mianserin has been researched along with Anorexia in 9 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Anorexia: The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.
Excerpt | Relevance | Reference |
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"We performed an open-label single-institution phase II trial of mirtazapine (15-30 mg by mouth [po] every day [qd]), a tetracyclic antidepressant that may lead to weight gain, for 8 weeks in nondepressed patients with cancer-related cachexia/anorexia (CRCA)." | 9.14 | Phase II trial of mirtazapine for cancer-related cachexia and anorexia. ( Burman, D; Riechelmann, RP; Rodin, G; Tannock, IF; Zimmermann, C, 2010) |
" Imipramine and mianserine potentiated amphetamine-induced anorexia both after acute administration or after prolonged previous treatment with each drug." | 7.68 | Lack of tolerance to imipramine or mianserine in two animal models of depression. ( Barros, HM; Tannhauser, M; Wainstein, M, 1990) |
"Mirtazapine is a new antidepressant called noradrenergic and specific serotonergic antidepressant(NaSSA)and blocks 5-HT3 receptors to improve nausea." | 5.38 | [Low-dose mirtazapine improved nausea and appetite loss during S-1 therapy]. ( Imai, E; Ito, T; Nishimura, D; Shibahara, H; Uematsu, N, 2012) |
"Cats with chronic kidney disease (CKD) often experience inappetence and vomiting and might benefit from the administration of mirtazapine, a medication with appetite stimulant and anti-nausea properties." | 5.17 | Mirtazapine as an appetite stimulant and anti-emetic in cats with chronic kidney disease: a masked placebo-controlled crossover clinical trial. ( Lunn, KF; Quimby, JM, 2013) |
"We performed an open-label single-institution phase II trial of mirtazapine (15-30 mg by mouth [po] every day [qd]), a tetracyclic antidepressant that may lead to weight gain, for 8 weeks in nondepressed patients with cancer-related cachexia/anorexia (CRCA)." | 5.14 | Phase II trial of mirtazapine for cancer-related cachexia and anorexia. ( Burman, D; Riechelmann, RP; Rodin, G; Tannock, IF; Zimmermann, C, 2010) |
" When anorexia developed, TB and NTB rats received bilateral intra-VMN microinjections of the serotonin antagonist mianserin (200 nmol) or the IL-1 receptor antagonist (IL-1ra, 25 ng)." | 3.70 | Effects of intra-VMN mianserin and IL-1ra on meal number in anorectic tumor-bearing rats. ( Cangiano, C; Gleason, JR; Laviano, A; Meguid, MM; Rossi Fanelli, F; Yang, ZJ, 2000) |
" Imipramine and mianserine potentiated amphetamine-induced anorexia both after acute administration or after prolonged previous treatment with each drug." | 3.68 | Lack of tolerance to imipramine or mianserine in two animal models of depression. ( Barros, HM; Tannhauser, M; Wainstein, M, 1990) |
"Amphetamine-induced anorexia and stereotyped behaviour were studied in rats, following pretreatment with the antidepressants DMI, inprindole and mianserin." | 3.67 | Changes in amphetamine-induced anorexia and stereotypy during chronic treatment with antidepressant drugs. ( Montgomery, T; Towell, A; Willner, P, 1984) |
"Depression is quite common among cancer patients." | 2.73 | An open-label long-term naturalistic study of mirtazapine treatment for depression in cancer patients. ( Elbi, H; Ersoy, MA; Noyan, AM, 2008) |
"Mirtazapine is a new antidepressant called noradrenergic and specific serotonergic antidepressant(NaSSA)and blocks 5-HT3 receptors to improve nausea." | 1.38 | [Low-dose mirtazapine improved nausea and appetite loss during S-1 therapy]. ( Imai, E; Ito, T; Nishimura, D; Shibahara, H; Uematsu, N, 2012) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (11.11) | 18.7374 |
