mexiletine has been researched along with Peripheral Nerve Diseases in 17 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although mexiletine, an antiarrhythmic with local anesthetic properties, has been reported to relieve discomfort in diabetic neuropathy, its usefulness in the treatment of HIV-related painful peripheral neuropathy (PPN) has not been determined." | 9.08 | Mexiletine for HIV-infected patients with painful peripheral neuropathy: a double-blind, placebo-controlled, crossover treatment trial. ( Burton, S; Deresinski, SC; Kemper, CA; Kent, G, 1998) |
| "Lidocaine is a use-dependent sodium channel blocker that produces analgesia when administered intravenously to patients with neuropathic pain." | 8.84 | Intravenous lidocaine for neuropathic pain: diagnostic utility and therapeutic efficacy. ( Carroll, I, 2007) |
| "The effect of the cyclooxygenase-2 (COX-2) inhibitor etodolac on the mechanical allodynia induced by paclitaxel was investigated in mice and compared with the effects of the nonselective COX inhibitors indomethacin and diclofenac, the selective COX-2 inhibitor celecoxib, the calcium channel α(2)δ subunit inhibitor pregabalin, the sodium channel blocker mexiletine, and the serotonin-norepinephrine reuptake inhibitor duloxetine." | 7.78 | Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. ( Banno, K; Inoue, N; Ito, S; Kotera, T; Kyoi, T; Nakamura, A; Nogawa, M; Sasagawa, T; Tajima, K; Takahashi, Y; Ueda, M; Yamashita, Y, 2012) |
| " Mexiletine, an orally available Na(+)-channel blocker, has widely been used in patients with chronic painful diabetic neuropathy." | 7.76 | Mexiletine reverses oxaliplatin-induced neuropathic pain in rats. ( Egashira, N; Hirakawa, S; Ikesue, H; Kawashiri, T; Oishi, R; Yano, T, 2010) |
| "Although mexiletine, an antiarrhythmic with local anesthetic properties, has been reported to relieve discomfort in diabetic neuropathy, its usefulness in the treatment of HIV-related painful peripheral neuropathy (PPN) has not been determined." | 5.08 | Mexiletine for HIV-infected patients with painful peripheral neuropathy: a double-blind, placebo-controlled, crossover treatment trial. ( Burton, S; Deresinski, SC; Kemper, CA; Kent, G, 1998) |
| "Lidocaine is a use-dependent sodium channel blocker that produces analgesia when administered intravenously to patients with neuropathic pain." | 4.84 | Intravenous lidocaine for neuropathic pain: diagnostic utility and therapeutic efficacy. ( Carroll, I, 2007) |
| "The effect of the cyclooxygenase-2 (COX-2) inhibitor etodolac on the mechanical allodynia induced by paclitaxel was investigated in mice and compared with the effects of the nonselective COX inhibitors indomethacin and diclofenac, the selective COX-2 inhibitor celecoxib, the calcium channel α(2)δ subunit inhibitor pregabalin, the sodium channel blocker mexiletine, and the serotonin-norepinephrine reuptake inhibitor duloxetine." | 3.78 | Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. ( Banno, K; Inoue, N; Ito, S; Kotera, T; Kyoi, T; Nakamura, A; Nogawa, M; Sasagawa, T; Tajima, K; Takahashi, Y; Ueda, M; Yamashita, Y, 2012) |
| " Mexiletine, an orally available Na(+)-channel blocker, has widely been used in patients with chronic painful diabetic neuropathy." | 3.76 | Mexiletine reverses oxaliplatin-induced neuropathic pain in rats. ( Egashira, N; Hirakawa, S; Ikesue, H; Kawashiri, T; Oishi, R; Yano, T, 2010) |
| "Mexiletine was found to produce a statistically significant reduction in reported pain when compared to baseline or placebo." | 2.67 | The use of oral mexiletine for the treatment of pain after peripheral nerve injury. ( Britell, CW; Chabal, C; Chaney, E; Jacobson, L; Mariano, A, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yokote, A | 1 |
| Tomita, S | 1 |
| Sawada, H | 1 |
| Yamamoto, S | 1 |
| Kawashiri, T | 2 |
| Higuchi, H | 1 |
| Tsutsumi, K | 1 |
| Ushio, S | 1 |
| Kaname, T | 1 |
| Shirahama, M | 1 |
| Egashira, N | 2 |
| Hirakawa, S | 1 |
| Yano, T | 1 |
| Ikesue, H | 1 |
| Oishi, R | 1 |
| Ito, S | 1 |
| Tajima, K | 1 |
| Nogawa, M | 1 |
| Inoue, N | 1 |
| Kyoi, T | 1 |
| Takahashi, Y | 1 |
| Sasagawa, T | 1 |
| Nakamura, A | 1 |
| Kotera, T | 1 |
| Ueda, M | 1 |
| Yamashita, Y | 1 |
| Banno, K | 1 |
| Ito, H | 2 |
| Yoshika, M | 1 |
| Ohnishi, S | 1 |
| Iimuro, R | 1 |
| Yagi, A | 1 |
| Nakano, S | 1 |
| Kusaka, H | 1 |
| Nakamura, S | 1 |
| Atsuta, Y | 1 |
| Lindia, JA | 1 |
| Köhler, MG | 1 |
| Martin, WJ | 1 |
| Abbadie, C | 1 |
| Tremont-Lukats, IW | 1 |
| Challapalli, V | 1 |
| McNicol, ED | 1 |
| Lau, J | 1 |
| Carr, DB | 1 |
| Carroll, I | 1 |
| Tanimoto-Mori, S | 1 |
| Nakazato-Imasato, E | 1 |
| Toide, K | 1 |
| Kita, Y | 1 |
| Nishiyama, K | 2 |
| Sakuta, M | 2 |
