mianserin has been researched along with Bipolar Disorder in 37 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 40-year-old woman with bipolar disorder who was taking mirtazapine presented with mydriasis, abnormal diaphoresis, myoclonus and muscle rigidity after taking metocloplamide." | 7.85 | Metoclopramide-induced Serotonin Syndrome. ( Harada, T; Hirosawa, T; Morinaga, K; Shimizu, T, 2017) |
| " There were more withdrawals and dosage changes with nomifensine than with mianserin." | 6.66 | Depression and anxiety: mianserin and nomifensine compared in a double-blind multicentre trial. ( Boscredon, J; Escande, M; Girard, M; Granier, F; Oules, J; Schmitt, L, 1985) |
| " Based on the case report of a patient who developed mania with higher than recommended dosage of mirtazapine, we review the literature on the atypical nature of manic symptoms with mirtazapine." | 5.31 | Dysphoric mania induced by high-dose mirtazapine: a case for 'norepinephrine syndrome'? ( Bhanji, NH; Chouinard, G; Margolese, HC; Saint-Laurent, M, 2002) |
| "A 40-year-old woman with bipolar disorder who was taking mirtazapine presented with mydriasis, abnormal diaphoresis, myoclonus and muscle rigidity after taking metocloplamide." | 3.85 | Metoclopramide-induced Serotonin Syndrome. ( Harada, T; Hirosawa, T; Morinaga, K; Shimizu, T, 2017) |
| " We report a case with no previous history of bipolar disorder, whereas developed full-blown psychotic manic symptoms soon after switch from fluoxetine to mirtazapine." | 3.75 | Antidepressant-associated mania: soon after switch from fluoxetine to mirtazapine in an elderly woman with mixed depressive features. ( Liang, KY; Liao, SC; Liu, CC, 2009) |
| "(1) Org GB94 (Mianserin hydrochloride), a new tetracyclic antidepressant, was administered to 21 patients with depression or with depressive states." | 3.66 | Clinical experience with Org GB94 (mianserin hydrochloride), a new tetracyclic antidepressant. ( Inanaga, K; Nakano, T; Okamoto, K, 1978) |
| "The citalopram-treated patients in whom AAM developed were significantly older than those in whom it did not (about 10 years, P < 0." | 2.69 | Is selectivity for serotonin uptake associated with a reduced emergence of manic episodes in depressed patients? ( Barak, Y; Kimhi, R; Weizman, R, 2000) |
| " There were more withdrawals and dosage changes with nomifensine than with mianserin." | 2.66 | Depression and anxiety: mianserin and nomifensine compared in a double-blind multicentre trial. ( Boscredon, J; Escande, M; Girard, M; Granier, F; Oules, J; Schmitt, L, 1985) |
| "The mianserin-treated group reported more side-effects of sedation (eg." | 2.66 | A double-blind out-patient trial of indalpine vs mianserin. ( Martin, B; Naylor, GJ, 1985) |
| "Mianserin is a recently introduced antidepressant but its mode of action is unknown." | 2.64 | Attempt to demonstrate an in vivo effect of mianserin hydrochloride on erythrocyte Na+-K+-ATPase activity and cyclic AMP concentration. ( Boardman, LJ; Buckley, DE; Moody, JP; Naylor, GS; Smith, AH, 1978) |
| "The pharmacologic treatment of schizophrenia and bipolar disorder leaves much to be desired." | 2.48 | Adjunct treatments for schizophrenia and bipolar disorder: what to try when you are out of ideas. ( Davis, JM; Torrey, EF, 2012) |
| "Unipolar depression is also strongly influenced by nongenetic environmental factors (e." | 2.42 | [Genetics of depression. Current knowledge and perspectives]. ( Maier, W, 2004) |
| " Based on the case report of a patient who developed mania with higher than recommended dosage of mirtazapine, we review the literature on the atypical nature of manic symptoms with mirtazapine." | 1.31 | Dysphoric mania induced by high-dose mirtazapine: a case for 'norepinephrine syndrome'? ( Bhanji, NH; Chouinard, G; Margolese, HC; Saint-Laurent, M, 2002) |
