mexiletine has been researched along with Pain, Intractable in 8 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Pain, Intractable: Persistent pain that is refractory to some or all forms of treatment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This is a retrospective case series of 10 cancer patients across four institutions, with attention to dosing of both agents, and subsequent decrease in morphine-equivalent daily dosing (MEDD)." | 5.56 | A Multi-Centered Case Series Highlighting the Clinical Use and Dosing of Lidocaine and Mexiletine for Refractory Cancer Pain. ( Atayee, RS; Edmonds, KP; Geiger-Hayes, J; Hausdorff, J; Naidu, D; Saphire, ML, 2020) |
| "Mexiletine was found to produce a statistically significant reduction in reported pain when compared to baseline or placebo." | 2.67 | The use of oral mexiletine for the treatment of pain after peripheral nerve injury. ( Britell, CW; Chabal, C; Chaney, E; Jacobson, L; Mariano, A, 1992) |
| " This is a retrospective case series of 10 cancer patients across four institutions, with attention to dosing of both agents, and subsequent decrease in morphine-equivalent daily dosing (MEDD)." | 1.56 | A Multi-Centered Case Series Highlighting the Clinical Use and Dosing of Lidocaine and Mexiletine for Refractory Cancer Pain. ( Atayee, RS; Edmonds, KP; Geiger-Hayes, J; Hausdorff, J; Naidu, D; Saphire, ML, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kadouh, NK | 1 |
| Lang, S | 1 |
| Shamoun, M | 1 |
| Scott, EL | 1 |
| Singh, SA | 1 |
| Smith, MA | 1 |
| Atayee, RS | 2 |
| Naidu, D | 1 |
| Geiger-Hayes, J | 1 |
| Saphire, ML | 1 |
| Hausdorff, J | 1 |
| Edmonds, KP | 2 |
| Hakim, RC | 1 |
| Edmondson, EA | 1 |
| Simpson, RK | 1 |
| Stubler, DK | 1 |
| Beric, A | 1 |
| Sloan, P | 1 |
| Basta, M | 1 |
| Storey, P | 1 |
| von Gunten, C | 1 |
| Chabal, C | 1 |
| Jacobson, L | 1 |
| Mariano, A | 1 |
| Chaney, E | 1 |
| Britell, CW | 1 |
| Nishiyama, K | 1 |
| Shimizu, J | 1 |
| Takeda, K | 1 |
| Sakuta, M | 1 |
| Petersen, P | 1 |
| Kastrup, J | 1 |
| Zeeberg, I | 1 |
| Boysen, G | 1 |
3 trials available for mexiletine and Pain, Intractable
| Article | Year |
|---|---|
Systemic lidocaine therapy for poststroke pain.
Topics: Adult; Aged; Algorithms; Cerebrovascular Disorders; Drug Monitoring; Female; Follow-Up Studies; Huma | 1993 |
The use of oral mexiletine for the treatment of pain after peripheral nerve injury.
Topics: Administration, Oral; Aged; Double-Blind Method; Humans; Male; Mexiletine; Middle Aged; Pain Measure | 1992 |
Chronic pain treatment with intravenous lidocaine.
Topics: Double-Blind Method; Humans; Infusions, Intravenous; Lidocaine; Mexiletine; Nervous System Diseases; | 1986 |
5 other studies available for mexiletine and Pain, Intractable
| Article | Year |
|---|---|
Mexiletine: An adjuvant option for refractory pain in patients with sickle cell disease and comorbid autism spectrum disorder.
Topics: Anemia, Sickle Cell; Autism Spectrum Disorder; Humans; Mexiletine; Pain, Intractable | 2022 |
A Multi-Centered Case Series Highlighting the Clinical Use and Dosing of Lidocaine and Mexiletine for Refractory Cancer Pain.
Topics: Administration, Oral; Adult; Aged; Anesthetics, Local; Cancer Pain; Female; Humans; Infusions, Intra | 2020 |
Case Report: Utility of Ketamine, Lidocaine, and Mexiletine as Nonopioid Adjuvants in Complex Cancer-Associated Pain.
Topics: Adult; Analgesics; Analgesics, Opioid; Anesthetics, Local; Cancer Pain; Carcinoma, Squamous Cell; Fe | 2018 |
Mexiletine as an adjuvant analgesic for the management of neuropathic cancer pain.
Topics: Adenocarcinoma; Analgesics, Non-Narcotic; Colonic Neoplasms; Female; Humans; Lumbosacral Plexus; Lun | 1999 |
[Remarkable effect of class Ib Na channel blocker on painful alcoholic neuropathy].
Topics: Alcoholism; Humans; Male; Mexiletine; Middle Aged; Neural Conduction; Pain, Intractable; Peripheral | 1990 |