavioural and Psychological Symptoms of Dementia."5.17Study of the use of antidepressants for depression in dementia: the HTA-SADD trial--a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine. ( Baldwin, R; Ballard, C; Banerjee, S; Bentham, P; Burns, A; Dewey, M; Fox, C; Hellier, J; Holmes, C; Katona, C; Knapp, M; Lawton, C; Lindesay, J; Livingston, G; McCrae, N; Moniz-Cook, E; Murray, J; Nurock, S; O'Brien, J; Orrell, M; Poppe, M; Romeo, R; Thomas, A; Walwyn, R; Wilson, K, 2013)
"To evaluate the cost-effectiveness of sertraline and mirtazapine compared with placebo for depression in dementia."5.17Cost-effectiveness analyses for mirtazapine and sertraline in dementia: randomised controlled trial. ( Baldwin, R; Ballard, C; Banerjee, S; Bentham, P; Burns, A; Dewey, M; Fox, C; Hellier, J; Holmes, C; Katona, C; Knapp, M; Lawton, C; Lindesay, J; Livingston, G; McCrae, N; Moniz-Cook, E; Murray, J; Nurock, S; O'Brien, J; Poppe, M; Romeo, R; Thomas, A; Walwyn, R; Wilson, K, 2013)
" Eighteen patients had at least moderate depression before mirtazapine treatment and 8 patients presented mild depressive symptoms."5.11Open trial of mirtazapine in patients with fibromyalgia. ( Lezanska-Szpera, M; Rybakowski, JK; Samborski, W, 2004)
"We assessed the prevalence and associations of symptoms of insomnia in patients with acute ischemic stroke, and evaluated whether mianserin as a sedative antidepressant is beneficial in the treatment of poststroke insomnia."5.10Complaints of poststroke insomnia and its treatment with mianserin. ( Berg, A; Kaste, M; Lehtihalmes, M; Lönnqvist, J; Lönnqvist, R; Meririnne, E; Palomäki, H, 2003)
" We sought to determine if the APOE epsilon4 allele influences response in geriatric depression to mirtazapine and paroxetine, two frequently prescribed antidepressants."5.10The apolipoprotein E epsilon4 allele and antidepressant efficacy in cognitively intact elderly depressed patients. ( Kremer, C; Murphy, GM; Rodrigues, H; Schatzberg, AF, 2003)
"(1) To test whether early prophylactic antidepressive treatment by mianserin is able to prevent poststroke depression, and (2) to discover whether mianserin as an antidepressant has any beneficial influence on the outcome of ischaemic stroke."5.09Prevention of poststroke depression: 1 year randomised placebo controlled double blind trial of mianserin with 6 month follow up after therapy. ( Berg, A; Hares, J; Kaste, M; Lehtihalmes, M; Lönnqvist, J; Lönnqvist, R; Palomäki, H, 1999)
"To examine the prophylactic effect of mianserin on depressive episode, 26 patients with recurrent depression were randomly allocated on a double-blind basis to treatment with either inactive placebo (PL group) or mianserin in daily dose of 20-60 mg (MIA group) for 18 months and the frequencies or durations of depressive episode during the treatment were compared between the two groups."5.07[A controlled study of the prophylactic effect of mianserin and placebo in recurrent depression]. ( Hazama, H; Kamase, H; Kishimoto, A; Kunimoto, N; Mizukawa, R; Tanaka, K, 1993)
"This 6-week, double-blind, randomised parallel group study was carried out to assess the efficacy and tolerability of 150 mg trazodone nocte and 30-60 mg mianserin nocte in the treatment of depression in general practice."5.06The efficacy and residual effects of trazodone (150 mg nocte) and mianserin in the treatment of depressed general practice patients. ( Davey, A; Moon, CA, 1988)
" Forty-six patients with moderate to severe degrees of depression were treated at random with mianserin or diazepam."5.04Comparative double-blind trial of mianserin hydrochloride (Organon GB94) and diazepam in patients with depressive illness. ( Niaz, U; Russell, GF; Slade, PD; Wakeling, A, 1978)
" In a third trial, mianserin was found to be as effective as diazepam in the treatment of anxiety states in general practice."5.04Mianserin in the treatment of depressive illness and anxiety states in general practice. ( Murphy, JE, 1978)
"Limited evidence suggests that for certain elderly patients, mirtazapine may be preferable to sertraline for treatment of depression."4.89Sertraline and mirtazapine as geriatric antidepressants. ( Bhogle, M; Holland, J, 2013)
"The aim of the present review was to assess the evidence on the efficacy and acceptability of mirtazapine compared with other antidepressive agents in the acute-phase treatment of major depression in adults."4.87Mirtazapine versus other antidepressive agents for depression. ( Barbui, C; Churchill, R; Cipriani, A; Furukawa, TA; Nakagawa, A; Omori, IM; Watanabe, N, 2011)
"Available data suggest that mirtazapine is a cost-effective alternative to amitriptyline and fluoxetine for the treatment of depression."4.80Mirtazapine. A pharmacoeconomic review of its use in depression. ( Foster, RH; Holm, KJ; Jarvis, B, 2000)
" Does this mean that the SSRIs, moclobemide and mianserin should be the treatment of first choice for depression? On balance, the evidence presented in this article would suggest rather that the new agents and TCAs should all be considered first-line agents."4.79The management of depression. Part 2. The place of the new antidepressants. ( Mitchell, MS; Mitchell, PB, 1994)
"Mianserin is a tetracyclic compound advocated for the treatment of depressive illness and depression associated with anxiety."4.75Mianserin: a review of its pharmacological properties and therapeutic efficacy in depressive illness. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1978)
"This study evaluated the clinical efficacy of mirtazapine and its effect on serum brain-derived neurotrophic factor (BDNF) and tumor necrosis factor-α (TNF-α) levels in patients of major-depressive disorder (MDD) with severe depression."3.83Effect of Mirtazapine Treatment on Serum Levels of Brain-Derived Neurotrophic Factor and Tumor Necrosis Factor-α in Patients of Major Depressive Disorder with Severe Depression. ( Bhatia, MS; Gupta, K; Gupta, LK; Gupta, R; Tripathi, AK, 2016)
" We suspected that these symptoms were related to side effects caused by the milnacipran she was taking for depression, prior to hospitalization."3.83Probable Serotonin Syndrome and Withdrawal Symptoms Caused by Milnacipran. ( Koshiishi, T; Okuyama, K, 2016)
"To assess whether the use of selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, mirtazapine, venlafaxine or other antidepressants is associated with late elective termination of pregnancy."3.81Use of antidepressants and association with elective termination of pregnancy: population based case-control study. ( Artama, M; Engeland, A; Furu, K; Gissler, M; Haglund, B; Kieler, H; Malm, H; Nørgaard, M; Stephansson, O; Valdimarsdottir, U; Zoega, H, 2015)
" The purpose of our study was to determine if antidepressants improve depression via the NO pathway using an acute depressive rat model induced by L-arginine (AR)."3.81Antidepressant action via the nitric oxide system: A pilot study in an acute depressive model induced by arginin. ( Abe, M; Mori, Y; Nakata, S; Ochi, S; Ueno, S; Yamazaki, K; Yoshino, Y, 2015)
" Authors report a case of a 65-year old male patient who was treated with venlafaxine-mirtazapine combination for recurrent depression."3.79[Antidepressant treatment associated hyponatremia -- case report]. ( Bognár, Z; Gazdag, G; Vonyik, G, 2013)
"We conducted a nested case-control study to evaluate the association between risk of cancer and mirtazapine use in depression patients in Taiwan."3.79Does use of tetracyclic antidepressant-mirtazapine reduce cancer risk in depression patients? ( Chang, SN; Chang, YJ; Kao, CH; Liang, JA; Lin, MC; Muo, CH; Sun, LM; Sung, FC, 2013)
" This report presents the beneficial effect of low-dose mirtazapine added onto selective serotonin reuptake inhibitors in the treatment of the symptoms of severe nausea, insomnia and loss of appetite accompanying psychiatric disorders during pregnancy, which is an important problem in clinical practice."3.79Low-dose mirtazapine added to selective serotonin reuptake inhibitors in pregnant women with major depression or panic disorder including symptoms of severe nausea, insomnia and decreased appetite: three cases. ( Uguz, F, 2013)
"Several clinical reports have postulated a beneficial effect of the addition of a low dose of risperidone to the ongoing treatment with antidepressants in treatment-resistant depression."3.78Effect of co-treatment with fluoxetine or mirtazapine and risperidone on the active behaviors and plasma corticosterone concentration in rats subjected to the forced swim test. ( Gądek-Michalska, A; Kabziński, M; Rachwalska, P; Rogóż, Z; Sadaj, W, 2012)
"The purpose of this study was to elucidate the mechanism underlying the clinical efficacy of mirtazapine-perospirone combination therapy for treatment-resistant depression in a rat model."3.77Mirtazapine in combination with perospirone synergistically enhances dopamine release in the rat prefrontal cortex via 5-HT1A receptor activation. ( Morita, M; Nakayama, K, 2011)
"Mirtazapine is a new antidepressant used in last years, however experience with it during pregnancy is unsatisfactory on the present."3.76Embryotoxicity of mirtazapine: a study using Chick Embryotoxicity Screening Test. ( Hubickova, L; Kostalova, J; Manakova, E; Zemanova, Z, 2010)
"We describe a patient originally suffering from a depressive syndrome who developed Stevens-Johnson syndrome after 12 days of treatment with lamotrigine."3.75Neopterin and C-reactive protein in the course of Stevens-Johnson syndrome: report of a case. ( Bertram, L; Grözinger, M; Liss, Y, 2009)
" Recent findings have shown, that adipocytokines leptin and adiponectin might play a role in both depression and MetS."3.75Leptin, adiponectin, leptin to adiponectin ratio and insulin resistance in depressive women. ( Jachymova, M; Jirak, R; Tvrzicka, E; Vecka, M; Zak, A; Zeman, M, 2009)
"Two patients, a 61-year-old man and a 79-year-old woman, developed profound hyponatremia (sodium levels, 112 and 113 mEq/L, respectively) 7 and 10 days after commencement of mirtazapine for symptoms of depression."3.74Mirtazapine associated with profound hyponatremia: two case reports. ( Cheah, CY; Fegan, PG; Ladhams, B, 2008)
"Mirtazapine is known to often provoke restless legs syndrome (RLS)."3.74Factors potentiating the risk of mirtazapine-associated restless legs syndrome. ( Kim, JM; Kim, SW; Park, KH; Shin, IS; Yoon, JS; Youn, T, 2008)
"To evaluate the safety, tolerability and efficacy of mirtazapine in patients with the primary diagnosis of chronic pain and concomitant depression in an open post-marketing surveillance study."3.73The effect of mirtazapine in patients with chronic pain and concomitant depression. ( Freynhagen, R; Lipfert, P; Muth-Selbach, U; Stevens, MF; Tölle, TR; von Giesen, HJ; Zacharowski, K, 2006)
"Shortly after initiation of mirtazapine (a noradrenergic and serotonergic antidepressant) treatment in four patients with parkinsonism, the authors observed the appearance of REM sleep behavior disorder (RBD)."3.72Mirtazapine induces REM sleep behavior disorder (RBD) in parkinsonism. ( D'Andreamatteo, G; Iacono, D; Luciano, AL; Onofrj, M; Thomas, A, 2003)
"Three patients with dementia and depression complicated by weight loss, insomnia, and anxiety were treated with mirtazapine at an outpatient memory loss clinic of a university hospital."3.71Mirtazapine for treatment of depression and comorbidities in Alzheimer disease. ( Brady, SR; Raji, MA, 2001)
"To document a case of serotonin syndrome (SS) associated with mirtazapine monotherapy, review the previously reported cases of SS associated with this tetracyclic antidepressant, and discuss the possible pathogenic mechanisms leading to this serious adverse drug reaction."3.71Severe serotonin syndrome induced by mirtazapine monotherapy. ( González-Macías, J; Hernández, JL; Infante, J; Ramos, FJ; Rebollo, M, 2002)
"This study modelled the economic impact of mirtazapine, compared to amitriptyline and fluoxetine, in the management of moderate and severe depression in the UK, as well as the costs related to discontinuation of antidepressant treatment."3.70Economic impact of using mirtazapine compared to amitriptyline and fluoxetine in the treatment of moderate and severe depression in the UK. ( Borghi, J; Guest, JF, 2000)
"In two women with depression a reduction in hot flushes was noticed by serendipity during treatment with mirtazapine 15-30 mg/daily."3.70Treatment of hot flushes with mirtazapine: four case reports. ( Berendsen, HH; Schweitzer, DH; Waldinger, MD, 2000)
" To further investigate a previous postulate that increased serotonergic activity may cause depression, the effects of chronic mianserin administration on 5-HT, its metabolites, and the subtypes of 5-HT receptors were studied."3.69Effects of chronic mianserin administration on serotonin metabolism and receptors in the 5-hydroxytryptophan depression model. ( Akiyoshi, J; Kuranaga, H; Mizobe, Y; Nagayama, H; Nakamura, M; Tsuchiyama, K, 1994)
"We have previously found that repeated phencyclidine (PCP) treatment enhances the immobility induced by forced swimming and suggested that this behavioral change could be used as a model of the negative symptoms, particularly depression, of schizophrenia."3.69Effects of antidepressants on phencyclidine-induced enhancement of immobility in a forced swimming test in mice. ( Furukawa, H; Mamiya, T; Nabeshima, T; Noda, Y, 1997)
" Imipramine and mianserine potentiated amphetamine-induced anorexia both after acute administration or after prolonged previous treatment with each drug."3.68Lack of tolerance to imipramine or mianserine in two animal models of depression. ( Barros, HM; Tannhauser, M; Wainstein, M, 1990)
"Acute pretreatment with clinically equivalent doses of antidepressive drugs has been observed to block D,L-5-hydroxytryptophan (5-HTP) induced behavioral depression in rats working on a food-reinforced operant schedule."3.67Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. ( Aprison, MH; Hendrie, HC; Hingtgen, JN, 1984)
"To further test the new hypersensitive postsynaptic serotonin (5-HT) receptor theory of depression bases on or animal model, it was necessary to demonstrate that some of the currently used antidepressive drugs can block D,L-5-hydroxytryptophan (5-HTP) induced depression acting through postsynaptic rather than presynaptic mechanisms."3.66Postsynaptic action by four antidepressive drugs in an animal model of depression. ( Aprison, MH; Hingtgen, JN; Nagayama, H, 1981)
"The introduction of two tricyclic compounds (iprindole and mianserin) that are reported to have antidepressant properties but to be relatively devoid of effects on central amine neurotransmitter systems has raised questions about the amine hypothesis of depression and about the mechanism of action of tricyclics in general."3.66Novel antidepressants and the biogenic amine hypothesis of depression. The case for iprindole and mianserin. ( Goodwin, FK; Zis, AP, 1979)
"(1) Org GB94 (Mianserin hydrochloride), a new tetracyclic antidepressant, was administered to 21 patients with depression or with depressive states."3.66Clinical experience with Org GB94 (mianserin hydrochloride), a new tetracyclic antidepressant. ( Inanaga, K; Nakano, T; Okamoto, K, 1978)
"People with depression are usually managed in primary care and antidepressants are often the first-line treatment, but only one third of patients respond fully to a single antidepressant."2.82Mirtazapine added to selective serotonin reuptake inhibitors for treatment-resistant depression in primary care (MIR trial): study protocol for a randomised controlled trial. ( Anderson, IM; Campbell, J; Chew-Graham, C; Davies, S; Dickens, C; Gilbody, S; Hollingworth, W; Kessler, D; Lewis, G; Macleod, U; Peters, TJ; Tallon, D; Wiles, N, 2016)
"Depression is common in schizophrenia and worsens its course."2.76Add-on mirtazapine improves depressive symptoms in schizophrenia: a double-blind randomized placebo-controlled study with an open-label extension phase. ( Burkin, M; Joffe, G; Joffe, M; Stenberg, JH; Tchoukhine, E; Terevnikov, V; Tiihonen, J, 2011)
"Mirtazapine is an established antidepressant with well-documented efficacy demonstrated in controlled clinical trials."2.74Efficacy, tolerability, and preference of mirtazapine orally disintegrating tablets in depressed patients: a 17-week naturalistic study in Lithuania. ( Adomaitiene, V; Danileviciūte, V; Fokas, V; Gumbrevicius, G; Sveikata, A; Sveikatiene, R, 2009)
" Maximum flexibility of the dosage of mirtazapine was allowed, and clinical assessments included MADRS, CGI, vital signs and spontaneous reporting of adverse events."2.72Mirtazapine naturalistic depression study (in Sweden)--MINDS(S): clinical efficacy and safety. ( Ahlner, J; Bengtsson, F; Dahl, ML; Odén, A; Prochazka, J; Sjödin, I; Wålinder, J, 2006)
"Depression is associated with stroke severity and functional impairment, and with the male sex at 18 months."2.71Poststroke depression: an 18-month follow-up. ( Berg, A; Kaste, M; Lehtihalmes, M; Lönnqvist, J; Palomäki, H, 2003)
"Mirtazapine is an effective treatment for major depression in perimenopausal and postmenopausal women whose depression precedes ERT use and does not respond to ERT or whose depression develops after ERT is initiated."2.70An open trial of mirtazapine in menopausal women with depression unresponsive to estrogen replacement therapy. ( Cohen, LS; Groninger, H; Joffe, H; Nonacs, R; Soares, C; Soares, CN, 2001)
"Imipramine was more effective against the clusters related to core symptoms of depression: "depression and guilt", "retardation", and "melancholia", respectively."2.69Depressed in-patients respond differently to imipramine and mirtazapine. ( Bruijn, JA; Moleman, P; Mulder, PG; van den Broek, WW, 1999)
" Adding risperidone to mirtazapine probably does not necessitate a change of the dosage of either drug, but more extensive investigations are needed."2.69Lack of drug interactions between mirtazapine and risperidone in psychiatric patients: a pilot study. ( Doorschot, CH; Loonen, AJ; Oostelbos, MC; Sitsen, JM, 1999)
"S-Desmethylmianserin was in most of the samples present in concentrations of < 10 nM (limit of detection)."2.68Enantioselective determination of mianserin and its desmethyl metabolite in plasma during treatment of depressed Japanese patients. ( Bertilsson, L; Fukushima, Y; Kaneko, S; Mihara, K; Otani, K; Tybring, G, 1995)
"Mood depression was evaluated at 0, 4 and 8 weeks by using Zung's Self-Rating Depression Scale and Hamilton Rating Scale for Depression."2.67Chronic tension-type headache, mood depression and serotonin: therapeutic effects of fluvoxamine and mianserine. ( Bolino, F; Di Cicco, L; Manna, V, 1994)
"Fluvoxamine and mianserin were both shown to be effective in the treatment of depressive illness."2.67The effects of psychomotor performance of fluvoxamine versus mianserin in depressed patients in general practice. ( Jesinger, DK; Moon, CA, 1991)
"Mianserin was given at a dose of 30 mg for the first 7 days followed by 60 mg daily for the remaining 5 weeks."2.66The drug treatment of depression in general practice: a comparison of nocte administration of trazodone with mianserin, dothiepin and amitriptyline. ( Blacker, R; Chapman, N; Davey, A; Shanks, NJ, 1988)
"Mood disturbances accompanying migraine syndromes suggest a mode of action of such a class of drugs."2.66Antidepressant drugs and migraine. ( Agnoli, A; Manna, V; Martucci, N, 1985)
"Depression is a major complication of cancer."2.66Efficacy and safety of mianserin in the treatment of depression of women with cancer. ( Costa, D; Mogos, I; Toma, T, 1985)
"Mianserin was significantly superior to diazepam in antidepressant efficacy from day 14 to the end of the trial, as measured by the Hamilton Rating Scale for Depression and the Beck Self-Rating Scale, and at day 28 as measured by the Clinical Global Impression."2.65A double-blind group comparative trial of mianserin and diazepam in depressed outpatients. ( Hamouz, W; Pinder, RM; Stulemeijer, SM, 1980)
"3."2.64Effect of mianserin hydrochloride on peripheral uptake mechanisms for noradrenaline and 5-hydroxytryptamine in man. ( Coppen, A; Ghose, K; Swade, C; Wood, K, 1978)
" There was no significant difference in antidepressant effect between the two dosage regimens in either patient group measured using Hamilton Rating Scale (HRS), the Beck Self-Rating Inventory (BSRI) and the new Montgomery and Asberg Depression Scale (MADS)."2.64Relationship between mianserin plasma levels and antidepressant effect in a double-blind trial comparing a single night-time and divided daily dose regimens. ( McAuley, R; Montgomery, DB; Montgomery, S, 1978)
"mianserin daily, and were rated on the Hamilton Rating Scale and on the Wakefield Self-Assessment Inventory on day 0, before starting therapy, and on days 7 and 28 of their treatment."2.64Mianserin hydrochloride: a new anti-depressant drug. ( Bennie, EH, 1978)
" After one year, the dosage of mianserin was increased to 30 mg t."2.64Mianserin and lithium in the prophylaxis of depression. ( Bailey, J; Coppen, A; Ghose, K; Peet, M; Rao, R, 1978)
"Amitriptyline and mianserin were compared in a double-blind trial."2.64Mianserin versus amitriptyline. A double-blind-trial evaluated by the AMP system. ( Bente, D; Bohacek, N; Brändli, A; Feder, J; Fleischhauer, J; Helmchen, H; Mihovilović, M; Müller-Oerlinghausen, B; Vogel, HP; Walcher, W, 1976)
"(Mianserin was compared with Amitriptyline in a double-blind-trial)."2.64[New diagnostic strategies in psychiatry by means of video-technique. I. The use of time-blind video analysis for the evaluation of antidepressant drug trials (author's transl)]. ( Busch, H; Renfordt, E, 1976)
"Buspirone has an indication for generalized anxiety disorder though studies show only a minimal benefit."2.53Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD. ( Bielefeldt, K; Szigethy, E; Thorkelson, G, 2016)
"Such approach to treatment of insomnia in depressed patients protects them against dependence on hypnotic drugs."2.47[The effects of antidepressants on sleep in depressed patients with particular reference to trazodone in comparison to agomelatine, amitriptyline, doxepin, mianserine and mirtazapine]. ( Wichniak, A; Wierzbicka, A, 2011)
"Mirtazapine is an effective antidepressant with unique and special mechanism of action characterized by high response and remission rates, relatively early onest of action and favourable side-effect profile."2.45[Mirtazapine--pharmacologic action and clinical advantages]. ( Purebl, G; Rihmer, Z, 2009)
"Emphasis is given to the treatment of depression and how the potential of one pure enantiomer-escitalopram, the S-enantiomer of the selective serotonin reuptake inhibitor citalopram-appears to be fulfilling its preclinical promise in the clinic."2.41Enantiomers' potential in psychopharmacology--a critical analysis with special emphasis on the antidepressant escitalopram. ( Baumann, P; Eap, CB; Zullino, DF, 2002)
"Direct costs for treating depression, i."2.41[Treatment of depression and cost efficiency. The cost of a tablet is a poor indicator seen from a socioeconomic perspective]. ( Häggström, L; Nordling, S; Norinder, A, 2000)
"Mirtazapine has demonstrated superior tolerability to the tricyclic antidepressants and trazodone, primarily on account of its relative absence of anticholinergic, adrenergic and serotonin-related adverse effects, in particular gastrointestinal adverse effects and sexual dysfunction."2.40A risk-benefit assessment of mirtazapine in the treatment of depression. ( Kasper, S; Praschak-Rieder, N; Tauscher, J; Wolf, R, 1997)
" With chronic administration each of the antidepressants produced effects which could potentially interfere with CRF function in the LC."2.38Pharmacology of locus coeruleus spontaneous and sensory-evoked activity. ( Curtis, AL; Valentino, RJ, 1991)
" Mianserin and mirtazapine (separately) induced dose-dependent antinociception, each one yielding a biphasic dose-response curve, and they were antagonized by naloxone."1.91Treatment-Resistant Depression (TRD): Is the Opioid System Involved? ( Keidan, L; Pick, CG; Schreiber, S, 2023)
"Depression is prevalent in primary biliary cholangitis (PBC) patients."1.48The impact of depression and antidepressant usage on primary biliary cholangitis clinical outcomes. ( Almishri, W; Frolkis, AD; Kaplan, GG; Patten, S; Shaheen, AA; Swain, MG; Vallerand, I, 2018)
"Mirtazapine is a widely-used antidepressant with a multimodal mechanism of action."1.48Tachyphylaxis to the Sedative Action of Mirtazapine. ( Papazisis, G; Siafis, S; Tzachanis, D, 2018)
"Fluoxetine was the reference treatment option in the medication models."1.39Influence of body mass index on the choice of therapy for depression and follow-up care. ( Arterburn, D; Bogart, A; Boudreau, DM; Haneuse, S; Simon, G; Theis, MK; Westbrook, E, 2013)
"Citalopram is a selective serotonin reuptake inhibitor with a favorable cardiac-safety profile."1.38Prolonged QTc interval and torsades de pointes induced by citalopram. ( Abuissa, H; Airey, K; Alla, V; Deshmukh, A; Ulveling, K, 2012)
"Mirtazapine is a widely used antidepressant and the aim of this study was to further investigate its antidepressant activity in rats."1.33Study of mirtazapine antidepressant effects in rats. ( Cassanelli, A; Gambarana, C; Raone, A; Rauggi, R; Tagliamonte, A, 2005)
"Depression is a common problem in elderly patients and frequently is treated with antidepressants."1.33Recurrent hyponatremia associated with citalopram and mirtazapine. ( Akcay, A; Bavbek, N; Kargili, A; Kaya, A, 2006)
"Depression is characterized by a lack of "motivation" rather than a lack of "physical space" to move around."1.32Open space swimming test to index antidepressant activity. ( Alkon, DL; Sun, MK, 2003)
"Taurine has been known to be related to certain modifications of the immune system."1.32Taurine concentration in human blood peripheral lymphocytes: major depression and treatment with the antidepressant mirtazapine. ( Baccichet, E; Carreira, I; Lima, L; Obregón, F; Peña, S; Urbina, M, 2003)
"Mirtazapine is a new antidepressant with a tetracyclic chemical structure that is not related to selective serotonin reuptake inhibitors, tricyclic antidepressants, or monoamine oxidase inhibitors."1.31Hypertensive urgency induced by an interaction of mirtazapine and clonidine. ( Abo-Zena, RA; Bobek, MB; Dweik, RA, 2000)
" Long-term administration with imipramine or mirtazapine (10 mg/kg, i."1.31Chronic treatment with imipramine or mirtazapine antagonizes stress- and FG7142-induced increase in cortical norepinephrine output in freely moving rats. ( Biggio, G; Dazzi, L; Ladu, S; Pira, L; Rivano, A; Spiga, F; Vacca, G, 2002)
"Thioridazine (40 mg/day) was coadministered for 1 week, and blood samplings were performed before and after thioridazine coadministration, 12 h after bedtime dosing."1.30Effects of thioridazine, an inhibitor of CYP2D6, on the steady-state plasma concentrations of the enantiomers of mianserin and its active metabolite, desmethylmianserin, in depressed Japanese patients. ( Kaneko, S; Mihara, K; Otani, K; Suzuki, A; Svensson, JO; Tybring, G; Yasui, N, 1997)
"The relationships between the plasma concentrations of mianserin and desmethylmianserin at 18 h after initial dosing and those at steady state were studied in 19 depressed patients receiving 30 mg of mianserin at bedtime."1.29Prediction of plasma concentrations of mianserin and desmethylmianserin at steady state from those after an initial dose of mianserin. ( Fukushima, Y; Kaneko, S; Mihara, K; Okada, M; Otani, K; Tanaka, O, 1993)
"Citalopram was inactive when given alone but it potentiated the antidepressant-like effect of MK-801."1.28Effects of MK-801 and antidepressant drugs in the forced swimming test in rats. ( Maj, J; Rogóz, Z; Skuza, G; Sowińska, H, 1992)
"Depression is the most common psychiatric condition encountered in elderly people."1.28[Depression in late life]. ( Aoba, A, 1991)
"Of these disorders, depression is the most accessible of these to pharmacological treatment; agitation, however, raises the institutional problem."1.28Psychiatrists and Alzheimer's disease. ( Cazas, A; Flame, E; Ginestet, D, 1989)

