Page last updated: 2024-10-31

mianserin and Anorexia

mianserin has been researched along with Anorexia in 9 studies

Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.

Anorexia: The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.

Research Excerpts

ExcerptRelevanceReference
"We performed an open-label single-institution phase II trial of mirtazapine (15-30 mg by mouth [po] every day [qd]), a tetracyclic antidepressant that may lead to weight gain, for 8 weeks in nondepressed patients with cancer-related cachexia/anorexia (CRCA)."9.14Phase II trial of mirtazapine for cancer-related cachexia and anorexia. ( Burman, D; Riechelmann, RP; Rodin, G; Tannock, IF; Zimmermann, C, 2010)
" Imipramine and mianserine potentiated amphetamine-induced anorexia both after acute administration or after prolonged previous treatment with each drug."7.68Lack of tolerance to imipramine or mianserine in two animal models of depression. ( Barros, HM; Tannhauser, M; Wainstein, M, 1990)
"Mirtazapine is a new antidepressant called noradrenergic and specific serotonergic antidepressant(NaSSA)and blocks 5-HT3 receptors to improve nausea."5.38[Low-dose mirtazapine improved nausea and appetite loss during S-1 therapy]. ( Imai, E; Ito, T; Nishimura, D; Shibahara, H; Uematsu, N, 2012)
"Cats with chronic kidney disease (CKD) often experience inappetence and vomiting and might benefit from the administration of mirtazapine, a medication with appetite stimulant and anti-nausea properties."5.17Mirtazapine as an appetite stimulant and anti-emetic in cats with chronic kidney disease: a masked placebo-controlled crossover clinical trial. ( Lunn, KF; Quimby, JM, 2013)
"We performed an open-label single-institution phase II trial of mirtazapine (15-30 mg by mouth [po] every day [qd]), a tetracyclic antidepressant that may lead to weight gain, for 8 weeks in nondepressed patients with cancer-related cachexia/anorexia (CRCA)."5.14Phase II trial of mirtazapine for cancer-related cachexia and anorexia. ( Burman, D; Riechelmann, RP; Rodin, G; Tannock, IF; Zimmermann, C, 2010)
" When anorexia developed, TB and NTB rats received bilateral intra-VMN microinjections of the serotonin antagonist mianserin (200 nmol) or the IL-1 receptor antagonist (IL-1ra, 25 ng)."3.70Effects of intra-VMN mianserin and IL-1ra on meal number in anorectic tumor-bearing rats. ( Cangiano, C; Gleason, JR; Laviano, A; Meguid, MM; Rossi Fanelli, F; Yang, ZJ, 2000)
" Imipramine and mianserine potentiated amphetamine-induced anorexia both after acute administration or after prolonged previous treatment with each drug."3.68Lack of tolerance to imipramine or mianserine in two animal models of depression. ( Barros, HM; Tannhauser, M; Wainstein, M, 1990)
"Amphetamine-induced anorexia and stereotyped behaviour were studied in rats, following pretreatment with the antidepressants DMI, inprindole and mianserin."3.67Changes in amphetamine-induced anorexia and stereotypy during chronic treatment with antidepressant drugs. ( Montgomery, T; Towell, A; Willner, P, 1984)
"Depression is quite common among cancer patients."2.73An open-label long-term naturalistic study of mirtazapine treatment for depression in cancer patients. ( Elbi, H; Ersoy, MA; Noyan, AM, 2008)
"Mirtazapine is a new antidepressant called noradrenergic and specific serotonergic antidepressant(NaSSA)and blocks 5-HT3 receptors to improve nausea."1.38[Low-dose mirtazapine improved nausea and appetite loss during S-1 therapy]. ( Imai, E; Ito, T; Nishimura, D; Shibahara, H; Uematsu, N, 2012)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19901 (11.11)18.7374
1990's2 (22.22)18.2507
2000's3 (33.33)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Quimby, JM1
Lunn, KF1
Riechelmann, RP1
Burman, D1
Tannock, IF1
Rodin, G1
Zimmermann, C1
Shibahara, H1
Ito, T1
Uematsu, N1
Imai, E1
Nishimura, D1
Fountoulakis, KN1
Iacovides, A1
Siamouli, M1
Koumaris, V1
Kaprinis, GS1
Ersoy, MA1
Noyan, AM1
Elbi, H1
Willner, P1
Towell, A1
Montgomery, T1
Laviano, A2
Cangiano, C2
Preziosa, I1
Meguid, MM2
Muscaritoli, M1
Conversano, L1
Cascino, A1
Torelli, GF1
Cherubini, S1
Rossi Fanelli, F2
Gleason, JR1
Yang, ZJ1
Wainstein, M1
Tannhauser, M1
Barros, HM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized, Double-blind Clinical Trial of the Use of Mirtazapine Versus Megestrol for the Control of Anorexia-cachexia in Cancer Patients in Palliative Care.[NCT03283488]Phase 252 participants (Actual)Interventional2019-03-26Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for mianserin and Anorexia

