mexiletine and Disease Models, Animal

mexiletine has been researched along with Disease Models, Animal in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (7.69)	18.7374
1990's	6 (15.38)	18.2507
2000's	22 (56.41)	29.6817
2010's	7 (17.95)	24.3611
2020's	1 (2.56)	2.80

Authors

Authors	Studies
Abbadie, C; Dean, B; Duffy, JL; Felix, JP; Garcia, ML; Gonzalez, E; Hoyt, SB; Jochnowitz, N; Kaczorowski, GJ; Karanam, BV; Li, X; London, C; Lyons, KA; Macintyre, DE; Martin, WJ; McGowan, E; Ok, H; Parsons, WH; Priest, BT; Smith, MM; Tschirret-Guth, R; Warren, VA; Williams, BS	1
Abbadie, C; Duffy, JL; Felix, JP; Garcia, ML; Hoyt, SB; Jochnowitz, N; Kaczorowski, GJ; Karanam, BV; Li, X; London, C; Lyons, KA; McGowan, E; Priest, BT; Smith, MM; Thomas-Fowlkes, BS; Warren, VA	1
Barnaby, O; Bourin, C; Bristow, LJ; Bronson, J; Chen, P; Dzierba, C; Easton, A; Guernon, J; Herrington, J; Knox, RJ; Luo, G; Matchett, M; McClure, A; Meanwell, NA; Mosure, K; Newton, A; Ng, A; Olson, R; Parker, D; Pieschl, R; Rajamani, R; Sivarao, DV; Soars, MG; Thompson, LA; Wu, YJ	1
Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ	1
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV	1
Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Garthmann, J; Köbe, J; Kochhäuser, S; Reinke, F; Wasmer, K	1
Carbonara, R; Conte Camerino, D; Costanza, T; Desaphy, JF	1
Jarrott, B; Staikopoulos, V; Subasinghe, KR; Weston, RM	1
Akar, A; Altinors, N; Caner, H; Cansever, T; Gulsen, S; Kabatas, S; Ozger, O; Yilmaz, C	1
Batcioglu, K; Demirtas, H; Djamgoz, MB; Guzel, RM; Onkal, R; Satilmis, B; Uyumlu, AB; Yildirim, B; Yucel, N	1
Banno, K; Inoue, N; Ito, S; Kotera, T; Kyoi, T; Nakamura, A; Nogawa, M; Sasagawa, T; Tajima, K; Takahashi, Y; Ueda, M; Yamashita, Y	1
Hashimoto, K; Ishida, Y; Kugiyama, K; Satoh, Y; Sugiyama, A; Yoshida, H	1
Iguchi, E; Kamei, J; Morita, K; Sasaki, M; Tanaka, S; Zushida, K	1
Blackburn-Munro, G; Erichsen, HK; Hao, JX; Xu, XJ	1
Breithardt, G; Carmeliet, E; Carmeliet, P; Fabritz, L; Franz, MR; Haverkamp, W; Kirchhof, P; Nuyens, D; Ottenhof, A; Rossenbacker, T	1
Akdemir, H; Koç, RK; Menkü, A; Narin, F; Saraymen, R; Tayfur, V	1
Hashimoto, K; Satoh, Y; Sugiyama, A; Takahara, A	1
Asano, K; Hisamitsu, T; Sameshima, T; Shirasawa, H	1
Camerino, DC; Corbo, F; De Luca, A; Desaphy, JF; Didonna, MP; Ferrannini, E; Franchini, C; Jockusch, H; Lentini, G; Liantonio, A; Natuzzi, F; Pierno, S; Tortorella, V	1
Imaki, R; Inuo, K; Izumi, T; Morohoshi, Y; Nakayama, S; Niwano, S; Yuge, M	1
Abbadie, C; Köhler, MG; Lindia, JA; Martin, WJ	1
Abbadie, C; Anderson, HA; Clapp, RH; Delaney, A; Fleetwood-Walker, SM; Garry, EM; Kinchington, PR; Krah, DL; Martin, WJ; Sirinathsinghji, EC	1
Balasubramaniam, R; Colledge, WH; Goddard, CA; Grace, AA; Head, CE; Huang, CL; Lei, M; Thomas, G	1
Altinors, N; Atalay, B; Aydin, MV; Bavbek, M; Caner, H; Ozen, O; Sen, O	1
Ates, O; Cakir, CO; Cayli, SR; Gurses, I; Kocak, A; Tarim, O; Turkoz, Y	1
Atalay, B; Can, A; Caner, H; Cekinmez, M	1
Kita, Y; Nakazato-Imasato, E; Tanimoto-Mori, S; Toide, K	1
Chézalviel-Guilbert, F; Davy, JM; Poirier, JM; Weissenburger, J	1
Kane, KA; Komori, S; Parratt, JR; Sawanobori, T; Tamura, K	1
Cantù, F; Napolitano, C; Paganini, V; Priori, SG; Schwartz, PJ	1
Antzelevitch, C; Shimizu, W	1
Camerino, DC; De Luca, A; Desaphy, JF; Tortorella, V	1
Horiuchi, J; Sato, Y	1
Nordmark, J; Wiesenfeld-Hallin, Z; Wu, WP; Xu, XJ	1
Ikeda, K; Inuo, K; Izumi, T; Kojima, J; Masuda, T; Morohoshi, Y; Nakayama, S; Niwano, S; Saito, J	1
de Bakker, JM; Effert, S; Henning, B; Merx, W	1
Hashimoto, H; Nakashima, M; Satoh, N	1
Harron, DW; Uprichard, AC	1
Schwartz, PJ; Vanoli, E; Zaza, A; Zuanetti, G	1