Research

Studies (258)

TimeframeStudies, this research(%)All Research%
pre-199092 (35.66)18.7374
1990's34 (13.18)18.2507
2000's69 (26.74)29.6817
2010's59 (22.87)24.3611
2020's4 (1.55)2.80

Authors

AuthorsStudies
Czopek, A1
Bucki, A1
Kołaczkowski, M1
Zagórska, A1
Drop, M1
Pawłowski, M1
Siwek, A1
Głuch-Lutwin, M1
Pękala, E1
Chrzanowska, A1
Struga, M1
Partyka, A1
Wesołowska, A1
Sato, A1
Yasui-Furukori, N1
Oda, Y1
Yang, M1
Suzuki, Y1
Shinozaki, M1
Shimizu, T1
Shimoda, K1
Milosavljević, MN1
Janković, SM1
Kostić, MJ1
Pejčić, AV1
Schreiber, S2
Keidan, L1
Pick, CG1
Davies, P1
Ijaz, S1
Williams, CJ1
Kessler, D2
Lewis, G2
Wiles, N2
Chmielarz, P1
Kuśmierczyk, J1
Rafa-Zabłocka, K1
Chorązka, K1
Kowalska, M1
Satała, G1
Nalepa, I1
Buschkamp, JA1
Frohn, C1
Juckel, G1
Leucht, S1
Fennema, H1
Engel, RR1
Kaspers-Janssen, M1
Szegedi, A1
Jha, MK1
Wakhlu, S1
Dronamraju, N1
Minhajuddin, A1
Greer, TL1
Trivedi, MH1
Shaheen, AA1
Kaplan, GG1
Almishri, W1
Vallerand, I1
Frolkis, AD1
Patten, S1
Swain, MG1
Papazisis, G1
Siafis, S1
Tzachanis, D1
Boudreau, DM1
Arterburn, D1
Bogart, A1
Haneuse, S1
Theis, MK1
Westbrook, E1
Simon, G1
Rogóż, Z2
Kabziński, M1
Sadaj, W1
Rachwalska, P1
Gądek-Michalska, A1
Banerjee, S2
Hellier, J2
Romeo, R2
Dewey, M2
Knapp, M2
Ballard, C2
Baldwin, R2
Bentham, P2
Fox, C2
Holmes, C2
Katona, C2
Lawton, C2
Lindesay, J2
Livingston, G2
McCrae, N2
Moniz-Cook, E2
Murray, J2
Nurock, S2
Orrell, M1
O'Brien, J2
Poppe, M2
Thomas, A3
Walwyn, R2
Wilson, K2
Burns, A2
Holland, J1
Bhogle, M1
Kjaersgaard, MI1
Parner, ET1
Vestergaard, M1
Sørensen, MJ1
Olsen, J1
Christensen, J1
Bech, BH1
Pedersen, LH1
Puzik, A1
Möller, J1
Meiss, F1
Kontny, U1
Rössler, J1
Bognár, Z1
Vonyik, G1
Gazdag, G1
Sun, LM1
Lin, MC1
Liang, JA1
Chang, YJ1
Chang, SN1
Sung, FC1
Muo, CH1
Kao, CH1
Purslow, C1
Munzer, A1
Sack, U1
Mergl, R1
Schönherr, J1
Petersein, C1
Bartsch, S1
Kirkby, KC1
Bauer, K1
Himmerich, H1
Künzel, H1
Paslakis, G2
Westphal, S1
Hamann, B1
Gilles, M3
Lederbogen, F3
Deuschle, M3
Wróbel, A1
Serefko, A2
Wlaź, P2
Poleszak, E2
Kieler, H1
Malm, H1
Artama, M1
Engeland, A1
Furu, K1
Gissler, M1
Nørgaard, M1
Stephansson, O1
Valdimarsdottir, U1
Zoega, H1
Haglund, B1
Tanidir, C1
Tanidir, IC1
Tuzcu, V1
Verster, JC1
van de Loo, AJ1
Roth, T1
Tripathi, P1
Tomar, LR1
Goyal, P1
Singh, P1
Yoshino, Y1
Ochi, S1
Yamazaki, K1
Nakata, S1
Abe, M1
Mori, Y1
Ueno, S1
Matsumoto, H1
Ohnishi, M1
Takegawa, R1
Hirose, T1
Hattori, Y1
Shimazu, T1
Grover, S1
Avasthi, A1
Tripathi, A1
Tanra, AJ1
Chee, KY1
He, YL1
Chiu, HF1
Kuga, H1
Lee, MS1
Chong, MY1
Udormatn, P1
Kanba, S1
Yang, SY1
Si, TM1
Sim, K1
Tan, CH1
Shen, WW1
Xiang, YT1
Sartorius, N1
Shinfuku, N1
Komulainen, E1
Heikkilä, R1
Meskanen, K1
Raij, TT1
Nummenmaa, L1
Lahti, J1
Jylhä, P1
Melartin, T1
Harmer, CJ1
Isometsä, E1
Ekelund, J1
Duncan, NA1
Clifford, KM1
Shvarts, OM1
Tallon, D1
Campbell, J1
Chew-Graham, C1
Dickens, C1
Macleod, U1
Peters, TJ1
Anderson, IM1
Gilbody, S1
Hollingworth, W1
Davies, S1
Gupta, R3
Gupta, K1
Tripathi, AK1
Bhatia, MS1
Gupta, LK1
Arora, S1
Vohora, D1
Huang, WL1
Liao, SC1
Kuo, TB1
Chang, LR1
Chen, TT1
Chen, IM1
Yang, CC1
Thorkelson, G1
Bielefeldt, K1
Szigethy, E1
Miki, K1
Murakami, M1
Oka, H1
Onozawa, K1
Yoshida, S2
Osada, K1
Jiang, SM1
Jia, L1
Liu, J1
Shi, MM1
Xu, MZ1
Cornelius, JR1
Chung, T1
Douaihy, AB1
Kirisci, L1
Glance, J1
Kmiec, J1
FitzGerald, D1
Wesesky, MA1
Salloum, I1
Stasiuk, W1
Szopa, A1
Wyska, E1
Świąder, K1
Koshiishi, T1
Okuyama, K1
Fusar-Poli, P1
Martinelli, V1
Politi, P1
Hobson, R1
Zimmermann-Viehoff, F1
Bergander, B1
Meissner, K1
Deter, HC1
Cheah, CY1
Ladhams, B1
Fegan, PG1
Kim, SW1
Shin, IS1
Kim, JM1
Park, KH1
Youn, T1
Yoon, JS1
Famularo, G1
Gasbarrone, L1
De Virgilio, A1
Minisola, G1
Bertram, L1
Liss, Y1
Grözinger, M1
Sarginson, JE1
Lazzeroni, LC1
Ryan, HS1
Schatzberg, AF2
Murphy, GM2
Belkahia, A1
Hillaire-Buys, D1
Dereure, O1
Guillot, B1
Raison-Peyron, N1
Rihmer, Z1
Purebl, G1
Zeman, M1
Jirak, R1
Jachymova, M1
Vecka, M1
Tvrzicka, E1
Zak, A1
Danileviciūte, V2
Sveikata, A2
Adomaitiene, V2
Gumbrevicius, G1
Fokas, V1
Sveikatiene, R1
Luppa, P1
Kopf, D2
Hamann-Weber, B1
Habermeyer, B1
Bayer, U1
Müller-Spahn, F1
Mischo, M1
Nigg, C1
Kiss, A1
Manakova, E1
Hubickova, L1
Kostalova, J1
Zemanova, Z1
Tulner, DM1
Smith, OR1
Schins, A1
de Jonge, P1
Quere, M1
Delanghe, JR1
Crijns, HJ1
den Boer, JA1
Korf, J1
Honig, A1
Terevnikov, V1
Stenberg, JH1
Tiihonen, J1
Joffe, M1
Burkin, M1
Tchoukhine, E1
Joffe, G1
Morita, M1
Nakayama, K1
Hannon, B1
Fitzgerald, P1
Murphy, M1
Wichniak, A2
Wierzbicka, A1
Linden, M1
Westram, A1
Watanabe, N1
Omori, IM1
Nakagawa, A1
Cipriani, A1
Barbui, C1
Churchill, R1
Furukawa, TA1
Clark, MS1
Smith, PO1
Jamieson, B1
Mogi, T1
Yoshino, A1
Ikemoto, G1
Nomura, S1
Deshmukh, A1
Ulveling, K1
Alla, V1
Abuissa, H1
Airey, K1
Masana, M1
Castañé, A1
Santana, N1
Bortolozzi, A1
Artigas, F1
McGuinness, J1
Delicata, M1
Knud Larsen, J1
Schilling, C1
Blum, WF1
Daseking, E1
Colla, M1
Weber-Hamann, B1
Krumm, B1
Heuser, I1
Wudy, SA1
Uguz, F1
Goldberg, RJ1
Ahmed, A1
Baumann, P1
Zullino, DF1
Eap, CB1
Kesim, M1
Yaris, F1
Kadioglu, M1
Yaris, E1
Kalyoncu, NI1
Ulku, C1
Rénéric, JP2
Bouvard, M2
Stinus, L2
Mavanji, V1
Meti, B1
Datta, S1
Palomäki, H3
Berg, A3
Meririnne, E1
Kaste, M3
Lönnqvist, R2
Lehtihalmes, M3
Lönnqvist, J3
Onofrj, M1
Luciano, AL1
Iacono, D1
D'Andreamatteo, G1
Teive, HA1
de Quadros, A1
Barros, FC1
Werneck, LC1
Van Gool, AR1
Bannink, M1
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di Michele, F1
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Kopecek, M1
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Aprison, MH2
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Nagayama, H2
Levin, A1
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Cole, JO1
Ghazvinian, S1
Lewis, J1
Cairncross, KD1
Wilson, WH1
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Williams, W1
Mehta, BM1
Spear, FG1
Whittington, JR1
Hamouz, W1
Stulemeijer, SM1
Akiyoshi, J1
Tsuchiyama, K1
Mizobe, Y1
Nakamura, M1
Kuranaga, H1
Mitchell, PB1
Mitchell, MS1
Manna, V2
Bolino, F1
Di Cicco, L1
Moreau, JL1
Bourson, A1
Jenck, F1
Martin, JR1
Mortas, P1
Kishimoto, A1
Mizukawa, R1
Hazama, H1
Tanaka, K1
Kamase, H1
Kunimoto, N1
Buist, A1
Dennerstein, L1
Otani, K6
Sasa, H1
Kaneko, S6
Kondo, T1
Fukushima, Y4
Mihara, K4
Okada, M1
Tanaka, O1
Tybring, G3
Bertilsson, L1
Noda, Y1
Mamiya, T1
Furukawa, H1
Nabeshima, T1
Yasui, N2
Suzuki, A1
Svensson, JO1
Kasper, S1
Praschak-Rieder, N1
Tauscher, J1
Wolf, R1
Ohkubo, T1
Nagasaki, T1
Sugawara, K1
Tabeeva, GR1
Levin, IaI1
Korotkova, SB1
Khanunov, IG1
Benazzi, F1
De León, OA1
Furmaga, KM1
Kaltsounis, J1
Hares, J1
Bruijn, JA1
Moleman, P1
Mulder, PG1
van den Broek, WW1
Davis, J1
Barkin, RL1
Loonen, AJ1
Doorschot, CH1
Oostelbos, MC1
Sitsen, JM1
Whale, R1
Clifford, EM1
Cowen, PJ1
Abo-Zena, RA1
Bobek, MB1
Dweik, RA1
Norinder, A1
Nordling, S1
Häggström, L1
García-Campayo, J1
Sanz Carrillo, C1
Arévalo, E1
Claraco, LM1
Holm, KJ1
Jarvis, B1
Foster, RH1
Srivastava, SK1
Nath, C1
Borghi, J1
Guest, JF1
Waldinger, MD1
Berendsen, HH1
Schweitzer, DH1
Iakovlev, VA1
Belinskiĭ, AV1
Dorovskikh, IV1
Zhbrykunov, VL1
Brady, SR1
Takamori, K1
Okuyama, S1
Dazzi, L1
Ladu, S1
Spiga, F1
Vacca, G1
Rivano, A1
Pira, L1
Biggio, G1
Joffe, H1
Groninger, H1
Soares, CN1
Nonacs, R1
Cohen, LS1
Soares, C1
Hernández, JL1
Ramos, FJ1
Infante, J1
Rebollo, M1
González-Macías, J1
Theobald, DE1
Kirsh, KL1
Holtsclaw, E1
Donaghy, K1
Passik, SD1
Spierings, EL1
Lynch, MA1
Busch, H3
Renfordt, E3
Ghose, K6
Coppen, A6
Hodel, J1
Trum, JM1
Zapletálek, M1
Hanus, H1
Kudrnová, K1
Swade, C1
Wood, K1
Burgess, CD1
Wadsworth, J1
Irwin, P1
Fink, M2
Russell, GF1
Niaz, U1
Wakeling, A1
Slade, PD1
Montgomery, S4
McAuley, R1
Montgomery, DB2
Cronholm, B1
Asberg, M2
Murphy, JE3
Pichot, P1
Dreyfus, JF1
Pull, C1
Bennie, EH1
Bridgman, KM1
Rao, R1
Bailey, J3
Peet, M2
Brogden, RN1
Heel, RC1
Speight, TM1
Avery, GS1
Jaskari, MO3
Ahfors, UG1
Ginman, L2
Lydekcne, K1
Tienari, P3
Burns, B2
de Ridder, JJ3
Magnus, RV1
Saldaña-Hernández, OH1
Oliva-Ruiz, H1
Arriaga-Gracia, JJ1
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Browne, PJ1
Morgan, E1
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Náhunek, K1
Cesková, E1
Rysánek, R1
Gonçalves, N1
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McHarg, AM1
McHarg, JF1
Schmid, E1
Ulrich, G2
Harms, K2
Ahlfors, UG1
Lydecken, K1
Zis, AP1
Goodwin, FK1
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Porsolt, RD1
Le Pichon, M1
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Kopera, H1
Okamoto, K1
Nakano, T1
Inanaga, K1
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Papić, D1
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Müller-Oerlinghausen, B2
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Ginestet, D1
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Majid, I1
Yokoyama, T1
Kuroda, K1
Uemoto, M1
Masui, M1
Ide, H1
Mita, T1
Magni, G1
Drijkoningen, GJ1
Cliff, G1
Martucci, N1
Agnoli, A1
Maguire, P1
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Donaldson, MD1

