mexiletine has been researched along with Multiple Sclerosis in 2 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mexiletine was generally well tolerated with only two patients experiencing transient nausea and dizziness." | 5.28 | Mexiletine for thalamic pain syndrome. ( Awerbuch, GI; Sandyk, R, 1990) |
| "Mexiletine was generally well tolerated with only two patients experiencing transient nausea and dizziness." | 1.28 | Mexiletine for thalamic pain syndrome. ( Awerbuch, GI; Sandyk, R, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sakurai, M | 1 |
| Kanazawa, I | 1 |
| Awerbuch, GI | 1 |
| Sandyk, R | 1 |
1 trial available for mexiletine and Multiple Sclerosis
| Article | Year |
|---|---|
Positive symptoms in multiple sclerosis: their treatment with sodium channel blockers, lidocaine and mexiletine.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; M | 1999 |
1 other study available for mexiletine and Multiple Sclerosis
| Article | Year |
|---|---|
Mexiletine for thalamic pain syndrome.
Topics: Cerebral Hemorrhage; Cerebral Infarction; Female; Humans; Male; Mexiletine; Middle Aged; Multiple Sc | 1990 |