mexiletine has been researched along with Tachycardia, Ventricular in 52 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Tachycardia, Ventricular: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the spontaneous variability of ventricular arrhythmias (VA) and evaluate anti-arrhythmic efficacy of mexiletine, sotalol, and a mexiletine-sotalol combination in German shepherd dogs (GSD) with inherited arrhythmias." | 9.14 | Combination therapy with mexiletine and sotalol suppresses inherited ventricular arrhythmias in German shepherd dogs better than mexiletine or sotalol monotherapy: a randomized cross-over study. ( Gelzer, AR; Hemsley, SA; Kraus, MS; Moïse, NS; Rishniw, M, 2010) |
| "Experimental studies and clinical reports suggest antiarrhythmic properties of mexiletine in different arrhythmias." | 7.88 | Broad antiarrhythmic effect of mexiletine in different arrhythmia models. ( Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Garthmann, J; Köbe, J; Kochhäuser, S; Reinke, F; Wasmer, K, 2018) |
| " However, the pharmacokinetic interaction between mexiletine and theophylline has not been clarified." | 5.28 | [The effect of mexiletine on theophylline pharmacokinetics in patients with bronchial asthma]. ( Hariya, Y; Hayakawa, H; Inafuku, M; Nagasawa, K; Nakahara, Y; Ohtsu, F; Suzuki, T; Yoshioka, Y, 1992) |
| "The aim of the study was to systematically review evidence on the effectiveness and safety of oral mexiletine administered in monotherapy or in combination with other antiarrhythmic drugs for recurrent ventricular arrhythmia (ventricular tachycardia/ventricular fibrillation, VT/VF) in adult patients with structural heart disease (SHD) and implantable cardioverter defibrillators (ICDs)." | 5.22 | Mexiletine for recurrent ventricular tachycardia in adult patients with structural heart disease and implantable cardioverter defibrillator: an EHRA systematic review. ( Anic, A; Boveda, S; Conte, G; de Asmundis, C; Farkowski, MM; Karlinski, M; Lewandowski, M; Marijon, E; Mugnai, G; Providencia, R; Pytkowski, M, 2022) |
| "To determine the spontaneous variability of ventricular arrhythmias (VA) and evaluate anti-arrhythmic efficacy of mexiletine, sotalol, and a mexiletine-sotalol combination in German shepherd dogs (GSD) with inherited arrhythmias." | 5.14 | Combination therapy with mexiletine and sotalol suppresses inherited ventricular arrhythmias in German shepherd dogs better than mexiletine or sotalol monotherapy: a randomized cross-over study. ( Gelzer, AR; Hemsley, SA; Kraus, MS; Moïse, NS; Rishniw, M, 2010) |
| "We enrolled all consecutive patients with unsuccessful/not feasible catheter ablation and ineffective/contraindicated amiodarone or beta-blockers, which started the mexiletine treatment for refractory ventricular tachycardia (VT) or ventricular fibrillation (VF) between January 2010 and January 2020." | 4.12 | Mexiletine for ventricular arrhythmias in patients with chronic coronary syndrome: a cohort study. ( Bilato, C; Cavedon, S; Mecenero, A; Mugnai, G; Paolini, C; Perrone, C, 2022) |
