mexiletine has been researched along with Nerve Degeneration in 2 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mexiletine pre-treatment reduced hippocampal damage by approximately half when compared to control animals receiving saline alone (45 vs." | 1.31 | The use-dependent sodium channel blocker mexiletine is neuroprotective against global ischemic injury. ( Hewitt, KE; Lesiuk, HJ; Stys, PK, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamamoto, S | 1 |
| Kawashiri, T | 1 |
| Higuchi, H | 1 |
| Tsutsumi, K | 1 |
| Ushio, S | 1 |
| Kaname, T | 1 |
| Shirahama, M | 1 |
| Egashira, N | 1 |
| Hewitt, KE | 1 |
| Stys, PK | 1 |
| Lesiuk, HJ | 1 |
2 other studies available for mexiletine and Nerve Degeneration
| Article | Year |
|---|---|
Behavioral and pharmacological characteristics of bortezomib-induced peripheral neuropathy in rats.
Topics: Administration, Ophthalmic; Analgesics; Animals; Antineoplastic Agents; Axons; Bortezomib; Duloxetin | 2015 |
The use-dependent sodium channel blocker mexiletine is neuroprotective against global ischemic injury.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Body Temperature; Brain Ischemia; Hippocampus; Hypo | 2001 |