Clinical Trials (33)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Mirtazapine Versus Placebo on Appetite, Nutritional Status and Quality of Life in Non-small Cell Lung cáncer Patients With Anorexia; Randomized Double-blind Clinical Trial.[NCT04748523]86 participants (Actual)Interventional2018-08-29Completed
Double-blind Pilot Trial of Mirtazapine for the Treatment of Co-occurring AD/MDD.[NCT02185131]Phase 216 participants (Actual)Interventional2013-09-30Completed
Treatment of Young Adults With Comorbid AUD/MDD: A Pilot Medication Trial[NCT02646449]Phase 211 participants (Actual)Interventional2015-06-30Completed
Hypothalamus-pituitary-adrenal System: Role of the Mineralocorticoid Receptor and Longitudinal Study in Depressed Patients[NCT01049347]Phase 3127 participants (Actual)Interventional1997-10-31Completed
A Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Agomelatine in the Prevention of Poststroke Depression[NCT05426304]Phase 4420 participants (Anticipated)Interventional2022-10-01Not yet recruiting
Efficacy and Safety Analyses of Mirtazapine in the Treatment of Malignant Tumor Related Depression: A Phase II, Placebo-controlled, Randomized, Double-blinded Clinical Trial in Advanced Non-small Cell Lung Cancer Patients[NCT02650544]Phase 2236 participants (Anticipated)Interventional2015-12-31Active, not recruiting
Randomized, Double-blind Clinical Trial of the Use of Mirtazapine Versus Megestrol for the Control of Anorexia-cachexia in Cancer Patients in Palliative Care.[NCT03283488]Phase 252 participants (Actual)Interventional2019-03-26Completed
Controlled Trial of Deep Brain Stimulation for Obsessive-Compulsive Disorder[NCT00640133]Phase 427 participants (Actual)Interventional2008-03-31Active, not recruiting
Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD[NCT03932773]Phase 2330 participants (Anticipated)Interventional2019-05-01Recruiting
Randomised Controlled Trial of Neurostimulation for Symptoms of Anorexia Nervosa[NCT05788042]70 participants (Anticipated)Interventional2023-08-02Recruiting
A Multisite, Assessor-blinded, Randomized Controlled Trial of Acupuncture for Post-stroke Depression[NCT02644161]91 participants (Actual)Interventional2015-10-31Completed
Understanding the Neurocognitive Effects of Fecal Microbiota Transplantation in Major Depressive Disorder Patients With and Without Irritable Bowel Syndrome[NCT05174273]Phase 2/Phase 3180 participants (Anticipated)Interventional2022-04-06Recruiting
The Safety and Effectiveness of Probiotic Supplementation on Bipolar Depression: a Proof of Concept Randomized Controlled Trial[NCT02155972]Phase 216 participants (Actual)Interventional2013-05-31Terminated (stopped due to The trial was terminated because of inability to recruit the needed number of participants)
A Single Ketamine Infusion Combined With Music for Suicidal Ideation During a Depressive Episode: A Randomized Open Label Clinical Trial[NCT04658420]Phase 2200 participants (Anticipated)Interventional2021-07-01Not yet recruiting
Structural Brain Plasticity in Elderly Depressed Patients Following Electroconvulsive Therapy[NCT02667353]110 participants (Actual)Interventional2011-06-30Completed
A Double-Blind, Randomized, Placebo-Controlled Trial of Ramelteon for the Treatment of Insomnia and Mood Stability in Patients With Euthymic Bipolar Disorder.[NCT00552760]Phase 490 participants (Actual)Interventional2007-11-30Completed
Clinical Validation Study for EDIT-B Test: an Aid for Differential Diagnosis of Bipolar Disorder, Based on RNA Editing Blood Biomarkers[NCT05603819]436 participants (Anticipated)Observational2022-06-29Recruiting
The Role of Orexin in Human Panic Disorder[NCT02593682]Phase 43 participants (Actual)Interventional2016-05-31Completed
Physical Fitness and Brain - Interventional Study of the Importance of Physical Fitness on Symptoms of Anxiety, Cognitive Ability and Sick Leave, in Primary Care.[NCT03247270]168 participants (Actual)Interventional2017-08-21Completed
Novel Neural Circuit Biomarkers of Major Depression Response to Computer-augmented CBT[NCT03096886]90 participants (Anticipated)Interventional2017-06-05Active, not recruiting
A Randomized Controlled Trial of the Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Bipolar Disorder[NCT03279224]Phase 2/Phase 335 participants (Actual)Interventional2018-01-01Active, not recruiting
Pre-treatment Biomarker for Clinical Response to Neuronavigation Repetitive Transcranial Magnetic Stimulation (rTMS) in the Acute Phase Treatment of Refractory Major Depressive Episode- Role of Intrinsic Functional Connectivity[NCT03348761]128 participants (Anticipated)Interventional2015-08-04Recruiting
Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776]Phase 254 participants (Actual)Interventional2017-08-07Completed
Study of Antidepressants in Parkinson's Disease[NCT00086190]Phase 3115 participants (Actual)Interventional2005-06-30Completed
Targeted Alterations in n-3 and n-6 Fatty Acids for the Management of Mood Variability in the Maintenance Phase of Bipolar Disorder[NCT02272010]83 participants (Actual)Interventional2014-10-31Completed
ED Treatment of Suicidal Patients With Ketamine Infusion[NCT03502551]Phase 20 participants (Actual)Interventional2019-04-01Withdrawn (stopped due to Trial never received funding.)
Prediction of the Therapeutic Response in Depression Based on an Early Neuro-computational Modeling Assessment of Motivation[NCT05866575]136 participants (Anticipated)Interventional2023-06-01Not yet recruiting
A Safe Ketamine-Based Therapy for Treatment Resistant Depression[NCT01179009]20 participants (Actual)Interventional2012-04-30Completed
Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD)[NCT01920555]Phase 299 participants (Actual)Interventional2014-12-31Completed
The Impact of Spiritual Healing on Moderate Depression in Adults: A Pilot Randomized Controlled Trial (RCT)[NCT04766242]28 participants (Anticipated)Interventional2021-03-01Not yet recruiting
Double-blind Trial of Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery[NCT03861988]Phase 445 participants (Actual)Interventional2019-08-22Completed
Analisi Dei Marcatori di Stress Ossidativo in Pazienti Affetti da Tumore Della Mammella, Sottoposte a Radioterapia Postoperatoria e Psicoterapia Con Elementi di Musicoterapia[NCT04446624]60 participants (Actual)Interventional2018-02-01Completed
[NCT05753943]0 participants Expanded AccessNo longer available
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Drinks Per Drinking Day

Level of drinking, as indicated by the number of drinks per day as recorded on the Timeline Follow-Back calendar. (NCT02185131)
Timeframe: 12 Weeks

InterventionDrinks per drinking day (Mean)
Mirtazapine3.5
Placebo4.4

Level of Depressive Symptoms

Level of depressive symptoms, as indicated by the score on the Beck Depression Inventory. The Beck Depression Inventory II scoring range is as follows: 0-13 minimal depressive symptoms, 14-19 mild depressive symptoms, 20-28 moderate depressive symptoms and 29-63 severe depressive symptoms. (NCT02185131)
Timeframe: 12 Weeks

InterventionUnits on a scale (Mean)
Mirtazapine27.6
Placebo26.1

Drinks Per Drinking Day

Level of drinking, as indicated by the number of drinks per day as recorded on the Timeline Follow-Back calendar. (NCT02646449)
Timeframe: 12 Weeks

InterventionDrinks per drinking day (Mean)
Mirtazapine2.8
Placebo2.0

Level of Depressive Symptoms

Level of depressive symptoms, as indicated by the score on the Beck Depression Inventory. The Beck Depression Inventory II scoring range is as follows: 0-13 minimal depressive symptoms, 14-19 mild depressive symptoms, 20-28 moderate depressive symptoms and 29-63 severe depressive symptoms. (NCT02646449)
Timeframe: 12 Weeks

Interventionunits on a scale (Mean)
Mirtazapine8.0
Placebo3.3

Behavioral Activation for Depression Scale (BADS)

The Behavioral Activation for Depression Scale (BADS) is a 29-item scale that measures the role of aversive controlling stimuli and escape and avoidance behavior in depression, specifically when and how participants become more activated over the course of treatment. Total scores range from 29-203 and lower scores indicate higher levels of escape and avoidance behavior from depression in the past week. (NCT00640133)
Timeframe: Total BADS score observed means at month-12 time point.

Interventionunits on a scale (Mean)
Active DBS85.3
Sham DBS80.3

Global Assessment of Functioning Scale (GAF)

A numeric scale (0 through 100) used to rate the social, occupational, and psychological overall functioning during the week of poorest functioning in the past month. Higher scores indicate a higher level of functioning, while low scores indicate impaired global functioning. (NCT00640133)
Timeframe: GAF score observed means at month-12

Interventionunits on a scale (Mean)
Active DBS54.8
Sham DBS53.7

Hamilton Anxiety Rating Scale (HARS)

Hamilton Anxiety Rating Scale (HARS) is a 14-item test measuring the severity of anxiety symptoms. It provides measures of overall anxiety, psychic anxiety (mental agitation and psychological distress), and somatic anxiety (physical complaints related to anxiety); total scores range from 0-56. Higher scores indicate higher levels of anxiety over the past week. (NCT00640133)
Timeframe: HARS total score observed means at month-12 time point.

Interventionunits on a scale (Mean)
Active DBS12.6
Sham DBS15.7

Hamilton Depression Rating Scale (HDRS)

The Hamilton Depression Rating Scale (HDRS) measures the severity of depressive symptoms in adults. The evaluator-administered ratings measure depressed mood, guilt, suicide, insomnia, work/activities, retardation, agitation, psychic and somatic anxiety, genital symptoms, hypochondriasis, and insight during the past week. Total scores range from 0-72 and higher scores indicate the presence of more severe depression over the past week. Note: this measure was only administered at baseline and month-3. (NCT00640133)
Timeframe: Total HDRS score observed means at month-3 time point.

Interventionunits on a scale (Mean)
Active DBS16.8
Sham DBS19.4

Montgomery-Asberg Depression Rating Scale (MADRS)

"The Montgomery Asberg Depression Rating Scale (MADRS) is an interviewer-administered measure assessing the ten symptoms of depression most sensitive to change. Apparent sadness, reported sadness, inner tension, reduced sleep, reduced appetite, concentration difficulties, lassitude, inability to feel, pessimistic thoughts, and suicidal thoughts are assessed and total scores range from 0-60 with higher scores representing the presence of more severe depression over the past week.~interviewer-administered measure assessing" (NCT00640133)
Timeframe: MADRS total score observed means at month-12 time point.

Interventionunits on a scale (Mean)
Active DBS17.1
Sham DBS18.5

Quality of Life Enjoyment and Satisfaction Questionnaire (QLESQ)

The Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) is a self-administered measure to assess the degree of enjoyment and satisfaction experienced by participants in various areas of daily functioning. We used the 16-item short form with total scores ranging from 16-80. Higher scores indicate greater satisfaction experienced during the past week. (NCT00640133)
Timeframe: QLESQ total score observed means at month-12 time point.

Interventionunits on a scale (Mean)
Active DBS39.8
Sham DBS42.7

Social and Occupational Functioning Assessment Scale (SOFAS)

A numeric scale (0 through 100) used to rate the social, occupational, and psychological functioning during the week of poorest functioning in the past month. Higher scores indicate higher levels of social and occupational functioning, while low scores represent social and occupational impairment. (NCT00640133)
Timeframe: SOFAS score observed means at month-12 time point.