| "Mirtazapine is a new antidepressant with a specific pharmacological profile which is different from all other currently available antidepressants." | 1.30 | [Mirtazapine in inpatient treatment of depressed patients]. ( Bailer, U; Kasper, S; Pezawas, L; Praschak-Rieder, N, 1998) |
| "Mianserin in a dosage of 20 mg 3 times daily, was given to 13 patients with bipolar affective illness, who were previously maintained on lithium." | 1.26 | Mianserin in the prophylactic treatment of bipolar affective illness. ( Coppen, A; Ghose, K; Peet, M; Rao, VA, 1977) |
| " Our quantitative pharmaco-EEG and clinical trials clearly demonstrated the significant value of quantitative EEG in early screening of psychoactive drugs in order to predict their clinical values and effective dosage ranges." | 1.25 | New drug developments in the Netherlands. "Tetracyclic" psychotropic drugs. ( Dincmen, K; Egilmez, S; Itil, TM; Polvan, N; Sungerbey, K, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (29.73) | 18.7374 |
| 1990's | 7 (18.92) | 18.2507 |
| 2000's | 13 (35.14) | 29.6817 |
| 2010's | 6 (16.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Harada, T | 1 |
| Hirosawa, T | 1 |
| Morinaga, K | 1 |
| Shimizu, T | 1 |
| Lackner, N | 1 |
| Birner, A | 1 |
| Bengesser, SA | 1 |
| Reininghaus, B | 1 |
| Kapfhammer, HP | 1 |
| Reininghaus, E | 1 |
| Liu, CC | 1 |
| Liang, KY | 1 |
| Liao, SC | 1 |
| Benedetti, F | 1 |
| Barbini, B | 1 |
| Bernasconi, A | 1 |
| Fulgosi, MC | 1 |
| Colombo, C | 1 |
| Dallaspezia, S | 1 |
| Gavinelli, C | 1 |
| Marino, E | 1 |
| Pirovano, A | 1 |
| Radaelli, D | 1 |
| Smeraldi, E | 1 |
| Horstmann, S | 1 |
| Dose, T | 1 |
| Lucae, S | 1 |
| Kloiber, S | 1 |
| Menke, A | 1 |
| Hennings, J | 1 |
| Spieler, D | 1 |
| Uhr, M | 1 |
| Holsboer, F | 1 |
| Ising, M | 1 |
| Goyal, N | 1 |
| Sinha, VK | 1 |
| Grønli, O | 1 |
| Stensland, GØ | 1 |
| Wynn, R | 1 |
| Olstad, R | 1 |
| Habermeyer, B | 1 |
| Bayer, U | 1 |
| Müller-Spahn, F | 1 |
| Basavraj, V | 1 |
| Nanjundappa, GB | 1 |
| Chandra, PS | 1 |
| Torrey, EF | 1 |
| Davis, JM | 1 |
| Estabrook, KR | 1 |
| Pheister, M | 1 |
| Bhanji, NH | 1 |
| Margolese, HC | 1 |
| Saint-Laurent, M | 1 |
| Chouinard, G | 1 |
| Maier, W | 1 |
| Wilson, MS | 1 |
| Apikoglu Rabus, S | 1 |
| Izzettin, F | 1 |
| Rabus, M | 1 |
| Bilici, M | 1 |
| Schüle, C | 1 |
| Baghai, TC | 1 |
| Eser, D | 1 |
| Hecht, S | 1 |
| Hermisson, I | 1 |
| Born, C | 1 |
| Häfner, S | 1 |
| Nothdurfter, C | 1 |
| Rupprecht, R | 1 |
| Itil, TM | 1 |
| Polvan, N | 1 |
| Dincmen, K | 1 |
| Egilmez, S | 1 |
| Sungerbey, K | 1 |
| Moody, JP | 3 |
| Smith, AH | 3 |
| Naylor, GJ | 2 |
| Soutullo, CA | 1 |
| McElroy, SL | 1 |
| Keck, PE | 1 |
| Bailer, U | 1 |
| Praschak-Rieder, N | 1 |
| Pezawas, L | 1 |
| Kasper, S | 1 |
| De León, OA | 1 |
| Furmaga, KM | 1 |
| Kaltsounis, J | 1 |
| MacCall, C | 1 |
| Callender, J | 1 |
| Barak, Y | 1 |
| Kimhi, R | 1 |
| Weizman, R | 1 |
| Ng, B | 1 |
| Raja, M | 1 |
| Azzoni, A | 1 |
| Naylor, GS | 2 |
| Buckley, DE | 1 |
| Boardman, LJ | 1 |
| Svestka, J | 1 |
| Náhunek, K | 1 |
| Cesková, E | 1 |
| Rysánek, R | 1 |
| Misurec, J | 1 |
| Okamoto, K | 1 |
| Nakano, T | 1 |
| Inanaga, K | 1 |
| Coppen, A | 1 |
| Ghose, K | 1 |
| Rao, VA | 1 |
| Peet, M | 1 |
| Kaneko, M | 1 |
| Watanabe, K | 1 |
| Kumashiro, H | 1 |
| Candito, M | 1 |
| Pringuey, D | 1 |
| Iordache, A | 1 |
| Souêtre, E | 1 |
| Chambon, P | 1 |
| Darcourt, G | 1 |
| Bell, A | 1 |
| Mertens, C | 1 |
| Pintens, H | 1 |
| Granier, F | 1 |
| Girard, M | 1 |
| Schmitt, L | 1 |
| Boscredon, J | 1 |
| Oules, J | 1 |
| Escande, M | 1 |
| Sturdy, JL | 1 |
| Mahapatra, SB | 1 |
| Martin, B | 1 |
2 reviews available for mianserin and Bipolar Disorder
| Article | Year |
|---|---|
Adjunct treatments for schizophrenia and bipolar disorder: what to try when you are out of ideas.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; An | 2012 |
[Genetics of depression. Current knowledge and perspectives].