| "Experimental studies and clinical reports suggest antiarrhythmic properties of mexiletine in different arrhythmias." | 3.88 | Broad antiarrhythmic effect of mexiletine in different arrhythmia models. ( Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Garthmann, J; Köbe, J; Kochhäuser, S; Reinke, F; Wasmer, K, 2018) |
| "Antiarrhythmic agents which belong to class Ia (quinidine) and Ic (flecainide) reportedly increase propensity to ventricular tachyarrhythmia, whereas class Ib agents (lidocaine and mexiletine) are recognized as safe antiarrhythmics." | 3.80 | Effects of Na+ channel blockers on extrasystolic stimulation-evoked changes in ventricular conduction and repolarization. ( Osadchii, OE, 2014) |
| "The electrophysiological effects of combination therapy of mexiletine and propafenone were assessed using standard 12-lead electrocardiogram (standard ECG), signal-averaged ECG (SAECG), and ambulatory ECG in 31 patients with ventricular arrhythmias." | 3.68 | Mexiletine and propafenone: a comparative study of monotherapy, low, and full dose combination therapy. ( Haruna, M; Kato, H; Lee, S; Machii, T; Nonokawa, M; Takanaka, C; Yabe, S, 1992) |
| "Mexiletine has limited efficacy in the treatment of recurrent VT despite high-dose amiodarone therapy, in patients with ischemic heart disease." | 2.87 | Mexiletine or catheter ablation after amiodarone failure in the VANISH trial. ( Deyell, MW; Doucette, S; Essebag, V; Gardner, M; Gray, C; Healey, JS; Hruczkowski, T; Leong-Sit, P; Nault, I; Nery, PB; Parkash, R; Rivard, L; Sapp, JL; Steinberg, C; Sterns, LD, 2018) |
| "In patients presenting with sustained ventricular tachyarrhythmias, when oral quinidine monotherapy fails as determined by programmed electrical stimulation, the degree of benefit observed with combination therapy with mexiletine is debated." | 2.67 | Usefulness of oral quinidine-mexiletine combination therapy for sustained ventricular tachyarrhythmias as assessed by programmed electrical stimulation when quinidine monotherapy has failed. ( Bonavita, GJ; Cuello, C; Greene, TO; Huang, SK; Mittleman, RS; Pires, LA; Wagshal, AB, 1994) |
| "Monomorphic sustained ventricular tachycardia (MSVT) was revisited in relation to the electrophysiologic findings and their relation to the drug efficacy." | 2.40 | Reentrant ventricular tachycardia. Interpretations of electrophysiologic findings and its applications. ( Aizawa, Y; Tanabe, Y; Yamaura, M, 1998) |
| "Electrical storm due to recurrent ventricular tachycardias (VTs) is a life-threatening arrhythmic emergency." | 1.91 | Use of mexiletine in therapy-refractory recurrent ventricular tachycardia storm. ( Pap, R; Szonyi, MD; Vamos, M, 2023) |
| "Ranolazine is a drug that exerts antianginal and antiischemic effects and also acts as an antiarrhythmic in isolation and in combination with other class III medications." | 1.37 | Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocks. ( Anderson, JL; Bair, TL; Bunch, TJ; Crandall, BG; Day, JD; Lappe, DL; Mader, KM; Mahapatra, S; May, HT; Molden, J; Muhlestein, JB; Murdock, D; Osborn, JS; Weiss, JP, 2011) |
| "Electrocardiography (ECG) showed ventricular tachycardia." | 1.35 | A case of myotonic dystrophy presenting with ventricular tachycardia and atrial fibrillation. ( Eroğlu, S; Müderrisoğlu, H; Ozbiçer, S; Ozin, B, 2009) |
