Page last updated: 2024-10-31

mianserin and Cachexia

mianserin has been researched along with Cachexia in 5 studies

Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.

Cachexia: General ill health, malnutrition, and weight loss, usually associated with chronic disease.

Research Excerpts

ExcerptRelevanceReference
"We performed an open-label single-institution phase II trial of mirtazapine (15-30 mg by mouth [po] every day [qd]), a tetracyclic antidepressant that may lead to weight gain, for 8 weeks in nondepressed patients with cancer-related cachexia/anorexia (CRCA)."9.14Phase II trial of mirtazapine for cancer-related cachexia and anorexia. ( Burman, D; Riechelmann, RP; Rodin, G; Tannock, IF; Zimmermann, C, 2010)
"To investigate the effect of mirtazapine on tumor growth, food intake, body weight, and nutritional status in gemcitabine-induced mild cachexia."7.78Intervention of mirtazapine on gemcitabine-induced mild cachexia in nude mice with pancreatic carcinoma xenografts. ( Jia, L; Jiang, SM; Wu, JH, 2012)
"Mirtazapine and olanzapine are easy-to-use psychiatric drugs with potent antinausea effects."7.74Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects. ( Foley, KF; Kast, RE, 2007)
"We performed an open-label single-institution phase II trial of mirtazapine (15-30 mg by mouth [po] every day [qd]), a tetracyclic antidepressant that may lead to weight gain, for 8 weeks in nondepressed patients with cancer-related cachexia/anorexia (CRCA)."5.14Phase II trial of mirtazapine for cancer-related cachexia and anorexia. ( Burman, D; Riechelmann, RP; Rodin, G; Tannock, IF; Zimmermann, C, 2010)
"To investigate the effect of mirtazapine on tumor growth, food intake, body weight, and nutritional status in gemcitabine-induced mild cachexia."3.78Intervention of mirtazapine on gemcitabine-induced mild cachexia in nude mice with pancreatic carcinoma xenografts. ( Jia, L; Jiang, SM; Wu, JH, 2012)
"Mirtazapine and olanzapine are easy-to-use psychiatric drugs with potent antinausea effects."3.74Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects. ( Foley, KF; Kast, RE, 2007)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fox, CB1
Treadway, AK1
Blaszczyk, AT1
Sleeper, RB1
Riechelmann, RP1
Burman, D1
Tannock, IF1
Rodin, G1
Zimmermann, C1
Jiang, SM1
Wu, JH1
Jia, L1
Schillerstrom, JE1
Seaman, JS1
Kast, RE1
Foley, KF1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized, Double-blind Clinical Trial of the Use of Mirtazapine Versus Megestrol for the Control of Anorexia-cachexia in Cancer Patients in Palliative Care.[NCT03283488]Phase 252 participants (Actual)Interventional2019-03-26Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for mianserin and Cachexia

ArticleYear
Megestrol acetate and mirtazapine for the treatment of unplanned weight loss in the elderly.
    Pharmacotherapy, 2009, Volume: 29, Issue:4

    Topics: Aged; Antidepressive Agents, Tricyclic; Appetite Stimulants; Cachexia; Case-Control Studies; Dose-Re

2009

Trials

1 trial available for mianserin and Cachexia

ArticleYear
Phase II trial of mirtazapine for cancer-related cachexia and anorexia.
    The American journal of hospice & palliative care, 2010, Volume: 27, Issue:2

    Topics: Aged; Aged, 80 and over; Anorexia; Antidepressive Agents, Tricyclic; Appetite; Body Weight; Cachexia

2010

Other Studies

3 other studies available for mianserin and Cachexia

ArticleYear
Intervention of mirtazapine on gemcitabine-induced mild cachexia in nude mice with pancreatic carcinoma xenografts.
    World journal of gastroenterology, 2012, Jun-14, Volume: 18, Issue:22

    Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Cachexia; Carcinoma; Cell Line, Tumor; Deoxyc

2012
Modafinil augmentation of mirtazapine in a failure-to-thrive geriatric inpatient.
    International journal of psychiatry in medicine, 2002, Volume: 32, Issue:4

    Topics: Aged; Antidepressive Agents, Tricyclic; Benzhydryl Compounds; Cachexia; Central Nervous System Stimu

2002
Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects.
    European journal of cancer care, 2007, Volume: 16, Issue:4

    Topics: Antiemetics; Antineoplastic Agents; Benzodiazepines; Cachexia; Humans; Mianserin; Mirtazapine; Nause

2007