mexiletine has been researched along with Seizures in 13 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intravenous drip infusions of lidocaine (IDIL; 1-5 mg/kg/h) were performed in ten patients with intractable seizures." | 7.69 | [Efficacy and side effects of lidocaine by intravenous drip infusion in children with intractable seizures]. ( Aihara, M; Hatakeyama, K; Hinohara, Y; Kamiya, Y; Kanemura, H; Nakazawa, S; Sata, Y; Shimoda, C, 1997) |
| "Furthermore, brain seizure activity recorded following 1 h MCAo and 72 h of recovery in injured rats was either completely blocked (30 min pre-MCAo treatment) or significantly reduced (30 min post-MCAo treatment) with RS100642 (1." | 5.31 | Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat. ( Tortella, FC; Williams, AJ, 2002) |
| "Using the mouse maximal electroshock test, the reference model of tonic-clonic seizures, the aim of the present study was to determine the type of interaction between mexiletine (a class IB antiarrhythmic drug) and classical antiepileptics: valproate, carbamazepine, phenytoin, and phenobarbital." | 3.83 | Mexiletine and its Interactions with Classical Antiepileptic Drugs: An Isobolographic Analysis. ( Banach, M; Borowicz-Reutt, KK; Piskorska, B, 2016) |
| "Intravenous drip infusions of lidocaine (IDIL; 1-5 mg/kg/h) were performed in ten patients with intractable seizures." | 3.69 | [Efficacy and side effects of lidocaine by intravenous drip infusion in children with intractable seizures]. ( Aihara, M; Hatakeyama, K; Hinohara, Y; Kamiya, Y; Kanemura, H; Nakazawa, S; Sata, Y; Shimoda, C, 1997) |
| "Furthermore, brain seizure activity recorded following 1 h MCAo and 72 h of recovery in injured rats was either completely blocked (30 min pre-MCAo treatment) or significantly reduced (30 min post-MCAo treatment) with RS100642 (1." | 1.31 | Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat. ( Tortella, FC; Williams, AJ, 2002) |
| "In conscious rats 20 mg/kg caused convulsions in 78-89% of rats when the plasma concentration of racemate was 20 +/- 2 microM." | 1.28 | Mexiletine's antifibrillatory actions are limited by the occurrence of convulsions in conscious animals. ( Beatch, GN; Igwemezie, LN; McErlane, KM; Walker, MJ, 1992) |
| "SUN 1165 had no effect on clonic convulsions induced by pentetrazol and pictrotoxin in mice, while both mexiletine and lidocaine prolonged the duration of clonic convulsions." | 1.27 | General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system. ( Hashimoto, Y; Hatta, M; Hattori, Y; Hirotsu, I; Ishihara, T; Kihara, T; Kitakaze, Y; Miyata, T; Nakamura, S; Takahama, K, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Grauert, M | 1 |
| Bechtel, WD | 1 |
| Weiser, T | 1 |
| Stransky, W | 1 |
| Nar, H | 1 |
| Carter, AJ | 1 |
| Shimshoni, JA | 1 |
| Bialer, M | 1 |
| Yagen, B | 1 |
| Avidan, OR | 1 |
| Tayebi, K | 1 |
| Del Toro, K | 1 |
| Warrier, R | 1 |
| Gomez-Galeno, J | 1 |
| Okolotowicz, K | 1 |
| Johnson, M | 1 |
| McKeithan, WL | 1 |
| Mercola, M | 1 |
| Cashman, JR | 1 |
| van der Peet, PL | 1 |
| Sandanayake, S | 1 |
| Jarrott, B | 1 |
| Williams, SJ | 1 |
| Borowicz-Reutt, KK | 1 |
| Banach, M | 1 |
| Piskorska, B | 1 |
| Yoshikane, Y | 1 |
| Yoshinaga, M | 1 |
| Hamamoto, K | 1 |
| Hirose, S | 1 |
| Kozer, E | 1 |
| Verjee, Z | 1 |
| Emelianova, S | 1 |
| Koren, G | 1 |
| Sata, Y | 1 |
| Aihara, M | 1 |
| Hatakeyama, K | 1 |
| Hinohara, Y | 1 |
| Kamiya, Y | 1 |
| Shimoda, C | 1 |
| Kanemura, H | 1 |
| Nakazawa, S | 1 |
| Sakurai, M | 1 |
| Kanazawa, I | 1 |
| Williams, AJ | 1 |
| Tortella, FC | 1 |
| Igwemezie, LN | 1 |
| Beatch, GN | 1 |
| McErlane, KM | 1 |
| Walker, MJ | 1 |
| Hirotsu, I | 1 |
| Kihara, T | 1 |
| Nakamura, S | 1 |
| Hattori, Y | 1 |
| Hatta, M | 1 |
| Kitakaze, Y | 1 |
| Takahama, K | 1 |
| Hashimoto, Y | 1 |
| Miyata, T | 1 |
| Ishihara, T | 1 |
1 trial available for mexiletine and Seizures
| Article | Year |
|---|---|
Positive symptoms in multiple sclerosis: their treatment with sodium channel blockers, lidocaine and mexiletine.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; M | 1999 |
12 other studies available for mexiletine and Seizures
| Article | Year |
|---|---|
Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke.
Topics: Animals; Benzomorphans; Cerebral Cortex; Corpus Striatum; Crystallography, X-Ray; Electroshock; Glut | 2002 |
Synthesis and anticonvulsant activity of aromatic tetramethylcyclopropanecarboxamide derivatives.
Topics: Administration, Oral; Amides; Animals; Anticonvulsants; Cyclopropanes; Electroshock; Isoxazoles; Mic | 2008 |
Seizure After Minor Head Trauma: A Red Herring?
Topics: Anti-Arrhythmia Agents; Child; Craniocerebral Trauma; Electrocardiography; Electrocardiography, Ambu | 2021 |
Human-induced pluripotent stem cell-derived cardiomyocytes: Cardiovascular properties and metabolism and pharmacokinetics of deuterated mexiletine analogs.
Topics: Animals; Behavior, Animal; Cells, Cultured; Female; Humans; Induced Pluripotent Stem Cells; Liver; L | 2021 |
Discovery of N-Aryloxypropylbenzylamines as Voltage-Gated Sodium Channel Na
Topics: Animals; Benzylamines; Drug Stability; Electric Stimulation; Humans; Mexiletine; Mice; Molecular Str | 2019 |
Mexiletine and its Interactions with Classical Antiepileptic Drugs: An Isobolographic Analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Drug Interactions; Electroshock; | 2016 |
A case of long QT syndrome with triple gene abnormalities: digenic mutations in KCNH2 and SCN5A and gene variant in KCNE1.
Topics: Child; DNA Mutational Analysis; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium | 2013 |
A patient with seizures and a positive drug screen: three wrongs don't make a right.
Topics: Adolescent; Anti-Arrhythmia Agents; Diagnosis, Differential; Emergency Treatment; Humans; Interprofe | 2003 |
[Efficacy and side effects of lidocaine by intravenous drip infusion in children with intractable seizures].
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Lidocain | 1997 |
Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat.
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Dose-Response Relationship, Drug; Electroenceph | 2002 |
Mexiletine's antifibrillatory actions are limited by the occurrence of convulsions in conscious animals.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Electric Stimulation; Electrocardiography | 1992 |
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system.
Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Body Temperature; Catalepsy; Cats; Central Ne | 1988 |