mexiletine has been researched along with Muscle Contraction in 14 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Considering the large number of rare diseases with a lack of treatment evidence, more experience with innovative trial designs is needed." | 6.80 | Combined N-of-1 trials to investigate mexiletine in non-dystrophic myotonia using a Bayesian approach; study rationale and protocol. ( Drost, G; Griggs, RC; Groenewoud, HM; Raaphorst, J; Saris, CG; Schouwenberg, BJ; Statland, JM; Stegeman, DF; Stunnenberg, BC; Timmermans, J; van der Wilt, GJ; van Engelen, BG; Woertman, W, 2015) |
| " Mexiletine increased the dose of ouabain required for the occurrence of arrhythmia and cardiac arrest." | 3.67 | Inhibition of sympathetic nervous system by mexiletine, an antiarrhythmic agent, and its antagonism against ouabain. ( Kitagawa, H; Kohei, H; Takeda, F, 1985) |
| "The effect of oral mexiletine and intravenous lignocaine was examined in elderly patients with urinary incontinence associated with detrusor instability." | 3.66 | In vivo and in vitro studies on the effect of sodium antagonists on the bladder in man and rat. ( Castleden, CM; Clarkson, EJ; Duffin, HM, 1983) |
| "Considering the large number of rare diseases with a lack of treatment evidence, more experience with innovative trial designs is needed." | 2.80 | Combined N-of-1 trials to investigate mexiletine in non-dystrophic myotonia using a Bayesian approach; study rationale and protocol. ( Drost, G; Griggs, RC; Groenewoud, HM; Raaphorst, J; Saris, CG; Schouwenberg, BJ; Statland, JM; Stegeman, DF; Stunnenberg, BC; Timmermans, J; van der Wilt, GJ; van Engelen, BG; Woertman, W, 2015) |
| "Mexiletine treatment did not affect these inhibitory responses." | 1.33 | Effects of mexiletine on electrical field stimulation-induced contractile responses in the ipsilateral and contralateral vasa deferentia after unilateral testicular torsion/detorsion. ( Barun, S; Ercan, ZS; Moralioğlu, S; Ozen, IO; Sarioğlu, Y; Vural, IM, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (28.57) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stunnenberg, BC | 1 |
| Woertman, W | 1 |
| Raaphorst, J | 1 |
| Statland, JM | 1 |
| Griggs, RC | 1 |
| Timmermans, J | 1 |
| Saris, CG | 1 |
| Schouwenberg, BJ | 1 |
| Groenewoud, HM | 1 |
| Stegeman, DF | 1 |
| van Engelen, BG | 1 |
| Drost, G | 1 |
| van der Wilt, GJ | 1 |
| Ginanneschi, F | 1 |
| Mignarri, A | 1 |
| Lucchiari, S | 1 |
| Ulzi, G | 1 |
| Comi, GP | 1 |
| Rossi, A | 1 |
| Dotti, MT | 1 |
| Blatt, LK | 1 |
| Lashinger, ES | 1 |
| Laping, NJ | 2 |
| Su, X | 2 |
| Tappenbeck, K | 1 |
| Hoppe, S | 1 |
| Hopster, K | 1 |
| Kietzmann, M | 1 |
| Feige, K | 1 |
| Huber, K | 1 |
| De Luca, A | 1 |
| Pierno, S | 1 |
| Liantonio, A | 1 |
| Desaphy, JF | 1 |
| Natuzzi, F | 1 |
| Didonna, MP | 1 |
| Ferrannini, E | 1 |
| Jockusch, H | 1 |
| Franchini, C | 1 |
| Lentini, G | 1 |
| Corbo, F | 1 |
| Tortorella, V | 1 |
| Camerino, DC | 1 |
| Ozen, IO | 1 |
| Vural, IM | 1 |
| Moralioğlu, S | 1 |
| Barun, S | 1 |
| Ercan, ZS | 1 |
| Sarioğlu, Y | 1 |
| Riedel, ES | 1 |
| Leon, LA | 1 |
| Courtney, KR | 1 |
| Castleden, CM | 1 |
| Duffin, HM | 1 |
| Clarkson, EJ | 1 |
| Fernández del Pozo, B | 1 |
| Pérez-Vizcaíno, F | 1 |
| Fernández, C | 1 |
| Zaragozá, F | 1 |
| Tamargo, J | 1 |
| Nakahara, T | 1 |
| Moriuchi, H | 1 |
| Yunoki, M | 1 |
| Kubota, Y | 1 |
| Tanaka, Y | 1 |
| Sakamato, K | 1 |
| Shigenobu, K | 1 |
| Ishii, K | 1 |
| Lampa, E | 1 |
| Pedone, P | 1 |
| Russo, G | 1 |
| Alise, G | 1 |
| Di Tonto, B | 1 |
| Sasso, M | 1 |
| Chiavarelli, M | 1 |
| Chiavarelli, R | 1 |
| Fabi, F | 1 |
| Stati, T | 1 |
| del Basso, P | 1 |
| Kitagawa, H | 1 |
| Takeda, F | 1 |
| Kohei, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Combining N-of-1 Trials to Estimate Population Clinical and Cost-effectiveness of Drugs Using Bayesian Hierarchical Modeling. The Case of Mexiletine for Patients With Non- Dystrophic Myotonia.[NCT02045667] | Phase 2 | 30 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for mexiletine and Muscle Contraction
| Article | Year |
|---|---|
Combined N-of-1 trials to investigate mexiletine in non-dystrophic myotonia using a Bayesian approach; study rationale and protocol.
