Page last updated: 2024-10-31

mianserin and Aging

mianserin has been researched along with Aging in 20 studies

Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"5 Factors that might predispose to seizures include relevant family and past medical history, starting treatment, a change in dose, benzodiazepine withdrawal and concomitant treatment with other drugs that have epileptogenic properties."5.27Mianserin and convulsive seizures. ( Edwards, JG; Glen-Bott, M, 1983)
" Setiptiline maleate (SPT) was administered orally to 45 subjects aged 22-86 years and steady state plasma levels were determined by mass fragment chromatography (GC-MF) to examine the effect of aging on those values."5.07The effect of age on plasma level of setiptiline maleate in depressed patients. ( Aoba, A; Chishima, T; Kamimura, M; Morokawa, Y; Negishi, K; Sakai, T; Takagi, H; Takeshita, T; Tsuneizumi, T; Yamaguchi, N, 1994)
"The prevalence of insomnia increases with age and affects up to 35% of community-dwelling adults with dementia."2.45Non-pharmacologic treatment of insomnia in persons with dementia. ( Darvishi, R; Kunik, ME; Shub, D, 2009)
"1."2.39Serum mianserin and ageing. ( Koponen, H; Leinonen, E; Lepola, U, 1994)
"5 Factors that might predispose to seizures include relevant family and past medical history, starting treatment, a change in dose, benzodiazepine withdrawal and concomitant treatment with other drugs that have epileptogenic properties."1.27Mianserin and convulsive seizures. ( Edwards, JG; Glen-Bott, M, 1983)
"2 Mianserin was administered to volunteers by intravenous infusion (0."1.27The pharmacokinetics of mianserin. ( Elliott, HL; Kelman, AW; Shami, M; Whiting, B, 1983)
" Caution may be needed on initial dosage of mianserin in young individuals who drive or undertake skilled tasks and in the elderly who may be unaware of psychomotor impairment."1.27"First-dose" response to mianserin: effects of age. ( Swift, CG; Swift, MR; Tiplady, B, 1988)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19906 (30.00)18.7374
1990's5 (25.00)18.2507
2000's5 (25.00)29.6817
2010's4 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Petrascheck, M4
Ye, X1
Buck, LB1
Rangaraju, S3
Solis, GM2
Andersson, SI1
Gomez-Amaro, RL2
Kardakaris, R1
Broaddus, CD1
Niculescu, AB3
Thompson, RC1
Kurian, L1
Encalada, SE1
Salomon, DR2
Kokras, N1
Polissidis, A1
Antoniou, K1
Dalla, C1
Levey, DF1
Nho, K1
Jain, N1
Andrews, KD1
Le-Niculescu, H1
Saykin, AJ1
Shub, D1
Darvishi, R1
Kunik, ME1
Jarriault, D1
Barrozo, RB1
de Carvalho Pinto, CJ1
Greiner, B1
Dufour, MC1
Masante-Roca, I1
Gramsbergen, JB1
Anton, S1
Gadenne, C1
Kuno, A1
Horio, Y1
Cavanagh, J1
Patterson, J1
Pimlott, S1
Dewar, D1
Eersels, J1
Dempsey, MF1
Wyper, D1
Burchinskiĭ, SG1
Altamura, AC1
Melorio, T1
Invernizzi, G1
Gomeni, R1
Edwards, JG1
Glen-Bott, M1
Shami, M1
Elliott, HL1
Kelman, AW1
Whiting, B1
Bonne, O1
Shalev, AY1
Bloch, M1
Kamimura, M1
Aoba, A1
Yamaguchi, N1
Tsuneizumi, T1
Takagi, H1
Chishima, T1
Sakai, T1
Negishi, K1
Morokawa, Y1
Takeshita, T1
Monteleone, P1
Fabrazzo, M1
Leinonen, E1
Koponen, H1
Lepola, U1
Dorman, T1
Swift, CG1
Swift, MR1
Tiplady, B1
Baksi, AK1
Hindmarch, I1
Shillingford, JS1

Reviews

4 reviews available for mianserin and Aging

ArticleYear
Non-pharmacologic treatment of insomnia in persons with dementia.
    Geriatrics, 2009, Volume: 64, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Antidepressive Agents, Tricyclic; Circadian Rhyth

2009
[Anti-aging drugs].
    Nihon rinsho. Japanese journal of clinical medicine, 2009, Volume: 67, Issue:7

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Anticonvulsants; Humans; Longevity; Mianserin; Phenylb

2009
[Biochemical aspects of using antidepressants in late middle age and the elderly (review)].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1983, Volume: 83, Issue:4