Interventionunits on a scale (Mean)
Active DBS55.9
Sham DBS53.9

Yale-Brown Obsessive-Compulsive Scale (YBOCS Severity Ratings)

The Yale-Brown Obsessive-Compulsive Scale (YBOCS) is a 10 question evaluator-administered measure assessing the severity of obsessions and compulsions over the past week. Obsession and compulsion severity are evaluated separately (ratings from 0-20 for each category) with total scores ranging from 0-40. Higher scores for obsessions, compulsions and total score indicate more severe symptoms over the past week. (NCT00640133)
Timeframe: YBOCS total score observed means at month-12

Interventionunits on a scale (Mean)
Active DBS20.5
Sham DBS20.9

Clinical Global Impressions Bipolar Version(CGI-BP) Severity of Illness Overall Score

3-part (mania, depression, overall bipolar illness), physician-administered scale used to assess global illness severity; used to measure change. Each part is rated from 1-7, higher scores represent more severe mental illness. Only overall bipolar rating was used. (NCT00552760)
Timeframe: Monthly for 6 months

,
Interventionunits on scale (Mean)
BaselineMonth 1Month 2Month 3Month 4Month 5Month 6
Placebo2.152.252.902.932.982.992.41
Ramelteon2.142.292.242.532.362.462.54

Cumulative Proportion of Participants in Each Arm Surviving Without Relapse

Survival analysis techniques, including Kaplan Meier curves, were used to evaluate group differences in time to relapse. Relapse was defined as a medication initiation or change for manic/depressed/mixed symptoms, a hospitalization for manic/depressed/mixed symptoms, MADRS score >= 16, YMRS score > 14, and suicide risk or imminent risk of suicide. Time to relapse was measured discretely in terms of the number of assessment visits until discontinued from the study. (NCT00552760)
Timeframe: Monthly for 6 months

,
InterventionCumulative proportion of participants (Number)
BaselineMonth 1Month 2Month 3Month 4Month 5Month 6
Placebo1.000.9510.5880.4480.3840.3200.320
Ramelteon1.000.9290.8490.7160.6610.6320.566

Montgomery-Asberg Depression Rating Scale (MADRS) Total Score

10-item, standardized, well-validated scale used to measure severity of depressive symptoms; sensitive to treatment effects in depressed outpatients. Scores range from 0-60, higher scores represent more severe depressive symptoms. (NCT00552760)
Timeframe: Monthly for 6 months

,
Interventionunits on scale (Mean)
BaselineMonth 1Month 2Month 3Month 4Month 5Month 6
Placebo8.278.9011.1311.8513.0311.5910.46
Ramelteon7.798.347.239.178.458.5610.40

Pittsburgh Sleep Quality Index (PSQI) Global Score

Self-rated scale to measure quality of sleep via questions regarding sleep latency, duration, efficiency, disturbances, use of sleep medication, and daytime dysfunction. Scores range from 0-21, higher scores represent more significant sleep disturbance. (NCT00552760)
Timeframe: Monthly for 6 months

,
Interventionunits on scale (Mean)
BaselineMonth 1Month 2Month 3Month 4Month 5Month 6
Placebo10.889.289.7110.389.038.668.76
Ramelteon10.178.167.937.897.216.626.90

Young Mania Rating Scale (YMRS) Total Score

11-item standardized, well-validated scale used to measure manic symptoms; sensitive to treatment effects in manic patients. Scores range from 0-60, higher scores represent more severe manic symptoms. (NCT00552760)
Timeframe: Monthly for 6 months

,
Interventionunits on scale (Mean)
BaselineMonth 1Month 2Month 3Month 4Month 5Month 6
Placebo6.596.467.758.094.955.716.72
Ramelteon7.025.895.916.605.935.186.51

Prefrontal GABA+ Concentrations

Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition

Interventionmmol/kg (Mean)
N-Acetylcysteine3.90
Gabapentin3.93
Placebo Oral Tablet3.73

Prefrontal Glx Concentrations

Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition

Interventionmmol/kg (Mean)
N-Acetylcysteine21.59
Gabapentin21.69
Placebo Oral Tablet22.25

Change in Beck Depression Inventory II (BDI-II)

Beck Depression Inventory II ranges from 0-63. Higher score indicates more severe depression. 0-13 minimal depression, 14-19 mild depression, 20-28 moderate depression, 29-63 severe depression. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in BDI-II score (Mean)
Paroxetine-9.7
Venlafaxine Extended Release-9.6
Placebo-5.2

Change in Brief Psychiatric Rating Scale (BPRS)

Brief Psychiatric Rating Scale. Maximum score 126. Higher score indicates greater psychiatric difficulties. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in BPRS score (Mean)
Paroxetine-9.0
Venlafaxine Extended Release-9.8
Placebo-4.4

Change in Geriatric Depression Rating Scale (GDS)

Geriatric Depression Scale ranges from 0-30. Higher score indicates more severe depression. 0-9 normal, 10-19 mild depression, 20-30 severe depression. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in GDS score (Mean)
Paroxetine-6.9
Venlafaxine Extended Release-6.9
Placebo-2.8

Change in Hamilton Depression Rating Scale (HAM-D) Scores

Change in Hamilton Rating Scale for Depression over 12 weeks. Hamilton Depression Rating Scale ranges from 0-50. Higher scores represent more significant depression. Mild depression ranges from 8-13, moderate depression from 14-18, severe 19-22 and very severe any score over 23. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in HAM-D score (Mean)
Paroxetine-13.0
Venlafaxine Extended Release-11.0
Placebo-6.8

Change in Montgomery-Asberg Depression Rating Scale (MADRS)

Montgomery-Asberg Depression Rating Scale ranges from 0-60. Higher score indicates more severe depression. 0-6 normal, 7-19 mild depression, 20-34 moderate depression, greater than 34 severe depression. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in MADRS score (Mean)
Paroxetine-13.6
Venlafaxine Extended Release-10.9
Placebo-6.6

Change in Parkinson's Disease Questionnaire (PDQ) - 39 - Emotional Well-Being

Parkinson's Disease Questionnaire (PDQ-39) - Emotional Well-Being maximum score 24, minimum score of 0.Lower score indicates a better perceived health status. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in PDQ-39 Emotional score (Mean)
Paroxetine-21.4
Venlafaxine Extended Release-20.7
Placebo-10.9

Change in Parkinson's Disease Questionnaire (PDQ) - 39 - Overall

Parkinson's Disease Questionnaire (PDQ-39) Total. Range 0-100. Lower score indicates a better perceived health status. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in PDQ-39 score (Mean)
Paroxetine-8.0
Venlafaxine Extended Release-8.4
Placebo-5.3

Change in Pittsburgh Sleep Quality Index (PSQI)

Pittsburgh Sleep Quality Index scores range from 0-21, with higher scores indicating severe sleep difficulties. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in PQSI score (Mean)
Paroxetine-2.1
Venlafaxine Extended Release-2.6
Placebo-1.1

Change in Short Form 36 Health Survey - Mental Component Summary

Short Form 36 Health Survey. Range 0-100. Higher score indicates a better perceived quality of life. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in SF-36 mental score (Mean)
Paroxetine11.4
Venlafaxine Extended Release9.5
Placebo4.8

Change in Short Form 36 Health Survey - Mental Health

Short Form 36 Health Survey - Mental Health subscale ranges from 0-100. Higher score indicates a better perceived quality of life. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in SF-36 Mental Health score (Mean)
Paroxetine16.7
Venlafaxine Extended Release17.4
Placebo9.7

Change in Short Form 36 Health Survey - Role-Emotional

Short Form 36 Health Survey - Emotional subscale ranges from 0-100. Higher score indicates a better perceived quality of life. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in SF-36 Role score (Mean)
Paroxetine39.5
Venlafaxine Extended Release26.9
Placebo12.7

Change in Short Form 36 Health Survey - Vitality

Short Form 36 Health Survey - Vitality subscale ranges from 0-100. Higher score indicates a better perceived quality of life. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in SF-36 vitality score (Mean)
Paroxetine13.5
Venlafaxine Extended Release9.1
Placebo4.7

Change in Snaith Clinical Anxiety Scale (CAS)

Snaith Clinical Anxiety Scale. Range 0-21. Higher scores indicate increased anxiety. Score greater than 8 indicates clinical anxiety. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in CAS score (Mean)
Paroxetine-3.6
Venlafaxine Extended Release-3.2
Placebo-2.4

Change in Unified Parkinson's Disease Rating Scale (UPDRS)

Unified Parkinson's Disease Rating Scale. Higher score indicates more severe Parkinson's disease symptoms. Total maximum = 176. Mental maximum = 52, Activities of Daily Living maximum = 52, Motor maximum = 72. Minimum = 0. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in UPDRS score (Mean)
Paroxetine-8.7
Venlafaxine Extended Release-7.0
Placebo-4.3

Change in Unified Parkinson's Disease Rating Scale (UPDRS) - Bulbar

Unified Parkinson's Disease Rating Scale - Bulbar maximum score 24, minimum score of 0. Higher score indicates more severe Parkinson's disease symptoms. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in UPDRS-Bulbar score (Mean)
Paroxetine-1.4
Venlafaxine Extended Release-1.4
Placebo-0.5

Change in Unified Parkinson's Disease Rating Scale (UPDRS) - Motor

Unified Parkinson's Disease Rating Scale - Motor has a maximum score of 72, minimum score of 0. Higher score indicates more severe Parkinson's disease symptoms. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in UPDRS-motor score (Mean)
Paroxetine-4.3
Venlafaxine Extended Release-2.0
Placebo-1.0

Change in Unified Parkinson's Disease Rating Scale (UPDRS) - Tremor

Unified Parkinson's Disease Rating Scale - Tremor subscale ranges from 0-23. Higher score indicates more severe Parkinson's disease symptoms. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

InterventionChange in UPDRS-tremor score (Mean)
Paroxetine0.4
Venlafaxine Extended Release0.5
Placebo-0.6

Montgomery-Asberg Depression Rating Scale (MADRS) Total Score

The Montgomery-Asberg Depression Rating Scale (MADRS) is a 10-item scale that measures the severity of depression, with a higher score indicating a higher level of depression. The range of scores is 0 to 60. (NCT01179009)
Timeframe: 8 weeks

InterventionScores on a scale (Mean)
Ketamine 100-hour Infusion-9.0
Ketamine 40-minute Infusion-6.4

Clinical Global Impressions-Improvement (CGI-I) Scale

"The CGI-I is a clinician rated single-item scale: Compared to the patient's condition at admission, how much has the patient changed?, rated on a 7-point response scale: 1 = Very much improved, 2 = Much improved, 3 = Minimally improved, 4 = No change, 5 = Minimally worse, 6 = Much worse, and 7 = Very much worse. In this case, admission referred to the CGI-S screening assessments performed between Day -28 an -7, one conducted during the screening visit, and a second rating conducted by a remote, independent rater." (NCT01920555)
Timeframe: A baseline assessment was made on Day 0, preceding infusion (i.e., treatment). Outcome assessments were made on days 1, 3, 5, 7, 14, and 30. The primary endpoint for this study was Day 3. Thus, the outcome measure table provides data on Days 0, 1 and 3

,,,,
Interventionunits on a scale (Mean)
Day 0Day 1Day 3
Ketamine 0.1mg3.88888893.06250002.9333333
Ketamine 0.2mg4.05000003.36842112.8421053
Ketamine 0.5mg4.13636362.63636362.5714286
Ketamine 1.0mg4.00000003.05000002.5500000
Midazolam 0.045mg4.15789473.61111113.1666667

Clinical Global Impressions-Severity (CGI-S)

"The CGI-S is a clinician rated single-item scale: How depressed is the patient at this time?, rated on a 7-point response scale: 1 = Normal, not at all depressed, 2 = Borderline depressed, 3 = Mildly depressed, 4 = Moderately depressed. 5 = Markedly depressed, 6 = severely depressed, 7 = Among the most severely depressed patients. When rating patients, clinicians were asked to consider the past 24 hours." (NCT01920555)
Timeframe: A baseline assessment was made on Day 0, preceding infusion (i.e., treatment). Outcome assessments were made on days 1, 3, 5, 7, 14, and 30. The primary endpoint for this study was Day 3. Thus, the outcome measure table provides data on Days 0, 1 and 3

,,,,
Interventionunits on a scale (Mean)
Day 0Day 1Day 3
Ketamine 0.1mg5.00000003.56250003.4000000
Ketamine 0.2mg5.20000004.26315793.7368421
Ketamine 0.5mg4.86363643.27272733.1428571
Ketamine 1.0mg5.20000003.50000003.3000000
Midazolam 0.045mg5.0000004.5555564.1666667

Clinical Positive Affect Scale (CPAS)

"The CPAS is a 16-item self-report scale to assess the level to which participants experience persistent distress due to feeling that they have not returned to their normal or premorbid state. Items (e.g., I look forward to things) are rated on a 5-point scale (0=not at all, 1=very much less than normal, 2=much less than normal, 3=slightly less than normal, 4=same as best or normal self). The possible scale range is 0 to 64, with higher scores indicating greater recovery from depression. Patients were asked to rate their experience of the past 24 hours." (NCT01920555)
Timeframe: A baseline assessment was made on Day 0, preceding infusion (i.e., treatment). Outcome assessments were made on days 1, 3, 5, 7, 14, and 30. The primary endpoint for this study was Day 3. Thus, the outcome measure table provides data on Days 0, 1 and 3

,,,,
Interventionunits on a scale (Mean)
Day 0Day 1Day 3
Ketamine 0.1mg19.333333335.250000038.8666667
Ketamine 0.2mg20.500000027.052631628.3888889
Ketamine 0.5mg20.636363640.869696439.7619048
Ketamine 1.0mg21.250000033.000000037.4500000
Midazolam 0.045mg21.263157924.444444433.3750000

Clinician-Administered Dissociative States Scale (CADSS) Scores During Infusion

"The CADSS is a 23-item self-report scale for the assessment of dissociative states. It is a reliable, valid self-report instrument. The severity of each dissociative symptom ranges from 0 (not present) to 4 (extreme). The total score is calculated by summing across items, with a total possible range of 0-92. The CADSS was administered right before infusion, and 40, 80 minute and 120 minutes after the start of infusion. The timeframe is at this moment." (NCT01920555)
Timeframe: Day 0/baseline at 0, 40, 80, and 120 minutes

,,,,
Interventionunits on a scale (Mean)
Minute 0Minute 40Minute 80Minute 120
Ketamine 0.1mg0.11111113.00000000.44444440.0555556
Ketamine 0.2mg0.10000004.05000000.10000000
Ketamine 0.5mg014.27272730.77272730.1363636
Ketamine 1.0mg0.100000024.68421051.80000000.6500000
Midazolam 0.045mg0.42105262.68421051.15789470.5789474

Hamilton Rating Scale for Depression - 6 Items

The HAMD6 is a 6-item clinician-rated scale, where clinicians rate the presence of depression symptoms (i.e., depressed mood, guilt, work and interests, psychomotor retardation, psychic anxiety, somatic symptoms) on a 5-point scale, where 0 = not present, and 1-4 represent increasingly severe symptoms. One item (i.e., somatic symptoms) is rated on only a 3-point scale, ranging from 0-2. The possible scale range is 0-22, where higher values represent more severe depression. This instrument is completed with a structured interview guide by the clinician based on his/her assessment of the patient's symptoms. This structured interview has been validated for use with time frames shorter than one week. In this study, the HAMD6 was used to assess symptoms occurring in the past 24 hours. (NCT01920555)
Timeframe: A baseline assessment was made on Day 0, preceding infusion (i.e., treatment). Outcome assessments were made on days 1, 3, 5, 7, 14, and 30. The primary endpoint for this study was Day 3. Thus, the outcome measure table provides data on Days 0, 1, & 3

,,,,
Interventionunits on a scale (Mean)
Day 0Day 1Day 3
Ketamine 0.1mg12.55555567.50000006.8000000
Ketamine 0.2mg12.75000009.26315798.4736842
Ketamine 0.5mg12.59090915.86363645.9047619
Ketamine 1.0mg12.63157896.90000007.2000000
Midazolam 0.045mg13.052631610.66666679.0555556

Montgomery-Asberg Depression Rating Scale (MADRS)

"The MADRS is a 10-item clinician-rated scale measuring depression severity. Symptoms are rated on a 7-point scale, where 0 = not present, and 1-6 represent increasing severity. Values 2, 4, and 6 have specific anchoring text (e.g., 2=Difficulties in starting activities. 4=Difficulties in starting simple routine activities which are carried out with effort, 6=Complete lassitude. Unable to do anything without help.) Values 1, 3, and 5 do not have specific text. The possible scale range is 0-60, where higher values represent higher severity. In this study, the MADRS was used to rate symptoms occurring in the past 3 days." (NCT01920555)
Timeframe: A baseline assessment was made on Day 0, preceding infusion (i.e., treatment). Outcome assessments were made on days 3, 5, 7, 14, and 30. The primary endpoint for this study was Day 3. Thus, the outcome measure table provides data on Days 0 and 3.

,,,,
Interventionunits on a scale (Mean)
Day 0Day 3
Ketamine 0.1mg33.833333319.6666667
Ketamine 0.2mg34.450000022.6315789
Ketamine 0.5mg31.590909114.7619048
Ketamine 1.0mg32.650000017.1000000
Midazolam 0.045mg33.631578924.8333333

Number of Participants Reporting Suicidal Ideation/Behavior on the Columbia Suicide Severity Rating Scale (C-SSRS)

The Columbia Suicide Severity Rating Scale (C-SSRS): The C-SSRS is a low-burden measure of the spectrum of suicidal ideation and behavior that was developed in the National Institute of Mental Health Treatment of Adolescent Suicide Attempters Study to assess severity and track suicidal events through any treatment. It is a clinical interview providing a summary of both ideation and behavior that can be administered during any evaluation or risk assessment to identify the level and type of suicidality present. The C-SSRS can also be used during treatment to monitor for clinical worsening or improvement. It contains 5 rating scale questions (yes/no) for suicidal ideation increasing severity and 5 rating scale questions (yes/no) for suicidal behavior of increasing severity. The time frame is for both lifetime and the past six months for the Baseline/Screening scale and since the last visit for the Since Last Visit scale. (NCT01920555)
Timeframe: Screening Visit and Days 0, 1, 3, 5, 7, 14 and 30 combined

,,,,
InterventionParticipants (Count of Participants)
Screening: # with suicidal ideation/behaviorFollow-Up: # with suicidal ideation/behavior
Ketamine 0.1mg1715
Ketamine 0.2mg159
Ketamine 0.5mg1710
Ketamine 1.0mg146
Midazolam 0.045mg1713

Number of Participants With Abnormal and Clinically Significant CBC and Chemistry Labs by Treatment

"CBC~Chemistry (Total bilirubin, AST, ALT, GGT, ALK Phosphatase, Creatinine, BUN/Urea, Glucose, Uric Acid)~Testing was performed by study site laboratories and used institutional normal lab value ranges." (NCT01920555)
Timeframe: Day 3 and Early Termination Visit (approximately 3 weeks following intervention)

,,,,
InterventionParticipants (Count of Participants)
Chemistry ALT(SGPT)Chemistry AST(SGOT)Chemistry Total BilirubinChemistry Remaining TestsCBC
Ketamine 0.1mg00000
Ketamine 0.2mg11100
Ketamine 0.5mg00000
Ketamine 1.0mg00000
Midazolam 0.045mg00000

Snaith-Hamilton Pleasure-Scale (SHAPS)

"The SHAPS is a 14-item self-report scale to measure hedonic tone. Items (e.g., I would enjoy reading a book, magazine, or newspaper.) are rated on a 4-point scale (1=strongly disagree, 2=disagree, 3=agree, 4=strongly agree). Either of the 'disagree' responses scores 1 point, and either of the 'agree' responses scores 0 points, for a total scale range of 0-14. Higher scores indicate greater inability to experience pleasure. Patients were asked to rate their experience of the past 24 hours." (NCT01920555)
Timeframe: A baseline assessment was made on Day 0, preceding infusion (i.e., treatment). Outcome assessments were made on days 1, 3, 5, 7, 14, and 30. The primary endpoint for this study was Day 3. Thus, the outcome measure table provides data on Days 0, 1 and 3

,,,,
Interventionunits on a scale (Mean)
Day 0Day 1Day 3
Ketamine 0.1mg7.22222223.93750003.5333333
Ketamine 0.2mg7.55000005.73684216.3888889
Ketamine 0.5mg6.59090912.227272733.0000000
Ketamine 1.0mg7.35000004.30000003.6500000
Midazolam 0.045mg6.47368425.00000004.2500000

Symptoms of Depression Questionnaire (SDQ)