Topics: Adolescent; Adult; Aged; Algorithms; Bayes Theorem; Cost-Benefit Analysis; Cross-Over Studies; Doubl | 2015 |
13 other studies available for mexiletine and Muscle Contraction
| Article | Year |
|---|---|
Neuromuscular excitability changes produced by sustained voluntary contraction and response to mexiletine in myotonia congenita.
Topics: Action Potentials; Adult; Electromyography; Female; Humans; Male; Mexiletine; Muscle Contraction; Mu | 2017 |
Evaluation of pressor and visceromotor reflex responses to bladder distension in urethane anesthetized rats.
Topics: Abdominal Muscles; Analgesics; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Pre | 2009 |
Lidocaine and structure-related mexiletine induce similar contractility-enhancing effects in ischaemia-reperfusion injured equine intestinal smooth muscle in vitro.
Topics: Animals; Creatine Kinase; Horses; Intestines; Lidocaine; Male; Mexiletine; Muscle Contraction; Muscl | 2013 |
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse.
Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Do | 2004 |
Effects of mexiletine on electrical field stimulation-induced contractile responses in the ipsilateral and contralateral vasa deferentia after unilateral testicular torsion/detorsion.
Topics: Animals; Anti-Arrhythmia Agents; Electric Stimulation; Male; Mexiletine; Muscle Contraction; Rabbits | 2006 |
Pharmacologic evaluation of pressor and visceromotor reflex responses to bladder distension.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2008 |
Depressant effects of drugs used in myotonia therapy.
Topics: Animals; In Vitro Techniques; Ion Channels; Lidocaine; Mexiletine; Muscle Contraction; Myotonia; Phe | 1982 |
In vivo and in vitro studies on the effect of sodium antagonists on the bladder in man and rat.
Topics: Adult; Aged; Animals; Dose-Response Relationship, Drug; Female; Humans; Ion Channels; Lidocaine; Mal | 1983 |
Effects of several class I antiarrhythmic drugs on isolated rat aortic vascular smooth muscle.
Topics: Animals; Anti-Arrhythmia Agents; Aorta; Desipramine; Disopyramide; Flecainide; Imipramine; In Vitro | 1997 |
Involvement of K(+) channel in procainamide-induced relaxation of bovine tracheal smooth muscle.
Topics: Albuterol; Animals; Anti-Arrhythmia Agents; Bronchoconstrictor Agents; Bronchodilator Agents; Cattle | 2000 |
[In vitro experimental evaluation of mexiletene on the heart and on intestinal and uterine musculature].
Topics: Animals; Anura; Depression, Chemical; Dose-Response Relationship, Drug; Duodenum; Female; Guinea Pig | 1978 |
Vascular effects of lignocaine after coronary artery surgery.
Topics: Coronary Artery Bypass; Drug Evaluation; Humans; Lidocaine; Mexiletine; Muscle Contraction; Phenytoi | 1990 |
Inhibition of sympathetic nervous system by mexiletine, an antiarrhythmic agent, and its antagonism against ouabain.
Topics: Animals; Aorta, Thoracic; Arrhythmias, Cardiac; Electric Stimulation; Epinephrine; Guinea Pigs; In V | 1985 |