mianserin and Aging
mianserin has been researched along with Aging in 20 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "5 Factors that might predispose to seizures include relevant family and past medical history, starting treatment, a change in dose, benzodiazepine withdrawal and concomitant treatment with other drugs that have epileptogenic properties." | 5.27 | Mianserin and convulsive seizures. ( Edwards, JG; Glen-Bott, M, 1983) |
| " Setiptiline maleate (SPT) was administered orally to 45 subjects aged 22-86 years and steady state plasma levels were determined by mass fragment chromatography (GC-MF) to examine the effect of aging on those values." | 5.07 | The effect of age on plasma level of setiptiline maleate in depressed patients. ( Aoba, A; Chishima, T; Kamimura, M; Morokawa, Y; Negishi, K; Sakai, T; Takagi, H; Takeshita, T; Tsuneizumi, T; Yamaguchi, N, 1994) |
| "The prevalence of insomnia increases with age and affects up to 35% of community-dwelling adults with dementia." | 2.45 | Non-pharmacologic treatment of insomnia in persons with dementia. ( Darvishi, R; Kunik, ME; Shub, D, 2009) |
| "1." | 2.39 | Serum mianserin and ageing. ( Koponen, H; Leinonen, E; Lepola, U, 1994) |
| "5 Factors that might predispose to seizures include relevant family and past medical history, starting treatment, a change in dose, benzodiazepine withdrawal and concomitant treatment with other drugs that have epileptogenic properties." | 1.27 | Mianserin and convulsive seizures. ( Edwards, JG; Glen-Bott, M, 1983) |
| "2 Mianserin was administered to volunteers by intravenous infusion (0." | 1.27 | The pharmacokinetics of mianserin. ( Elliott, HL; Kelman, AW; Shami, M; Whiting, B, 1983) |
| " Caution may be needed on initial dosage of mianserin in young individuals who drive or undertake skilled tasks and in the elderly who may be unaware of psychomotor impairment." | 1.27 | "First-dose" response to mianserin: effects of age. ( Swift, CG; Swift, MR; Tiplady, B, 1988) |
Research
Studies (20)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (30.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Petrascheck, M | 4 |
| Ye, X | 1 |
| Buck, LB | 1 |
| Rangaraju, S | 3 |
| Solis, GM | 2 |
| Andersson, SI | 1 |
| Gomez-Amaro, RL | 2 |
| Kardakaris, R | 1 |
| Broaddus, CD | 1 |
| Niculescu, AB | 3 |
| Thompson, RC | 1 |
| Kurian, L | 1 |
| Encalada, SE | 1 |
| Salomon, DR | 2 |
| Kokras, N | 1 |
| Polissidis, A | 1 |
| Antoniou, K | 1 |
| Dalla, C | 1 |
| Levey, DF | 1 |
| Nho, K | 1 |
| Jain, N | 1 |
| Andrews, KD | 1 |
| Le-Niculescu, H | 1 |
| Saykin, AJ | 1 |
| Shub, D | 1 |
| Darvishi, R | 1 |
| Kunik, ME | 1 |
| Jarriault, D | 1 |
| Barrozo, RB | 1 |
| de Carvalho Pinto, CJ | 1 |
| Greiner, B | 1 |
| Dufour, MC | 1 |
| Masante-Roca, I | 1 |
| Gramsbergen, JB | 1 |
| Anton, S | 1 |
| Gadenne, C | 1 |
| Kuno, A | 1 |
| Horio, Y | 1 |
| Cavanagh, J | 1 |
| Patterson, J | 1 |
| Pimlott, S | 1 |
| Dewar, D | 1 |
| Eersels, J | 1 |
| Dempsey, MF | 1 |
| Wyper, D | 1 |
| Burchinskiĭ, SG | 1 |
| Altamura, AC | 1 |
| Melorio, T | 1 |
| Invernizzi, G | 1 |
| Gomeni, R | 1 |
| Edwards, JG | 1 |
| Glen-Bott, M | 1 |
| Shami, M | 1 |
| Elliott, HL | 1 |
| Kelman, AW | 1 |
| Whiting, B | 1 |
| Bonne, O | 1 |
| Shalev, AY | 1 |
| Bloch, M | 1 |
| Kamimura, M | 1 |
| Aoba, A | 1 |
| Yamaguchi, N | 1 |
| Tsuneizumi, T | 1 |
| Takagi, H | 1 |
| Chishima, T | 1 |
| Sakai, T | 1 |
| Negishi, K | 1 |
| Morokawa, Y | 1 |
| Takeshita, T | 1 |
| Monteleone, P | 1 |
| Fabrazzo, M | 1 |
| Leinonen, E | 1 |
| Koponen, H | 1 |
| Lepola, U | 1 |
| Dorman, T | 1 |
| Swift, CG | 1 |
| Swift, MR | 1 |
| Tiplady, B | 1 |
| Baksi, AK | 1 |
| Hindmarch, I | 1 |
| Shillingford, JS | 1 |
Reviews
4 reviews available for mianserin and Aging
| Article | Year |
|---|---|
Non-pharmacologic treatment of insomnia in persons with dementia.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Antidepressive Agents, Tricyclic; Circadian Rhyth | 2009 |
[Anti-aging drugs].
