mexiletine has been researched along with Sensitivity and Specificity in 16 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinidine and procainamide have the potential for major organ toxicity, whereas mexiletine has been reported to have little risk of organ toxicity, serious proarrhythmia or congestive heart failure, but a relatively high incidence of nuisance side effects." | 4.78 | Comparative cost-effectiveness analysis of quinidine, procainamide and mexiletine. ( Arnold, RJ; Beck, JR; Beshansky, JR; Frishman, WH; Kaniecki, DJ; Kowey, PR; Podrid, PJ, 1991) |
| "Mexiletine was used as the internal standard." | 1.37 | Highly sensitive determination and validation of gabapentin in pharmaceutical preparations by HPLC with 4-fluoro-7-nitrobenzofurazan derivatization and fluorescence detection. ( Kel, E; Ulu, ST, 2011) |
| " A simple and effective on-line dilution approach was adopted in order to expand the linearity and apply the method to assay, dosage uniformity and dissolution tests with minimum sample preparation." | 1.35 | Novel automated assay for the quality control of mexiletine hydrochloride formulations using sequential injection and on-line dilution. ( Rigas, P; Tzanavaras, PD; Zacharis, CK, 2008) |
| "Anti-mexiletine antibody was obtained by immunizing rabbits with an antigen conjugated with mercaptosuccinyl bovine serum albumin using N-(epsilon-maleimidocaproyloxy)succinimide as a heterobifunctional coupling agent." | 1.32 | Development of enzyme-linked immunosorbent assay for therapeutic drug monitoring of mexiletine. ( Fujito, H; Mori, M; Saita, T, 2003) |
| "Mexiletine is an antiarrhythmic agent used in the treatment of ventricular arrhythmia." | 1.30 | Gas chromatographic-mass spectrometric determination of serum mexiletine concentration after derivatization with perfluorooctanoyl chloride, a new derivative. ( Dasgupta, A; Yousef, O, 1998) |
| "Mexiletine (Mexitil) is an antiarrhythmic agent used in the treatment of ventricular arrhythmia." | 1.30 | Gas chromatography-electron ionization and chemical ionization mass spectrometric analysis of serum mexiletine concentration after derivatization with 2,2,2-trichloroethyl chloroformate: a novel derivative. ( Appenzeller, P; Dasgupta, A; Moore, J, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (43.75) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhushan, R | 3 |
| Vashistha, VK | 1 |
| Tzanavaras, PD | 1 |
| Zacharis, CK | 1 |
| Rigas, P | 1 |
| Tanwar, S | 2 |
| Dixit, S | 1 |
| Ulu, ST | 1 |
| Kel, E | 1 |
| Saita, T | 1 |
| Fujito, H | 1 |
| Mori, M | 1 |
| Katsu, T | 2 |
| Tsunamoto, Y | 1 |
| Hanioka, N | 1 |
| Komagoe, K | 1 |
| Masuda, K | 1 |
| Narimatsu, S | 1 |
| Tekewe, A | 1 |
| Singh, S | 1 |
| Singh, M | 1 |
| Mohan, U | 1 |
| Banerjee, UC | 1 |
| Yan, H | 1 |
| Xiang, P | 1 |
| Bo, J | 1 |
| Shen, M | 1 |
| Lanchote, VL | 1 |
| Bonato, PS | 1 |
| Dreossi, SA | 1 |
| Gonçalves, PV | 1 |
| Cesarino, EJ | 1 |
| Bertucci, C | 1 |
| Dasgupta, A | 2 |
| Yousef, O | 1 |
| Appenzeller, P | 1 |
| Moore, J | 1 |
| Mori, Y | 1 |
| Furuno, K | 1 |
| Gomita, Y | 1 |
| Lensmeyer, GL | 1 |
| Wiebe, DA | 1 |
| Doran, TC | 1 |
| LeGatt, DF | 1 |
| Audette, RJ | 1 |
| Youzwishen, O | 1 |
| Stewart, T | 1 |
| Podrid, PJ | 1 |
| Kowey, PR | 1 |
| Frishman, WH | 1 |
| Arnold, RJ | 1 |
| Kaniecki, DJ | 1 |
| Beck, JR | 1 |
| Beshansky, JR | 1 |
1 review available for mexiletine and Sensitivity and Specificity
| Article | Year |
|---|---|
Comparative cost-effectiveness analysis of quinidine, procainamide and mexiletine.