| "Sustained ventricular tachyarrhythmias were induced in 12 of the 56 trials of the VSP." | 1.32 | Ventricular tachyarrhythmias in a canine model of LQT3: arrhythmogenic effects of sympathetic activity and therapeutic effects of mexiletine. ( Aizawa, Y; Chinushi, M; Hosaka, Y; Komura, S; Sugiura, H; Tagawa, M; Washizuka, T, 2003) |
| "Five days later, ventricular tachycardia following short-coupled ventricular premature contractions suddenly occurred and was not responsive to class IB drugs (lidocaine and mexiletine), requiring frequent electrical cardioversion." | 1.32 | Nifekalant hydrochloride, a novel class III antiarrhythmic agent, suppressed postoperative recurrent ventricular tachycardia in a patient undergoing coronary artery bypass grafting and the Dor approach. ( Fu, LT; Iinuma, H; Sagara, K; Sahara, M; Watanabe, H; Yamashita, T, 2003) |
| "Our objective was to elucidate the mechanism of pharmacokinetic interaction between lidocaine and mexiletine, because an unexpected increase in plasma lidocaine concentration accompanied by severe side effects was observed when mexiletine was administered to a patient with dilated cardiomyopathy." | 1.31 | Possible mechanism for pharmacokinetic interaction between lidocaine and mexiletine. ( Fukuzawa, M; Funakoshi, S; Kugaya, Y; Maeda, Y; Murakami, T; Nakamura, M; Takano, M; Tsukiai, S; Yamasaki, M, 2002) |
| "Mexiletine was confirmed to preferentially depress conduction in the diseased myocardium at the VT origin, and this action occurred at a higher rate during VT." | 1.30 | Does mexiletine have a preferential action (versus healthy myocardium) on the reentrant circuit of ventricular tachycardia? ( Abe, A; Aizawa, Y; Ma, M, 1997) |
| "Mexiletine was recently shown to antagonize the effects of sotalol on repolarization of canine Purkinje fibers." | 1.29 | Antiarrhythmic effect of a sotalol-mexiletine combination on induced ventricular tachycardia in dogs. ( Cheymol, G; Chézalviel, F; Davy, JM; Guhennec, C; Jagueux, M; Poirier, JM; Simandoux, V; Vernhet, L; Weissenburger, J, 1993) |
| "Monomorphic sustained ventricular tachycardia (VT) can often be entrained and interrupted at a critical paced cycle length." | 1.29 | Discrepant effects of mexiletine on cycle length of ventricular tachycardia and on the effective refractory period in the area of slow conduction. ( Abe, A; Aizawa, Y; Chinushi, M; Kitazawa, H; Kodama, I; Shibata, A; Washizuka, T, 1996) |
| " However, the pharmacokinetic interaction between mexiletine and theophylline has not been clarified." | 1.28 | [The effect of mexiletine on theophylline pharmacokinetics in patients with bronchial asthma]. ( Hariya, Y; Hayakawa, H; Inafuku, M; Nagasawa, K; Nakahara, Y; Ohtsu, F; Suzuki, T; Yoshioka, Y, 1992) |
| "In 5 patients (71%) ventricular tachycardia was abolished." | 1.28 | Effect of the combination of low-dose mexiletine and metoprolol on ventricular arrhythmia. ( Graboys, TB; Lampert, S; Ravid, S, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 25 (48.08) | 18.2507 |
| 2000's | 9 (17.31) | 29.6817 |
| 2010's | 12 (23.08) | 24.3611 |
