mianserin has been researched along with Acute Liver Injury, Drug-Induced in 15 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mirtazapine is a commonly used drug indicated for the treatment of severe depression." | 1.46 | Mirtazapine-induced steatosis
. ( Ch'ng, CL; Haboubi, H; Lloyd, A; Thomas, E; Williams, N, 2017) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| " However, this theory cannot be rejected as the mechanisms causing toxic hepatitis from tricyclic and tetracyclic antidepressants may well differ." | 1.28 | [Possible cross hepatotoxicity between tricyclic and tetracyclic antidepressive agents]. ( Quedens, JH; Rasmussen, S, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Thomas, E | 1 |
| Haboubi, H | 1 |
| Williams, N | 1 |
| Lloyd, A | 1 |
| Ch'ng, CL | 1 |
| Rodriguez-Pecci, MS | 1 |
| Fuente-Aguado, Jde L | 1 |
| Montero-Tinnirello, J | 1 |
| Fernandez-Fernandez, FJ | 1 |
| Kang, SG | 1 |
| Yoon, BM | 1 |
| Park, YM | 1 |
| Zarski, JP | 1 |
| Aubert, H | 1 |
| Rachail, M | 1 |
| Barbare, JC | 1 |
| Biour, M | 1 |
| Cadot, T | 1 |
| Latrive, JP | 1 |
| Rasmussen, S | 1 |
| Quedens, JH | 1 |
| Otani, K | 1 |
| Kaneko, S | 1 |
| Tasaki, H | 1 |
| Fukushima, Y | 1 |
| Burrows, GD | 1 |
| Norman, TR | 1 |
| Dennerstein, L | 1 |
| Davies, BM | 1 |
| Urbain, D | 1 |
| Rodzynek, JJ | 1 |
| Wettendorff, P | 1 |
| Meyer, P | 1 |
| Delcourt, A | 1 |
1 review available for mianserin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Antidepressant therapy: benefits and risks in perspective.
Topics: Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Depressive Disorder; Dibenzazepines | 1985 |
14 other studies available for mianserin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Mirtazapine-induced steatosis
.
Topics: Adrenergic alpha-2 Receptor Antagonists; Antidepressive Agents, Tricyclic; Biopsy; Chemical and Drug | 2017 |
[Mirtazapine-associated hepatotoxicity].
Topics: Antidepressive Agents; Chemical and Drug Induced Liver Injury; Cholestasis; Depressive Disorder; Dru | 2010 |
Mirtazapine-induced hepatocellular-type liver injury.
Topics: Antidepressive Agents, Tricyclic; Chemical and Drug Induced Liver Injury; Depressive Disorder, Major | 2011 |
Adverse Drug Reactions Advisory Committee: ADRAC report for 1980.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Australia; Bronchial Spasm; Chemical and Drug Induced Live | 1982 |
[Hepatic toxicity of new antidepressive drugs. Apropos of a case].
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Dibenzazepines; Female; Humans; Isoquinolines | 1983 |
[Hepatotoxicity of mianserin: a case with positive reintroduction].
Topics: Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Depressiv | 1992 |
[Possible cross hepatotoxicity between tricyclic and tetracyclic antidepressive agents].
Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Dothiepin; Drug Interactions; Female; H | 1991 |
Hepatic injury caused by mianserin.
Topics: Chemical and Drug Induced Liver Injury; Depression; Female; Humans; Liver; Male; Mianserin; Middle A | 1989 |
[Hepatic toxicity of mianserin].
Topics: Aged; Chemical and Drug Induced Liver Injury; Dibenzazepines; Humans; Male; Mianserin | 1985 |