ArticleYear
Mirtazapine as an appetite stimulant and anti-emetic in cats with chronic kidney disease: a masked placebo-controlled crossover clinical trial.
    Veterinary journal (London, England : 1997), 2013, Volume: 197, Issue:3

    Topics: Animals; Anorexia; Antiemetics; Appetite Stimulants; Cat Diseases; Cats; Cross-Over Studies; Female;

2013
Phase II trial of mirtazapine for cancer-related cachexia and anorexia.
    The American journal of hospice & palliative care, 2010, Volume: 27, Issue:2

    Topics: Aged; Aged, 80 and over; Anorexia; Antidepressive Agents, Tricyclic; Appetite; Body Weight; Cachexia

2010
An open-label long-term naturalistic study of mirtazapine treatment for depression in cancer patients.
    Clinical drug investigation, 2008, Volume: 28, Issue:2

    Topics: Administration, Oral; Adult; Aged; Anorexia; Antidepressive Agents, Tricyclic; Depressive Disorder;

2008

Other Studies

6 other studies available for mianserin and Anorexia

ArticleYear
[Low-dose mirtazapine improved nausea and appetite loss during S-1 therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2012, Volume: 39, Issue:1

    Topics: Aged, 80 and over; Anorexia; Antimetabolites, Antineoplastic; Drug Combinations; Histamine H1 Antago

2012
Successful treatment of anorexia with a combination of high-dose olanzapine, fluoxetine and mirtazapine.
    International journal of clinical pharmacology and therapeutics, 2006, Volume: 44, Issue:9

    Topics: Adult; Anorexia; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsy

2006
Changes in amphetamine-induced anorexia and stereotypy during chronic treatment with antidepressant drugs.
    European journal of pharmacology, 1984, Mar-02, Volume: 98, Issue:3-4

    Topics: Animals; Anorexia; Antidepressive Agents, Tricyclic; Desipramine; Dextroamphetamine; Dose-Response R

1984
Serotoninergic block in the ventromedial nucleus of hypothalamus improves food intake in anorectic tumor bearing rats.
    Advances in experimental medicine and biology, 1996, Volume: 398

    Topics: Animals; Anorexia; Feeding Behavior; Male; Mianserin; Rats; Rats, Inbred F344; Sarcoma, Experimental

1996
Effects of intra-VMN mianserin and IL-1ra on meal number in anorectic tumor-bearing rats.
    Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2000, Volume: 48, Issue:1

    Topics: Animals; Anorexia; Eating; Interleukin 1 Receptor Antagonist Protein; Male; Mianserin; Rats; Rats, I

2000
Lack of tolerance to imipramine or mianserine in two animal models of depression.
    Pharmacology, 1990, Volume: 41, Issue:6

    Topics: Amphetamine; Animals; Anorexia; Behavior, Animal; Depression; Disease Models, Animal; Dose-Response

1990