| 2020's | 6 (11.54) | 2.80 |
| Authors | Studies |
|---|---|
| Farkowski, MM | 1 |
| Karlinski, M | 1 |
| Pytkowski, M | 1 |
| de Asmundis, C | 1 |
| Lewandowski, M | 1 |
| Mugnai, G | 2 |
| Conte, G | 1 |
| Marijon, E | 1 |
| Anic, A | 1 |
| Boveda, S | 1 |
| Providencia, R | 1 |
| Ali, H | 1 |
| Cristiano, E | 1 |
| Lupo, P | 1 |
| Foresti, S | 1 |
| DE Ambroggi, G | 1 |
| DE Lucia, C | 1 |
| Turturiello, D | 1 |
| Paganini, EM | 1 |
| Bessi, R | 1 |
| Farghaly, AA | 1 |
| Nicolì, L | 1 |
| Cappato, R | 1 |
| Szonyi, MD | 1 |
| Pap, R | 1 |
| Vamos, M | 1 |
| Kang, Y | 1 |
| Wei, J | 1 |
| Boles, U | 1 |
| Refila, B | 1 |
| Gul, EE | 1 |
| Szeplaki, G | 1 |
| Keaney, J | 1 |
| Galvin, J | 1 |
| Keelan, E | 1 |
| Frutos-López, M | 1 |
| Pedrote, A | 1 |
| Acosta-Martínez, J | 1 |
| Arana-Rueda, E | 1 |
| Xu, B | 1 |
| Li, K | 1 |
| Liu, F | 1 |
| Kong, L | 1 |
| Yang, J | 1 |
| Zhou, B | 1 |
| Lv, T | 1 |
| Liu, Y | 1 |
| She, F | 1 |
| He, R | 1 |
| Zhang, P | 1 |
| Paolini, C | 1 |
| Cavedon, S | 1 |
| Mecenero, A | 1 |
| Perrone, C | 1 |
| Bilato, C | 1 |
| Pokorney, SD | 1 |
| Mi, X | 1 |
| Hammill, BG | 1 |
| Allen LaPointe, NM | 1 |
| Curtis, LH | 1 |
| Al-Khatib, SM | 1 |
| Frommeyer, G | 1 |
| Garthmann, J | 1 |
| Ellermann, C | 1 |
| Dechering, DG | 1 |
| Kochhäuser, S | 1 |
| Reinke, F | 1 |
| Köbe, J | 1 |
| Wasmer, K | 1 |
| Eckardt, L | 1 |
| Deyell, MW | 1 |
| Steinberg, C | 1 |
| Doucette, S | 1 |
| Parkash, R | 1 |
| Nault, I | 1 |
| Gray, C | 1 |
| Essebag, V | 1 |
| Gardner, M | 1 |
| Sterns, LD | 1 |
| Healey, JS | 1 |
| Hruczkowski, T | 1 |
| Rivard, L | 1 |
| Leong-Sit, P | 1 |
| Nery, PB | 1 |
| Sapp, JL | 1 |
| Gao, D | 1 |
| Van Herendael, H | 1 |
| Alshengeiti, L | 1 |
| Dorian, P | 1 |
| Mangat, I | 1 |
| Korley, V | 1 |
| Ahmad, K | 1 |
| Golovchiner, G | 1 |
| Aves, T | 1 |
| Pinter, A | 1 |
| Sanders, RA | 1 |
| Kurosawa, TA | 1 |
| Ermakov, S | 1 |
| Hoffmayer, KS | 1 |
| Gerstenfeld, EP | 1 |
| Scheinman, MM | 1 |
| Osadchii, OE | 1 |
| Romano, G | 1 |
| Raffa, GM | 1 |
| Ruggieri, A | 1 |
| Sgarito, G | 1 |
| Falletta, C | 1 |
| Sciacca, S | 1 |
| Pilato, M | 1 |
| Clemenza, F | 1 |
| Eroğlu, S | 1 |
| Ozin, B | 1 |
| Ozbiçer, S | 1 |
| Müderrisoğlu, H | 1 |
| Gelzer, AR | 1 |
| Kraus, MS | 1 |
| Rishniw, M | 1 |
| Hemsley, SA | 1 |
| Moïse, NS | 1 |
| Bunch, TJ | 1 |
| Mahapatra, S | 1 |
| Murdock, D | 1 |
| Molden, J | 1 |
| Weiss, JP | 1 |
| May, HT | 1 |
| Bair, TL | 1 |
| Mader, KM | 1 |
| Crandall, BG | 1 |
| Day, JD | 1 |
| Osborn, JS | 1 |
| Muhlestein, JB | 1 |
| Lappe, DL | 1 |
| Anderson, JL | 1 |
| Kolb, C | 1 |
| Lehmann, G | 1 |
| Schreieck, J | 1 |
| Ndrepepa, G | 1 |
| Schmitt, C | 1 |
| Chinushi, M | 5 |
| Tagawa, M | 1 |
| Sugiura, H | 1 |
| Komura, S | 1 |
| Hosaka, Y | 1 |
| Washizuka, T | 2 |
| Aizawa, Y | 8 |
| Sahara, M | 1 |
| Sagara, K | 1 |
| Yamashita, T | 1 |
| Iinuma, H | 1 |
| Fu, LT | 1 |
| Watanabe, H | 1 |
| Takada, Y | 1 |
| Isobe, S | 1 |
| Okada, M | 1 |
| Ando, A | 1 |
| Nonokawa, M | 2 |
| Inden, Y | 1 |
| Tomita, Y | 1 |
| Suzuki, A | 1 |
| Hirai, M | 1 |
| Murohara, T | 1 |
| Sekiguchi, A | 1 |
| Kashiwagi, T | 1 |
| Ishida-Yamamoto, A | 1 |