Topics: Adolescent; Adult; Age Factors; Aged; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depressive | 2004 |
9 trials available for mianserin and Bipolar Disorder
| Article | Year |
|---|---|
Suppressive effect of mirtazapine on the HPA system in acutely depressed women seems to be transient and not related to antidepressant action.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Antidepressive Agents, Tricyclic; Bipolar Disorder; | 2009 |
Mirtazapine monotherapy versus combination therapy with mirtazapine and aripiprazole in depressed patients without psychotic features: a 4-week open-label parallel-group study.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Aripiprazole; Bipolar Disorder; | 2007 |
Is selectivity for serotonin uptake associated with a reduced emergence of manic episodes in depressed patients?
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Bipolar Disorder; Citalopr | 2000 |
Attempt to demonstrate an in vivo effect of mianserin hydrochloride on erythrocyte Na+-K+-ATPase activity and cyclic AMP concentration.
Topics: Adenosine Triphosphatases; Bipolar Disorder; Cyclic AMP; Dibenzazepines; Erythrocytes; Female; Human | 1978 |
Placebo-controlled double-blind trial of mianserin hydrochloride.
Topics: Bipolar Disorder; Clinical Trials as Topic; Dibenzazepines; Double-Blind Method; Drug Evaluation; Fe | 1978 |
Controlled comparison of mianserine with imipramine in endogenous depressions.
Topics: Adolescent; Adult; Aged; Bipolar Disorder; Dibenzazepines; Double-Blind Method; Electroencephalograp | 1979 |
A double-blind, multicentre study of paroxetine and mianserin in depression.
Topics: Antidepressive Agents; Bipolar Disorder; Clinical Trials as Topic; Depressive Disorder; Double-Blind | 1989 |
Depression and anxiety: mianserin and nomifensine compared in a double-blind multicentre trial.
Topics: Adjustment Disorders; Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety; Bipolar Disorder; Depre | 1985 |
A double-blind out-patient trial of indalpine vs mianserin.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Bipolar Disorder; Clinical Trials as Topic; Depressi | 1985 |
26 other studies available for mianserin and Bipolar Disorder
| Article | Year |
|---|---|
Metoclopramide-induced Serotonin Syndrome.
Topics: Adult; Antiemetics; Bipolar Disorder; Drug Interactions; Female; Humans; Metoclopramide; Mianserin; | 2017 |
[Pediatric bipolar disorder - case report of a bipolar patient with disease onset in childhood and adolescence: implications for diagnosis and therapy].
Topics: Adolescent; Age of Onset; Antipsychotic Agents; Bipolar Disorder; Child; Diagnosis, Differential; Di | 2014 |
Antidepressant-associated mania: soon after switch from fluoxetine to mirtazapine in an elderly woman with mixed depressive features.
Topics: Adrenergic alpha-Antagonists; Aged; Bipolar Disorder; Depressive Disorder, Major; Dose-Response Rela | 2009 |
Serotonin 5-HT2A receptor gene variants influence antidepressant response to repeated total sleep deprivation in bipolar depression.
