mexiletine has been researched along with Epilepsy in 9 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a patient with lidocaine-responsive neonatal epilepsy treated successfully with oral mexiletine." | 7.79 | Oral mexiletine for lidocaine-responsive neonatal epilepsy. ( Hirose, S; Nakazawa, M; Niijima, S; Okumura, A; Shimizu, T; Shimono, K; Yamashita, S, 2013) |
| "Twenty-four patients with refractory epilepsy were treated with mexiletine as an additional antiepileptic drug." | 5.09 | [Clinical applications and the effect of mexiletine on refractory epilepsies]. ( Enoki, H; Hata, H; Kobayashi, K; Maniwa, S; Ohmori, I; Ohta, H, 2000) |
| "We report a patient with lidocaine-responsive neonatal epilepsy treated successfully with oral mexiletine." | 3.79 | Oral mexiletine for lidocaine-responsive neonatal epilepsy. ( Hirose, S; Nakazawa, M; Niijima, S; Okumura, A; Shimizu, T; Shimono, K; Yamashita, S, 2013) |
| "In preparation for a prospective controlled study of mexiletine in the treatment of epilepsy, a preliminary study of serum concentrations after multiple doses was performed with 8 institutionalized Caucasian adult males with uncontrolled seizures and similar weight, medical regimen, and seizure classification." | 3.65 | A multiple-dose study of mexiletine (Kö 1173). ( Brock, JT; Cereghino, JJ; Kupferberg, HJ; Penry, JK; Smith, LD; Van Meter, JC; White, BG, 1975) |
| "Mexiletine was subsequently used in a second infant with reduction in seizure frequency." | 1.46 | Infantile Epileptic Encephalopathy Associated With SCN2A Mutation Responsive to Oral Mexiletine. ( Foster, LA; Henry, TR; Johnson, MR; Karachunski, PI; MacDonald, JT; Moran, BP; Nascene, DR; Raymond, GV, 2017) |
| ", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule." | 1.43 | Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anger, T | 1 |
| Madge, DJ | 1 |
| Mulla, M | 1 |
| Riddall, D | 1 |
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Waszkielewicz, AM | 1 |
| Gunia-Krzyżak, A | 1 |
| Powroźnik, B | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Walczak, M | 1 |
| Bednarski, M | 1 |
| Żesławska, E | 1 |
| Nitek, W | 1 |
| Marona, H | 1 |
| Foster, LA | 1 |
| Johnson, MR | 1 |
| MacDonald, JT | 1 |
| Karachunski, PI | 1 |
| Henry, TR | 1 |
| Nascene, DR | 1 |
| Moran, BP | 1 |
| Raymond, GV | 1 |
| Nakazawa, M | 1 |
| Okumura, A | 1 |
| Niijima, S | 1 |
| Yamashita, S | 1 |
| Shimono, K | 1 |
| Hirose, S | 1 |
| Shimizu, T | 1 |
| Enoki, H | 1 |
| Hata, H | 1 |
| Ohmori, I | 1 |
| Maniwa, S | 1 |
| Ohta, H | 1 |
| Kobayashi, K | 1 |
| Cereghino, JJ | 2 |
| Wilder, BJ | 1 |
| Kupferberg, HJ | 2 |
| Yonekawa, WD | 1 |
| Perchalski, RJ | 1 |
| Ramsey, RE | 1 |
| White, BG | 2 |
| Penry, JK | 2 |
| Smith, LD | 2 |
| Brock, JT | 1 |
| Van Meter, JC | 1 |
| Kohyama, J | 1 |
| Shimohira, M | 1 |
| Watanabe, S | 1 |
| Fukuda, C | 1 |
| Iwakawa, Y | 1 |
2 reviews available for mexiletine and Epilepsy
| Article | Year |
|---|---|
Medicinal chemistry of neuronal voltage-gated sodium channel blockers.
Topics: Amyotrophic Lateral Sclerosis; Analgesics; Anticonvulsants; Epilepsy; Humans; Ion Channel Gating; Mo | 2001 |
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
1 trial available for mexiletine and Epilepsy
| Article | Year |
|---|---|
[Clinical applications and the effect of mexiletine on refractory epilepsies].
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Child; Child, Preschool; Drug Therapy, Combination; Elect | 2000 |
6 other studies available for mexiletine and Epilepsy
| Article | Year |
|---|---|
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru | 2016 |
Infantile Epileptic Encephalopathy Associated With SCN2A Mutation Responsive to Oral Mexiletine.
Topics: Administration, Oral; Anti-Arrhythmia Agents; Anticonvulsants; Epilepsy; Humans; Infant; Infant, New | 2017 |
Oral mexiletine for lidocaine-responsive neonatal epilepsy.
Topics: Administration, Oral; Anti-Arrhythmia Agents; Electroencephalography; Epilepsy; Humans; Infant, Newb | 2013 |
A single-dose study of mexiletine (Kö 1173).
Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Humans; Male; Mexiletine; Middle | 1975 |
A multiple-dose study of mexiletine (Kö 1173).
Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Humans; Male; Mexiletine; Propyl | 1975 |
Mexiletine hydrochloride in an infant with intractable epilepsy.
Topics: Electroencephalography; Epilepsy; Female; Humans; Infant; Mexiletine | 1988 |