mexiletine has been researched along with Muscle Relaxation in 11 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Four mexiletine analogues have been tested for their antiarrhythmic, inotropic, and chronotropic effects on isolated guinea pig heart tissues and to assess calcium antagonist activity, in comparison with the parent compound mexiletine." | 1.43 | Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues. ( Bruno, C; Budriesi, R; Carocci, A; Catalano, A; Cavalluzzi, MM; Chiarini, A; Colabufo, NA; Contino, M; De Palma, A; Di Cesare Mannelli, L; Franchini, C; Ghelardini, C; Habtemariam, S; Lentini, G; Lovece, A; Micucci, M; Perrone, MG; Roselli, M; Toma, M, 2016) |
| "SUN 1165 had no effect on clonic convulsions induced by pentetrazol and pictrotoxin in mice, while both mexiletine and lidocaine prolonged the duration of clonic convulsions." | 1.27 | General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system. ( Hashimoto, Y; Hatta, M; Hattori, Y; Hirotsu, I; Ishihara, T; Kihara, T; Kitakaze, Y; Miyata, T; Nakamura, S; Takahama, K, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Roselli, M | 1 |
| Carocci, A | 1 |
| Budriesi, R | 1 |
| Micucci, M | 1 |
| Toma, M | 1 |
| Di Cesare Mannelli, L | 1 |
| Lovece, A | 1 |
| Catalano, A | 1 |
| Cavalluzzi, MM | 1 |
| Bruno, C | 1 |
| De Palma, A | 1 |
| Contino, M | 1 |
| Perrone, MG | 1 |
| Colabufo, NA | 1 |
| Chiarini, A | 1 |
| Franchini, C | 1 |
| Ghelardini, C | 1 |
| Habtemariam, S | 1 |
| Lentini, G | 1 |
| Kimoto, Y | 2 |
| Kinoshita, H | 3 |
| Nakahata, K | 1 |
| Dojo, M | 2 |
| Iranami, H | 2 |
| Hatano, Y | 3 |
| Kohjitani, A | 1 |
| Miyawaki, T | 1 |
| Funahashi, M | 1 |
| Mitoh, Y | 1 |
| Matsuo, R | 1 |
| Shimada, M | 1 |
| Dohi, Y | 1 |
| Kojima, M | 1 |
| Sato, K | 1 |
| Fernández del Pozo, B | 1 |
| Pérez-Vizcaíno, F | 1 |
| Fernández, C | 1 |
| Zaragozá, F | 1 |
| Tamargo, J | 1 |
| Ishikawa, T | 1 |
| Nakahara, T | 3 |
| Moriuchi, H | 3 |
| Yunoki, M | 3 |
| Kubota, Y | 2 |
| Tanaka, Y | 1 |
| Sakamato, K | 3 |
| Shigenobu, K | 1 |
| Ishii, K | 3 |
| Hirotsu, I | 1 |
| Kihara, T | 1 |
| Nakamura, S | 1 |
| Hattori, Y | 1 |
| Hatta, M | 1 |
| Kitakaze, Y | 1 |
| Takahama, K | 1 |
| Hashimoto, Y | 1 |
| Miyata, T | 1 |
| Ishihara, T | 1 |
11 other studies available for mexiletine and Muscle Relaxation
| Article | Year |
|---|---|
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues.
Topics: Animals; Anti-Arrhythmia Agents; Aorta; Cell Survival; Chemistry Techniques, Synthetic; Dogs; Guinea | 2016 |
Mexiletine differentially modulates vasorelaxation mediated by adenosine triphosphate-sensitive K+ channels in aortas from normotensive and hypertensive rats.
Topics: Animals; Anti-Arrhythmia Agents; Aorta, Thoracic; ATP-Binding Cassette Transporters; Cromakalim; Dos | 2003 |
Mexiletine inhibits nonadrenergic noncholinergic lower oesophageal sphincter relaxation in rabbits.
Topics: Animals; Anti-Arrhythmia Agents; Cyclic GMP; Dose-Response Relationship, Drug; Esophagogastric Junct | 2003 |
Vasorelaxant effect of mexiletine in mesenteric resistance arteries of rats.
Topics: Animals; Caffeine; Drug Interactions; Endothelium, Vascular; In Vitro Techniques; Kinetics; Male; Me | 1994 |
Effects of several class I antiarrhythmic drugs on isolated rat aortic vascular smooth muscle.
Topics: Animals; Anti-Arrhythmia Agents; Aorta; Desipramine; Disopyramide; Flecainide; Imipramine; In Vitro | 1997 |
Role of K+ channels in augmented relaxations to sodium nitroprusside induced by mexiletine in rat aortas.
Topics: Animals; Anti-Arrhythmia Agents; Aorta; Apamin; Drug Synergism; Glyburide; Hydrazines; In Vitro Tech | 2000 |
Involvement of K(+) channel in procainamide-induced relaxation of bovine tracheal smooth muscle.
Topics: Albuterol; Animals; Anti-Arrhythmia Agents; Bronchoconstrictor Agents; Bronchodilator Agents; Cattle | 2000 |
Mild alkalinization and acidification differentially modify the effects of lidocaine or mexiletine on vasorelaxation mediated by ATP-sensitive K+ channels.
Topics: Acids; Alkalies; Animals; Anti-Arrhythmia Agents; Aorta, Thoracic; ATP-Binding Cassette Transporters | 2001 |
Lidocaine potentiates atrial natriuretic peptide-induced relaxation of bovine tracheal smooth muscle.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Natriuretic Factor; Cattle; Cyclic GMP; Drug Interactions; D | 2001 |
Mexiletine inhibits pharmacological actions of salbutamol through blockade of beta2-adrenoceptors in bovine tracheal smooth muscle.
Topics: Adrenergic beta-Antagonists; Albuterol; Animals; Anti-Arrhythmia Agents; Bronchodilator Agents; Catt | 2001 |
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system.
Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Body Temperature; Catalepsy; Cats; Central Ne | 1988 |