    Topics: Age Factors; Aged; Aging; Antidepressive Agents; Catechol O-Methyltransferase; Depression; Depressiv

1983
Serum mianserin and ageing.
    Progress in neuro-psychopharmacology & biological psychiatry, 1994, Volume: 18, Issue:5

    Topics: Adult; Aged; Aging; Humans; Mianserin; Middle Aged

1994

Trials

4 trials available for mianserin and Aging

ArticleYear
Delirium associated with mianserin.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1995, Volume: 5, Issue:2

    Topics: Aged; Aging; Delirium; Depressive Disorder; Female; Humans; Male; Mianserin; Middle Aged; Prevalence

1995
The effect of age on plasma level of setiptiline maleate in depressed patients.
    Progress in neuro-psychopharmacology & biological psychiatry, 1994, Volume: 18, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aging; Antidepressive Agents; Depressive Disorder; Female; Gas Chrom

1994
Blood levels of mianserin and amitriptyline and clinical response in aged depressed patients.
    Pharmacopsychiatry, 1994, Volume: 27, Issue:6

    Topics: Aged; Aged, 80 and over; Aging; Amitriptyline; Chromatography, High Pressure Liquid; Depressive Diso

1994
Sleep and paroxetine: a comparison with mianserin in elderly depressed patients.
    International clinical psychopharmacology, 1992, Volume: 6 Suppl 4

    Topics: Aged; Aging; Depressive Disorder; Double-Blind Method; Humans; Mianserin; Paroxetine; Psychiatric St

1992

Other Studies

12 other studies available for mianserin and Aging

ArticleYear
An antidepressant that extends lifespan in adult Caenorhabditis elegans.
    Nature, 2007, Nov-22, Volume: 450, Issue:7169

    Topics: Aging; Animals; Antidepressive Agents; Caenorhabditis elegans; Caloric Restriction; Humans; Longevit

2007
Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response.
    Aging cell, 2015, Volume: 14, Issue:6

    Topics: Aging; Animals; Antidepressive Agents, Second-Generation; Caenorhabditis elegans; Caenorhabditis ele

2015
Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality.
    eLife, 2015, Dec-01, Volume: 4

    Topics: Aging; Animals; Caenorhabditis elegans; Gene Expression Profiling; Gene Expression Regulation; Longe

2015
Head shaking in the forced swim test: A robust but unexplored sex difference.
    Pharmacology, biochemistry, and behavior, 2017, Volume: 152

    Topics: Adrenalectomy; Aging; Animals; Behavior, Animal; Castration; Corticosterone; Female; Head; Male; Mia

2017
Mood, stress and longevity: convergence on ANK3.
    Molecular psychiatry, 2016, Volume: 21, Issue:8

    Topics: Aging; Animals; Ankyrins; Biomarkers; Caenorhabditis elegans; Gene Expression; Gene Expression Profi

2016
Age-dependent plasticity of sex pheromone response in the moth, Agrotis ipsilon: combined effects of octopamine and juvenile hormone.
    Hormones and behavior, 2009, Volume: 56, Issue:1

    Topics: Action Potentials; Aging; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Juvenile

2009
Serotonin transporter residual availability during long-term antidepressant therapy does not differentiate responder and nonresponder unipolar patients.
    Biological psychiatry, 2006, Feb-15, Volume: 59, Issue:4

    Topics: Adult; Aging; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cyclohexanols; Depressive Dis

2006
Influence of age on mianserin pharmacokinetics.
    Psychopharmacology, 1982, Volume: 78, Issue:4

    Topics: Adult; Aged; Aging; Dibenzazepines; Female; Humans; Kinetics; Male; Mianserin; Middle Aged

1982
Mianserin and convulsive seizures.
    British journal of clinical pharmacology, 1983, Volume: 15 Suppl 2

    Topics: Adolescent; Adult; Aged; Aging; Child; Dibenzazepines; Female; Follow-Up Studies; Humans; Male; Mian

1983
The pharmacokinetics of mianserin.
    British journal of clinical pharmacology, 1983, Volume: 15 Suppl 2

    Topics: Administration, Oral; Adult; Aged; Aging; Biological Availability; Dibenzazepines; Female; Half-Life

1983
"First-dose" response to mianserin: effects of age.
    Psychopharmacology, 1988, Volume: 96, Issue:2

    Topics: Adult; Aged; Aging; Attention; Blood Pressure; Decision Making; Female; Flicker Fusion; Humans; Male

1988
A commentary on Swift, Swift and Tiplady (1988) 'first dose' response to mianserin: effects of age.
    Psychopharmacology, 1988, Volume: 96, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Hypotension; Male; Mianserin; Serotonin

1988