Reviews

1 review(s) available for mexiletine and Disease Models, Animal

Article	Year
Molecular biology of the long QT syndrome: impact on management. Pacing and clinical electrophysiology : PACE, 1997, Volume: 20, Issue:8 Pt 2 Topics: Action Potentials; Adrenergic Antagonists; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Cardiotonic Agents; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 7; Disease Models, Animal; Electrocardiography; Genetic Therapy; Guinea Pigs; Heart Rate; Humans; Intercellular Signaling Peptides and Proteins; Long QT Syndrome; Mexiletine; Molecular Biology; Myocardium; Peptides; Phenethylamines; Potassium; Potassium Channel Blockers; Potassium Channels; Receptors, Adrenergic; Risk Factors; Sodium Channel Blockers; Sodium Channels; Sulfonamides; Syncope; Tachycardia, Ventricular	1997

Article

Year

Molecular biology of the long QT syndrome: impact on management.

Pacing and clinical electrophysiology : PACE, 1997, Volume: 20, Issue:8 Pt 2

Topics: Action Potentials; Adrenergic Antagonists; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Cardiotonic Agents; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 7; Disease Models, Animal; Electrocardiography; Genetic Therapy; Guinea Pigs; Heart Rate; Humans; Intercellular Signaling Peptides and Proteins; Long QT Syndrome; Mexiletine; Molecular Biology; Myocardium; Peptides; Phenethylamines; Potassium; Potassium Channel Blockers; Potassium Channels; Receptors, Adrenergic; Risk Factors; Sodium Channel Blockers; Sodium Channels; Sulfonamides; Syncope; Tachycardia, Ventricular

