mexiletine has been researched along with Phantom Limb in 3 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Phantom Limb: Perception of painful and nonpainful phantom sensations that occur following the complete or partial loss of a limb. The majority of individuals with an amputated extremity will experience the impression that the limb is still present, and in many cases, painful. (From Neurol Clin 1998 Nov;16(4):919-36; Brain 1998 Sep;121(Pt 9):1603-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Morphine treatment provided lower pain scores compared with placebo and mexiletine (P = 0." | 2.73 | Morphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trial. ( Agarwal, S; Clark, MR; Haythornthwaite, JA; Klick, B; Max, MB; Raja, SN; Tella, PK; Wu, CL, 2008) |
| "Mexiletine was used in an open-label study to evaluate its effectiveness in the treatment of this disorder." | 2.38 | Successful treatment for phantom pain. ( Davis, RW, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Klass, M | 1 |
| Csete, M | 1 |
| Wu, CL | 1 |
| Agarwal, S | 1 |
| Tella, PK | 1 |
| Klick, B | 1 |
| Clark, MR | 1 |
| Haythornthwaite, JA | 1 |
| Max, MB | 1 |
| Raja, SN | 1 |
| Davis, RW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Placebo-Controlled, Double-Blind Cross-Over Trial of Opioids Versus Mexiletine in the Treatment of Postamputation Pain[NCT00383682] | Phase 2 | 60 participants | Interventional | 1997-07-31 | Completed | ||
| Management of Chronic Pain in Rehabilitation Project II Management of Chronic Pain in Persons With Amputation[NCT00006427] | Phase 4 | 125 participants | Interventional | 1996-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for mexiletine and Phantom Limb
| Article | Year |
|---|---|
Successful treatment for phantom pain.
Topics: Administration, Cutaneous; Aged; Chronic Disease; Clonidine; Drug Therapy, Combination; Female; Huma | 1993 |
1 trial available for mexiletine and Phantom Limb
| Article | Year |
|---|---|
Morphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trial.
Topics: Amputation, Surgical; Anti-Arrhythmia Agents; Cross-Over Studies; Dose-Response Relationship, Drug; | 2008 |
1 other study available for mexiletine and Phantom Limb
| Article | Year |
|---|---|
One from column A and one from column B: may I take your order?
Topics: Amines; Analgesics, Opioid; Anti-Arrhythmia Agents; Cyclohexanecarboxylic Acids; Gabapentin; gamma-A | 2008 |