mezerein and Edema

mezerein has been researched along with Edema* in 2 studies

Reviews

1 review(s) available for mezerein and Edema

ArticleYear
Models of acute inflammation in the ear.
    Methods in molecular biology (Clifton, N.J.), 2003, Volume: 225

    Topics: Alkynes; Animals; Anthralin; Arachidonic Acid; Cantharidin; Capsaicin; Carrageenan; Croton Oil; Dermatitis; Disease Models, Animal; Diterpenes; Edema; Foot; Inflammation; Irritants; Male; Mice; Models, Animal; Mustard Plant; Otitis Externa; Plant Extracts; Plant Oils; Rats; Reproducibility of Results; Terpenes; Tetradecanoylphorbol Acetate; Zymosan

2003

Other Studies

1 other study(ies) available for mezerein and Edema

ArticleYear
Effect of triterpenoids on the inflammation induced by protein kinase C activators, neuronally acting irritants and other agents.
    European journal of pharmacology, 2000, Dec-20, Volume: 410, Issue:1

    In order to establish the mode of the anti-inflammatory activity of triterpenoids, 11 naturally occurring compounds were assayed on mouse ear oedema induced by the protein kinase C activators, mezerein, 12-O-tetradecanoylphorbol-13-acetate (TPA), two 12-deoxyphorbol-13-monoesters (13-tetradecanoate (DPT) and 13-phenylacetate (DPP)) and bryostatin 1, and by resiniferatoxin, xylene and arachidonic acid. The effects on bradykinin-induced paw oedema and on the rat skin inflammation caused by hydrogen peroxide were also examined. The oedema induced by mezerein and DPT was reduced to different extents by the triterpenoids administered epicutaneously (0.5 mg per ear). Against DPT-induced oedema, lupane and oleanane derivatives were the most effective compounds. Oleananes and lupanes possessing a carboxyl group were active against bryostatin 1-induced oedema. Most of the triterpenoids were ineffective against the neurogenic inflammation caused by resiniferatoxin and xylene. Many triterpenoids, especially oleanane and lupane alcoholic derivatives, were active against the plantar oedema induced by bradykinin and on the intradermal inflammation induced by hydrogen peroxide. In conclusion, the anti-inflammatory activity of triterpenoids may depend on inhibition of protein kinase C, without any involvement of neurogenic inflammatory mechanisms.

    Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Bradykinin; Dermatitis, Irritant; Diterpenes; Ear; Edema; Enzyme Activators; Female; Glucose Oxidase; Irritants; Mice; Molecular Structure; Neurogenic Inflammation; Protein Kinase C; Rats; Rats, Wistar; Reactive Oxygen Species; Skin; Terpenes; Time Factors; Triterpenes

2000