| Takahashi, H | 1 |
| Hashimoto, Y | 1 |
| Kimura, H | 1 |
| Tohyama, M | 1 |
| Hashimoto, K | 2 |
| Iizuka, H | 1 |
| Head, CE | 1 |
| Balasubramaniam, R | 1 |
| Thomas, G | 1 |
| Goddard, CA | 1 |
| Lei, M | 1 |
| Colledge, WH | 1 |
| Grace, AA | 1 |
| Huang, CL | 1 |
| Komori, S | 1 |
| Sano, S | 1 |
| Li, BH | 1 |
| Matsumura, K | 1 |
| Naitoh, A | 1 |
| Mochizuki, S | 1 |
| Ishihara, T | 1 |
| Watanabe, A | 1 |
| Umetani, K | 1 |
| Ijiri, H | 1 |
| Chézalviel, F | 1 |
| Weissenburger, J | 1 |
| Guhennec, C | 1 |
| Jagueux, M | 1 |
| Davy, JM | 1 |
| Vernhet, L | 1 |
| Simandoux, V | 1 |
| Poirier, JM | 1 |
| Cheymol, G | 1 |
| Jung, W | 2 |
| Mletzko, R | 1 |
| Manz, M | 2 |
| Nitsch, J | 1 |
| Lüderitz, B | 2 |
| Awaji, T | 1 |
| Biblo, LA | 1 |
| Carlson, MD | 1 |
| Waldo, AL | 1 |
| Bonavita, GJ | 1 |
| Pires, LA | 1 |
| Wagshal, AB | 1 |
| Cuello, C | 1 |
| Mittleman, RS | 1 |
| Greene, TO | 1 |
| Huang, SK | 1 |
| Fiksinski, E | 1 |
| Martin, D | 1 |
| Venditti, F | 1 |
| Libersa, C | 1 |
| Caron, J | 1 |
| Broly, F | 1 |
| Lacroix, D | 1 |
| Lhermitte, M | 1 |
| Christie, JM | 1 |
| Valdes, C | 1 |
| Markowsky, SJ | 1 |
| Omae, A | 1 |
| Katayama, K | 1 |
| Kakiuchi, Y | 1 |
| Okada, N | 1 |
| Hijioka, Y | 1 |
| Nagai, Y | 1 |
| Ito, Y | 1 |
| Hagiwara, H | 1 |
| Kasahara, A | 1 |
| Hayashi, N | 1 |
| Miyazaki, T | 1 |
| Mitamura, H | 1 |
| Miyoshi, S | 1 |
| Soejima, K | 1 |
| Ogawa, S | 1 |
| Naitoh, N | 1 |
| Shibata, A | 2 |
| Kitazawa, H | 1 |
| Abe, A | 3 |
| Kodama, I | 1 |
| Ohira, K | 2 |
| Furushima, H | 2 |
| Fujita, S | 1 |
| Priori, SG | 1 |
| Napolitano, C | 1 |
| Paganini, V | 1 |
| Cantù, F | 1 |
| Schwartz, PJ | 1 |
| Schuster, MM | 1 |
| Ma, M | 1 |
| Tanabe, Y | 1 |
| Yamaura, M | 1 |
| Niwano, S | 1 |
| Taneda, K | 1 |
| Manolis, AG | 1 |
| Katsivas, AG | 1 |
| Vassilopoulos, C | 1 |
| Tsatiris, CG | 1 |
| Maeda, Y | 1 |
| Funakoshi, S | 1 |
| Nakamura, M | 1 |
| Fukuzawa, M | 1 |
| Kugaya, Y | 1 |
| Yamasaki, M | 1 |
| Tsukiai, S | 1 |
| Murakami, T | 1 |
| Takano, M | 1 |
| Takanaka, C | 1 |
| Machii, T | 1 |
| Lee, S | 1 |
| Kato, H | 1 |
| Haruna, M | 1 |
| Yabe, S | 1 |
| Lombardi, F | 1 |
| Torzillo, D | 1 |
| Sandrone, G | 1 |
| Dalla Vecchia, L | 1 |
| Cappiello, E | 1 |
| Inafuku, M | 1 |
| Suzuki, T | 1 |
| Ohtsu, F | 1 |
| Hariya, Y | 1 |
| Nagasawa, K | 1 |
| Yoshioka, Y | 1 |
| Nakahara, Y | 1 |
| Hayakawa, H | 1 |
| Pizzulli, L | 1 |
| Pfeiffer, D | 1 |
| Bach, P | 1 |
| Gonschior, P | 1 |
| Prinz, C | 1 |
| Kreuzer, E | 1 |
| Autenrieth, G | 1 |
| Steinbeck, G | 1 |
| Ravid, S | 1 |
| Lampert, S | 1 |
| Graboys, TB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00000518] | Phase 3 | 0 participants | Interventional | 1985-07-31 | Completed | ||
| aMsa and amiOdarone Study in cArdiaC Arrest[NCT04997980] | 500 participants (Anticipated) | Observational | 2015-01-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for mexiletine and Tachycardia, Ventricular
| Article | Year |
|---|---|
Mexiletine for recurrent ventricular tachycardia in adult patients with structural heart disease and implantable cardioverter defibrillator: an EHRA systematic review.
Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Catheter Ablation; Defibrillators, Implantable; Humans; M | 2022 |
Oral mexiletine for ventricular tachyarrhythmias treatment in implantable cardioverter-defibrillator patients: a systematic review of the literature.
Topics: Anti-Arrhythmia Agents; Defibrillators, Implantable; Humans; Mexiletine; Tachycardia, Ventricular; T | 2023 |
Recurrent ventricular tachycardia in a patient with continuous flow left ventricle assist device: Successful management with radiofrequency ablation and medical treatment.
Topics: Anti-Arrhythmia Agents; Catheter Ablation; Disease Management; Heart Ventricles; Heart-Assist Device | 2015 |
Molecular biology of the long QT syndrome: impact on management.
Topics: Action Potentials; Adrenergic Antagonists; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artifici | 1997 |
Reentrant ventricular tachycardia. Interpretations of electrophysiologic findings and its applications.
Topics: Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Cardiomyopathies; Disopyramide; Electrocardiogra | 1998 |
[Ventricular tachycardia in anterior wall aneurysm after myocardial infarct].
Topics: Aged; Amiodarone; Drug Therapy, Combination; Electrocardiography, Ambulatory; Heart Aneurysm; Heart | 1992 |
6 trials available for mexiletine and Tachycardia, Ventricular
| Article | Year |
|---|---|
Mexiletine or catheter ablation after amiodarone failure in the VANISH trial.
Topics: Action Potentials; Aged; Amiodarone; Anti-Arrhythmia Agents; Catheter Ablation; Drug Substitution; F | 2018 |
Combination therapy with mexiletine and sotalol suppresses inherited ventricular arrhythmias in German shepherd dogs better than mexiletine or sotalol monotherapy: a randomized cross-over study.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cross-Over Studies; Dog Diseases; Dogs; Drug | 2010 |
Effects of antiarrhythmic agents on left ventricular function during exercise in patients with chronic left ventricular dysfunction.
Topics: Aged; Anti-Asthmatic Agents; Chronic Disease; Disopyramide; Exercise; Exercise Test; Female; Heart V | 2004 |
Insights into the Electrophysiology Study Versus Electrocardiographic Monitoring Trial: its programmed stimulation protocol may introduce bias when assessing long-term antiarrhythmic drug therapy.
Topics: Anti-Arrhythmia Agents; Bias; Cardiac Pacing, Artificial; Drug Combinations; Electrocardiography, Am | 1995 |
Usefulness of oral quinidine-mexiletine combination therapy for sustained ventricular tachyarrhythmias as assessed by programmed electrical stimulation when quinidine monotherapy has failed.
Topics: Adult; Aged; Cardiac Pacing, Artificial; Drug Therapy, Combination; Electric Stimulation; Electrocar | 1994 |
Effects of chronic amiodarone therapy on defibrillation threshold.
Topics: Amiodarone; Defibrillators, Implantable; Electrodes, Implanted; Female; Follow-Up Studies; Humans; M | 1992 |
40 other studies available for mexiletine and Tachycardia, Ventricular
| Article | Year |
|---|---|
Use of mexiletine in therapy-refractory recurrent ventricular tachycardia storm.