1997

Other Studies

38 other study(ies) available for mexiletine and Disease Models, Animal

Article	Year
Benzazepinone Nav1.7 blockers: potential treatments for neuropathic pain. Bioorganic & medicinal chemistry letters, 2007, Nov-15, Volume: 17, Issue:22 Topics: Animals; Benzodiazepinones; Biological Availability; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Molecular Structure; NAV1.7 Voltage-Gated Sodium Channel; Neuralgia; Rats; Sodium Channel Blockers; Sodium Channels	2007
A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain. Bioorganic & medicinal chemistry letters, 2013, Jun-15, Volume: 23, Issue:12 Topics: Animals; Benzazepines; Disease Models, Animal; Neuralgia; Rats; Sodium Channel Blockers	2013
Discovery of non-zwitterionic aryl sulfonamides as Na Bioorganic & medicinal chemistry, 2017, 10-15, Volume: 25, Issue:20 Topics: Administration, Oral; Animals; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Freund's Adjuvant; HEK293 Cells; Humans; Inflammation; Male; Mice; Models, Biological; Molecular Structure; NAV1.7 Voltage-Gated Sodium Channel; Neurons; Nociception; Structure-Activity Relationship; Sulfonamides	2017
Inhibition of natriuretic peptide receptor 1 reduces itch in mice. Science translational medicine, 2019, 07-10, Volume: 11, Issue:500 Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries	2019
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49 Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection	2020
Broad antiarrhythmic effect of mexiletine in different arrhythmia models. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2018, 08-01, Volume: 20, Issue:8 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Disease Models, Animal; Heart Conduction System; Heart Rate; Isolated Heart Preparation; Long QT Syndrome; Mexiletine; Rabbits; Tachycardia, Ventricular; Time Factors	2018
Preclinical evaluation of marketed sodium channel blockers in a rat model of myotonia discloses promising antimyotonic drugs. Experimental neurology, 2014, Volume: 255 Topics: Animals; Carbamazepine; Disease Models, Animal; Flecainide; HEK293 Cells; Humans; Mexiletine; Muscle, Skeletal; Myotonia Congenita; Orphenadrine; Piperidines; Propafenone; Rats; Rats, Wistar; Riluzole; Sodium Channel Blockers; Thiazoles	2014
Design and assessment of a potent sodium channel blocking derivative of mexiletine for minimizing experimental neuropathic pain in several rat models. Neurochemical research, 2009, Volume: 34, Issue:10 Topics: Analgesics; Animals; Disease Models, Animal; Drug Discovery; Drug Evaluation, Preclinical; Male; Mexiletine; Neuralgia; Pain Measurement; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels	2009
The preventive effect of mexiletine on cerebral ischemic injury following experimental middle cerebral artery occlusion. Turkish neurosurgery, 2009, Volume: 19, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Brain Ischemia; Calcium Channel Blockers; Disease Models, Animal; Infarction, Middle Cerebral Artery; KATP Channels; Male; Mexiletine; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers	2009
Oxidative stress in the in vivo DMBA rat model of breast cancer: suppression by a voltage-gated sodium channel inhibitor (RS100642). Basic & clinical pharmacology & toxicology, 2012, Volume: 111, Issue:2 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Models, Animal; Female; Glutathione Peroxidase; Malondialdehyde; Mammary Neoplasms, Experimental; Mexiletine; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium Channel Blockers; Superoxide Dismutase	2012
Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 342, Issue:1 Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Drug Interactions; Duloxetine Hydrochloride; Etodolac; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mexiletine; Mice; Paclitaxel; Peripheral Nervous System Diseases; Pregabalin; Thiophenes; Tissue Distribution	2012
Effects of disopyramide and mexiletine on the terminal repolarization process of the in situ heart assessed using the halothane-anesthetized in vivo canine model. Circulation journal : official journal of the Japanese Circulation Society, 2002, Volume: 66, Issue:9 Topics: Action Potentials; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Output; Disease Models, Animal; Disopyramide; Dogs; Electrocardiography; Halothane; Heart Rate; Long QT Syndrome; Mexiletine; Ventricular Function, Left	2002
Modification of the fenvalerate-induced nociceptive response in mice by diabetes. Brain research, 2002, Sep-06, Volume: 948, Issue:1-2 Topics: Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Enzyme Activators; Enzyme Inhibitors; Hindlimb; Injections, Spinal; Male; Mexiletine; Mice; Mice, Inbred ICR; Naphthalenes; Nitriles; Pain Measurement; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrethrins; Sodium Channels; Streptozocin	2002
A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain. European journal of pharmacology, 2003, Jan-05, Volume: 458, Issue:3 Topics: Analgesics; Analysis of Variance; Anesthetics, Local; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hindlimb; Lamotrigine; Lidocaine; Male; Mexiletine; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Time Factors; Tocainide; Triazines	2003
Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice. Cardiovascular research, 2003, Mar-15, Volume: 57, Issue:4 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disease Models, Animal; Electrocardiography; Gene Deletion; Long QT Syndrome; Mexiletine; Mice; Mice, Transgenic; NAV1.5 Voltage-Gated Sodium Channel; Organ Culture Techniques; Sodium Channels; Torsades de Pointes	2003
Effects of mexiletine, ginkgo biloba extract (EGb 761), and their combination on experimental head injury. Neurosurgical review, 2003, Volume: 26, Issue:4 Topics: Animals; Brain Edema; Disease Models, Animal; Drug Therapy, Combination; Ginkgo biloba; Head Injuries, Closed; Lipid Peroxidation; Male; Mexiletine; Neuroprotective Agents; Plant Extracts; Rats	2003
Effects of mexiletine on the canine model of sparfloxacin-induced long QT syndrome. European journal of pharmacology, 2003, Aug-22, Volume: 476, Issue:1-2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Blood Pressure; Bundle of His; Chromatography, High Pressure Liquid; Disease Models, Animal; Dogs; Electrocardiography; Female; Fluoroquinolones; Heart Rate; Injections, Intravenous; Long QT Syndrome; Mexiletine; Refractory Period, Electrophysiological; Time Factors; Ventricular Function, Left	2003
Attenuating effect of mexiletine hydrochloride on herpetic pain in mice infected with herpes simplex virus. The Journal of pharmacy and pharmacology, 2003, Volume: 55, Issue:10 Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Herpes Simplex; Infusions, Parenteral; Mexiletine; Mice; Mice, Inbred BALB C; Pain; Pain Threshold; Simplexvirus	2003
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse. Neuromuscular disorders : NMD, 2004, Volume: 14, Issue:7 Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Conductivity; Electromyography; Female; In Vitro Techniques; Inhibitory Concentration 50; Male; Mexiletine; Mice; Mice, Mutant Strains; Muscle Contraction; Myotonic Disorders; Patch-Clamp Techniques; Sodium Channels; Structure-Activity Relationship; Time Factors; Tocainide	2004
Mexiletine protects myocardium during acute ischemia by opening sarcolemmal K-ATP channel: studies in closed-chest acute ischemia model in rabbits. Journal of cardiovascular pharmacology, 2004, Volume: 44, Issue:6 Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Disease Models, Animal; Electrocardiography; Hemodynamics; KATP Channels; Lidocaine; Mexiletine; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rabbits; Sarcolemma; Sodium Channel Blockers; Stroke Volume; Ventricular Function, Left	2004
Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats. Pain, 2005, Volume: 117, Issue:1-2 Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Immunohistochemistry; Lamotrigine; Male; Mexiletine; NAV1.3 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Neurons; Oligonucleotides; Pain; Pain Measurement; Peripheral Nerves; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Skin; Sodium Channels; Time Factors; Triazines; Up-Regulation	2005
Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs. Pain, 2005, Volume: 118, Issue:1-2 Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models, Animal; Fluorescent Antibody Technique; Gabapentin; Galanin; gamma-Aminobutyric Acid; Ganglia, Spinal; Herpes Zoster; Herpesvirus 3, Human; Immediate-Early Proteins; Immunohistochemistry; Lamotrigine; Mexiletine; Neuralgia; Neuralgia, Postherpetic; Neurons, Afferent; Neuropeptide Y; Rats; Receptors, N-Methyl-D-Aspartate; Reflex; Sodium Channels; Trans-Activators; Triazines; Viral Envelope Proteins; Virus Latency	2005
Paced electrogram fractionation analysis of arrhythmogenic tendency in DeltaKPQ Scn5a mice. Journal of cardiovascular electrophysiology, 2005, Volume: 16, Issue:12 Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disease Models, Animal; Electric Stimulation; Gene Deletion; Long QT Syndrome; Mexiletine; Mice; Mice, Transgenic; Muscle Cells; NAV1.5 Voltage-Gated Sodium Channel; Sodium Channels; Tachycardia, Ventricular	2005
The effect of mexiletine on the level of lipid peroxidation and apoptosis of endothelium following experimental subarachnoid hemorrhage. Neurological research, 2006, Volume: 28, Issue:8 Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Apoptosis; Arteries; Disease Models, Animal; Endothelium; In Situ Nick-End Labeling; Lipid Peroxidation; Mexiletine; Rabbits; Random Allocation; Subarachnoid Hemorrhage	2006
Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2007, Volume: 14, Issue:7 Topics: Animals; Behavior, Animal; Disease Models, Animal; Lipid Peroxidation; Locomotion; Male; Mexiletine; Motor Activity; Phenytoin; Psychomotor Performance; Rats; Rats, Wistar; Riluzole; Sodium Channel Blockers; Spinal Cord Injuries; Statistics, Nonparametric; Time Factors; Water	2007
Attenuation of microtubule associated protein-2 degradation after mild head injury by mexiletine and calpain-2 inhibitor. British journal of neurosurgery, 2007, Volume: 21, Issue:3 Topics: Animals; Brain; Calpain; Cytoskeleton; Disease Models, Animal; Head Injuries, Closed; Immunologic Techniques; Injections, Intraperitoneal; Leupeptins; Lipid Peroxidation; Male; Mexiletine; Microtubule-Associated Proteins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Time Factors	2007