| Zapp, JJ | 1 |
| Short, S | 1 |
| Kemper, CA | 1 |
| Kent, G | 1 |
| Burton, S | 1 |
| Deresinski, SC | 1 |
| Horiuchi, J | 1 |
| Sato, Y | 1 |
| Lein, B | 1 |
| Chabal, C | 1 |
| Jacobson, L | 1 |
| Mariano, A | 1 |
| Chaney, E | 1 |
| Britell, CW | 1 |
| Shimizu, J | 1 |
| Takeda, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| High Dose Intravenous Lidocaine vs Hydromorphone for Acute Abdominal Pain in the Emergency Department: A Randomized, Comparative Efficacy Trial[NCT04398316] | Phase 4 | 187 participants (Anticipated) | Interventional | 2021-02-18 | Recruiting | ||
| A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection[NCT00000793] | Phase 2 | 240 participants | Interventional | Completed | |||
| A Phase II, Double-Blind Trial of Recombinant Human Nerve Growth Factor for Treatment of HIV-Associated Sensory Neuropathy[NCT00000842] | Phase 2 | 270 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for mexiletine and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Systemic administration of local anesthetics to relieve neuropathic pain: a systematic review and meta-analysis.
Topics: Anesthetics, Local; Humans; Lidocaine; Mexiletine; Pain; Peripheral Nervous System Diseases; Randomi | 2005 |
Intravenous lidocaine for neuropathic pain: diagnostic utility and therapeutic efficacy.
Topics: Anesthetics, Local; Humans; Infusions, Intravenous; Lidocaine; Mexiletine; Pain; Peripheral Nervous | 2007 |
2 trials available for mexiletine and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Mexiletine for HIV-infected patients with painful peripheral neuropathy: a double-blind, placebo-controlled, crossover treatment trial.
Topics: Adult; Analgesics; Cross-Over Studies; Double-Blind Method; HIV Infections; Humans; Mexiletine; Pain | 1998 |
The use of oral mexiletine for the treatment of pain after peripheral nerve injury.
Topics: Administration, Oral; Aged; Double-Blind Method; Humans; Male; Mexiletine; Middle Aged; Pain Measure | 1992 |
13 other studies available for mexiletine and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Sensory ganglionopathy associated with drug-induced hypersensitivity syndrome caused by mexiletine.
Topics: Aged; Anti-Arrhythmia Agents; Drug Hypersensitivity Syndrome; Female; Ganglia, Sensory; Glucocortico | 2018 |
Behavioral and pharmacological characteristics of bortezomib-induced peripheral neuropathy in rats.
Topics: Administration, Ophthalmic; Analgesics; Animals; Antineoplastic Agents; Axons; Bortezomib; Duloxetin | 2015 |
Mexiletine reverses oxaliplatin-induced neuropathic pain in rats.
Topics: Animals; Anti-Arrhythmia Agents; Mexiletine; Organoplatinum Compounds; Oxaliplatin; Pain; Peripheral | 2010 |
Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Drug Int | 2012 |
[Intractable hiccups treated with mexiletine hydrochloride].
Topics: Hiccup; Humans; Male; Mexiletine; Middle Aged; Neural Conduction; Peripheral Nervous System Diseases | 2003 |
Effect of sodium channel blocker (mexiletine) on pathological ectopic firing pattern in a rat chronic constriction nerve injury model.
Topics: Animals; Evoked Potentials; Male; Mexiletine; Neural Conduction; Peripheral Nervous System Diseases; | 2005 |
Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Gan | 2005 |
Pharmacologic investigation of the mechanism underlying cold allodynia using a new cold plate procedure in rats with chronic constriction injuries.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Calcium Channel Blockers; Chronic Disease; Cold Tempe | 2008 |
Mexiletine for painful alcoholic neuropathy.
Topics: Administration, Oral; Aged; Alcoholism; Humans; Male; Mexiletine; Middle Aged; Peripheral Nervous Sy | 1995 |
Temporomandibular joint pain as a neuropathy.
Topics: Administration, Oral; Drug Therapy, Combination; Facial Pain; Humans; Injections, Intravenous; Lidoc | 1995 |
[Effect of mexiletine on spontaneous sensory afferent activity in spontaneous diabetic rats (WBN/Kob rats)].
Topics: Action Potentials; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Depression, Chemical; Diabet | 2000 |
Potential therapy for painful neuropathy.
Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain; | 1995 |
Potential therapy for painful neuropathy.
Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain; | 1995 |
Potential therapy for painful neuropathy.
Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain; | 1995 |
Potential therapy for painful neuropathy.
Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain; | 1995 |
[Remarkable effect of class Ib Na channel blocker on painful alcoholic neuropathy].
Topics: Alcoholism; Humans; Male; Mexiletine; Middle Aged; Neural Conduction; Pain, Intractable; Peripheral | 1990 |