"The SDQ is a 44-item self-report scale, which aims to measure depression more comprehensively by including the assessment of symptoms in the anxiety-depression spectrum, including symptoms of irritability, anger attacks, and anxiety. Items are rated on an 6-point Likert scale, where participants are asked to rate if a specific symptom (e.g. How has your mood been over the past 24 hours?) is normal for him or her (score = 2), what is better than normal (score = 1), and what is worse than normal (scores = 3-6). The total scale score is calculated by averaging across the items, resulting in a possible range from 1 to 6. Higher scores indicate greater depression severity. When rating, patients were asked to consider their symptoms during the past 24 hours." (NCT01920555)
Timeframe: A baseline assessment was made on Day 0, preceding infusion (i.e., treatment). Outcome assessments were made on days 1, 3, 5, 7, 14, and 30. The primary endpoint for this study was Day 3. Thus, the outcome measure table provides data on Days 0, 1 and 3

,,,,
Interventionunits on a scale (Mean)
Day 0Day 1Day 3
Ketamine 0.1mg3.51641412.57528432.5106061
Ketamine 0.2mg3.46363642.90961952.7828283
Ketamine 0.5mg3.53925622.31095042.5573593
Ketamine 1.0mg3.41136362.61136362.5909091
Midazolam 0.045mg3.42645072.92005732.8751353

Hospital Length of Stay

Number of days from admission (day of surgery) through discharge after surgery. (NCT03861988)
Timeframe: Average approximately 3 days post-intervention

Interventiondays (Mean)
Open Label Ketamine3.7
Double Blind Ketamine1.9
Double Blind Placebo4.0

Number of Participants With Remission

Remission defined as a MADRS score of <=12 on day 14. MADRS score range: 0 to 60, a lower score indicates lower severity of symptoms. (NCT03861988)
Timeframe: Post-intervention day 14

InterventionParticipants (Count of Participants)
Open Label Ketamine3
Double Blind Ketamine8
Double Blind Placebo10

Brief Pain Inventory Pain Intensity Scale Score

"Average pain intensity in the past 24 hours, rated on a numerical scale from 0 to 10 (with 0 representing No pain and 10 representing Pain as bad as you can imagine)." (NCT03861988)
Timeframe: Post-intervention days 1, 2, 3, 5, 7 and 14

,,
Interventionscore on a scale (Mean)
Day 1Day 2Day 3Day 5Day 7Day 14
Double Blind Ketamine6.05.35.55.55.14.8
Double Blind Placebo5.26.05.24.44.43.7
Open Label Ketamine4.65.53.54.44.84.4

Brief Pain Inventory Pain Interference Scale Score

"Pain interference in the past 24 hours, rated on a numerical scale from 0 to 10 (with 0 representing Does not interfere and 10 representing Completely interferes)." (NCT03861988)
Timeframe: Post-intervention days 1, 2, 3, 5, 7 and 14

,,
Interventionunits on a scale (Mean)
Day 1Day 2Day 3Day 5Day 7Day 14
Double Blind Ketamine8.18.07.57.06.76.2
Double Blind Placebo7.68.17.77.07.25.7
Open Label Ketamine6.06.34.86.67.64.8

Cumulative Opioid Use

This outcome measures how many cumulative morphine-equivalents milligrams of opioid pain medication the patient has taken as an inpatient and after discharge from hospital (NCT03861988)
Timeframe: Post-intervention days 1, 2, 3, 5, 7 and 14

Interventionmilligram morphine equivalents (Mean)
Day 1Day 2Day 3
Open Label Ketamine108.5249.3361.5

Cumulative Opioid Use

This outcome measures how many cumulative morphine-equivalents milligrams of opioid pain medication the patient has taken as an inpatient and after discharge from hospital (NCT03861988)
Timeframe: Post-intervention days 1, 2, 3, 5, 7 and 14

,
Interventionmilligram morphine equivalents (Mean)
Day 1Day 2Day 3Day 5Day 7Day 14
Double Blind Ketamine60.9104.6137.9150.6171.6206.1
Double Blind Placebo56.1107.7144.3156.2163.3186.4

Hospital Anxiety and Depression Scale (HADS) Scale Score

This outcome measures self-reported symptoms of anxiety and depression on a scale that ranges from 0 to 42. A lower score indicates lower severity of symptoms. (NCT03861988)
Timeframe: Post-intervention days 1, 2, 3, 5, 7 and 14

,,
Interventionscore on a scale (Mean)
Day 1Day 2Day 3Day 5Day 7Day 14
Double Blind Ketamine17.818.819.318.318.416.4
Double Blind Placebo19.921.220.818.919.617.2
Open Label Ketamine14.822.613.016.619.214.0

Montgomery-Asberg Depression Rating Scale (MADRS) Score

The MADRS is a 10-item scale for the evaluation of depressive symptoms (Montgomery et al 1979). Each MADRS item is rated on a 0 to 6 scale. Total score range from 0-60, where lower MADRS scores indicate lower levels of depressive symptoms. The assessment for this outcome will be taken once daily on days 1, 2 and 3 post procedure. A mixed model for repeated measures (MMRM) was used to analyze the difference in postoperative MADRS score between ketamine and placebo groups.. (NCT03861988)
Timeframe: Post-intervention days 1, 2 and 3

,,
Interventionscore on a scale (Mean)
Day 1Day 2Day 3
Double Blind Ketamine12.715.117.0
Double Blind Placebo16.417.517.2
Open Label Ketamine17.025.410.5

Number of Participants With Clinical Response

Clinical response defined as >=50% reduction in MADRS score from baseline. MADRS score range: 0 to 60, a lower score indicates lower severity of symptoms. (NCT03861988)
Timeframe: Post-intervention days 1, 2 and 3

,,
InterventionParticipants (Count of Participants)
Day 1Day 2Day 3
Double Blind Ketamine12109
Double Blind Placebo101210
Open Label Ketamine213

Reviews

24 reviews available for mianserin and Depression

ArticleYear
Mirtazapine-induced Acute Pancreatitis in Patients With Depression: A Systematic Review.
    Journal of psychiatric practice, 2023, 01-01, Volume: 29, Issue:1

    Topics: Acute Disease; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depression; Female; Humans;

2023
Pharmacological interventions for treatment-resistant depression in adults.
    The Cochrane database of systematic reviews, 2019, 12-17, Volume: 12

    Topics: Antidepressive Agents; Antipsychotic Agents; Depression; Drug Resistance; Drug Therapy, Combination;

2019
Sertraline and mirtazapine as geriatric antidepressants.
    Psychiatria Danubina, 2013, Volume: 25 Suppl 2

    Topics: Aged; Antidepressive Agents; Depression; Geriatric Psychiatry; Humans; Mianserin; Mirtazapine; Pract

2013
Mirtazapine as positive control drug in studies examining the effects of antidepressants on driving ability.
    European journal of pharmacology, 2015, Apr-15, Volume: 753

    Topics: Antidepressive Agents, Tricyclic; Automobile Driving; Computer Simulation; Depression; Dose-Response

2015
Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD.
    Inflammatory bowel diseases, 2016, Volume: 22, Issue:6

    Topics: Adolescent; Adult; Affect; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Bupropion

2016
[Mirtazapine--pharmacologic action and clinical advantages].
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2009, Volume: 11, Issue:1

    Topics: Adrenergic alpha-Antagonists; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Depress

2009
[Depression].
    Praxis, 2010, Mar-03, Volume: 99, Issue:5

    Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; C

2010
[The effects of antidepressants on sleep in depressed patients with particular reference to trazodone in comparison to agomelatine, amitriptyline, doxepin, mianserine and mirtazapine].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2011, Volume: 31, Issue:181

    Topics: Amitriptyline; Antidepressive Agents; Depression; Doxepin; Humans; Mianserin; Mirtazapine; Sleep; Sl

2011
Mirtazapine versus other antidepressive agents for depression.
    The Cochrane database of systematic reviews, 2011, Dec-07, Issue:12

    Topics: Adult; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cyclohexanols; Depression; Humans; M

2011
Enantiomers' potential in psychopharmacology--a critical analysis with special emphasis on the antidepressant escitalopram.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2002, Volume: 12, Issue:5

    Topics: Animals; Antidepressive Agents, Second-Generation; Citalopram; Depression; Fluoxetine; Humans; Menta

2002
New formulations of existing antidepressants: advantages in the management of depression.
    CNS drugs, 2004, Volume: 18, Issue:8

    Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tri

2004
[Suspected depression].
    MMW Fortschritte der Medizin, 2006, Aug-17, Volume: 148, Issue:33-34

    Topics: Adult; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressiv

2006
[Biochemical aspects of using antidepressants in late middle age and the elderly (review)].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1983, Volume: 83, Issue:4

    Topics: Age Factors; Aged; Aging; Antidepressive Agents; Catechol O-Methyltransferase; Depression; Depressiv

1983
On the mode of action of mianserin.
    Advances in biochemical psychopharmacology, 1982, Volume: 31

    Topics: Animals; Behavior, Animal; Brain; Depression; Dibenzazepines; Humans; Mianserin; Norepinephrine; Rat

1982
Serotonin antagonists.
    Australian and New Zealand journal of medicine, 1984, Volume: 14, Issue:6

    Topics: Cyproheptadine; Depression; Ergotamine; Humans; Hypertension; Ketanserin; Lisuride; Methysergide; Mi

1984
Pharmacological properties of some "second generation" antidepressant drugs.
    Neuropharmacology, 1980, Volume: 19, Issue:12

    Topics: Animals; Antidepressive Agents; Brompheniramine; Depression; Electroconvulsive Therapy; Humans; Mian

1980
Maprotiline, nomifensine, mianserin, zimelidine: a review of antidepressant efficacy in in-patients.
    Neuropharmacology, 1980, Volume: 19, Issue:12

    Topics: Antidepressive Agents; Brompheniramine; Clinical Trials as Topic; Depression; Humans; Maprotiline; M

1980
The management of depression. Part 2. The place of the new antidepressants.
    Australian family physician, 1994, Volume: 23, Issue:9

    Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Benzamides; Depression; Drug Interactions;

1994
A risk-benefit assessment of mirtazapine in the treatment of depression.
    Drug safety, 1997, Volume: 17, Issue:4

    Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Depression; Depressive Disorder; Depressive Disorder,

1997
Mirtazapine--another new class of antidepressant.
    Drug and therapeutics bulletin, 1999, Volume: 37, Issue:1

    Topics: Adrenergic alpha-Antagonists; Antidepressive Agents, Tricyclic; Depression; Histamine H1 Antagonists

1999
[Treatment of depression and cost efficiency. The cost of a tablet is a poor indicator seen from a socioeconomic perspective].
    Lakartidningen, 2000, Apr-05, Volume: 97, Issue:14

    Topics: Adrenergic alpha-Agonists; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive A

2000
Mirtazapine. A pharmacoeconomic review of its use in depression.
    PharmacoEconomics, 2000, Volume: 17, Issue:5

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Humans; Mianserin; Mirtazapine; Quality

2000
Mianserin: a review of its pharmacological properties and therapeutic efficacy in depressive illness.
    Drugs, 1978, Volume: 16, Issue:4

    Topics: Amitriptyline; Animals; Antidepressive Agents; Carbohydrate Metabolism; Cardiovascular Diseases; Dep

1978
Pharmacology of locus coeruleus spontaneous and sensory-evoked activity.
    Progress in brain research, 1991, Volume: 88

    Topics: 1-Naphthylamine; Action Potentials; Animals; Antidepressive Agents; Corticotropin-Releasing Hormone;

1991

Trials

83 trials available for mianserin and Depression

ArticleYear
Validating pre-treatment body mass index as moderator of antidepressant treatment outcomes: Findings from CO-MED trial.
    Journal of affective disorders, 2018, Volume: 234

    Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Biomarkers; Body

2018
Study of the use of antidepressants for depression in dementia: the HTA-SADD trial--a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:7

    Topics: Aged; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cost-Benefit Analysis; Dementia; Depr

2013
Unstimulated and glucose-stimulated ghrelin in depressed patients and controls.
    Journal of psychopharmacology (Oxford, England), 2014, Volume: 28, Issue:6

    Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Appetite Regulati

2014
A single dose of mirtazapine attenuates neural responses to self-referential processing.
    Journal of psychopharmacology (Oxford, England), 2016, Volume: 30, Issue:1

    Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Cerebral Cortex; Depression; Emotions; Female;

2016
Mirtazapine added to selective serotonin reuptake inhibitors for treatment-resistant depression in primary care (MIR trial): study protocol for a randomised controlled trial.
    Trials, 2016, Feb-03, Volume: 17

    Topics: Antidepressive Agents, Tricyclic; Clinical Protocols; Depression; Drug Resistance; Humans; Mianserin

2016
Efficacy of mirtazapine for the treatment of fibromyalgia without concomitant depression: a randomized, double-blind, placebo-controlled phase IIa study in Japan.
    Pain, 2016, Volume: 157, Issue:9

    Topics: Adult; Analysis of Variance; Antidepressive Agents, Tricyclic; Depression; Double-Blind Method; Fema

2016
Beneficial effects of antidepressant mirtazapine in functional dyspepsia patients with weight loss.
    World journal of gastroenterology, 2016, Jun-14, Volume: 22, Issue:22

    Topics: Adiposity; Adult; Affect; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic

2016
Mirtazapine in comorbid major depression and an alcohol use disorder: A double-blind placebo-controlled pilot trial.
    Psychiatry research, 2016, Aug-30, Volume: 242

    Topics: Adult; Alcohol Drinking; Alcohol-Related Disorders; Antidepressive Agents; Comorbidity; Depression;

2016
Mirtazapine in comorbid major depression and an alcohol use disorder: A double-blind placebo-controlled pilot trial.
    Psychiatry research, 2016, Aug-30, Volume: 242

    Topics: Adult; Alcohol Drinking; Alcohol-Related Disorders; Antidepressive Agents; Comorbidity; Depression;

2016
Mirtazapine in comorbid major depression and an alcohol use disorder: A double-blind placebo-controlled pilot trial.
    Psychiatry research, 2016, Aug-30, Volume: 242

    Topics: Adult; Alcohol Drinking; Alcohol-Related Disorders; Antidepressive Agents; Comorbidity; Depression;

2016
Mirtazapine in comorbid major depression and an alcohol use disorder: A double-blind placebo-controlled pilot trial.
    Psychiatry research, 2016, Aug-30, Volume: 242

    Topics: Adult; Alcohol Drinking; Alcohol-Related Disorders; Antidepressive Agents; Comorbidity; Depression;

2016
FKBP5 polymorphisms and antidepressant response in geriatric depression.
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2010, Mar-05, Volume: 153B, Issue:2

    Topics: Aged; Antidepressive Agents; Depression; Double-Blind Method; Female; Genetic Variation; Geriatrics;

2010
Efficacy, tolerability, and preference of mirtazapine orally disintegrating tablets in depressed patients: a 17-week naturalistic study in Lithuania.
    Medicina (Kaunas, Lithuania), 2009, Volume: 45, Issue:10

    Topics: Administration, Oral; Adult; Aged; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzodiaz

2009
Venlafaxine and mirtazapine treatment lowers serum concentrations of dehydroepiandrosterone-sulfate in depressed patients remitting during the course of treatment.
    Journal of psychiatric research, 2010, Volume: 44, Issue:8

    Topics: Adult; Age Factors; Aged; Analysis of Variance; Antidepressive Agents; Case-Control Studies; Cyclohe

2010
Antidepressive effect of mirtazapine in post-myocardial infarction depression is associated with soluble TNF-R1 increase: data from the MIND-IT.
    Neuropsychobiology, 2011, Volume: 63, Issue:3

    Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Depression; Female; Humans; Inflammation Mediators; M

2011
Add-on mirtazapine improves depressive symptoms in schizophrenia: a double-blind randomized placebo-controlled study with an open-label extension phase.
    Human psychopharmacology, 2011, Volume: 26, Issue:3

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Depression; Double-

2011
Cost-effectiveness analyses for mirtazapine and sertraline in dementia: randomised controlled trial.
    The British journal of psychiatry : the journal of mental science, 2013, Volume: 202

    Topics: Antidepressive Agents; Caregivers; Cost-Benefit Analysis; Dementia; Depression; Health Care Costs; H

2013
Leptin plasma concentrations increase during antidepressant treatment with amitriptyline and mirtazapine, but not paroxetine and venlafaxine: leptin resistance mediated by antihistaminergic activity?
    Journal of clinical psychopharmacology, 2013, Volume: 33, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Analysis of Variance; Antidepressive Agents; Biomarke

2013
Complaints of poststroke insomnia and its treatment with mianserin.
    Cerebrovascular diseases (Basel, Switzerland), 2003, Volume: 15, Issue:1-2

    Topics: Age Factors; Aged; Antidepressive Agents, Second-Generation; Depression; Dose-Response Relationship,

2003
Poststroke depression: an 18-month follow-up.
    Stroke, 2003, Volume: 34, Issue:1

    Topics: Antidepressive Agents, Second-Generation; Depression; Female; Follow-Up Studies; Humans; Male; Mians

2003
The apolipoprotein E epsilon4 allele and antidepressant efficacy in cognitively intact elderly depressed patients.
    Biological psychiatry, 2003, Oct-01, Volume: 54, Issue:7

    Topics: Aged; Aged, 80 and over; Alleles; Antidepressive Agents; Apolipoproteins E; Chromatography, High Pre

2003
Open trial of mirtazapine in patients with fibromyalgia.
    Pharmacopsychiatry, 2004, Volume: 37, Issue:4

    Topics: Adrenergic alpha-Antagonists; Adult; Depression; Drug Administration Schedule; Female; Fibromyalgia;

2004
Changes of sleep architecture, spectral composition of sleep EEG, the nocturnal secretion of cortisol, ACTH, GH, prolactin, melatonin, ghrelin, and leptin, and the DEX-CRH test in depressed patients during treatment with mirtazapine.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:4

    Topics: Adrenocorticotropic Hormone; Adult; Animals; Antidepressive Agents, Tricyclic; Area Under Curve; Bod

2006
Mirtazapine naturalistic depression study (in Sweden)--MINDS(S): clinical efficacy and safety.
    Human psychopharmacology, 2006, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Body Mass Index; Depre

2006
Effects of combination treatment with mood stabilizers and mirtazapine on plasma concentrations of neuroactive steroids in depressed patients.
    Psychoneuroendocrinology, 2007, Volume: 32, Issue:6

    Topics: Adult; Antidepressive Agents, Tricyclic; Depression; Drug Therapy, Combination; Female; Humans; Lith

2007
Maprotiline, nomifensine, mianserin, zimelidine: a review of antidepressant efficacy in in-patients.
    Neuropharmacology, 1980, Volume: 19, Issue:12

    Topics: Antidepressive Agents; Brompheniramine; Clinical Trials as Topic; Depression; Humans; Maprotiline; M

1980
The clinical efficacy and side-effects of mianserin and nortriptyline in depressed out-patients: a double-blind randomized trial.
    Current medical research and opinion, 1982, Volume: 8, Issue:4