Pharmacologic investigation of the mechanism underlying cold allodynia using a new cold plate procedure in rats with chronic constriction injuries. Behavioural pharmacology, 2008, Volume: 19, Issue:1 Topics: Analgesics, Opioid; Animals; Behavior, Animal; Calcium Channel Blockers; Chronic Disease; Cold Temperature; Constriction, Pathologic; Disease Models, Animal; Diterpenes; gamma-Aminobutyric Acid; Male; Mexiletine; Morphine; Nerve Fibers, Unmyelinated; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pregabalin; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatic Nerve; Sodium Channel Blockers; TRPV Cation Channels	2008
Mexiletine antagonizes effects of sotalol on QT interval duration and its proarrhythmic effects in a canine model of torsade de pointes. Journal of the American College of Cardiology, 1995, Volume: 26, Issue:3 Topics: Analysis of Variance; Animals; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Drug Interactions; Drug Therapy, Combination; Electrocardiography; Electrophysiology; Mexiletine; Sotalol; Torsades de Pointes	1995
Effects of NS-2, a new class 1 antiarrhythmic agent, and AFD-19, its active metabolite, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats: comparison with disopyramide and mexiletine. Japanese journal of pharmacology, 1994, Volume: 65, Issue:3 Topics: Amino Alcohols; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Disease Models, Animal; Disopyramide; Drug Administration Schedule; Heart Rate; Injections, Intravenous; Male; Mexiletine; Myocardial Ischemia; Myocardial Reperfusion; Rats; Rats, Sprague-Dawley; Ventricular Fibrillation	1994
Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: effects of beta-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes. Circulation, 1998, Nov-24, Volume: 98, Issue:21 Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Isoproterenol; KCNQ Potassium Channels; Long QT Syndrome; Membrane Potentials; Mexiletine; Perfusion; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Sodium Channel Blockers; Torsades de Pointes	1998
Effect of mexiletine on sea anemone toxin-induced non-inactivating sodium channels of rat skeletal muscle: a model of sodium channel myotonia. Neuromuscular disorders : NMD, 1999, Volume: 9, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Cnidarian Venoms; Disease Models, Animal; In Vitro Techniques; Membrane Potentials; Mexiletine; Muscle Fibers, Skeletal; Muscle, Skeletal; Myotonia; Rats; Sodium Channels	1999
[Effect of mexiletine on spontaneous sensory afferent activity in spontaneous diabetic rats (WBN/Kob rats)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2000, Volume: 115, Issue:6 Topics: Action Potentials; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Depression, Chemical; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Disease Models, Animal; Lidocaine; Mexiletine; Nerve Fibers; Neurons, Afferent; Peripheral Nervous System Diseases; Rats; Rats, Inbred Strains; Rats, Wistar	2000
Lack of stereoselectivity for the antiallodynic effect of mexiletine in spinally injured rats. European journal of pain (London, England), 2000, Volume: 4, Issue:4 Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Hyperalgesia; Mexiletine; Motor Activity; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Stereoisomerism; Vocalization, Animal	2000
Cardioprotective effect of mexiletine in acute myocardial ischemia tudies in the rabbit closed chest ischemia mode. Circulation journal : official journal of the Japanese Circulation Society, 2002, Volume: 66, Issue:4 Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Coronary Angiography; Coronary Vessels; Disease Models, Animal; Ion Channel Gating; Membrane Proteins; Mexiletine; Myocardial Ischemia; Potassium Channels; Rabbits; Time Factors; Ventricular Function, Left	2002
[The antifibrillatory effect of mexiletine (Kö 1173) in experimentally induced myocardial infarct]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1976, Volume: 82 Pt 2 Topics: Animals; Atrial Fibrillation; Disease Models, Animal; Dogs; Mexiletine; Myocardial Infarction; Propylamines	1976
Coupling interval-related effects of class I antiarrhythmic drugs, mexiletine, cibenzoline and disopyramide, on ventricular activation in canine myocardial infarction. Japanese journal of pharmacology, 1991, Volume: 57, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Disopyramide; Dogs; Electric Stimulation; Electrocardiography; Heart Rate; Imidazoles; Injections, Intravenous; Mexiletine; Myocardial Infarction; Ventricular Function, Right	1991
Atenolol, but not mexiletine, protects against stimulus-induced ventricular tachycardia in a chronic canine model. British journal of pharmacology, 1989, Volume: 96, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Atenolol; Blood Pressure; Coronary Circulation; Disease Models, Animal; Dogs; Electric Stimulation; Female; Heart Rate; Ligation; Male; Mexiletine; Tachycardia	1989
The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity. American heart journal, 1985, Volume: 109, Issue:5 Pt 1 Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Disease Models, Animal; Electrocardiography; Hemodynamics; Lidocaine; Mexiletine; Prazosin; Propranolol; Stellate Ganglion	1985