mezerein and Prostatic-Neoplasms--Castration-Resistant

mezerein has been researched along with Prostatic-Neoplasms--Castration-Resistant* in 1 studies

Other Studies

1 other study(ies) available for mezerein and Prostatic-Neoplasms--Castration-Resistant

Article	Year
Discovery of Highly Potent Daphnane Diterpenoids Uncovers Importin-β1 as a Druggable Vulnerability in Castration-Resistant Prostate Cancer. Journal of the American Chemical Society, 2022, 09-28, Volume: 144, Issue:38 Importins are overexpressed in many cancers and mediate the abnormal nuclear transport of oncogenic factors. The druggable potential of importins still remains unclear, largely because of the lack of potent inhibitors. Herein, the anti-castration-resistant prostate cancer (CRPC) screening of a Euphorbiaceae diterpenoid library followed by target fishing led to the identification of a highly potent importin-β1 inhibitor, daphnane diterpenoid Topics: Cell Line, Tumor; Cell Proliferation; Diterpenes; Humans; Karyopherins; Male; Prostatic Neoplasms, Castration-Resistant	2022

Article

Year

Discovery of Highly Potent Daphnane Diterpenoids Uncovers Importin-β1 as a Druggable Vulnerability in Castration-Resistant Prostate Cancer.

Journal of the American Chemical Society, 2022, 09-28, Volume: 144, Issue:38

Importins are overexpressed in many cancers and mediate the abnormal nuclear transport of oncogenic factors. The druggable potential of importins still remains unclear, largely because of the lack of potent inhibitors. Herein, the anti-castration-resistant prostate cancer (CRPC) screening of a Euphorbiaceae diterpenoid library followed by target fishing led to the identification of a highly potent importin-β1 inhibitor, daphnane diterpenoid

Topics: Cell Line, Tumor; Cell Proliferation; Diterpenes; Humans; Karyopherins; Male; Prostatic Neoplasms, Castration-Resistant

2022