    Topics: Adult; Aged; Ambulatory Care; Clinical Trials as Topic; Depression; Depressive Disorder; Dibenzazepi

1982
The use of mianserin in the treatment of depression.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1980, Jun-07, Volume: 57, Issue:23

    Topics: Aged; Clinical Trials as Topic; Depression; Dibenzazepines; Double-Blind Method; Female; Humans; Mia

1980
Mianserin and clomipramine in the treatment of depression.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1982, May-08, Volume: 61, Issue:19

    Topics: Adult; Aged; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Double-Blind Method

1982
A double-blind study of trazodone and mianserin in the treatment of depression in general practice.
    The Journal of international medical research, 1982, Volume: 10, Issue:3

    Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Depression; Diazepam; Dibenzazepines; Dose-Respon

1982
A double-blind controlled trial of mianserin and amitriptyline in depression.
    Current medical research and opinion, 1980, Volume: 7, Issue:1

    Topics: Adolescent; Adult; Aged; Amitriptyline; Delayed-Action Preparations; Depression; Dibenzazepines; Dou

1980
A double-blind group comparative trial of mianserin and diazepam in depressed outpatients.
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1980, Volume: 13, Issue:2

    Topics: Adolescent; Adult; Depression; Diazepam; Dibenzazepines; Double-Blind Method; Female; Humans; Male;

1980
Chronic tension-type headache, mood depression and serotonin: therapeutic effects of fluvoxamine and mianserine.
    Headache, 1994, Volume: 34, Issue:1

    Topics: Adult; Chronic Disease; Depression; Double-Blind Method; Female; Fluvoxamine; Headache; Humans; Male

1994
[A controlled study of the prophylactic effect of mianserin and placebo in recurrent depression].
    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology, 1993, Volume: 13, Issue:4

    Topics: Adult; Depression; Double-Blind Method; Female; Humans; Male; Mianserin; Middle Aged; Premedication;

1993
Enantioselective determination of mianserin and its desmethyl metabolite in plasma during treatment of depressed Japanese patients.
    Therapeutic drug monitoring, 1995, Volume: 17, Issue:5

    Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Chromatography, High Pressure Liquid; Depress

1995
Prevention of poststroke depression: 1 year randomised placebo controlled double blind trial of mianserin with 6 month follow up after therapy.
    Journal of neurology, neurosurgery, and psychiatry, 1999, Volume: 66, Issue:4

    Topics: Adult; Antidepressive Agents, Second-Generation; Cerebrovascular Disorders; Depression; Depressive D

1999
Depressed in-patients respond differently to imipramine and mirtazapine.
    Pharmacopsychiatry, 1999, Volume: 32, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adult; Analysis of Variance; Antidepressive Agents, Tricyclic; Anxiety

1999
Lack of drug interactions between mirtazapine and risperidone in psychiatric patients: a pilot study.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1999, Volume: 10, Issue:1

    Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Depression; Depressive Disorder

1999
[Comparative efficacy of remeron (mirtazapine) and amitriptyline in treatment of patients with depression of moderate intensity].
    Voenno-meditsinskii zhurnal, 2000, Volume: 321, Issue:10

    Topics: Adrenergic alpha-Antagonists; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Hi

2000
An open trial of mirtazapine in menopausal women with depression unresponsive to estrogen replacement therapy.
    Journal of women's health & gender-based medicine, 2001, Volume: 10, Issue:10

    Topics: Adult; Antidepressive Agents; Depression; Estradiol; Female; Hormone Replacement Therapy; Humans; Me

2001
An open-label, crossover trial of mirtazapine (15 and 30 mg) in cancer patients with pain and other distressing symptoms.
    Journal of pain and symptom management, 2002, Volume: 23, Issue:5

    Topics: Antidepressive Agents, Tricyclic; Cross-Over Studies; Depression; Dose-Response Relationship, Drug;

2002
An open-label, crossover trial of mirtazapine (15 and 30 mg) in cancer patients with pain and other distressing symptoms.
    Journal of pain and symptom management, 2002, Volume: 23, Issue:5

    Topics: Antidepressive Agents, Tricyclic; Cross-Over Studies; Depression; Dose-Response Relationship, Drug;

2002
An open-label, crossover trial of mirtazapine (15 and 30 mg) in cancer patients with pain and other distressing symptoms.
    Journal of pain and symptom management, 2002, Volume: 23, Issue:5

    Topics: Antidepressive Agents, Tricyclic; Cross-Over Studies; Depression; Dose-Response Relationship, Drug;

2002
An open-label, crossover trial of mirtazapine (15 and 30 mg) in cancer patients with pain and other distressing symptoms.
    Journal of pain and symptom management, 2002, Volume: 23, Issue:5

    Topics: Antidepressive Agents, Tricyclic; Cross-Over Studies; Depression; Dose-Response Relationship, Drug;

2002
[New strategies in psychiatric diagnosis through the use of audio-visual technics. 2. Importance of verbal and non-verbal information for assessment of depressive patients].
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1976, Volume: 9, Issue:5

    Topics: Amitriptyline; Antidepressive Agents; Audiovisual Aids; Depression; Humans; Methods; Mianserin

1976
Autonomic actions and interactions of mianserin hydrochloride (Org. GB 94) and amitriptyline in patients with depressive illness.
    Psychopharmacology, 1976, Sep-17, Volume: 49, Issue:2

    Topics: Amitriptyline; Autonomic Nervous System; Blood Pressure; Clinical Trials as Topic; Depression; Diben

1976
[Results of a field trial with a new anti-depressive compound in ambulatory and hospitalized patients (author's transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1977, Aug-23, Volume: 66, Issue:34

    Topics: Adolescent; Adult; Aged; Ambulatory Care; Clinical Trials as Topic; Depression; Dibenzazepines; Drug

1977
[Mianserin and imipramin in depressive conditions (author's transl)].
    Ceskoslovenska psychiatrie, 1977, Volume: 73, Issue:4

    Topics: Adult; Clinical Trials as Topic; Depression; Dibenzazepines; Drug Evaluation; Female; Humans; Imipra

1977
Effect of mianserin hydrochloride on peripheral uptake mechanisms for noradrenaline and 5-hydroxytryptamine in man.
    British journal of clinical pharmacology, 1978, Volume: 5 Suppl 1

    Topics: Antidepressive Agents; Bethanidine; Blood Platelets; Clinical Trials as Topic; Depression; Dibenzaze

1978
Cardiovascular responses to mianserin hydrochloride: a comparison with tricyclic antidepressant drugs.
    British journal of clinical pharmacology, 1978, Volume: 5 Suppl 1

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Bethanidine; Blood Pressure; Cardiovascular

1978
Electroencephalogram study of mianserin in depressed patients.
    British journal of clinical pharmacology, 1978, Volume: 5 Suppl 1

    Topics: Adolescent; Adult; Aged; Brain; Clinical Trials as Topic; Depression; Dibenzazepines; Dose-Response

1978
Comparative double-blind trial of mianserin hydrochloride (Organon GB94) and diazepam in patients with depressive illness.
    British journal of clinical pharmacology, 1978, Volume: 5 Suppl 1

    Topics: Adjustment Disorders; Adolescent; Adult; Aged; Clinical Trials as Topic; Depression; Diazepam; Diben

1978
Relationship between mianserin plasma levels and antidepressant effect in a double-blind trial comparing a single night-time and divided daily dose regimens.
    British journal of clinical pharmacology, 1978, Volume: 5 Suppl 1

    Topics: Adult; Clinical Trials as Topic; Depression; Dibenzazepines; Double-Blind Method; Drug Administratio

1978
Differential effects on suicidal ideation of mianserin, maprotiline and amitriptyline.
    British journal of clinical pharmacology, 1978, Volume: 5 Suppl 1

    Topics: Adult; Amitriptyline; Anthracenes; Clinical Trials as Topic; Depression; Dibenzazepines; Double-Blin

1978
Mianserin in the treatment of depressive illness and anxiety states in general practice.
    British journal of clinical pharmacology, 1978, Volume: 5 Suppl 1

    Topics: Adolescent; Adult; Anxiety; Clinical Trials as Topic; Depression; Diazepam; Dibenzazepines; Double-B

1978
A double-blind multicentre trial comparing mianserin with imipramine.
    British journal of clinical pharmacology, 1978, Volume: 5 Suppl 1

    Topics: Adjustment Disorders; Adolescent; Adult; Affective Disorders, Psychotic; Aged; Clinical Trials as To

1978
Mianserin hydrochloride: a new anti-depressant drug.
    Scottish medical journal, 1978, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Aged; Antidepressive Agents; Clinical Trials as Topic; Depression; Dibenzazepines

1978
A comparative clinical trial of mianserin (Norval) and amitriptyline in the treatment of depression in general practice.
    The Journal of international medical research, 1978, Volume: 6, Issue:3

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depression; Dibenzazepines; Double

1978
Mianserin and lithium in the prophylaxis of depression.
    The British journal of psychiatry : the journal of mental science, 1978, Volume: 133

    Topics: Administration, Oral; Adult; Aged; Clinical Trials as Topic; Depression; Dibenzazepines; Double-Blin

1978
Three double-blind comparative trials of mianserine (ORG GB 94) and amitriptyline in the treatment of depressive illness.
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1977, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Alanine Transaminase; Alkaline Phosphatase; Amitriptyline; Aspartate Aminotransfe

1977
A comparison of the cardiac effects of mianserin and amitriptyline in man.
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1977, Volume: 10, Issue:6

    Topics: Adult; Amitriptyline; Clinical Trials as Topic; Depression; Dibenzazepines; Electrocardiography; Fem

1977
[A new antidepressive agent. Mianserin hydrochloride (Tolvin)].
    ZFA. Zeitschrift fur Allgemeinmedizin, 1978, Oct-31, Volume: 54, Issue:30

    Topics: Amitriptyline; Clinical Trials as Topic; Depression; Dibenzazepines; Humans; Mianserin

1978
Mianserin--a study of different dosage regimes in psychiatric outpatients.
    The British journal of clinical practice, 1979, Volume: 33, Issue:9

    Topics: Adolescent; Adult; Clinical Trials as Topic; Depression; Dibenzazepines; Drug Administration Schedul

1979
[Clinical evaluation of the ORG GB 94 in the treatment of depression].
    Neurologia, neurocirugia, psiquiatria, 1978, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Clinical Trials as Topic; Depression; Dibenzazepines; Drug Evaluation; Female; He

1978
Mianserin--a new tetracyclic antidepressant.
    Psychopharmacology bulletin, 1979, Volume: 15, Issue:3

    Topics: Clinical Trials as Topic; Depression; Dibenzazepines; Humans; Mianserin

1979
Mianserin in the treatment of depressive illness: a comparison with amitriptyline.
    Irish journal of medical science, 1979, Volume: 148, Issue:4

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depression; Dibenzazepines; Double

1979
[Therapeutical effect of mianserin and imipramine in endogenous depressions (controlled comparison) (author's transl)].
    Ceskoslovenska psychiatrie, 1979, Volume: 75, Issue:5

    Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Depression; Dibenzazepines; Double-Blind Method;

1979
[Comparison of the effects of lofepramin and mianserin in depressed patients in a double blind trial].
    International pharmacopsychiatry, 1979, Volume: 14, Issue:6

    Topics: Adult; Aged; Clinical Trials as Topic; Depression; Dibenzazepines; Double-Blind Method; Female; Huma

1979
[Treatment of depression. Comparative study on the effects of mianserin (Tolvin) and amitriptyline].
    Therapie der Gegenwart, 1979, Volume: 118, Issue:5

    Topics: Adolescent; Adult; Aged; Amitriptyline; Depression; Dibenzazepines; Female; Humans; Male; Mianserin;

1979
Workshop on the clinical pharmacology and efficacy of mianserin.
    British journal of clinical pharmacology, 1978, Volume: 5 Suppl 1

    Topics: Animals; Brain; Depression; Dibenzazepines; Drug Interactions; Female; Heart; Humans; Mianserin; Mid

1978
[Mianserin (Tolvin) in the management of glaucoma patients with depression].
    Die Medizinische Welt, 1978, Oct-06, Volume: 29, Issue:40

    Topics: Adolescent; Adult; Aged; Depression; Dibenzazepines; Glaucoma; Humans; Intraocular Pressure; Mianser

1978
Proceedings: Mianserin vs. amitriptyline--a double-blind-trial evaluated by the AMP-system.
    Activitas nervosa superior, 1975, Volume: 17, Issue:4

    Topics: Amitriptyline; Clinical Trials as Topic; Depression; Dibenzazepines; Humans; Mianserin

1975
Mianserin versus amitriptyline. A double-blind-trial evaluated by the AMP system.
    International pharmacopsychiatry, 1976, Volume: 11, Issue:1

    Topics: Amitriptyline; Circadian Rhythm; Clinical Trials as Topic; Depression; Dibenzazepines; Electroenceph

1976
[New diagnostic strategies in psychiatry by means of video-technique. I. The use of time-blind video analysis for the evaluation of antidepressant drug trials (author's transl)].
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1976, Volume: 9, Issue:2

    Topics: Amitriptyline; Clinical Trials as Topic; Depression; Dibenzazepines; Drug Evaluation; Female; Humans

1976
Time-blind analysis of TV-stored interviews. An objective method to study antidepressive drug-effects.
    International pharmacopsychiatry, 1976, Volume: 11, Issue:3

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depression; Drug Evaluati

1976
Mianserin in the treatment of depression in general practice.
    The Practitioner, 1976, Volume: 217, Issue:1297

    Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Depression; Dibenzazepines; Female; Humans; Imipr

1976
Controlled clinical trial of a new antidepressant (Org. GB 94) of novel chemical formulation.
    Current therapeutic research, clinical and experimental, 1975, Volume: 18, Issue:6

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depression; Dibenzazepines; Female

1975
[Studies with a behavior-oriented evaluation scale for depressive inhibition and agitation. Results of a video-documented amitriptyline-mianserine study].
    Arzneimittel-Forschung, 1976, Volume: 26, Issue:6

    Topics: Amitriptyline; Anxiety; Depression; Female; Humans; Inhibition, Psychological; Mianserin; Psychologi

1976
[Therapeutic efficacy of tricyclic and antidepressive agents. Comparative double blind test of amitriptyline and mianserin (Org GB 94)].
    Acta medica Iugoslavica, 1976, Volume: 30, Issue:5

    Topics: Adolescent; Adult; Aged; Amitriptyline; Depression; Dibenzazepines; Drug Evaluation; Female; Humans;

1976
The effects of psychomotor performance of fluvoxamine versus mianserin in depressed patients in general practice.
    The British journal of clinical practice, 1991,Winter, Volume: 45, Issue:4

    Topics: Adolescent; Adult; Aged; Depression; Double-Blind Method; Female; Fluvoxamine; Humans; Male; Mianser

1991
A double-blind group comparison of mianserin and clomipramine in the treatment of mildly depressed psychiatric out-patients.
    Acta psychiatrica Scandinavica. Supplementum, 1985, Volume: 320

    Topics: Adult; Anti-Anxiety Agents; Anxiety; Clomipramine; Depression; Dibenzazepines; Female; Humans; Male;

1985
The drug treatment of depression in general practice: a comparison of nocte administration of trazodone with mianserin, dothiepin and amitriptyline.
    Psychopharmacology, 1988, Volume: 95 Suppl

    Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Clinical Trials as Topic; Depression;

1988
The efficacy and residual effects of trazodone (150 mg nocte) and mianserin in the treatment of depressed general practice patients.
    Psychopharmacology, 1988, Volume: 95 Suppl

    Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Depression; Double-Blind Method; Drug Tolerance;

1988
Mianserin and trazodone for cardiac patients with depression.
    European journal of clinical pharmacology, 1988, Volume: 33, Issue:6

    Topics: Adult; Aged; Clinical Trials as Topic; Depression; Double-Blind Method; Female; Heart Diseases; Hemo

1988
Interpreting significance in an antidepressant drug trial.
    International clinical psychopharmacology, 1987, Volume: 2, Issue:4

    Topics: Adult; Clinical Trials as Topic; Depression; Dibenzothiepins; Dothiepin; Female; Humans; Male; Mians

1987
A double-blind comparison of once-daily flupenthixol and mianserin in depressed hospital out-patients.
    Pharmatherapeutica, 1986, Volume: 4, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Aged; Clinical Trials as Topic; Depression; Dibenzazepines;

1986
Antidepressant drugs and migraine.
    Cephalalgia : an international journal of headache, 1985, Volume: 5 Suppl 2

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depression; Female

1985
Treatment of depression in cancer patients.
    Acta psychiatrica Scandinavica. Supplementum, 1985, Volume: 320

    Topics: Amitriptyline; Breast Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Depression; Fe

1985
Efficacy and safety of mianserin in the treatment of depression of women with cancer.
    Acta psychiatrica Scandinavica. Supplementum, 1985, Volume: 320

    Topics: Adult; Aged; Clinical Trials as Topic; Depression; Dibenzazepines; Female; Humans; Mianserin; Middle

1985

Other Studies

152 other studies available for mianserin and Depression

ArticleYear
Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability.
    Bioorganic & medicinal chemistry, 2019, 09-15, Volume: 27, Issue:18

    Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Humans; Receptors, Serotonin; St

2019
Asymptomatic syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following duloxetine treatment for pain with depression: Two case reports.
    Neuropsychopharmacology reports, 2022, Volume: 42, Issue:3

    Topics: Aged; Aged, 80 and over; Depression; Duloxetine Hydrochloride; Female; Humans; Hyponatremia; Inappro

2022
Treatment-Resistant Depression (TRD): Is the Opioid System Involved?
    International journal of molecular sciences, 2023, Jul-06, Volume: 24, Issue:13

    Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Depression; Dose-Response Relationship, Drug; Fl

2023
Antidepressants Differentially Regulate Intracellular Signaling from α1-Adrenergic Receptor Subtypes In Vitro.
    International journal of molecular sciences, 2021, May-01, Volume: 22, Issue:9

    Topics: Animals; Antidepressive Agents; Citalopram; Depression; Desipramine; Fluoxetine; Gene Expression Reg

2021
Mirtazapine Induces Nightmares in Depressed Patients.
    Pharmacopsychiatry, 2017, Volume: 50, Issue:4

    Topics: Antidepressive Agents, Tricyclic; Depression; Dreams; Humans; Male; Mianserin; Middle Aged; Mirtazap

2017
Translating the HAM-D into the MADRS and vice versa with equipercentile linking.
    Journal of affective disorders, 2018, 01-15, Volume: 226

    Topics: Adult; Antidepressive Agents, Tricyclic; Depression; Depressive Disorder, Major; Female; Humans; Mal

2018
The impact of depression and antidepressant usage on primary biliary cholangitis clinical outcomes.
    PloS one, 2018, Volume: 13, Issue:4

