mexiletine has been researched along with Liver Diseases in 5 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Liver Diseases: Pathological processes of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The clinical relevance of changes in pharmacokinetics of oral mexiletine (600 mg daily dose) was studied in 82 patients with ventricular arrhythmias and impaired liver, renal or heart function (control group n = 51, patients with liver cirrhosis n = 9, with renal insufficiency n = 14, or heart failure n = 8)." | 3.66 | Increase of mexiletine plasma levels due to delayed hepatic metabolism in patients with chronic liver disease. ( Lüderitz, B; Nitsch, J; Steinbeck, G, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Akhtar, M | 1 |
| Nitsch, J | 2 |
| Steinbeck, G | 2 |
| Lüderitz, B | 2 |
| Winter, M | 1 |
| Brunner, H | 1 |
| Horwatitsch, H | 1 |
| Grabner, G | 1 |
| Joeres, R | 1 |
| Klinker, H | 1 |
| Huesler, H | 1 |
| Epping, J | 1 |
| Hofstetter, G | 1 |
| Drost, D | 1 |
| Reuss, H | 1 |
| Zilly, W | 1 |
| Richter, E | 1 |
1 review available for mexiletine and Liver Diseases
| Article | Year |
|---|---|
Practical considerations in the treatment of ventricular arrhythmias with mexiletine.
Topics: Adult; Aged; Animals; Arrhythmias, Cardiac; Dogs; Electrocardiography; Gastrointestinal Diseases; Hu | 1984 |
1 trial available for mexiletine and Liver Diseases
| Article | Year |
|---|---|
[Effect of kidney, liver or heart insufficiency on blood mexiletine levels].
Topics: Arrhythmias, Cardiac; Biological Availability; Chromatography, Gas; Chronic Disease; Heart Failure; | 1982 |
3 other studies available for mexiletine and Liver Diseases
| Article | Year |
|---|---|
Increase of mexiletine plasma levels due to delayed hepatic metabolism in patients with chronic liver disease.
Topics: Arrhythmias, Cardiac; Chronic Disease; Heart Failure; Humans; Kidney Diseases; Kinetics; Liver; Live | 1983 |
[Blood level of mexiletine in liver-damaged patients].
Topics: Humans; Liver Cirrhosis; Liver Diseases; Mexiletine; Propylamines; Time Factors | 1978 |
Factors influencing the caffeine test for cytochrome P 448-dependent liver function.
Topics: Caffeine; Cytochrome P-450 CYP1A2; Cytochromes; Drug Interactions; Humans; Kinetics; Liver; Liver Di | 1987 |