mf-5137 and Sepsis

mf-5137 has been researched along with Sepsis* in 1 studies

Other Studies

1 other study(ies) available for mf-5137 and Sepsis

ArticleYear
Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-methylquinolones.
    Journal of medicinal chemistry, 1996, Jan-19, Volume: 39, Issue:2

    The 6-aminoquinolone had previously been identified as a new class of quinolone antibacterial agents. To continue our structure-activity relationship (SAR) study in this series, novel 6-amino-8-methylquinolone derivatives have now been synthesized and evaluated for in vitro antibacterial activity. We have shown that the coupled presence of a methyl group at the C-8 position with an amino group at C-6 is effective for enhancing antibacterial activity, particularly against Gram-positive bacteria. The SARs associated with the N-1, C-6, and C-7 are discussed. The 1,2,3,4-tetrahydroisoquinolinyl derivative 19v showed the highest antibacterial activity with MIC values on Gram-positive bacteria superior to that of ciprofloxacin, especially against Staphylococcus aureus strains, including those strains which are methicillin-and ciprofloxacin-resistant.

    Topics: Animals; Anti-Bacterial Agents; Female; Magnetic Resonance Spectroscopy; Male; Mice; Quinolones; Sepsis; Staphylococcus aureus; Structure-Activity Relationship

1996