Topics: Adult; Analysis of Variance; Antidepressive Agents, Tricyclic; Bipolar Disorder; Female; Humans; Mal | 2008 |
Mirtazapine-induced manic switch in adolescent unipolar depression.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Antimanic Agents; Bipolar Disorder; Depressive Disorde | 2008 |
Neurotrophic factors in serum following ECT: a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Bipolar Disorder; Combined Modality Therapy; Cyclohexanols; Depressi | 2009 |
Mania associated with mirtazepine treatment and mixed depression.
Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Depression; Humans; Male; Mianserin; Middle Aged | 2010 |
Mirtazapine induced mania in a woman with major depression in the absence of features of bipolarity.
Topics: Adult; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depressive Disorder, Major; Female; Human | 2011 |
A case of quetiapine XR and divalproex-associated neutropenia followed by successful use of ziprasidone.
Topics: Adult; Anti-Anxiety Agents; Antimanic Agents; Antipsychotic Agents; Anxiety Disorders; Bipolar Disor | 2012 |
Dysphoric mania induced by high-dose mirtazapine: a case for 'norepinephrine syndrome'?
Topics: Adult; Antidepressive Agents, Second-Generation; Bipolar Disorder; Depressive Disorder; Dose-Respons | 2002 |
Mirtazapine for akathisia in bipolar disorder.
Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Bipolar Disorder; Female; Humans; Male; Mianse | 2005 |
Severe creatine kinase increase during quetiapine and mirtazapine treatment.
Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Creatine Kinase; Dibenzothiazepines; Drug Therapy, Co | 2006 |
New drug developments in the Netherlands. "Tetracyclic" psychotropic drugs.
Topics: Adjustment Disorders; Anxiety Disorders; Bipolar Disorder; Brain; Clinical Trials as Topic; Dibenzox | 1974 |
The effect of mianserin on urinary catecholamine excretion in psychiatric patients.
Topics: Bipolar Disorder; Catecholamines; Dibenzazepines; Female; Humans; Metanephrine; Mianserin; Vanilmand | 1981 |
Hypomania associated with mirtazapine augmentation of sertraline.
Topics: 1-Naphthylamine; Ambulatory Care; Antipsychotic Agents; Bipolar Disorder; Depressive Disorder; Drug | 1998 |
[Mirtazapine in inpatient treatment of depressed patients].
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Bipolar Disorder; Contraindication | 1998 |
Mirtazapine-induced mania in a case of poststroke depression.
Topics: Aged; Antidepressive Agents, Tricyclic; Bipolar Disorder; Cerebrovascular Disorders; Depression; Hum | 1999 |
Mirtazapine withdrawal causing hypomania.
Topics: Aged; Antidepressive Agents, Tricyclic; Bipolar Disorder; Female; Humans; Mianserin; Mirtazapine; Su | 1999 |
Mania associated with mirtazapine augmentation of fluoxetine.
Topics: Adrenergic alpha-Antagonists; Bipolar Disorder; Dose-Response Relationship, Drug; Drug Administratio | 2002 |
Mirtazapine overdose with benign outcome.
Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Drug Overdose; Female; Humans; Mianserin; Middle | 2002 |
Clinical experience with Org GB94 (mianserin hydrochloride), a new tetracyclic antidepressant.
Topics: Adolescent; Adult; Age Factors; Aged; Antidepressive Agents; Bipolar Disorder; Depression; Dibenzaze | 1978 |
Mianserin in the prophylactic treatment of bipolar affective illness.
Topics: Adult; Affective Symptoms; Bipolar Disorder; Dibenzazepines; Female; Humans; Male; Mianserin; Middle | 1977 |
Plasma ratios of tryptophan and tyrosine to other large neutral amino acids in manic-depressive patients.
Topics: Adolescent; Adult; Aged; Amino Acids; Amitriptyline; Antipsychotic Agents; Bipolar Disorder; Dibenzo | 1992 |
Circadian variation in total plasma tryptophan. Antidepressant treatment: drugs and phase advance.
Topics: Adult; Aged; Bipolar Disorder; Chromatography, High Pressure Liquid; Circadian Rhythm; Female; Human | 1992 |
Calcium channel blockers.
Topics: Aged; Atrial Fibrillation; Bipolar Disorder; Combined Modality Therapy; Electroconvulsive Therapy; H | 1990 |
Mianserin and mania.
Topics: Bipolar Disorder; Female; Humans; Huntington Disease; Mianserin; Middle Aged | 1988 |