mianserin and Chemical Dependence
mianserin has been researched along with Chemical Dependence in 8 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two depressive patients with systemic lupus erythematosus (SLE) and cerebral infarction, while being treated with corticosteroid, are described." | 5.29 | Antidepressant effect of lithium in patients with systemic lupus erythematosus and cerebral infarction, treated with corticosteroid. ( Abe, K; Mizuki, T; Ohji, T; Terao, T, 1994) |
| "Most patients with major depressive disorder (MDD) report clinically significant sleep problems." | 2.80 | Pre-treatment insomnia as a predictor of single and combination antidepressant outcomes: a CO-MED report. ( Luther, JF; Rush, AJ; Sung, SC; Trivedi, MH; Wisniewski, SR, 2015) |
| "The co-occurrence of substance use disorder (SUD) and major depressive disorder (MDD) is common and is often thought to impair response to antidepressant therapy." | 2.77 | Effect of concurrent substance use disorder on the effectiveness of single and combination antidepressant medications for the treatment of major depression: an exploratory analysis of a single-blind randomized trial. ( Balasubramani, GK; Davis, LL; Fava, M; Gaynes, BN; Howland, RH; Pilkinton, P; Rush, AJ; Trivedi, MH; Wisniewski, SR; Zisook, S, 2012) |
| "Mirtazapine (Remeron®) is a unique FDA-approved antidepressant, with negligible affinity for reuptake proteins, indirectly augments monoamine transmission presumably through antagonist activity at multiple receptors including the norepinephrine (NE)(α2), and serotonin (5-HT)(2A/C) receptors." | 2.48 | Mirtazapine, and mirtazapine-like compounds as possible pharmacotherapy for substance abuse disorders: evidence from the bench and the bedside. ( Graves, SM; Napier, TC; Rafeyan, R; Watts, J, 2012) |
| "Mirtazapine is a comparatively new antidepressant that selectively blocks central alpha2-adrenergic autoreceptors and postsynaptic 5-HT2 and 5-HT3 receptors, causing reduced neuronal norepinephrine and serotonin reuptake." | 1.34 | Lack of significant toxicity after mirtazapine overdose: a five-year review of cases admitted to a regional toxicology unit. ( Bateman, DN; Good, AM; Waring, WS, 2007) |
| "Two depressive patients with systemic lupus erythematosus (SLE) and cerebral infarction, while being treated with corticosteroid, are described." | 1.29 | Antidepressant effect of lithium in patients with systemic lupus erythematosus and cerebral infarction, treated with corticosteroid. ( Abe, K; Mizuki, T; Ohji, T; Terao, T, 1994) |
Research
Studies (8)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Rosenqvist, TW | 1 |
| Osler, M | 1 |
| Wium-Andersen, MK | 1 |
| Wium-Andersen, IK | 1 |
| Sung, SC | 1 |
| Wisniewski, SR | 2 |
| Luther, JF | 1 |
| Trivedi, MH | 2 |
| Rush, AJ | 2 |
| Holt, C | 1 |
| Butler, S | 1 |
| Agius, M | 1 |
| Zaman, R | 1 |
| Davis, LL | 1 |
| Pilkinton, P | 1 |
| Gaynes, BN | 1 |
| Howland, RH | 1 |
| Zisook, S | 1 |
| Balasubramani, GK | 1 |
| Fava, M | 1 |
| Graves, SM | 1 |
| Rafeyan, R | 1 |
| Watts, J | 1 |
| Napier, TC | 1 |
| Waring, WS | 1 |
| Good, AM | 1 |
| Bateman, DN | 1 |
| Terao, T | 1 |
| Mizuki, T | 1 |
| Ohji, T | 1 |
| Abe, K | 1 |
| Fink, M | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Clinical Studies on Anti-addictive Therapeutic Effects of Mirtazapine in Human Subjects Addicted to Cocaine.[NCT01949571] | Phase 2 | 64 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
1 review available for mianserin and Chemical Dependence
| Article | Year |
|---|---|
Mirtazapine, and mirtazapine-like compounds as possible pharmacotherapy for substance abuse disorders: evidence from the bench and the bedside.
Topics: Animals; Antidepressive Agents, Tricyclic; Central Nervous System Stimulants; Conditioning, Psycholo | 2012 |
Trials
2 trials available for mianserin and Chemical Dependence
| Article | Year |
|---|---|
Pre-treatment insomnia as a predictor of single and combination antidepressant outcomes: a CO-MED report.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Anxiety Disorders; Bupropion; Citalopram; Comorbidit | 2015 |
Effect of concurrent substance use disorder on the effectiveness of single and combination antidepressant medications for the treatment of major depression: an exploratory analysis of a single-blind randomized trial.
Topics: Adolescent; Antidepressive Agents; Bupropion; Chronic Disease; Citalopram; Cyclohexanols; Depressive | 2012 |
Other Studies
5 other studies available for mianserin and Chemical Dependence
| Article | Year |
|---|---|
Sedative drug-use in Denmark, 2000 to 2019: a nationwide drug utilization study.
Topics: Benzodiazepines; Denmark; Drug Prescriptions; Drug Utilization; Female; Humans; Hypnotics and Sedati | 2023 |
An audit to compare patient factors (age, sex, social background & associated physical diagnoses) in people with refractory depression in a Bedfordshire Community Mental Health Team (BCMHT) being augmented with (A) mirtazepine, (B) atypical antipsychotics
Topics: Adult; Age Distribution; Alcoholism; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Combine | 2011 |
Lack of significant toxicity after mirtazapine overdose: a five-year review of cases admitted to a regional toxicology unit.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Drug Overdose; Female; | 2007 |
Antidepressant effect of lithium in patients with systemic lupus erythematosus and cerebral infarction, treated with corticosteroid.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Cerebral Infarction; Depressive Disorder; Dose-Response | 1994 |
EEG and psychopharmacology.
Topics: Animals; Benzodiazepines; Biological Availability; Bromazepam; Cannabinoids; Cycloserine; Diazepam; | 1978 |