Topics: Ambulatory Care; Arrhythmias, Cardiac; Cost-Benefit Analysis; Costs and Cost Analysis; Decision Maki | 1991 |
15 other studies available for mexiletine and Sensitivity and Specificity
| Article | Year |
|---|---|
Synthesis of variants of Marfey's reagent having d-amino acids as chiral auxiliaries and liquid-chromatographic enantioseparation of (RS)-Mexiletine in spiked plasma: assessment and comparison with L-amino acid analogs.
Topics: Alanine; Amides; Amino Acids; Blood Chemical Analysis; Chromatography, Liquid; Dinitrobenzenes; Huma | 2015 |
Novel automated assay for the quality control of mexiletine hydrochloride formulations using sequential injection and on-line dilution.
Topics: Anti-Arrhythmia Agents; Biological Assay; Capsules; Chromatography, High Pressure Liquid; Fluorometr | 2008 |
Synthesis of dinitrophenyl-L-Pro-N-hydroxysuccinimide ester and four new variants of Sanger's reagent having chiral amines and their application for enantioresolution of mexiletine using reversed-phase high-performance liquid chromatography.
Topics: Amines; Chromatography, High Pressure Liquid; Indicators and Reagents; Mexiletine; Sensitivity and S | 2009 |
Indirect enantioresolution of (R,S)-mexiletine by reversed-phase high-performance liquid chromatography via diastereomerization with [(S,S)-O,O'-di-p-toluoyl tartaric acid anhydride], (S)-naproxen and nine chiral reagents synthesized as variants of Marfey
Topics: Alanine; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Dinitrobenzenes; Mexil | 2011 |
Highly sensitive determination and validation of gabapentin in pharmaceutical preparations by HPLC with 4-fluoro-7-nitrobenzofurazan derivatization and fluorescence detection.
Topics: 4-Chloro-7-nitrobenzofurazan; Amines; Capsules; Chromatography, High Pressure Liquid; Cyclohexanecar | 2011 |
Development of enzyme-linked immunosorbent assay for therapeutic drug monitoring of mexiletine.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; beta-Galactosidase; Binding, Competitive; Chr | 2003 |
S,S,S-Tris(2-ethylhexyl) phosphorotrithioate as an effective solvent mediator for a mexiletine-sensitive membrane electrode.
Topics: Anti-Arrhythmia Agents; Electrodes; Humans; Hydrogen-Ion Concentration; Mexiletine; Molecular Struct | 2007 |
Development and validation of HPLC method for the resolution of drug intermediates: DL-3-Phenyllactic acid, DL-O-acetyl-3-phenyllactic acid and (+/-)-mexiletine acetamide enantiomers.
Topics: Acetamides; Chromatography, High Pressure Liquid; Lactates; Lactic Acid; Mexiletine; Molecular Struc | 2008 |
[Determination of mexiletine in human blood by liquid chromatography-tandem mass spectrometry].
Topics: Anti-Arrhythmia Agents; Forensic Medicine; Humans; Mexiletine; Molecular Structure; Naloxone; Reprod | 2007 |
High-performance liquid chromatographic determination of mexiletine enantiomers in plasma using direct and indirect enantioselective separations.
Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Capsules; Chromatography, High Pressure Liquid; | 1996 |
Gas chromatographic-mass spectrometric determination of serum mexiletine concentration after derivatization with perfluorooctanoyl chloride, a new derivative.
Topics: Caprylates; Fluorocarbons; Gas Chromatography-Mass Spectrometry; Humans; Mexiletine; Reference Stand | 1998 |
Gas chromatography-electron ionization and chemical ionization mass spectrometric analysis of serum mexiletine concentration after derivatization with 2,2,2-trichloroethyl chloroformate: a novel derivative.
Topics: Anti-Arrhythmia Agents; Chromatography, Gas; Drug Monitoring; Humans; Mass Spectrometry; Mexiletine; | 1998 |
Mexiletine-sensitive membrane electrode for medical application.
Topics: Anti-Arrhythmia Agents; Borates; Calibration; Chromatography, High Pressure Liquid; Crown Ethers; Et | 1999 |
Application of the Empore solid-phase extraction membrane to the isolation of drugs from blood: II. Mexiletine and flecainide.
Topics: Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Flecainide; Humans; Membrane | 1992 |
Mexiletine determination in serum by capillary gas chromatography with nitrogen-selective detection.
Topics: Chromatography, Gas; Drug Monitoring; Mexiletine; Molecular Structure; Nitrogen; Reproducibility of | 1991 |