mianserin has been researched along with Agranulocytosis in 34 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "A patient suffering from endogenous depression was treated with mianserin and developed agranulocytosis." | 7.68 | [Mianserin agranulocytosis followed by oxitriptan eosinophilia]. ( García, C, 1992) |
| "The frequency with which agranulocytosis was associated with mianserin in New Zealand was calculated, by two methods, from spontaneous reports to the Intensive Medicines Monitoring Programme (IMMP)--one gave a frequency of 1 in 1354 (95% CI 1 in 3145 to 1 in 685) and the other gave a rate of 1 in 1743 (95% CI 1 in 2895 to 1 in 1116)." | 7.68 | Mianserin and agranulocytosis in New Zealand. ( Coulter, DM; Edwards, IR, 1990) |
| "Two cases of mianserin induced neutropenia associated with prolonged elimination of the drug were studied." | 7.67 | Possible mechanism for mianserin induced neutropenia associated with saturable elimination kinetics. ( Begg, EJ; Colls, BM; Moller, PW; O'Donnell, JL; Sharman, JR, 1985) |
| "A case of Mianserin induced agranulocytosis presenting as a localised infection is presented and the literature reviewed." | 7.66 | Mianserin induced agranulocytosis presenting as an abscess. ( Bennet, RA; Brumé, J; Meehan, SE, 1983) |
| "Four episodes of neutropenia or agranulocytosis possibly caused by the tetracyclic antidepressant drug, mianserin hydrochloride, were reported to the Australian Adverse Drug Reactions Advisory Committee during the first year of the drug's general availability in Australia." | 7.66 | Mianserin: a possible cause of neutropenia and agranulocytosis. Adverse Drug Reactions Advisory Committee. ( , 1980) |
| "Haematological examination indicated agranulocytosis." | 5.26 | Mianserin and agranulocytosis. ( Curson, DA; Hale, AS, 1979) |
| "A 40-year old woman with a history of acute psychotic symptoms developed agranulocytosis and neutropenia after starting therapy that included lamotrigine, mirtazapine, quetiapine, and venlafaxine." | 3.78 | Fatal agranulocytosis associated with psychotropic medication use. ( Al-Najjar, T; Ali, BA; Nazer, LH; Shankar, G, 2012) |
| "A patient suffering from endogenous depression was treated with mianserin and developed agranulocytosis." | 3.68 | [Mianserin agranulocytosis followed by oxitriptan eosinophilia]. ( García, C, 1992) |
| "Two cases of mianserin induced neutropenia associated with prolonged elimination of the drug were studied." | 3.67 | Possible mechanism for mianserin induced neutropenia associated with saturable elimination kinetics. ( Begg, EJ; Colls, BM; Moller, PW; O'Donnell, JL; Sharman, JR, 1985) |
| "A case of Mianserin induced agranulocytosis presenting as a localised infection is presented and the literature reviewed." | 3.66 | Mianserin induced agranulocytosis presenting as an abscess. ( Bennet, RA; Brumé, J; Meehan, SE, 1983) |
| "Four episodes of neutropenia or agranulocytosis possibly caused by the tetracyclic antidepressant drug, mianserin hydrochloride, were reported to the Australian Adverse Drug Reactions Advisory Committee during the first year of the drug's general availability in Australia." | 3.66 | Mianserin: a possible cause of neutropenia and agranulocytosis. Adverse Drug Reactions Advisory Committee. ( , 1980) |
| "3 A reversible agranulocytosis has been most commonly observed, occurring between four and six weeks of treatment." | 1.27 | Mianserin and blood dyscrasias. ( Clink, HM, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (61.76) | 18.7374 |
| 1990's | 7 (20.59) | 18.2507 |
| 2000's | 5 (14.71) | 29.6817 |
