mexiletine has been researched along with Orphan Diseases in 3 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Orphan Diseases: Rare diseases that have not been well studied.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effectiveness of mexiletine in nondystrophic myotonia using an aggregated N-of-1 trials design and compare results between this innovative design and a previously conducted RCT." | 7.88 | Effect of Mexiletine on Muscle Stiffness in Patients With Nondystrophic Myotonia Evaluated Using Aggregated N-of-1 Trials. ( Drost, G; Griggs, RC; Groenewoud, HM; Matthews, E; Raaphorst, J; Saris, CGJ; Schouwenberg, BJ; Statland, JM; Stegeman, DF; Stunnenberg, BC; Timmermans, J; Trivedi, J; van der Wilt, GJ; van Engelen, BGM; Woertman, W, 2018) |
| "Considering the large number of rare diseases with a lack of treatment evidence, more experience with innovative trial designs is needed." | 6.80 | Combined N-of-1 trials to investigate mexiletine in non-dystrophic myotonia using a Bayesian approach; study rationale and protocol. ( Drost, G; Griggs, RC; Groenewoud, HM; Raaphorst, J; Saris, CG; Schouwenberg, BJ; Statland, JM; Stegeman, DF; Stunnenberg, BC; Timmermans, J; van der Wilt, GJ; van Engelen, BG; Woertman, W, 2015) |
| "To investigate the effectiveness of mexiletine in nondystrophic myotonia using an aggregated N-of-1 trials design and compare results between this innovative design and a previously conducted RCT." | 3.88 | Effect of Mexiletine on Muscle Stiffness in Patients With Nondystrophic Myotonia Evaluated Using Aggregated N-of-1 Trials. ( Drost, G; Griggs, RC; Groenewoud, HM; Matthews, E; Raaphorst, J; Saris, CGJ; Schouwenberg, BJ; Statland, JM; Stegeman, DF; Stunnenberg, BC; Timmermans, J; Trivedi, J; van der Wilt, GJ; van Engelen, BGM; Woertman, W, 2018) |
| "Considering the large number of rare diseases with a lack of treatment evidence, more experience with innovative trial designs is needed." | 2.80 | Combined N-of-1 trials to investigate mexiletine in non-dystrophic myotonia using a Bayesian approach; study rationale and protocol. ( Drost, G; Griggs, RC; Groenewoud, HM; Raaphorst, J; Saris, CG; Schouwenberg, BJ; Statland, JM; Stegeman, DF; Stunnenberg, BC; Timmermans, J; van der Wilt, GJ; van Engelen, BG; Woertman, W, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, Y | 1 |
| Wei, J | 1 |
| Stunnenberg, BC | 2 |
| Raaphorst, J | 2 |
| Groenewoud, HM | 2 |
| Statland, JM | 2 |
| Griggs, RC | 2 |
| Woertman, W | 2 |
| Stegeman, DF | 2 |
| Timmermans, J | 2 |
| Trivedi, J | 1 |
| Matthews, E | 1 |
| Saris, CGJ | 1 |
| Schouwenberg, BJ | 2 |
| Drost, G | 2 |
| van Engelen, BGM | 1 |
| van der Wilt, GJ | 2 |
| Saris, CG | 1 |
| van Engelen, BG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Combining N-of-1 Trials to Estimate Population Clinical and Cost-effectiveness of Drugs Using Bayesian Hierarchical Modeling. The Case of Mexiletine for Patients With Non- Dystrophic Myotonia.[NCT02045667] | Phase 2 | 30 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for mexiletine and Orphan Diseases
| Article | Year |
|---|---|
Combined N-of-1 trials to investigate mexiletine in non-dystrophic myotonia using a Bayesian approach; study rationale and protocol.
Topics: Adolescent; Adult; Aged; Algorithms; Bayes Theorem; Cost-Benefit Analysis; Cross-Over Studies; Doubl | 2015 |
2 other studies available for mexiletine and Orphan Diseases
| Article | Year |
|---|---|
Mexiletine Suppressed Recurrent Ventricular Tachycardia Triggered by Hemodialysis in an Old Patient with LQT2.
Topics: Anti-Arrhythmia Agents; Electrocardiography; Female; Follow-Up Studies; Humans; Kidney Failure, Chro | 2019 |
Effect of Mexiletine on Muscle Stiffness in Patients With Nondystrophic Myotonia Evaluated Using Aggregated N-of-1 Trials.
Topics: Adult; Bayes Theorem; Double-Blind Method; Female; Humans; Male; Mexiletine; Models, Statistical; My | 2018 |