    Topics: Aged; Antidepressive Agents; Bile Ducts; Cholagogues and Choleretics; Cholangitis; Cohort Studies; D

2018
Tachyphylaxis to the Sedative Action of Mirtazapine.
    The American journal of case reports, 2018, Apr-07, Volume: 19

    Topics: Adult; Antidepressive Agents, Tricyclic; Conscious Sedation; Depression; Dose-Response Relationship,

2018
Influence of body mass index on the choice of therapy for depression and follow-up care.
    Obesity (Silver Spring, Md.), 2013, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Aged; Antidepressive Agents; Body Mass Index; Choice Behavior; Cohort Studies; De

2013
Effect of co-treatment with fluoxetine or mirtazapine and risperidone on the active behaviors and plasma corticosterone concentration in rats subjected to the forced swim test.
    Pharmacological reports : PR, 2012, Volume: 64, Issue:6

    Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsychotic A

2012
Prenatal antidepressant exposure and risk of spontaneous abortion - a population-based study.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Abortion, Spontaneous; Adult; Antidepressive Agents; Cyclohexanols; Depression; Duloxetine Hydrochlo

2013
Side effects of interferon therapy in adolescent melanoma.
    Pediatric hematology and oncology, 2014, Volume: 31, Issue:4

    Topics: Adolescent; Adrenergic alpha-Antagonists; Depression; Humans; Immunologic Factors; Interferon-alpha;

2014
[Antidepressant treatment associated hyponatremia -- case report].
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2013, Volume: 15, Issue:3

    Topics: Aged; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Critical Care; Cyc

2013
Does use of tetracyclic antidepressant-mirtazapine reduce cancer risk in depression patients?
    Pharmacoepidemiology and drug safety, 2013, Volume: 22, Issue:12

    Topics: Adult; Age Factors; Aged; Antidepressive Agents; Case-Control Studies; Chi-Square Distribution; Como

2013
Linking Clostridium difficile infection with depression.
    Expert review of anti-infective therapy, 2013, Volume: 11, Issue:8

    Topics: Antidepressive Agents; Clostridioides difficile; Clostridium Infections; Depression; Fluoxetine; Hum

2013
Impact of antidepressants on cytokine production of depressed patients in vitro.
    Toxins, 2013, Nov-19, Volume: 5, Issue:11

    Topics: Adult; Antidepressive Agents; CD40 Antigens; Citalopram; Cytokines; Depression; Female; Humans; Inte

2013
[Use of psychotropic drugs in patients with chronic pain].
    Revue medicale suisse, 2014, Jan-29, Volume: 10, Issue:415

    Topics: Chronic Pain; Cortisone; Depression; Guillain-Barre Syndrome; Humans; Mianserin; Middle Aged; Mirtaz

2014
The depressogenic-like effect of acute and chronic treatment with dexamethasone and its influence on the activity of antidepressant drugs in the forced swim test in adult mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2014, Oct-03, Volume: 54

    Topics: Amitriptyline; Animals; Antidepressive Agents; Citalopram; Depression; Dexamethasone; Dose-Response

2014
Use of antidepressants and association with elective termination of pregnancy: population based case-control study.
    BJOG : an international journal of obstetrics and gynaecology, 2015, Volume: 122, Issue:12

    Topics: Abortion, Induced; Adult; Antidepressive Agents; Antidepressive Agents, Tricyclic; Case-Control Stud

2015
Treatment of depression in an adolescent with cardiomyopathy and arrhythmia.
    Cardiology in the young, 2015, Volume: 25, Issue:7

    Topics: Adolescent; Antidepressive Agents, Tricyclic; Anxiety; Cardiomyopathy, Hypertrophic; Depression; Ele

2015
An unusual presentation of dose dependent SIADH secondary to mirtazapine therapy.
    The Australian and New Zealand journal of psychiatry, 2015, Volume: 49, Issue:11

    Topics: Aged; Antidepressive Agents; Citalopram; Depression; Dose-Response Relationship, Drug; Humans; Inapp

2015
Antidepressant action via the nitric oxide system: A pilot study in an acute depressive model induced by arginin.
    Neuroscience letters, 2015, Jul-10, Volume: 599

    Topics: Acute Disease; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Arginine; Cyclopropanes

2015
Effect of lipid emulsion during resuscitation of a patient with cardiac arrest after overdose of chlorpromazine and mirtazapine.
    The American journal of emergency medicine, 2015, Volume: 33, Issue:10

    Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Cardiopulmonary Resuscitation; Chlorpromazin

2015
Antidepressant Prescription Pattern in the Presence of Medical Co-morbidity: REAP-AD 2013 Study.
    East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan, 2015, Volume: 25, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents; Antidepressive Agents, Tricyclic;

2015
Mirtazapine-Associated Hypertriglyceridemia and Hyperglycemia.
    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2015, Volume: 30, Issue:11

    Topics: Aged; Antidepressive Agents, Tricyclic; Depression; Humans; Hyperglycemia; Hypertriglyceridemia; Mal

2015
Effect of Mirtazapine Treatment on Serum Levels of Brain-Derived Neurotrophic Factor and Tumor Necrosis Factor-α in Patients of Major Depressive Disorder with Severe Depression.
    Pharmacology, 2016, Volume: 97, Issue:3-4

    Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Brain-Derived Neurotrophic Factor; Depression;

2016
Comparative Evaluation of Partial α2 -Adrenoceptor Agonist and Pure α2 -Adrenoceptor Antagonist on the Behavioural Symptoms of Withdrawal after Chronic Alcohol Administration in Mice.
    Basic & clinical pharmacology & toxicology, 2016, Volume: 119, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Alcoholism; Animals; Anxiety; Be

2016
The Effects of Antidepressants and Quetiapine on Heart Rate Variability.
    Pharmacopsychiatry, 2016, Volume: 49, Issue:5

    Topics: Adult; Aged; Antidepressive Agents; Anxiety; Depression; Female; Heart Rate; Humans; Linear Models;

2016
Traxoprodil augments the antidepressant-like activity of agomelatine but not of mianserin or tianeptine in the forced swim test in mice.
    Pharmacological reports : PR, 2016, Volume: 68, Issue:5

    Topics: Acetamides; Animals; Antidepressive Agents; Brain; Depression; Depressive Disorder; Drug Synergism;

2016
Probable Serotonin Syndrome and Withdrawal Symptoms Caused by Milnacipran.
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2016, Volume: 136, Issue:12

    Topics: Aged; Antidepressive Agents; Cerebral Hemorrhage; Cyclopropanes; Depression; Drug Substitution; Fema

2016
Successful antidepressive treatment with mirtazapine following lung transplantation.
    Progress in neuro-psychopharmacology & biological psychiatry, 2008, Oct-01, Volume: 32, Issue:7

    Topics: Adult; Antidepressive Agents, Tricyclic; Depression; Humans; Lung Transplantation; Male; Mianserin;

2008
[Integrative therapy of a patient with complex psychosomatic complaints].
    Forschende Komplementarmedizin (2006), 2008, Volume: 15, Issue:3

    Topics: Aged; Antidepressive Agents, Tricyclic; Depression; Dyspepsia; Female; Humans; Integrative Medicine;

2008
Mirtazapine associated with profound hyponatremia: two case reports.
    The American journal of geriatric pharmacotherapy, 2008, Volume: 6, Issue:2

    Topics: Adverse Drug Reaction Reporting Systems; Aged; Antidepressive Agents, Tricyclic; Depression; Female;

2008
Factors potentiating the risk of mirtazapine-associated restless legs syndrome.
    Human psychopharmacology, 2008, Volume: 23, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Antidepressive Agents, Tricycl

2008
Mirtazapine-associated hyponatremia in an elderly patient.
    The Annals of pharmacotherapy, 2009, Volume: 43, Issue:6

    Topics: Aged; Antidepressive Agents, Tricyclic; Depression; Female; Humans; Hypertension; Hyponatremia; Mian

2009
Neopterin and C-reactive protein in the course of Stevens-Johnson syndrome: report of a case.
    Acta dermato-venereologica, 2009, Volume: 89, Issue:3

    Topics: Anticonvulsants; Antidepressive Agents, Tricyclic; Biopsy; C-Reactive Protein; Depression; Drug Ther

2009
Stevens-Johnson syndrome due to mirtazapine - first case.
    Allergy, 2009, Volume: 64, Issue:10

    Topics: Adult; Antidepressive Agents, Tricyclic; Depression; Humans; Male; Mianserin; Mirtazapine; Patch Tes

2009
Leptin, adiponectin, leptin to adiponectin ratio and insulin resistance in depressive women.
    Neuro endocrinology letters, 2009, Volume: 30, Issue:3

    Topics: Adiponectin; Adult; Aged; Antidepressive Agents; Blood Glucose; Body Mass Index; Chi-Square Distribu

2009
Mania associated with mirtazepine treatment and mixed depression.
    Pharmacopsychiatry, 2010, Volume: 43, Issue:1

    Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Depression; Humans; Male; Mianserin; Middle Aged

2010
Embryotoxicity of mirtazapine: a study using Chick Embryotoxicity Screening Test.
    Neuro endocrinology letters, 2010, Volume: 31 Suppl 2

    Topics: Abnormalities, Drug-Induced; Animals; Antidepressive Agents, Tricyclic; Chick Embryo; Depression; Do

2010
Mirtazapine in combination with perospirone synergistically enhances dopamine release in the rat prefrontal cortex via 5-HT1A receptor activation.
    Psychiatry and clinical neurosciences, 2011, Volume: 65, Issue:3

    Topics: Animals; Depression; Disease Models, Animal; Dopamine; Drug Resistance; Drug Synergism; Drug Therapy

2011
Treatment of depression as part of end-of-life care.
    BMJ case reports, 2008, Volume: 2008

    Topics: Aged; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Carcinoma, Squamou

2008
What do psychiatrists talk about with their depressed patients parallel to prescribing an antidepressant?
    International journal of psychiatry in clinical practice, 2011, Volume: 15, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Combined Modality Therapy; Depression; Depres

2011
FPIN's clinical inquiries: Antidepressants for the treatment of insomnia in patients with depression.
    American family physician, 2011, Nov-01, Volume: 84, Issue:9

    Topics: Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depression; Dose-Response Re

2011
Mirtazapine as an alternative for selective-serotonin-reuptake-inhibitor-induced syndrome of inappropriate secretion of antidiuretic hormone.
    Psychiatry and clinical neurosciences, 2012, Volume: 66, Issue:1

    Topics: Aged; Antidepressive Agents, Tricyclic; Depression; Humans; Inappropriate ADH Syndrome; Male; Mianse

2012
Prolonged QTc interval and torsades de pointes induced by citalopram.
    Texas Heart Institute journal, 2012, Volume: 39, Issue:1

    Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopram; Depre

2012
Noradrenergic antidepressants increase cortical dopamine: potential use in augmentation strategies.
    Neuropharmacology, 2012, Volume: 63, Issue:4

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agent

2012
Antidepressants and unresponsive episodes in the elderly.
    BMJ case reports, 2012, Jul-17, Volume: 2012

    Topics: Age Factors; Aged, 80 and over; Antidepressive Agents, Tricyclic; Depression; Guidelines as Topic; H

2012
[Mirtazapine versus other antidepressive agents for depression].
    Ugeskrift for laeger, 2012, Nov-12, Volume: 174, Issue:46

    Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; D

2012
Low-dose mirtazapine added to selective serotonin reuptake inhibitors in pregnant women with major depression or panic disorder including symptoms of severe nausea, insomnia and decreased appetite: three cases.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2013, Volume: 26, Issue:11

    Topics: Adult; Antidepressive Agents, Tricyclic; Depression; Dose-Response Relationship, Drug; Feeding and E

2013
Weight change in depressed nursing home patients on mirtazapine.
    Journal of the American Geriatrics Society, 2002, Volume: 50, Issue:8

    Topics: Aged; Antidepressive Agents, Tricyclic; Depression; Female; Homes for the Aged; Humans; Male; Mianse

2002
Neutropenia associated with mirtazapine use: is a drop in the neutrophil count in a symptomatic older adults a cause for concern?
    Journal of the American Geriatrics Society, 2002, Volume: 50, Issue:8

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antidepressive Agents, Tricyclic; Depression; Female; Hu

2002
Mirtazapine use in two pregnant women: is it safe?
    Teratology, 2002, Volume: 66, Issue:5

    Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Depression; Drug Therapy, Combination; Female; Fol

2002
In the rat forced swimming test, chronic but not subacute administration of dual 5-HT/NA antidepressant treatments may produce greater effects than selective drugs.
    Behavioural brain research, 2002, Nov-15, Volume: 136, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Second-Gene

2002
Sleep-wake effects of meta-chlorophenyl piperazine and mianserin in the behaviorally depressed rat.
    European journal of pharmacology, 2002, Nov-22, Volume: 455, Issue:1

    Topics: Animals; Behavior, Animal; Depression; Injections, Intraventricular; Male; Mianserin; Piperazines; R

2002
Mirtazapine induces REM sleep behavior disorder (RBD) in parkinsonism.
    Neurology, 2003, Jan-14, Volume: 60, Issue:1

    Topics: Aged; Antidepressive Agents, Tricyclic; Depression; Electroencephalography; Humans; Levodopa; Male;

2003
[Worsening of autosomal dominant restless legs syndrome after use of mirtazapine: case report].
    Arquivos de neuro-psiquiatria, 2002, Volume: 60, Issue:4

    Topics: Aged; Antidepressive Agents, Tricyclic; Depression; Female; Genes, Dominant; Humans; Mianserin; Mirt

2002
Re: Mirtazapine in cancer patients.
    Journal of pain and symptom management, 2003, Volume: 25, Issue:1

    Topics: Antidepressive Agents, Tricyclic; Depression; Female; Humans; Male; Mianserin; Middle Aged; Mirtazap

2003
Mirtazapine: another drug responsible for drug-induced acute pancreatitis? A letter of warning.
    Pancreas, 2003, Volume: 26, Issue:2

    Topics: Acute Disease; Adult; Antidepressive Agents, Tricyclic; Depression; Female; Humans; Mianserin; Mirta

2003
Mirtazapine in suicidal Huntington's disease.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:3

    Topics: Adult; Antidepressive Agents, Tricyclic; Depression; Female; Humans; Huntington Disease; Mianserin;

2003
Open space swimming test to index antidepressant activity.
    Journal of neuroscience methods, 2003, Jun-15, Volume: 126, Issue:1

    Topics: Alanine; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Drug

2003
Taurine concentration in human blood peripheral lymphocytes: major depression and treatment with the antidepressant mirtazapine.
    Advances in experimental medicine and biology, 2003, Volume: 526

    Topics: Adolescent; Adult; Depression; Female; Humans; Lymphocytes; Male; Mianserin; Middle Aged; Mirtazapin

2003
Chairmen's introduction.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2003, Volume: 13 Suppl 3

    Topics: Antidepressive Agents, Tricyclic; Depression; Humans; Mianserin; Mirtazapine; Patient Compliance; Pr

2003
Mirtazapine-induced hyponatraemia.
    The Medical journal of Australia, 2003, Oct-20, Volume: 179, Issue:8

    Topics: Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic;

2003
[Unclear chronic aches. Often depression plays a part therein].
    MMW Fortschritte der Medizin, 2003, May-26, Volume: 145 Suppl 2

    Topics: Acetates; Amines; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Age

2003
[Enlargement of QT-interval in a patient with coronary disease treated with mianserin].
    Anales de medicina interna (Madrid, Spain : 1984), 2003, Volume: 20, Issue:12

    Topics: Aged; Antidepressive Agents, Second-Generation; Coronary Disease; Depression; Electrocardiography; F

2003
Mirtazapine: not a dual action antidepressant?
    The Australian and New Zealand journal of psychiatry, 2004, Volume: 38, Issue:4

    Topics: Antidepressive Agents, Tricyclic; Depression; Humans; Mianserin; Mirtazapine; Serotonin; Synaptic Tr

2004
Mechanism of action of mirtazapine: dual action or dual effect?
    The Australian and New Zealand journal of psychiatry, 2004, Volume: 38, Issue:4

    Topics: Antidepressive Agents, Tricyclic; Depression; Humans; Mianserin; Mirtazapine; Serotonin; Serotonin S

2004
Study of mirtazapine antidepressant effects in rats.
    The international journal of neuropsychopharmacology, 2005, Volume: 8, Issue:3

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Drug Admin

2005
Non-lethal mirtazapine overdose with rhabdomyolysis.
    The Australian and New Zealand journal of psychiatry, 2005, Volume: 39, Issue:4

    Topics: Adult; Antidepressive Agents, Tricyclic; Depression; Drug Overdose; Humans; Male; Mianserin; Mirtaza

2005
36-Year-old woman with loss of consciousness, fever, and tachycardia.
    Mayo Clinic proceedings, 2005, Volume: 80, Issue:5

    Topics: Adult; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Back Pain; Depression; Diagnosis, Diffe

2005
The effect of mirtazapine in patients with chronic pain and concomitant depression.
    Current medical research and opinion, 2006, Volume: 22, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Chronic Disease; Depre

2006
A suspicious bathtub death in a suicidal patient on mirtazapine.
    Clinical toxicology (Philadelphia, Pa.), 2006, Volume: 44, Issue:1

    Topics: Antidepressive Agents, Tricyclic; Asphyxia; Depression; Diagnosis, Differential; Drowning; Female; F

2006
Recurrent hyponatremia associated with citalopram and mirtazapine.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2006, Volume: 48, Issue:4

    Topics: Aged; Antidepressive Agents; Antidepressive Agents, Tricyclic; Citalopram; Depression; Diagnosis, Di

2006
[Compliance in psychiatry: results of a survey of depressed patients using orally disintegrating tablet].
    Medicina (Kaunas, Lithuania), 2006, Volume: 42, Issue:12

    Topics: Administration, Oral; Adult; Age Factors; Antidepressive Agents, Tricyclic; Chi-Square Distribution;

2006
Cessation of complex visual hallucinations during treatment with mirtazapine.
    Pharmacopsychiatry, 2007, Volume: 40, Issue:2

    Topics: Aged; Antidepressive Agents, Tricyclic; Depression; Female; Hallucinations; Humans; Mianserin; Middl

2007
Mirtazapine for depression and comorbidities in older patients with cancer.
    The Annals of pharmacotherapy, 2007, Volume: 41, Issue:9

    Topics: Aged; Antidepressive Agents, Tricyclic; Antiemetics; Comorbidity; Depression; Humans; Mianserin; Mir

2007
Can prefrontal theta cordance differentiate between depression recovery and dissimulation?
    Neuro endocrinology letters, 2007, Volume: 28, Issue:4

    Topics: Adult; Antidepressive Agents, Tricyclic; Depression; Fatal Outcome; Female; Humans; Mianserin; Mirta