| 2010's | 1 (2.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nazer, LH | 1 |
| Shankar, G | 1 |
| Ali, BA | 1 |
| Al-Najjar, T | 1 |
| Anghelescu, I | 1 |
| Klawe, C | 1 |
| Dahmen, N | 1 |
| Iverson, S | 1 |
| Zahid, N | 1 |
| Uetrecht, JP | 1 |
| Ozcanli, T | 1 |
| Unsalver, B | 1 |
| Ozdemir, S | 1 |
| Ozmen, M | 1 |
| Mashford, ML | 1 |
| Brumé, J | 1 |
| Meehan, SE | 1 |
| Bennet, RA | 1 |
| Page, CE | 1 |
| Braye, SG | 1 |
| Copplestone, JA | 1 |
| Gartell, PC | 1 |
| Clink, HM | 1 |
| Adams, PC | 1 |
| Robinson, A | 1 |
| Reid, MM | 1 |
| Vishu, MC | 1 |
| Livingston, M | 1 |
| Wilcox, JB | 1 |
| Skallgård, F | 1 |
| Meyboom, RH | 1 |
| Edwards, IR | 4 |
| Egberts, AC | 1 |
| Davis, J | 1 |
| Barkin, RL | 1 |
| Lucht, MJ | 1 |
| Kleinschmidt, R | 1 |
| Maier, W | 1 |
| Rietschel, M | 1 |
| Launay, D | 1 |
| Queyrel, V | 1 |
| Hatron, PY | 1 |
| Michon-Pasturel, U | 1 |
| Caron, J | 1 |
| Hachulla, E | 1 |
| Devulder, B | 1 |
| Curson, DA | 1 |
| Hale, AS | 1 |
| García, C | 1 |
| Coulter, DM | 1 |
| Farmer, R | 1 |
| Girard, M | 1 |
| Thomas, CS | 1 |
| Read, DA | 1 |
| Inman, WH | 1 |
| Chaplin, S | 1 |
| O'Donnell, JL | 1 |
| Sharman, JR | 1 |
| Begg, EJ | 1 |
| Colls, BM | 1 |
| Moller, PW | 1 |
| Morgan, CA | 1 |
| Donaldson, MD | 1 |
| Forgan-Smith, J | 1 |
| Leslie, P | 1 |
1 review available for mianserin and Agranulocytosis
| Article | Year |
|---|---|
Bone marrow depression due to mianserin, phenylbutazone, oxyphenbutazone, and chloramphenicol--Part I.
Topics: Agranulocytosis; Anemia, Aplastic; Bone Marrow; Cell Membrane; Chloramphenicol; Dibenzazepines; DNA | 1986 |
33 other studies available for mianserin and Agranulocytosis
| Article | Year |
|---|---|
Fatal agranulocytosis associated with psychotropic medication use.
Topics: Adult; Agranulocytosis; Antidepressive Agents, Second-Generation; Antimanic Agents; Antipsychotic Ag | 2012 |
Venlafaxine in a patient with idiopathic leukopenia and mirtazapine-induced severe neutropenia.
Topics: Agranulocytosis; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Comorbi | 2002 |
Predicting drug-induced agranulocytosis: characterizing neutrophil-generated metabolites of a model compound, DMP 406, and assessing the relevance of an in vitro apoptosis assay for identifying drugs that may cause agranulocytosis.
Topics: Agranulocytosis; Antipsychotic Agents; Apoptosis; Benzodiazepines; Chromatography, High Pressure Liq | 2002 |
Sertraline- and mirtazapine-induced severe neutropenia.
Topics: Adult; Agranulocytosis; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Female; Humans | 2005 |
Mianserin. An example of balancing benefits and risks in therapy.
Topics: Agranulocytosis; Cost-Benefit Analysis; Depression; Dibenzazepines; Humans; Joint Diseases; Kinetics | 1984 |
Mianserin induced agranulocytosis presenting as an abscess.
Topics: Abscess; Agranulocytosis; Diagnosis, Differential; Dibenzazepines; Humans; Male; Mianserin; Middle A | 1983 |
Mianserin-induced agranulocytosis.
Topics: Aged; Agranulocytosis; Depressive Disorder; Dibenzazepines; Female; Humans; Mianserin | 1982 |
Mianserin-induced agranulocytosis.
Topics: Aged; Agranulocytosis; Dibenzazepines; Humans; Leukopenia; Male; Mianserin | 1982 |
Adverse Drug Reactions Advisory Committee: ADRAC report for 1980.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Australia; Bronchial Spasm; Chemical and Drug Induced Live | 1982 |
Mianserin-induced agranulocytosis.
Topics: Agranulocytosis; Dibenzazepines; Female; Humans; Mianserin | 1982 |
Neutropenic enterocolitis during mianserin-induced agranulocytosis.
