mianserin has been researched along with Adverse Drug Event in 8 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Maximum flexibility of the dosage of mirtazapine was allowed, and clinical assessments included MADRS, CGI, vital signs and spontaneous reporting of adverse events." | 6.72 | Mirtazapine naturalistic depression study (in Sweden)--MINDS(S): clinical efficacy and safety. ( Ahlner, J; Bengtsson, F; Dahl, ML; Odén, A; Prochazka, J; Sjödin, I; Wålinder, J, 2006) |
| " Maximum flexibility of the dosage of mirtazapine was allowed, and clinical assessments included MADRS, CGI, vital signs and spontaneous reporting of adverse events." | 2.72 | Mirtazapine naturalistic depression study (in Sweden)--MINDS(S): clinical efficacy and safety. ( Ahlner, J; Bengtsson, F; Dahl, ML; Odén, A; Prochazka, J; Sjödin, I; Wålinder, J, 2006) |
| " Cyclodextrins, which are most commonly used to reduce the undesirable features of contained drugs within their hydrophobic interior, also have the potential to alter the toxic behavior of the drug." | 1.62 | The Interaction of Heptakis (2,6-di-O-Methyl)-β-cyclodextrin with Mianserin Hydrochloride and Its Influence on the Drug Toxicity. ( Belica-Pacha, S; Bryszewska, M; Budryn, G; Daśko, M; Małecka, M; Miłowska, K; Oracz, J; Pałecz, B, 2021) |
| " The objectives of this study were to determine the most common adverse effects reported and the dose associated with these signs." | 1.43 | Mirtazapine toxicity in cats: retrospective study of 84 cases (2006-2011). ( Bates, JA; Ferguson, LE; McLean, MK; Quimby, JM, 2016) |
| "Since pulmonary fibrosis is a recognized, if rare, complication of certain drug exposures, including antidepressants, betablockers, antibiotics, anticonvulsants, and nonsteroidal antiinflammatory drugs (NSAIDs), we tested the hypothesis that exposure to these drugs might contribute to the etiology of cryptogenic fibrosing alveolitis." | 1.30 | Exposure to commonly prescribed drugs and the etiology of cryptogenic fibrosing alveolitis: a case-control study. ( Britton, J; Cooper, M; Hubbard, R; Johnston, I; Smith, C; Venn, A, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Belica-Pacha, S | 1 |
| Małecka, M | 1 |
| Daśko, M | 1 |
| Miłowska, K | 1 |
| Bryszewska, M | 1 |
| Budryn, G | 1 |
| Oracz, J | 1 |
| Pałecz, B | 1 |
| Ferguson, LE | 1 |
| McLean, MK | 1 |
| Bates, JA | 1 |
| Quimby, JM | 1 |
| Schuch, LG | 1 |
| Yip, A | 1 |
| Nouri, KF | 1 |
| Gregersen, M | 1 |
| Cason, B | 1 |
| Kukreja, J | 1 |
| Wozniak, C | 1 |
| Brzezinski, M | 1 |
| Shen, J | 1 |
| Moller, HJ | 1 |
| Wang, X | 1 |
| Chung, SA | 1 |
| Shapiro, GK | 1 |
| Li, X | 1 |
| Shapiro, CM | 1 |
| Wålinder, J | 1 |
| Prochazka, J | 1 |
| Odén, A | 1 |
| Sjödin, I | 1 |
| Dahl, ML | 1 |
| Ahlner, J | 1 |
| Bengtsson, F | 1 |
| Hubbard, R | 1 |
| Venn, A | 1 |
| Smith, C | 1 |
| Cooper, M | 1 |
| Johnston, I | 1 |
| Britton, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antidepressant Response to a Sedating Antidepressant Improves Driving Safety in Patients With Major Depressive Disorder[NCT00385437] | Phase 2 | 16 participants | Interventional | 2003-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for mianserin and Adverse Drug Event
| Article | Year |
|---|---|
Mirtazapine, a sedating antidepressant, and improved driving safety in patients with major depressive disorder: a prospective, randomized trial of 28 patients.
Topics: Accidents, Traffic; Adult; Aged; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tr | 2009 |
Mirtazapine naturalistic depression study (in Sweden)--MINDS(S): clinical efficacy and safety.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Body Mass Index; Depre | 2006 |
6 other studies available for mianserin and Adverse Drug Event
| Article | Year |
|---|---|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
The Interaction of Heptakis (2,6-di-O-Methyl)-β-cyclodextrin with Mianserin Hydrochloride and Its Influence on the Drug Toxicity.
Topics: Animals; beta-Cyclodextrins; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Drug Interaction | 2021 |
Mirtazapine toxicity in cats: retrospective study of 84 cases (2006-2011).
Topics: Animals; Appetite Stimulants; Cat Diseases; Cats; Drug-Related Side Effects and Adverse Reactions; F | 2016 |
Serotonin Syndrome Following an Uncomplicated Orthopedic Surgery in a Patient With Post-Traumatic Stress Disorder.
Topics: Adult; Citalopram; Diskectomy; Drug-Related Side Effects and Adverse Reactions; Humans; Low Back Pai | 2016 |
Adverse Drug Reactions Advisory Committee: ADRAC report for 1980.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Australia; Bronchial Spasm; Chemical and Drug Induced Live | 1982 |
Exposure to commonly prescribed drugs and the etiology of cryptogenic fibrosing alveolitis: a case-control study.
Topics: Adrenergic beta-Antagonists; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; A | 1998 |