mexiletine has been researched along with Familial Periodic Paralysis in 4 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Skeletal muscle ion channelopathies are rare genetic diseases mainly characterized by myotonia (muscle stiffness) or periodic paralysis (muscle weakness)." | 3.01 | Drug repurposing in skeletal muscle ion channelopathies. ( Altamura, C; Campanale, C; Desaphy, JF; Laghetti, P; Saltarella, I, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Altamura, C | 2 |
| Saltarella, I | 2 |
| Campanale, C | 2 |
| Laghetti, P | 2 |
| Desaphy, JF | 3 |
| Sah, RL | 1 |
| Tsushima, RG | 1 |
| Backx, PH | 1 |
| De Luca, A | 1 |
| Tortorella, P | 1 |
| De Vito, D | 1 |
| George, AL | 1 |
| Conte Camerino, D | 1 |
| Takahashi, MP | 1 |
| Cannon, SC | 1 |
1 review available for mexiletine and Familial Periodic Paralysis
| Article | Year |
|---|---|
Drug repurposing in skeletal muscle ion channelopathies.
Topics: Channelopathies; Dichlorphenamide; Drug Repositioning; Humans; Mexiletine; Muscle, Skeletal; Mutatio | 2023 |
Drug repurposing in skeletal muscle ion channelopathies.
Topics: Channelopathies; Dichlorphenamide; Drug Repositioning; Humans; Mexiletine; Muscle, Skeletal; Mutatio | 2023 |
Drug repurposing in skeletal muscle ion channelopathies.
Topics: Channelopathies; Dichlorphenamide; Drug Repositioning; Humans; Mexiletine; Muscle, Skeletal; Mutatio | 2023 |
Drug repurposing in skeletal muscle ion channelopathies.
Topics: Channelopathies; Dichlorphenamide; Drug Repositioning; Humans; Mexiletine; Muscle, Skeletal; Mutatio | 2023 |
3 other studies available for mexiletine and Familial Periodic Paralysis
| Article | Year |
|---|---|
Effects of local anesthetics on Na+ channels containing the equine hyperkalemic periodic paralysis mutation.
Topics: Anesthetics, Local; Animals; Benzocaine; Electrophysiology; Female; Horse Diseases; Horses; Hyperkal | 1998 |
Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative.
Topics: Cell Line, Transformed; DNA Mutational Analysis; Dose-Response Relationship, Drug; Humans; Ion Chann | 2001 |
Mexiletine block of disease-associated mutations in S6 segments of the human skeletal muscle Na(+) channel.
Topics: Binding, Competitive; Cell Line; Computer Simulation; Electric Stimulation; Humans; Ion Channel Gati | 2001 |