mexiletine has been researched along with HIV Coinfection in 3 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although mexiletine, an antiarrhythmic with local anesthetic properties, has been reported to relieve discomfort in diabetic neuropathy, its usefulness in the treatment of HIV-related painful peripheral neuropathy (PPN) has not been determined." | 9.08 | Mexiletine for HIV-infected patients with painful peripheral neuropathy: a double-blind, placebo-controlled, crossover treatment trial. ( Burton, S; Deresinski, SC; Kemper, CA; Kent, G, 1998) |
| "Neither amitriptyline nor mexiletine provide significant pain relief in patients with HIV-associated painful sensory neuropathy." | 9.08 | A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team. ( Clifford, DB; Cohen, B; Dal Pan, GJ; Ellis, RJ; Hall, CD; Kieburtz, K; Marra, CM; Max, MB; McKendall, R; Simpson, D; Singer, E; Tucker, T; Yiannoutsos, C, 1998) |
| "Although mexiletine, an antiarrhythmic with local anesthetic properties, has been reported to relieve discomfort in diabetic neuropathy, its usefulness in the treatment of HIV-related painful peripheral neuropathy (PPN) has not been determined." | 5.08 | Mexiletine for HIV-infected patients with painful peripheral neuropathy: a double-blind, placebo-controlled, crossover treatment trial. ( Burton, S; Deresinski, SC; Kemper, CA; Kent, G, 1998) |
| "Neither amitriptyline nor mexiletine provide significant pain relief in patients with HIV-associated painful sensory neuropathy." | 5.08 | A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team. ( Clifford, DB; Cohen, B; Dal Pan, GJ; Ellis, RJ; Hall, CD; Kieburtz, K; Marra, CM; Max, MB; McKendall, R; Simpson, D; Singer, E; Tucker, T; Yiannoutsos, C, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kemper, CA | 1 |
| Kent, G | 1 |
| Burton, S | 1 |
| Deresinski, SC | 1 |
| Kieburtz, K | 1 |
| Simpson, D | 1 |
| Yiannoutsos, C | 1 |
| Max, MB | 1 |
| Hall, CD | 1 |
| Ellis, RJ | 1 |
| Marra, CM | 1 |
| McKendall, R | 1 |
| Singer, E | 1 |
| Dal Pan, GJ | 1 |
| Clifford, DB | 1 |
| Tucker, T | 1 |
| Cohen, B | 1 |
| Lein, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection[NCT00000793] | Phase 2 | 240 participants | Interventional | Completed | |||
| A Phase II, Double-Blind Trial of Recombinant Human Nerve Growth Factor for Treatment of HIV-Associated Sensory Neuropathy[NCT00000842] | Phase 2 | 270 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for mexiletine and HIV Coinfection
| Article | Year |
|---|---|
Mexiletine for HIV-infected patients with painful peripheral neuropathy: a double-blind, placebo-controlled, crossover treatment trial.
Topics: Adult; Analgesics; Cross-Over Studies; Double-Blind Method; HIV Infections; Humans; Mexiletine; Pain | 1998 |
A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team.
Topics: Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Anti-Arrhythmia Agents; Double-Blind Method; Dru | 1998 |
1 other study available for mexiletine and HIV Coinfection
| Article | Year |
|---|---|
Potential therapy for painful neuropathy.
Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain; | 1995 |
Potential therapy for painful neuropathy.
Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain; | 1995 |
Potential therapy for painful neuropathy.
Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain; | 1995 |
Potential therapy for painful neuropathy.
Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain; | 1995 |