Topics: Aged; Agranulocytosis; Dibenzazepines; Enterocolitis, Pseudomembranous; Female; Humans; Mianserin; N | 1982 |
Mianserin and blood dyscrasias.
Topics: Adult; Aged; Agranulocytosis; Dibenzazepines; Female; Hematologic Diseases; Hematopoietic Stem Cells | 1983 |
Blood dyscrasias and mianserin.
Topics: Adult; Aged; Agranulocytosis; Anemia, Aplastic; Dibenzazepines; Female; Humans; Mianserin; Middle Ag | 1983 |
Neutropenia following mianserin.
Topics: Adult; Agranulocytosis; Dibenzazepines; Female; Humans; Mianserin; Neutropenia | 1982 |
Mianserin: a possible cause of neutropenia and agranulocytosis. Adverse Drug Reactions Advisory Committee.
Topics: Adult; Aged; Agranulocytosis; Depressive Disorder; Dibenzazepines; Female; Humans; Male; Mianserin; | 1980 |
[Agranulocytosis during treatment with mianserin (Tolvon)].
Topics: Aged; Agranulocytosis; Dibenzazepines; Female; Humans; Mianserin | 1981 |
Mirtazapine and the granulocytes--so far so good.
Topics: Adverse Drug Reaction Reporting Systems; Agranulocytosis; Antidepressive Agents, Second-Generation; | 1999 |
Clinical pharmacology of mirtazapine: revisited.
Topics: Agranulocytosis; Antidepressive Agents, Tricyclic; Anxiety; Depression; Humans; Mianserin; Mirtazapi | 1999 |
Agranulocytosis during treatment with mianserin and venlafaxine.
Topics: Aged; Agranulocytosis; Antidepressive Agents, Second-Generation; Cyclohexanols; Depressive Disorder; | 2000 |
[Agranulocytosis connected with the taking of mianserin: a complication to be feared in the aged].
Topics: Adjustment Disorders; Aged; Aged, 80 and over; Agranulocytosis; Antidepressive Agents, Second-Genera | 2000 |
Mianserin and agranulocytosis.
Topics: Agranulocytosis; Dibenzazepines; Female; Humans; Mianserin; Middle Aged | 1979 |
[Mianserin agranulocytosis followed by oxitriptan eosinophilia].
Topics: 5-Hydroxytryptophan; Agranulocytosis; Blood Cell Count; Depressive Disorder; Eosinophilia; Eosinophi | 1992 |
Mianserin and agranulocytosis in New Zealand.
Topics: Adult; Age Factors; Aged; Agranulocytosis; Bias; Cohort Studies; Dose-Response Relationship, Drug; F | 1990 |
Mianserin and agranulocytosis.
Topics: Agranulocytosis; Humans; Mianserin; Product Surveillance, Postmarketing; Risk Factors; Time Factors | 1990 |
Mianserin side-effects.
Topics: Agranulocytosis; Humans; Mianserin; Research | 1990 |
Mianserin, agranulocytosis, and suicide.
Topics: Agranulocytosis; Antidepressive Agents, Tricyclic; Humans; Mianserin; New Zealand; Suicide | 1990 |
Mianserin.
Topics: Agranulocytosis; Drug Utilization; Humans; Mianserin; Product Surveillance, Postmarketing; Truth Dis | 1989 |
Safety of mianserin.
Topics: Aged; Agranulocytosis; Humans; Mianserin | 1988 |
Agranulocytosis and mianserin.
Topics: Adult; Aged; Agranulocytosis; Dibenzazepines; Female; Humans; Male; Mianserin; Middle Aged; Neutrope | 1985 |
Mianserin.
Topics: Agranulocytosis; Dibenzazepines; Drug Interactions; Humans; Mianserin | 1985 |
Possible mechanism for mianserin induced neutropenia associated with saturable elimination kinetics.
Topics: Aged; Agranulocytosis; Bone Marrow; Dibenzazepines; Female; Humans; Kinetics; Leukocyte Count; Metab | 1985 |
Mianserin and agranulocytosis.
Topics: Aged; Agranulocytosis; Depression; Dibenzazepines; Female; Humans; Mianserin | 1986 |
Neutropenia and mianserin.
Topics: Aged; Agranulocytosis; Dibenzazepines; Humans; Male; Mianserin; Neutropenia | 1985 |