1990's | 2 (22.22) | 18.2507 |
2000's | 3 (33.33) | 29.6817 |
2010's | 3 (33.33) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Quimby, JM | 1 |
Lunn, KF | 1 |
Riechelmann, RP | 1 |
Burman, D | 1 |
Tannock, IF | 1 |
Rodin, G | 1 |
Zimmermann, C | 1 |
Shibahara, H | 1 |
Ito, T | 1 |
Uematsu, N | 1 |
Imai, E | 1 |
Nishimura, D | 1 |
Fountoulakis, KN | 1 |
Iacovides, A | 1 |
Siamouli, M | 1 |
Koumaris, V | 1 |
Kaprinis, GS | 1 |
Ersoy, MA | 1 |
Noyan, AM | 1 |
Elbi, H | 1 |
Willner, P | 1 |
Towell, A | 1 |
Montgomery, T | 1 |
Laviano, A | 2 |
Cangiano, C | 2 |
Preziosa, I | 1 |
Meguid, MM | 2 |
Muscaritoli, M | 1 |
Conversano, L | 1 |
Cascino, A | 1 |
Torelli, GF | 1 |
Cherubini, S | 1 |
Rossi Fanelli, F | 2 |
Gleason, JR | 1 |
Yang, ZJ | 1 |
Wainstein, M | 1 |
Tannhauser, M | 1 |
Barros, HM | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
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Randomized, Double-blind Clinical Trial of the Use of Mirtazapine Versus Megestrol for the Control of Anorexia-cachexia in Cancer Patients in Palliative Care.[NCT03283488] | Phase 2 | 52 participants (Actual) | Interventional | 2019-03-26 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
3 trials available for mianserin and Anorexia
Article | Year |
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Mirtazapine as an appetite stimulant and anti-emetic in cats with chronic kidney disease: a masked placebo-controlled crossover clinical trial.
Topics: Animals; Anorexia; Antiemetics; Appetite Stimulants; Cat Diseases; Cats; Cross-Over Studies; Female; | 2013 |
Phase II trial of mirtazapine for cancer-related cachexia and anorexia.
Topics: Aged; Aged, 80 and over; Anorexia; Antidepressive Agents, Tricyclic; Appetite; Body Weight; Cachexia | 2010 |
An open-label long-term naturalistic study of mirtazapine treatment for depression in cancer patients.
Topics: Administration, Oral; Adult; Aged; Anorexia; Antidepressive Agents, Tricyclic; Depressive Disorder; | 2008 |
6 other studies available for mianserin and Anorexia
Article | Year |
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[Low-dose mirtazapine improved nausea and appetite loss during S-1 therapy].
Topics: Aged, 80 and over; Anorexia; Antimetabolites, Antineoplastic; Drug Combinations; Histamine H1 Antago | 2012 |
Successful treatment of anorexia with a combination of high-dose olanzapine, fluoxetine and mirtazapine.
Topics: Adult; Anorexia; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsy | 2006 |
Changes in amphetamine-induced anorexia and stereotypy during chronic treatment with antidepressant drugs.
Topics: Animals; Anorexia; Antidepressive Agents, Tricyclic; Desipramine; Dextroamphetamine; Dose-Response R | 1984 |
Serotoninergic block in the ventromedial nucleus of hypothalamus improves food intake in anorectic tumor bearing rats.
Topics: Animals; Anorexia; Feeding Behavior; Male; Mianserin; Rats; Rats, Inbred F344; Sarcoma, Experimental | 1996 |
Effects of intra-VMN mianserin and IL-1ra on meal number in anorectic tumor-bearing rats.
Topics: Animals; Anorexia; Eating; Interleukin 1 Receptor Antagonist Protein; Male; Mianserin; Rats; Rats, I | 2000 |
Lack of tolerance to imipramine or mianserine in two animal models of depression.
Topics: Amphetamine; Animals; Anorexia; Behavior, Animal; Depression; Disease Models, Animal; Dose-Response | 1990 |