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mianserin and Arrhythmia

mianserin has been researched along with Arrhythmia in 5 studies

Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.

Research Excerpts

ExcerptRelevanceReference
"The effects of mianserin, a tetracyclic antidepressant, and adinazolam, a new triazolobenzodiazepine which has antidepressant activity, on intraventricular conduction and the incidence of arrhythmias induced by programmed ventricular stimulation were studied in the dog heart after myocardial infarction and compared to the effects of amitriptyline, a standard tricyclic antidepressant."3.68Effects of antidepressants on the intraventricular conduction and the incidence of arrhythmias induced by programmed ventricular stimulation in the dog heart after myocardial infarction. ( Hashimoto, H; Nagashima, S; Nakashima, M; Nishimoto, M; Ozaki, T, 1990)
"The presence or absence of cardiac arrhythmias was recorded."2.65Mianserin, maprotiline and intracardiac conduction. ( Edwards, JG; Goldie, A, 1983)
"Amineptine, however, was ineffective in preventing reperfusion arrhythmias even in a high concentration, this agent did not decrease heart rate."1.27Comparison of the effect of antidepressant drugs on arrhythmias in the isolated rat heart subjected to myocardial ischaemia and reperfusion. ( Bril, A; Rochette, L, 1987)
" It is concluded that all four drugs show the toxic effects classically associated with tricyclic antidepressants but the relative toxicity amongst these agents varies considerably and is in the order amitriptyline greater than imipramine greater than maprotiline greater than mianserin."1.26The relative toxicity of amitriptyline, imipramine, maprotiline and mianserin in rabbits in vivo. ( Hughes, IE; Radwan, S, 1979)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19904 (80.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Edwards, JG1
Goldie, A1
Hughes, IE2
Radwan, S1
Harper, B1
Nishimoto, M1
Hashimoto, H1
Ozaki, T1
Nagashima, S1
Nakashima, M1
Bril, A1
Rochette, L1

Trials

1 trial available for mianserin and Arrhythmia

ArticleYear
Mianserin, maprotiline and intracardiac conduction.
    British journal of clinical pharmacology, 1983, Volume: 15 Suppl 2

    Topics: Adolescent; Adult; Anthracenes; Arrhythmias, Cardiac; Depressive Disorder; Dibenzazepines; Double-Bl

1983

Other Studies

4 other studies available for mianserin and Arrhythmia

ArticleYear
The relative toxicity of amitriptyline, imipramine, maprotiline and mianserin in rabbits in vivo.
    British journal of pharmacology, 1979, Volume: 65, Issue:2

    Topics: Amitriptyline; Anesthesia; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Behavior

1979
A comparison in rabbit isolated hearts of the dysrhythmogenic potential of amitriptyline, maprotiline and mianserin in relation to their ability to block noradrenaline uptake.
    British journal of pharmacology, 1977, Volume: 59, Issue:4

    Topics: Amitriptyline; Animals; Anthracenes; Arrhythmias, Cardiac; Dibenzazepines; Drug Interactions; Female

1977
Effects of antidepressants on the intraventricular conduction and the incidence of arrhythmias induced by programmed ventricular stimulation in the dog heart after myocardial infarction.
    Naunyn-Schmiedeberg's archives of pharmacology, 1990, Volume: 341, Issue:3

    Topics: Amitriptyline; Animals; Anti-Anxiety Agents; Antidepressive Agents; Arrhythmias, Cardiac; Benzodiaze

1990
Comparison of the effect of antidepressant drugs on arrhythmias in the isolated rat heart subjected to myocardial ischaemia and reperfusion.
    Pharmacology & toxicology, 1987, Volume: 60, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Antidepressive Agents; Arrhythmias, Cardiac; Coronary Disease; Dibe

1987