mezerein has been researched along with Colorectal-Neoplasms* in 1 studies
1 other study(ies) available for mezerein and Colorectal-Neoplasms
| Article | Year |
|---|---|
Daphnanes diterpenes from the latex of Hura crepitans L. and their PKCĪ¶-dependent anti-proliferative activity on colorectal cancer cells.
Hura crepitans L. (Euphorbiaceae) is a thorn-covered tree widespread in South America, Africa and Asia which produces an irritating milky latex containing numerous secondary metabolites, notably daphnane-type diterpenes known as Protein Kinase C activators. Fractionation of a dichloromethane extract of the latex led to the isolation of five new daphnane diterpenes (1-5), along with two known analogs (6-7) including huratoxin. Huratoxin (6) and 4',5'-epoxyhuratoxin (4) were found to exhibit significant and selective cell growth inhibition against colorectal cancer cell line Caco-2 and primary colorectal cancer cells cultured as colonoids. The underlying mechanism of 4 and 6 was further investigated revealing the involvement of PKCĪ¶ in the cytostatic activity. Topics: Caco-2 Cells; Colorectal Neoplasms; Diterpenes; Euphorbiaceae; Humans; Latex | 2023 |