mexiletine has been researched along with Muscle Weakness in 6 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Muscle Weakness: A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)
| Excerpt | Relevance | Reference |
|---|---|---|
| " After treatment with mexiletine, cooling and exercise induced almost no muscle weakness and no changes in 23Na MR signal intensity in patients." | 3.73 | Evaluation of patients with paramyotonia at 23Na MR imaging during cold-induced weakness. ( Essig, M; Huttner, HB; Jurkat-Rott, K; Kauczor, HU; Lehmann-Horn, F; Meinck, HM; Nielles-Vallespin, S; Schad, LR; Weber, MA; Wöhrle, JC, 2006) |
| "Patients with spinal and bulbar muscular atrophy (SBMA) often experience muscular weakness under cold exposure." | 3.11 | Mexiletine in spinal and bulbar muscular atrophy: a randomized controlled trial. ( Hashizume, A; Hijikata, Y; Hirakawa, A; Inagaki, T; Ito, D; Katsuno, M; Kinoshita, F; Kishimoto, Y; Nakamura, T; Shimizu, S; Yamada, S, 2022) |
| "Non-dystrophic myotonias are rare diseases caused by mutations in skeletal muscle chloride and sodium ion channels with considerable phenotypic overlap between diseases." | 1.39 | Non-dystrophic myotonia: prospective study of objective and patient reported outcomes. ( Amato, A; Barohn, RJ; Bundy, B; Cannon, S; Cleland, J; Fialho, D; Gorham, N; Griggs, RC; Hanna, MG; Herbelin, L; Matthews, E; Rayan, DR; Salajegheh, M; Statland, J; Trivedi, JR; Venance, SL; Wang, Y, 2013) |
| "Recessive myotonia congenita (Becker's disease)." | 1.33 | Myotonia congenita--a cause of muscle weakness and stiffness. ( Bouchard, JP; Chrestian, N; Dupré, N; Puymirat, J, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Yamada, S | 1 |
| Hashizume, A | 1 |
| Hijikata, Y | 1 |
| Inagaki, T | 1 |
| Ito, D | 1 |
| Kishimoto, Y | 1 |
| Kinoshita, F | 1 |
| Hirakawa, A | 1 |
| Shimizu, S | 1 |
| Nakamura, T | 1 |
| Katsuno, M | 1 |
| Stunnenberg, BC | 1 |
| LoRusso, S | 1 |
| Arnold, WD | 1 |
| Barohn, RJ | 2 |
| Cannon, SC | 1 |
| Fontaine, B | 1 |
| Griggs, RC | 2 |
| Hanna, MG | 2 |
| Matthews, E | 2 |
| Meola, G | 1 |
| Sansone, VA | 1 |
| Trivedi, JR | 2 |
| van Engelen, BGM | 1 |
| Vicart, S | 1 |
| Statland, JM | 1 |
| Bundy, B | 1 |
| Statland, J | 1 |
| Salajegheh, M | 1 |
| Rayan, DR | 1 |
| Venance, SL | 1 |
| Wang, Y | 1 |
| Fialho, D | 1 |
| Cleland, J | 1 |
| Gorham, N | 1 |
| Herbelin, L | 1 |
| Cannon, S | 1 |
| Amato, A | 1 |
| Ginanneschi, F | 1 |
| Mignarri, A | 1 |
| Lucchiari, S | 1 |
| Ulzi, G | 1 |
| Comi, GP | 1 |
| Rossi, A | 1 |
| Dotti, MT | 1 |
| Weber, MA | 1 |
| Nielles-Vallespin, S | 1 |
| Huttner, HB | 1 |
| Wöhrle, JC | 1 |
| Jurkat-Rott, K | 1 |
| Lehmann-Horn, F | 1 |
| Schad, LR | 1 |
| Kauczor, HU | 1 |
| Essig, M | 1 |
| Meinck, HM | 1 |
| Chrestian, N | 1 |
| Puymirat, J | 1 |
| Bouchard, JP | 1 |
| Dupré, N | 1 |
1 review available for mexiletine and Muscle Weakness
| Article | Year |
|---|---|
Guidelines on clinical presentation and management of nondystrophic myotonias.
Topics: Acetazolamide; Age of Onset; Carbonic Anhydrase Inhibitors; Chloride Channels; Electrodiagnosis; Ele | 2020 |
1 trial available for mexiletine and Muscle Weakness
| Article | Year |
|---|---|
Mexiletine in spinal and bulbar muscular atrophy: a randomized controlled trial.
Topics: Bulbo-Spinal Atrophy, X-Linked; Humans; Mexiletine; Muscle Weakness; Paresis; Pressure; Tongue | 2022 |
4 other studies available for mexiletine and Muscle Weakness
| Article | Year |
|---|---|
Non-dystrophic myotonia: prospective study of objective and patient reported outcomes.
Topics: Adult; Chloride Channels; Cohort Studies; Electrodiagnosis; Exercise; Female; Humans; International | 2013 |
Neuromuscular excitability changes produced by sustained voluntary contraction and response to mexiletine in myotonia congenita.
Topics: Action Potentials; Adult; Electromyography; Female; Humans; Male; Mexiletine; Muscle Contraction; Mu | 2017 |
Evaluation of patients with paramyotonia at 23Na MR imaging during cold-induced weakness.
Topics: Adult; Case-Control Studies; Cold Temperature; Female; Humans; Leg; Magnetic Resonance Spectroscopy; | 2006 |
Myotonia congenita--a cause of muscle weakness and stiffness.
Topics: Diagnosis, Differential; Electromyography; Female; Genes, Recessive; Humans; Mexiletine; Middle Aged | 2006 |