2007
[Differentiated approach to the therapy of endogenous anxious depression].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 2007, Issue:12

    Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Carbon Radioisotopes; Depression; Female; Follow-U

2007
Enhancing effect of mirtazapine on cognitive functions associated with prefrontal cortex in patients with recurrent depression.
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2007, Volume: 9, Issue:3

    Topics: Adult; Aged; Analysis of Variance; Antidepressive Agents, Tricyclic; Case-Control Studies; Cognition

2007
Unusual appetites in patients on mianserin.
    Lancet (London, England), 1980, Mar-15, Volume: 1, Issue:8168 Pt 1

    Topics: Appetite; Body Weight; Depression; Dibenzazepines; Female; Humans; Male; Mianserin; Middle Aged

1980
Interactions of anticonvulsant drugs with mianserin and nomifensine.
    Lancet (London, England), 1981, Oct-17, Volume: 2, Issue:8251

    Topics: Adult; Anticonvulsants; Depression; Dibenzazepines; Drug Interactions; Humans; Isoquinolines; Mianse

1981
Glossitis associated with mianserin.
    Lancet (London, England), 1984, Jan-28, Volume: 1, Issue:8370

    Topics: Aged; Depression; Dibenzazepines; Female; Glossitis; Humans; Male; Mianserin; Middle Aged

1984
Mianserin reduces plasma levels of beta-endorphin immunoreactivity in depressed patients.
    Experientia, 1982, Jun-15, Volume: 38, Issue:6

    Topics: Adult; beta-Endorphin; Depression; Dibenzazepines; Endorphins; Female; Humans; Male; Mianserin; Midd

1982
Mianserin. An example of balancing benefits and risks in therapy.
    The Medical journal of Australia, 1984, Sep-01, Volume: 141, Issue:5

    Topics: Agranulocytosis; Cost-Benefit Analysis; Depression; Dibenzazepines; Humans; Joint Diseases; Kinetics

1984
[Athymil].
    Soins. Psychiatrie, 1984, Issue:41

    Topics: Depression; Dibenzazepines; Humans; Mianserin

1984
Mianserin and jaundice.
    The New Zealand medical journal, 1983, Nov-23, Volume: 96, Issue:744

    Topics: Adult; Cholestasis; Depression; Dibenzazepines; Female; Humans; Mianserin; Multiple Sclerosis

1983
Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 20, Issue:3

    Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Depression; Disease Models, Animal; Humans; Male; Methy

1984
Postsynaptic action by four antidepressive drugs in an animal model of depression.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 15, Issue:1

    Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Di

1981
The therapeutic profile of mianserin in mild elderly depressives [proceedings].
    Psychopharmacology bulletin, 1981, Volume: 17, Issue:1

    Topics: Aged; Amitriptyline; Depression; Dibenzazepines; Double-Blind Method; Humans; Mianserin; Placebos

1981
A simplified method for the estimation of mianserin in plasma.
    British journal of clinical pharmacology, 1981, Volume: 12, Issue:4

    Topics: Depression; Dibenzazepines; Humans; Mianserin

1981
Possible lack of anticholinergic effects with mianserin: a pilot study.
    The Journal of clinical psychiatry, 1980, Volume: 41, Issue:2

    Topics: Adult; Depression; Dibenzazepines; Female; Humans; Male; Mianserin; Middle Aged; Receptors, Choliner

1980
Possible use of mianserin in cases of unacceptable weight gain due to tricyclic anti-depressant therapy.
    The Medical journal of Australia, 1980, Feb-09, Volume: 1, Issue:3

    Topics: Adult; Amitriptyline; Body Weight; Depression; Dibenzazepines; Female; Humans; Mianserin

1980
Effects of chronic mianserin administration on serotonin metabolism and receptors in the 5-hydroxytryptophan depression model.
    Progress in neuro-psychopharmacology & biological psychiatry, 1994, Volume: 18, Issue:1

    Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain Chemistry; Cerebral Cort

1994
Curative effects of the atypical antidepressant mianserin in the chronic mild stress-induced anhedonia model of depression.
    Journal of psychiatry & neuroscience : JPN, 1994, Volume: 19, Issue:1

    Topics: Animals; Behavior, Animal; Depression; Male; Mianserin; Rats; Self Stimulation; Stress, Psychologica

1994
Mianserin in breast milk.
    British journal of clinical pharmacology, 1993, Volume: 36, Issue:2

    Topics: Adult; Depression; Female; Humans; Lactation; Mianserin; Milk, Human; Postpartum Period

1993
Steady-state plasma concentrations of mianserin and its major active metabolite, desmethylmianserin.
    Therapeutic drug monitoring, 1993, Volume: 15, Issue:2

    Topics: Adult; Age Factors; Aged; Chromatography, High Pressure Liquid; Depression; Female; Humans; Male; Mi

1993
Prediction of plasma concentrations of mianserin and desmethylmianserin at steady state from those after an initial dose of mianserin.
    Therapeutic drug monitoring, 1993, Volume: 15, Issue:2

    Topics: Adult; Aged; Animals; Depression; Female; Humans; Male; Mianserin; Middle Aged

1993
Mirtazapine--a new antidepressant.
    The Medical letter on drugs and therapeutics, 1996, Dec-20, Volume: 38, Issue:990

    Topics: Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depression; Histamine H1 Antagonists; Hu

1996
Effects of antidepressants on phencyclidine-induced enhancement of immobility in a forced swimming test in mice.
    European journal of pharmacology, 1997, Apr-18, Volume: 324, Issue:2-3

    Topics: Animals; Antidepressive Agents; Depression; Desipramine; Hallucinogens; Hydroxyindoleacetic Acid; Ma

1997
Effects of thioridazine, an inhibitor of CYP2D6, on the steady-state plasma concentrations of the enantiomers of mianserin and its active metabolite, desmethylmianserin, in depressed Japanese patients.
    Pharmacogenetics, 1997, Volume: 7, Issue:5

    Topics: Antidepressive Agents, Second-Generation; Cytochrome P-450 CYP2D6 Inhibitors; Depression; Enzyme Inh

1997
Correlation between steady-state plasma concentrations of mianserin and trazodone in depressed patients.
    European journal of clinical pharmacology, 1998, Volume: 53, Issue:5

    Topics: Antidepressive Agents, Second-Generation; Cytochrome P-450 CYP2D6; Depression; Female; Humans; Male;

1998
[Treatment of fibromyalgia].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1998, Volume: 98, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Second-Generation; Anxiety Di

1998
Serotonin syndrome with mirtazapine-fluoxetine combination.
    International journal of geriatric psychiatry, 1998, Volume: 13, Issue:7

    Topics: Adrenergic alpha-Antagonists; Aged; Antidepressive Agents, Tricyclic; Depression; Drug Interactions;

1998
[Mirtazapin--fast and strong effects].
    Fortschritte der Neurologie-Psychiatrie, 1998, Volume: 66, Issue:10 Suppl M

    Topics: Antidepressive Agents, Tricyclic; Depression; Fluoxetine; Humans; Mianserin; Mirtazapine; Selective

1998
Mirtazapine-induced mania in a case of poststroke depression.
    The Journal of neuropsychiatry and clinical neurosciences, 1999,Winter, Volume: 11, Issue:1

    Topics: Aged; Antidepressive Agents, Tricyclic; Bipolar Disorder; Cerebrovascular Disorders; Depression; Hum

1999
Clinical pharmacology of mirtazapine: revisited.
    American family physician, 1999, Sep-15, Volume: 60, Issue:4

    Topics: Agranulocytosis; Antidepressive Agents, Tricyclic; Anxiety; Depression; Humans; Mianserin; Mirtazapi

1999
[Mirtazapine--the new standard].
    Fortschritte der Neurologie-Psychiatrie, 1999, Volume: 67, Issue:8 Suppl

    Topics: Antidepressive Agents, Tricyclic; Depression; Depressive Disorder; Humans; Mianserin; Mirtazapine

1999
Does mirtazapine enhance serotonergic neurotransmission in depressed patients?
    Psychopharmacology, 2000, Volume: 148, Issue:3

    Topics: Adult; Antidepressive Agents, Tricyclic; Depression; Female; Humans; Male; Mianserin; Middle Aged; M

2000
Hypertensive urgency induced by an interaction of mirtazapine and clonidine.
    Pharmacotherapy, 2000, Volume: 20, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Antidepressive Agents; Antihypertens

2000
[Macroglossia and tongue papular injury due to mirtazapine treatment].
    Medicina clinica, 2000, Jun-10, Volume: 115, Issue:2

    Topics: Adult; Antidepressive Agents, Tricyclic; Depression; Humans; Macroglossia; Male; Mianserin; Mirtazap

2000
The differential effects of calcium channel blockers in the behavioural despair test in mice.
    Pharmacological research, 2000, Volume: 42, Issue:4

    Topics: Animals; Antidepressive Agents; Calcium Channel Blockers; Clomipramine; Clonidine; Cyproheptadine; D

2000
Economic impact of using mirtazapine compared to amitriptyline and fluoxetine in the treatment of moderate and severe depression in the UK.
    European psychiatry : the journal of the Association of European Psychiatrists, 2000, Volume: 15, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Cost-Be

2000
Treatment of hot flushes with mirtazapine: four case reports.
    Maturitas, 2000, Oct-31, Volume: 36, Issue:3

    Topics: Adult; Antidepressive Agents, Tricyclic; Depression; Female; Hot Flashes; Humans; Mianserin; Middle

2000
Mirtazapine for treatment of depression and comorbidities in Alzheimer disease.
    The Annals of pharmacotherapy, 2001, Volume: 35, Issue:9

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antidepressive Agents, Tricyclic; Comorbidity; Depressio

2001
Availability of learned helplessness test as a model of depression compared to a forced swimming test in rats.
    Pharmacology, 2001, Volume: 63, Issue:3

    Topics: Amoxapine; Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Depression; Disease Model

2001
[Interference in the serotoninergic and noradrenergic system. Faster out of depression].
    MMW Fortschritte der Medizin, 2001, Nov-01, Volume: 143, Issue:44

    Topics: Adrenergic alpha-Antagonists; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricy

2001
Chronic treatment with imipramine or mirtazapine antagonizes stress- and FG7142-induced increase in cortical norepinephrine output in freely moving rats.
    Synapse (New York, N.Y.), 2002, Volume: 43, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Carbolines; Cerebral Cortex

2002
In the rat forced swimming test, NA-system mediated interactions may prevent the 5-HT properties of some subacute antidepressant treatments being expressed.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2002, Volume: 12, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Biogenic Monoamines; Brain; Depression

2002
Severe serotonin syndrome induced by mirtazapine monotherapy.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:4

    Topics: Aged; Antidepressive Agents, Tricyclic; Depression; Humans; Male; Mianserin; Mirtazapine; Serotonin

2002
Acute and chronic hypertensive headache and hypertensive encephalopathy.
    Cephalalgia : an international journal of headache, 2002, Volume: 22, Issue:4

    Topics: Acute Disease; Antidepressive Agents; Antihypertensive Agents; Anxiety; Arterioles; Cerebral Arterie

2002
Effect of chronic amphetamine administration on the behaviour of rats in the open field apparatus: reversal of post-withdrawal depression by two antidepressants.
    The Journal of pharmacy and pharmacology, 1978, Volume: 30, Issue:12

    Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Dextroamphetamine; Huma

1978
Leucopenia in association with mianserin treatment.
    British medical journal, 1979, Mar-03, Volume: 1, Issue:6163

    Topics: Aged; Chronic Disease; Depression; Dibenzazepines; Female; Humans; Leukopenia; Mianserin

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
A new depression scale designed to be sensitive to change.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Aged; Amitriptyline; Clomipramine; Depression; England; Female; Humans; Male; Map

1979
[Treatment of depressed out-patients with mianserin (author's transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1979, Jul-24, Volume: 68, Issue:30

    Topics: Ambulatory Care; Depression; Dibenzazepines; Female; Humans; Male; Mianserin

1979
Video-analytic study of manual kinesics and its lateralization in the course of treatment of depressive syndromes.
    Acta psychiatrica Scandinavica, 1979, Volume: 59, Issue:5

    Topics: Amitriptyline; Depression; Humans; Interview, Psychological; Kinesics; Mianserin; Videotape Recordin

1979
Novel antidepressants and the biogenic amine hypothesis of depression. The case for iprindole and mianserin.
    Archives of general psychiatry, 1979, Volume: 36, Issue:10

    Topics: Adjustment Disorders; Affective Disorders, Psychotic; Amitriptyline; Biogenic Amines; Brain; Depress

1979
Effect of mianserin on cardiac conduction.
    The Medical journal of Australia, 1979, Jul-28, Volume: 2, Issue:2

    Topics: Adult; Depression; Dibenzazepines; Female; Heart; Heart Conduction System; Hemodynamics; Humans; Mal

1979
Depression: a new animal model sensitive to antidepressant treatments.
    Nature, 1977, Apr-21, Volume: 266, Issue:5604

    Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Electroshock; Humans; Iprindole;

1977
Two more new antidepressives: mianserin and butriptyline.
    Drug and therapeutics bulletin, 1977, Jan-07, Volume: 15, Issue:1

    Topics: Depression; Dibenzazepines; Dibenzocycloheptenes; Humans; Mianserin

1977
Clinical experience with Org GB94 (mianserin hydrochloride), a new tetracyclic antidepressant.
    Folia psychiatrica et neurologica japonica, 1978, Volume: 32, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aged; Antidepressive Agents; Bipolar Disorder; Depression; Dibenzaze

1978
[Study report on the lack of interaction between mianserine and noradrenaline in man].
    Fortschritte der Medizin, 1978, Jul-06, Volume: 96, Issue:25

    Topics: Antidepressive Agents, Tricyclic; Depression; Dibenzazepines; Drug Evaluation; Drug Interactions; Hu

1978
Mass fragmentographic assay of nanogram amounts of the antidepressant drug mianserin hydrochloride (Org GB 94) in human plasma.
    Journal of chromatography, 1977, May-01, Volume: 143, Issue:3

    Topics: Adult; Depression; Dibenzazepines; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Male; Mia

1977
Poisoning with antidepressants.
    British medical journal, 1977, Sep-03, Volume: 2, Issue:6087

    Topics: Antidepressive Agents; Depression; Dibenzazepines; Family Practice; Flupenthixol; Humans; Mianserin;

1977
Mianserin hydrochloride: a novel antidepressant.
    The British journal of psychiatry : the journal of mental science, 1976, Volume: 129

    Topics: Adjustment Disorders; Amitriptyline; Depression; Dibenzazepines; Drug Evaluation; Female; Humans; Ma

1976
[Symptoms of Creutzfeldt-Jakob disease during mianserin therapy].
    Duodecim; laaketieteellinen aikakauskirja, 1991, Volume: 107, Issue:3

    Topics: Aged; Creutzfeldt-Jakob Syndrome; Depression; Epilepsy; Epilepsy, Tonic-Clonic; Female; Humans; Male

1991
[Lithium augmentation for mianserin-resistant depression in the elderly].
    Harefuah, 1992, Volume: 123, Issue:7-8

    Topics: Aged; Depression; Drug Resistance; Drug Therapy, Combination; Humans; Lithium; Male; Mianserin

1992
Effects of MK-801 and antidepressant drugs in the forced swimming test in rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1992, Volume: 2, Issue:1

    Topics: Animals; Antidepressive Agents; Citalopram; Depression; Dizocilpine Maleate; Haloperidol; Imipramine

1992
Depression in Alzheimer's disease significantly improved under treatment with mianserine.
    Journal of the American Geriatrics Society, 1991, Volume: 39, Issue:11

    Topics: Aged; Alzheimer Disease; Depression; Female; Humans; Mianserin

1991
Comparison of the effects of mianserin and its enantiomers and metabolites on a behavioral screen for antidepressant activity.
    Psychopharmacology, 1991, Volume: 105, Issue:4

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Conditioning, Operant; Depre

1991
[Depression in late life].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1991, Volume: 28, Issue:4

    Topics: Age Factors; Aged; Antidepressive Agents; Depression; Electric Stimulation Therapy; Humans; Japan; M

1991
Mianserin as a cause of arthritis.
    British journal of rheumatology, 1991, Volume: 30, Issue:1

    Topics: Arthritis; Depression; Humans; Joint Diseases; Mianserin; Pain

1991
Lack of tolerance to imipramine or mianserine in two animal models of depression.
    Pharmacology, 1990, Volume: 41, Issue:6

    Topics: Amphetamine; Animals; Anorexia; Behavior, Animal; Depression; Disease Models, Animal; Dose-Response

1990
[Determination of 3-methoxy-4-hydroxyphenyethylene-glycol and its urinary conjugates. Value in the diagnosis and therapeutic follow-up of depression].
    Pathologie-biologie, 1988, Volume: 36, Issue:3

    Topics: Clomipramine; Depression; Drug Therapy, Combination; Follow-Up Studies; Glycols; Humans; Hydroxyindo

1988
Hepatic injury caused by mianserin.
    BMJ (Clinical research ed.), 1989, Aug-19, Volume: 299, Issue:6697

    Topics: Chemical and Drug Induced Liver Injury; Depression; Female; Humans; Liver; Male; Mianserin; Middle A

1989
The efficacy of mianserin (Lerivon) in various forms of depression.
    Activitas nervosa superior, 1989, Volume: 31, Issue:1

    Topics: Adult; Antidepressive Agents, Tricyclic; Depression; Dose-Response Relationship, Drug; Female; Human

1989
Psychiatrists and Alzheimer's disease.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1989, Volume: 43, Issue:7

    Topics: Alzheimer Disease; Circadian Rhythm; Cognition; Dementia; Depression; Diagnosis, Differential; Human

1989
Mianserin plasma levels and clinical response in primary depression.
    The Kobe journal of medical sciences, 1986, Volume: 32, Issue:6

    Topics: Adult; Aged; Depression; Female; Humans; Male; Mianserin; Middle Aged; Psychiatric Status Rating Sca

1986
Mianserin in the treatment of elderly depressives.
    Journal of the American Geriatrics Society, 1987, Volume: 35, Issue:7

    Topics: Aged; Depression; Humans; Mianserin

1987
[2d-generation antidepressive agents].
    Nederlands tijdschrift voor geneeskunde, 1987, Aug-08, Volume: 131, Issue:32

    Topics: Depression; Humans; Mianserin; Serotonin Antagonists

1987
Mianserin.
    The New Zealand medical journal, 1985, Mar-27, Volume: 98, Issue:775

    Topics: Antidepressive Agents, Tricyclic; Depression; Dibenzazepines; Humans; Mianserin; Suicide

1985
Mianserin and agranulocytosis.
    The Medical journal of Australia, 1986, Feb-03, Volume: 144, Issue:3

    Topics: Aged; Agranulocytosis; Depression; Dibenzazepines; Female; Humans; Mianserin

1986