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mexiletine and Epilepsy

mexiletine has been researched along with Epilepsy in 9 studies

Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"We report a patient with lidocaine-responsive neonatal epilepsy treated successfully with oral mexiletine."7.79Oral mexiletine for lidocaine-responsive neonatal epilepsy. ( Hirose, S; Nakazawa, M; Niijima, S; Okumura, A; Shimizu, T; Shimono, K; Yamashita, S, 2013)
"Twenty-four patients with refractory epilepsy were treated with mexiletine as an additional antiepileptic drug."5.09[Clinical applications and the effect of mexiletine on refractory epilepsies]. ( Enoki, H; Hata, H; Kobayashi, K; Maniwa, S; Ohmori, I; Ohta, H, 2000)
"We report a patient with lidocaine-responsive neonatal epilepsy treated successfully with oral mexiletine."3.79Oral mexiletine for lidocaine-responsive neonatal epilepsy. ( Hirose, S; Nakazawa, M; Niijima, S; Okumura, A; Shimizu, T; Shimono, K; Yamashita, S, 2013)
"In preparation for a prospective controlled study of mexiletine in the treatment of epilepsy, a preliminary study of serum concentrations after multiple doses was performed with 8 institutionalized Caucasian adult males with uncontrolled seizures and similar weight, medical regimen, and seizure classification."3.65A multiple-dose study of mexiletine (Kö 1173). ( Brock, JT; Cereghino, JJ; Kupferberg, HJ; Penry, JK; Smith, LD; Van Meter, JC; White, BG, 1975)
"Mexiletine was subsequently used in a second infant with reduction in seizure frequency."1.46Infantile Epileptic Encephalopathy Associated With SCN2A Mutation Responsive to Oral Mexiletine. ( Foster, LA; Henry, TR; Johnson, MR; Karachunski, PI; MacDonald, JT; Moran, BP; Nascene, DR; Raymond, GV, 2017)
", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule."1.43Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19903 (33.33)18.7374
1990's0 (0.00)18.2507
2000's2 (22.22)29.6817
2010's4 (44.44)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Anger, T1
Madge, DJ1
Mulla, M1
Riddall, D1
Vivier, D1
Bennis, K1
Lesage, F1
Ducki, S1
Waszkielewicz, AM1
Gunia-Krzyżak, A1
Powroźnik, B1
Słoczyńska, K1
Pękala, E1
Walczak, M1
Bednarski, M1
Żesławska, E1
Nitek, W1
Marona, H1
Foster, LA1
Johnson, MR1
MacDonald, JT1
Karachunski, PI1
Henry, TR1
Nascene, DR1
Moran, BP1
Raymond, GV1
Nakazawa, M1
Okumura, A1
Niijima, S1
Yamashita, S1
Shimono, K1
Hirose, S1
Shimizu, T1
Enoki, H1
Hata, H1
Ohmori, I1
Maniwa, S1
Ohta, H1
Kobayashi, K1
Cereghino, JJ2
Wilder, BJ1
Kupferberg, HJ2
Yonekawa, WD1
Perchalski, RJ1
Ramsey, RE1
White, BG2
Penry, JK2
Smith, LD2
Brock, JT1
Van Meter, JC1
Kohyama, J1
Shimohira, M1
Watanabe, S1
Fukuda, C1
Iwakawa, Y1

Reviews

2 reviews available for mexiletine and Epilepsy

ArticleYear
Medicinal chemistry of neuronal voltage-gated sodium channel blockers.
    Journal of medicinal chemistry, 2001, Jan-18, Volume: 44, Issue:2

    Topics: Amyotrophic Lateral Sclerosis; Analgesics; Anticonvulsants; Epilepsy; Humans; Ion Channel Gating; Mo

2001
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
    Journal of medicinal chemistry, 2016, 06-09, Volume: 59, Issue:11

    Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc

2016

Trials

1 trial available for mexiletine and Epilepsy

ArticleYear
[Clinical applications and the effect of mexiletine on refractory epilepsies].
    No to hattatsu = Brain and development, 2000, Volume: 32, Issue:1

    Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Child; Child, Preschool; Drug Therapy, Combination; Elect

2000

Other Studies

6 other studies available for mexiletine and Epilepsy

ArticleYear
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
    Bioorganic & medicinal chemistry, 2016, Apr-15, Volume: 24, Issue:8

    Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru

2016
Infantile Epileptic Encephalopathy Associated With SCN2A Mutation Responsive to Oral Mexiletine.
    Pediatric neurology, 2017, Volume: 66

    Topics: Administration, Oral; Anti-Arrhythmia Agents; Anticonvulsants; Epilepsy; Humans; Infant; Infant, New

2017
Oral mexiletine for lidocaine-responsive neonatal epilepsy.
    Brain & development, 2013, Volume: 35, Issue:7

    Topics: Administration, Oral; Anti-Arrhythmia Agents; Electroencephalography; Epilepsy; Humans; Infant, Newb

2013
A single-dose study of mexiletine (Kö 1173).
    Epilepsia, 1975, Volume: 16, Issue:5

    Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Humans; Male; Mexiletine; Middle

1975
A multiple-dose study of mexiletine (Kö 1173).
    Epilepsia, 1975, Volume: 16, Issue:5

    Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Humans; Male; Mexiletine; Propyl

1975
Mexiletine hydrochloride in an infant with intractable epilepsy.
    Brain & development, 1988, Volume: 10, Issue:4

    Topics: Electroencephalography; Epilepsy; Female; Humans; Infant; Mexiletine

1988