mexiletine has been researched along with Machado-Joseph Disease in 1 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Machado-Joseph Disease: A dominantly-inherited ATAXIA first described in people of Azorean and Portuguese descent, and subsequently identified in Brazil, Japan, China, and Australia. This disorder is classified as one of the SPINOCEREBELLAR ATAXIAS (Type 3) and has been associated with a mutation of the MJD1 gene on chromosome 14. Clinical features include progressive ataxia, DYSARTHRIA, postural instability, nystagmus, eyelid retraction, and facial FASCICULATIONS. DYSTONIA is prominent in younger patients (referred to as Type I Machado-Joseph Disease). Type II features ataxia and ocular signs; Type III features MUSCULAR ATROPHY and a sensorimotor neuropathy; and Type IV features extrapyramidal signs combined with a sensorimotor neuropathy. (From Clin Neurosci 1995;3(1):17-22; Ann Neurol 1998 Mar;43(3):288-96)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Muscle cramps are often associated with lower motoneuron disorders, but features of cramps in Machado-Joseph disease patients have never been studied." | 5.32 | Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment. ( Arai, K; Hattori, T; Kanai, K; Kuwabara, S; Ogawara, K; Sung, JY, 2003) |
| "Muscle cramps are often associated with lower motoneuron disorders, but features of cramps in Machado-Joseph disease patients have never been studied." | 1.32 | Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment. ( Arai, K; Hattori, T; Kanai, K; Kuwabara, S; Ogawara, K; Sung, JY, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kanai, K | 1 |
| Kuwabara, S | 1 |
| Arai, K | 1 |
| Sung, JY | 1 |
| Ogawara, K | 1 |
| Hattori, T | 1 |
1 other study available for mexiletine and Machado-Joseph Disease
| Article | Year |
|---|---|
Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment.
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Axons; Electromyography; Female; Humans; Machado-Joseph D | 2003 |