Topics: Aged; Anti-Arrhythmia Agents; Catheter Ablation; Defibrillators, Implantable; Humans; Male; Mexileti | 2023 |
Mexiletine Suppressed Recurrent Ventricular Tachycardia Triggered by Hemodialysis in an Old Patient with LQT2.
Topics: Anti-Arrhythmia Agents; Electrocardiography; Female; Follow-Up Studies; Humans; Kidney Failure, Chro | 2019 |
Ventricular Tachycardia Storm After Standard Radiofrequency Pulmonary Vein Isolation.
Topics: Aged; Anti-Arrhythmia Agents; Cicatrix; Electric Countershock; Heart Ventricles; Humans; Lidocaine; | 2019 |
Dramatic reduction of ventricular tachycardia burden after dronedarone plus mexiletine treatment in a patient refractory to hybrid ablation.
Topics: Amiodarone; Anti-Arrhythmia Agents; Catheter Ablation; Defibrillators, Implantable; Dronedarone; Dru | 2020 |
Mexiletine Shortened QT Interval and Reduced Ventricular Arrhythmias in a Pedigree of Type 2 Long QT Syndrome Combined with Left Ventricular Non-Compaction.
Topics: Anti-Arrhythmia Agents; Echocardiography; Electrocardiography; Female; Heart Ventricles; Humans; Lon | 2021 |
Mexiletine for ventricular arrhythmias in patients with chronic coronary syndrome: a cohort study.
Topics: Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Cohort Studies; Coronary Artery Disease | 2022 |
Use of Antiarrhythmic Medications in Medicare Part D Patients With an Implantable Cardioverter-Defibrillator and Ventricular Tachycardia.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Databases, | 2017 |
Broad antiarrhythmic effect of mexiletine in different arrhythmia models.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Disea | 2018 |
Mexiletine as an adjunctive therapy to amiodarone reduces the frequency of ventricular tachyarrhythmia events in patients with an implantable defibrillator.
Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Cardiomyopathies; Cohort Studies | 2013 |
ECG of the month. Ventricular arrhythmia in a dog.
Topics: Animals; Anti-Arrhythmia Agents; Dog Diseases; Dogs; Electrocardiography; Fatal Outcome; Female; Mex | 2013 |
Combination drug therapy for patients with intractable ventricular tachycardia associated with right ventricular cardiomyopathy.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmogenic Right Ventricular Dysplasia; Chronic Disease; Dr | 2014 |
Effects of Na+ channel blockers on extrasystolic stimulation-evoked changes in ventricular conduction and repolarization.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiological Pheno | 2014 |
A case of myotonic dystrophy presenting with ventricular tachycardia and atrial fibrillation.
Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Defibrillators, Implantable | 2009 |
Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocks.
Topics: Acetanilides; Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Cohort Studies; Def | 2011 |
Storms of ventricular tachyarrhythmias associated with primary hyperparathyroidism in a patient with dilated cardiomyopathy.
Topics: Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Bisoprolol; Cardiomyopathy, Dilated; Def | 2003 |
Ventricular tachyarrhythmias in a canine model of LQT3: arrhythmogenic effects of sympathetic activity and therapeutic effects of mexiletine.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Dogs; Electrocardiography; Heart Rate | 2003 |
Nifekalant hydrochloride, a novel class III antiarrhythmic agent, suppressed postoperative recurrent ventricular tachycardia in a patient undergoing coronary artery bypass grafting and the Dor approach.
Topics: Aged; Anti-Arrhythmia Agents; Coronary Artery Bypass; Drug Resistance; Electric Countershock; Electr | 2003 |
Drug-induced hypersensitivity syndrome due to mexiletine associated with human herpes virus 6 and cytomegalovirus reactivation.
Topics: Aged; Anti-Arrhythmia Agents; Blood Chemical Analysis; Cytomegalovirus Infections; Diagnosis, Differ | 2005 |
Paced electrogram fractionation analysis of arrhythmogenic tendency in DeltaKPQ Scn5a mice.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Art | 2005 |
Effects of bidisomide (SC-40230), a new class I antiarrhythmic agent, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats; comparison with mexiletine and disopyramide.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Complexes, Premature; Coronary Disease; Dis | 1995 |
Antiarrhythmic effect of a sotalol-mexiletine combination on induced ventricular tachycardia in dogs.
