mhc-binding-peptide and Muscular-Dystrophies

mhc-binding-peptide has been researched along with Muscular-Dystrophies* in 1 studies

Other Studies

1 other study(ies) available for mhc-binding-peptide and Muscular-Dystrophies

Article	Year
Down-regulation of an ankyrin repeat-containing protein, V-1, during skeletal muscle differentiation and its re-expression in the regenerative process of muscular dystrophy. Neuromuscular disorders : NMD, 2003, Volume: 13, Issue:1 Using Western blot analysis and immunohistochemical methods, we examined the expression of V-1, a member of the ankyrin repeat-containing protein family, during differentiation and regeneration of skeletal muscle. The expression of V-1 was high in cultured myoblasts and decreased during their differentiation into myotubes, while high expression was maintained when muscle differentiation was inhibited by treatment with basic fibroblast growth factor. Down-regulation of V-1 also occurred during in vivo muscle differentiation from embryonic to postnatal stages, reaching an undetectable level in mature skeletal muscle. In contrast, strong V-1 immunoreactivity was detected again in myoblasts and regenerating muscle fibers with a small diameter, which were observed in Duchenne muscular dystrophy and its animal model, mdx mouse. Thus, it seems that V-1 is a good marker for early stage of muscle regeneration and changes of its expression suggest that V-1 plays a role in prenatal muscle differentiation and postnatal muscle regeneration. Topics: Adult; Animals; Ankyrin Repeat; Blotting, Western; Cell Differentiation; Cyclic AMP-Dependent Protein Kinases; Desmin; Diaphragm; Down-Regulation; Female; Humans; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Dystrophies; Myoblasts; Myogenin; Myosins; Nerve Tissue Proteins; Oligopeptides; Rats; Rats, Wistar; Regeneration	2003

Article

Year

Down-regulation of an ankyrin repeat-containing protein, V-1, during skeletal muscle differentiation and its re-expression in the regenerative process of muscular dystrophy.

Neuromuscular disorders : NMD, 2003, Volume: 13, Issue:1

Using Western blot analysis and immunohistochemical methods, we examined the expression of V-1, a member of the ankyrin repeat-containing protein family, during differentiation and regeneration of skeletal muscle. The expression of V-1 was high in cultured myoblasts and decreased during their differentiation into myotubes, while high expression was maintained when muscle differentiation was inhibited by treatment with basic fibroblast growth factor. Down-regulation of V-1 also occurred during in vivo muscle differentiation from embryonic to postnatal stages, reaching an undetectable level in mature skeletal muscle. In contrast, strong V-1 immunoreactivity was detected again in myoblasts and regenerating muscle fibers with a small diameter, which were observed in Duchenne muscular dystrophy and its animal model, mdx mouse. Thus, it seems that V-1 is a good marker for early stage of muscle regeneration and changes of its expression suggest that V-1 plays a role in prenatal muscle differentiation and postnatal muscle regeneration.

Topics: Adult; Animals; Ankyrin Repeat; Blotting, Western; Cell Differentiation; Cyclic AMP-Dependent Protein Kinases; Desmin; Diaphragm; Down-Regulation; Female; Humans; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Dystrophies; Myoblasts; Myogenin; Myosins; Nerve Tissue Proteins; Oligopeptides; Rats; Rats, Wistar; Regeneration

2003