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Anticonvulsants; Humans; Longevity; Mianserin; Phenylb | 2009 |
[Biochemical aspects of using antidepressants in late middle age and the elderly (review)].
Topics: Age Factors; Aged; Aging; Antidepressive Agents; Catechol O-Methyltransferase; Depression; Depressiv | 1983 |
Serum mianserin and ageing.
Topics: Adult; Aged; Aging; Humans; Mianserin; Middle Aged | 1994 |
Trials
4 trials available for mianserin and Aging
| Article | Year |
|---|---|
Delirium associated with mianserin.
Topics: Aged; Aging; Delirium; Depressive Disorder; Female; Humans; Male; Mianserin; Middle Aged; Prevalence | 1995 |
The effect of age on plasma level of setiptiline maleate in depressed patients.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antidepressive Agents; Depressive Disorder; Female; Gas Chrom | 1994 |
Blood levels of mianserin and amitriptyline and clinical response in aged depressed patients.
Topics: Aged; Aged, 80 and over; Aging; Amitriptyline; Chromatography, High Pressure Liquid; Depressive Diso | 1994 |
Sleep and paroxetine: a comparison with mianserin in elderly depressed patients.
Topics: Aged; Aging; Depressive Disorder; Double-Blind Method; Humans; Mianserin; Paroxetine; Psychiatric St | 1992 |
Other Studies
12 other studies available for mianserin and Aging
| Article | Year |
|---|---|
An antidepressant that extends lifespan in adult Caenorhabditis elegans.
Topics: Aging; Animals; Antidepressive Agents; Caenorhabditis elegans; Caloric Restriction; Humans; Longevit | 2007 |
Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response.
Topics: Aging; Animals; Antidepressive Agents, Second-Generation; Caenorhabditis elegans; Caenorhabditis ele | 2015 |
Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality.
Topics: Aging; Animals; Caenorhabditis elegans; Gene Expression Profiling; Gene Expression Regulation; Longe | 2015 |
Head shaking in the forced swim test: A robust but unexplored sex difference.
Topics: Adrenalectomy; Aging; Animals; Behavior, Animal; Castration; Corticosterone; Female; Head; Male; Mia | 2017 |
Mood, stress and longevity: convergence on ANK3.
Topics: Aging; Animals; Ankyrins; Biomarkers; Caenorhabditis elegans; Gene Expression; Gene Expression Profi | 2016 |
Age-dependent plasticity of sex pheromone response in the moth, Agrotis ipsilon: combined effects of octopamine and juvenile hormone.
Topics: Action Potentials; Aging; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Juvenile | 2009 |
Serotonin transporter residual availability during long-term antidepressant therapy does not differentiate responder and nonresponder unipolar patients.
Topics: Adult; Aging; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cyclohexanols; Depressive Dis | 2006 |
Influence of age on mianserin pharmacokinetics.
Topics: Adult; Aged; Aging; Dibenzazepines; Female; Humans; Kinetics; Male; Mianserin; Middle Aged | 1982 |
Mianserin and convulsive seizures.
Topics: Adolescent; Adult; Aged; Aging; Child; Dibenzazepines; Female; Follow-Up Studies; Humans; Male; Mian | 1983 |
The pharmacokinetics of mianserin.
Topics: Administration, Oral; Adult; Aged; Aging; Biological Availability; Dibenzazepines; Female; Half-Life | 1983 |
"First-dose" response to mianserin: effects of age.
Topics: Adult; Aged; Aging; Attention; Blood Pressure; Decision Making; Female; Flicker Fusion; Humans; Male | 1988 |
A commentary on Swift, Swift and Tiplady (1988) 'first dose' response to mianserin: effects of age.
Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Hypotension; Male; Mianserin; Serotonin | 1988 |