Topics: Animals; Coronary Vessels; Dogs; Drug Combinations; Electric Stimulation; Electrocardiography; Elect | 1993 |
Efficacy and safety of combination therapy with amiodarone and type I agents for treatment of inducible ventricular tachycardia.
Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Drug Therapy, Combinati | 1993 |
Antiarrhythmic effects of combined application of class I antiarrhythmic drugs; addition of low-dose mexiletine-enhanced antiarrhythmic effects of disopyramide and aprindine in various-rate canine ventricular tachycardias.
Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Blood Pressure; Coronary Vessels; Disopyramide; Dogs; Dr | 1993 |
Electrical proarrhythmia with procainamide: a new ICD-drug interaction.
Topics: Aged; Defibrillators, Implantable; Disopyramide; Humans; Male; Mexiletine; Procainamide; Tachycardia | 1994 |
Interaction of propafenone and mexiletine.
Topics: Drug Interactions; Drug Therapy, Combination; Humans; Mexiletine; Propafenone; Tachycardia, Ventricu | 1993 |
Neurotoxicity of lidocaine combined with mexiletine.
Topics: Administration, Oral; Cardiomyopathies; Drug Therapy, Combination; Humans; Injections, Intravenous; | 1993 |
[A case of ventricular tachycardia occurred during interferon therapy in chronic hepatitis C].
Topics: Anti-Arrhythmia Agents; Antiviral Agents; Hepatitis C; Humans; Interferon-alpha; Male; Mexiletine; M | 1995 |
Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome.
Topics: Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Disopyramide; Electrocardiography; Humans; | 1996 |
Drug-induced narrowing of the width of the zone of entrainment as a predictor of the subsequent non-inducibility of reentrant ventricular tachycardia after an additional dose of an antiarrhythmic drug.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disopyramide; Drug Administration S | 1996 |
Discrepant effects of mexiletine on cycle length of ventricular tachycardia and on the effective refractory period in the area of slow conduction.
Topics: Action Potentials; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Elec | 1996 |
Preferential action of mexiletine on central common pathway of reentrant ventricular tachycardia.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Electrocardiography; Female; Heart | 1996 |
Management of incessant ventricular tachycardia in a 39-year-old woman with cardiomyopathy.
Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Critical Illness; Defibrillators | 1997 |
Does mexiletine have a preferential action (versus healthy myocardium) on the reentrant circuit of ventricular tachycardia?
Topics: Adult; Aged; Anti-Arrhythmia Agents; Electrocardiography; Female; Heart Conduction System; Humans; K | 1997 |
The use of the block cycle length as a safe and efficient means of interrupting sustained ventricular tachycardia and its pharmacological modification.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Bundle-Branch Block; Cardiac | 1998 |
Electrical storms in an ICD-recipient with 429 delivered appropriate shocks: therapeutic management with antiarrhythmic drug combination.
Topics: Aged; Amiodarone; Cardiomyopathy, Dilated; Defibrillators, Implantable; Electrocardiography; Follow- | 2002 |
Possible mechanism for pharmacokinetic interaction between lidocaine and mexiletine.
Topics: Aged; Aged, 80 and over; Animals; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Drug Interactions | 2002 |
Mexiletine and propafenone: a comparative study of monotherapy, low, and full dose combination therapy.
Topics: Arrhythmias, Cardiac; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; | 1992 |
Autonomic effects of antiarrhythmic drugs and their importance.
Topics: Adult; Autonomic Nervous System; Cardiac Complexes, Premature; Electrocardiography; Female; Flecaini | 1992 |
[The effect of mexiletine on theophylline pharmacokinetics in patients with bronchial asthma].
Topics: Aged; Aged, 80 and over; Asthma; Cardiac Complexes, Premature; Drug Interactions; Female; Humans; Ma | 1992 |
Effect of the combination of low-dose mexiletine and metoprolol on ventricular arrhythmia.
Topics: Aged; Cardiac Complexes, Premature; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ele | 1991 |