mianserin has been researched along with Anorexia in 9 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Anorexia: The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We performed an open-label single-institution phase II trial of mirtazapine (15-30 mg by mouth [po] every day [qd]), a tetracyclic antidepressant that may lead to weight gain, for 8 weeks in nondepressed patients with cancer-related cachexia/anorexia (CRCA)." | 9.14 | Phase II trial of mirtazapine for cancer-related cachexia and anorexia. ( Burman, D; Riechelmann, RP; Rodin, G; Tannock, IF; Zimmermann, C, 2010) |
| " Imipramine and mianserine potentiated amphetamine-induced anorexia both after acute administration or after prolonged previous treatment with each drug." | 7.68 | Lack of tolerance to imipramine or mianserine in two animal models of depression. ( Barros, HM; Tannhauser, M; Wainstein, M, 1990) |
| "Mirtazapine is a new antidepressant called noradrenergic and specific serotonergic antidepressant(NaSSA)and blocks 5-HT3 receptors to improve nausea." | 5.38 | [Low-dose mirtazapine improved nausea and appetite loss during S-1 therapy]. ( Imai, E; Ito, T; Nishimura, D; Shibahara, H; Uematsu, N, 2012) |
| "Cats with chronic kidney disease (CKD) often experience inappetence and vomiting and might benefit from the administration of mirtazapine, a medication with appetite stimulant and anti-nausea properties." | 5.17 | Mirtazapine as an appetite stimulant and anti-emetic in cats with chronic kidney disease: a masked placebo-controlled crossover clinical trial. ( Lunn, KF; Quimby, JM, 2013) |
| "We performed an open-label single-institution phase II trial of mirtazapine (15-30 mg by mouth [po] every day [qd]), a tetracyclic antidepressant that may lead to weight gain, for 8 weeks in nondepressed patients with cancer-related cachexia/anorexia (CRCA)." | 5.14 | Phase II trial of mirtazapine for cancer-related cachexia and anorexia. ( Burman, D; Riechelmann, RP; Rodin, G; Tannock, IF; Zimmermann, C, 2010) |
| " When anorexia developed, TB and NTB rats received bilateral intra-VMN microinjections of the serotonin antagonist mianserin (200 nmol) or the IL-1 receptor antagonist (IL-1ra, 25 ng)." | 3.70 | Effects of intra-VMN mianserin and IL-1ra on meal number in anorectic tumor-bearing rats. ( Cangiano, C; Gleason, JR; Laviano, A; Meguid, MM; Rossi Fanelli, F; Yang, ZJ, 2000) |
| " Imipramine and mianserine potentiated amphetamine-induced anorexia both after acute administration or after prolonged previous treatment with each drug." | 3.68 | Lack of tolerance to imipramine or mianserine in two animal models of depression. ( Barros, HM; Tannhauser, M; Wainstein, M, 1990) |
| "Amphetamine-induced anorexia and stereotyped behaviour were studied in rats, following pretreatment with the antidepressants DMI, inprindole and mianserin." | 3.67 | Changes in amphetamine-induced anorexia and stereotypy during chronic treatment with antidepressant drugs. ( Montgomery, T; Towell, A; Willner, P, 1984) |
| "Depression is quite common among cancer patients." | 2.73 | An open-label long-term naturalistic study of mirtazapine treatment for depression in cancer patients. ( Elbi, H; Ersoy, MA; Noyan, AM, 2008) |
| "Mirtazapine is a new antidepressant called noradrenergic and specific serotonergic antidepressant(NaSSA)and blocks 5-HT3 receptors to improve nausea." | 1.38 | [Low-dose mirtazapine improved nausea and appetite loss during S-1 therapy]. ( Imai, E; Ito, T; Nishimura, D; Shibahara, H; Uematsu, N, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Quimby, JM | 1 |
| Lunn, KF | 1 |
| Riechelmann, RP | 1 |
| Burman, D | 1 |
| Tannock, IF | 1 |
| Rodin, G | 1 |
| Zimmermann, C | 1 |
| Shibahara, H | 1 |
| Ito, T | 1 |
| Uematsu, N | 1 |
| Imai, E | 1 |
| Nishimura, D | 1 |
| Fountoulakis, KN | 1 |
| Iacovides, A | 1 |
| Siamouli, M | 1 |
| Koumaris, V | 1 |
| Kaprinis, GS | 1 |
| Ersoy, MA | 1 |
| Noyan, AM | 1 |
| Elbi, H | 1 |
| Willner, P | 1 |
| Towell, A | 1 |
| Montgomery, T | 1 |
| Laviano, A | 2 |
| Cangiano, C | 2 |
| Preziosa, I | 1 |
| Meguid, MM | 2 |
| Muscaritoli, M | 1 |
| Conversano, L | 1 |
| Cascino, A | 1 |
| Torelli, GF | 1 |
| Cherubini, S | 1 |
| Rossi Fanelli, F | 2 |
| Gleason, JR | 1 |
| Yang, ZJ | 1 |
| Wainstein, M | 1 |
| Tannhauser, M | 1 |
| Barros, HM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double-blind Clinical Trial of the Use of Mirtazapine Versus Megestrol for the Control of Anorexia-cachexia in Cancer Patients in Palliative Care.[NCT03283488] | Phase 2 | 52 participants (Actual) | Interventional | 2019-03-26 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for mianserin and Anorexia
| Article | Year |
|---|---|
Mirtazapine as an appetite stimulant and anti-emetic in cats with chronic kidney disease: a masked placebo-controlled crossover clinical trial.
Topics: Animals; Anorexia; Antiemetics; Appetite Stimulants; Cat Diseases; Cats; Cross-Over Studies; Female; | 2013 |
Phase II trial of mirtazapine for cancer-related cachexia and anorexia.
Topics: Aged; Aged, 80 and over; Anorexia; Antidepressive Agents, Tricyclic; Appetite; Body Weight; Cachexia | 2010 |
An open-label long-term naturalistic study of mirtazapine treatment for depression in cancer patients.
Topics: Administration, Oral; Adult; Aged; Anorexia; Antidepressive Agents, Tricyclic; Depressive Disorder; | 2008 |
6 other studies available for mianserin and Anorexia
| Article | Year |
|---|---|
[Low-dose mirtazapine improved nausea and appetite loss during S-1 therapy].
Topics: Aged, 80 and over; Anorexia; Antimetabolites, Antineoplastic; Drug Combinations; Histamine H1 Antago | 2012 |
Successful treatment of anorexia with a combination of high-dose olanzapine, fluoxetine and mirtazapine.
Topics: Adult; Anorexia; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsy | 2006 |
Changes in amphetamine-induced anorexia and stereotypy during chronic treatment with antidepressant drugs.
Topics: Animals; Anorexia; Antidepressive Agents, Tricyclic; Desipramine; Dextroamphetamine; Dose-Response R | 1984 |
Serotoninergic block in the ventromedial nucleus of hypothalamus improves food intake in anorectic tumor bearing rats.
Topics: Animals; Anorexia; Feeding Behavior; Male; Mianserin; Rats; Rats, Inbred F344; Sarcoma, Experimental | 1996 |
Effects of intra-VMN mianserin and IL-1ra on meal number in anorectic tumor-bearing rats.
Topics: Animals; Anorexia; Eating; Interleukin 1 Receptor Antagonist Protein; Male; Mianserin; Rats; Rats, I | 2000 |
Lack of tolerance to imipramine or mianserine in two animal models of depression.
Topics: Amphetamine; Animals; Anorexia; Behavior, Animal; Depression; Disease Models, Animal; Dose-Response | 1990 |