mexiletine has been researched along with Diabetic Neuropathies in 19 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the efficacy and safety of mexiletine in the treatment of painful diabetic neuropathy." | 9.08 | Efficacy and safety of mexiletine in the treatment of painful diabetic neuropathy. The Mexiletine Study Group. ( Lins, PE; Ljunggren, JG; Oskarsson, P, 1997) |
| "Physicians caring for patients with CSPN should consider mexiletine to address pain and fatigue, although nortriptyline and duloxetine are better medications to trial first since they are better tolerated." | 5.51 | A secondary analysis of PAIN-CONTRoLS: Pain's impact on sleep, fatigue, and activities of daily living. ( Barohn, RJ; Bhai, SF; Brown, A; Gajewski, B; Kimminau, KS; Pasnoor, M; Waitman, LR, 2022) |
| "To investigate the efficacy and safety of mexiletine in the treatment of painful diabetic neuropathy." | 5.08 | Efficacy and safety of mexiletine in the treatment of painful diabetic neuropathy. The Mexiletine Study Group. ( Lins, PE; Ljunggren, JG; Oskarsson, P, 1997) |
| "To prove the efficacy of mexiletine in painful diabetic neuropathy." | 5.07 | Mexiletine in the treatment of diabetic neuropathy. ( Federlin, K; Meyer, UE; Schumacher, HE; Stracke, H, 1992) |
| " With an increase in dosage the efficacy does not rise proportionally." | 2.67 | [Mexiletine in treatment of painful diabetic neuropathy]. ( Armbrecht, U; Beroniade, S; Buch, KD; Federlin, K; Haupt, E; Husstedt, IW; Kampmann, B; Meyer, U; Schumacher, H; Stracke, H, 1994) |
| "Mexiletine is an orally active local anaesthetic agent which is structurally related to lidocaine (lignocaine) and has been used for alleviating neuropathic pain of various origins." | 2.40 | Mexiletine. A review of its therapeutic use in painful diabetic neuropathy. ( Coukell, AJ; Jarvis, B, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 13 (68.42) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Bhai, SF | 1 |
| Brown, A | 1 |
| Gajewski, B | 1 |
| Kimminau, KS | 1 |
| Waitman, LR | 1 |
| Pasnoor, M | 1 |
| Barohn, RJ | 1 |
| Ida, M | 1 |
| Kuroiwa, Y | 1 |
| Maeda, K | 1 |
| Yasuda, H | 1 |
| Kamei, J | 2 |
| Saitoh, A | 1 |
| Kasuya, Y | 1 |
| Fukuda, H | 1 |
| Kasuda, H | 1 |
| Nemoto, K | 1 |
| Shimizu, R | 1 |
| Stracke, H | 2 |
| Meyer, U | 1 |
| Schumacher, H | 1 |
| Armbrecht, U | 1 |
| Beroniade, S | 1 |
| Buch, KD | 1 |
| Federlin, K | 2 |
| Haupt, E | 1 |
| Husstedt, IW | 1 |
| Kampmann, B | 1 |
| Boulton, AJ | 1 |
| Pfeifer, MA | 1 |
| Ross, DR | 1 |
| Schrage, JP | 1 |
| Gelber, DA | 1 |
| Schumer, MP | 1 |
| Crain, GM | 1 |
| Markwell, SJ | 1 |
| Jung, S | 1 |
| Wright, JM | 1 |
| Oki, JC | 1 |
| Graves, L | 1 |
| Oskarsson, P | 1 |
| Ljunggren, JG | 1 |
| Lins, PE | 1 |
| Jarvis, B | 1 |
| Coukell, AJ | 1 |
| Horiuchi, J | 1 |
| Sato, Y | 1 |
| Meyer, UE | 1 |
| Schumacher, HE | 1 |
| Ziegler, D | 1 |
| Gries, FA | 1 |
| Ackerman, WE | 1 |
| Colclough, GW | 1 |
| Juneja, MM | 1 |
| Bellinger, K | 1 |
| Kubota, K | 1 |
| Joshita, Y | 1 |
| Tamura, J | 1 |
| Ikeda, M | 1 |
| Kurabayashi, H | 1 |
| Kawada, E | 1 |
| Okamoto, K | 1 |
| Shirakura, T | 1 |
| Suzuki, K | 1 |
| Toyota, T | 1 |
| Kudo, M | 1 |
| Ono, Y | 1 |
| Kato, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) Randomised, Double-blind,Placebo-controlled Multicentre Trial With 4 Parallel Groups[NCT00328601] | Phase 3 | 170 participants | Interventional | 2005-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for mexiletine and Diabetic Neuropathies
| Article | Year |
|---|---|
[Diabetic neuropathy--concept, staging, diagnosis, treatment].
Topics: Aldehyde Reductase; Chronic Disease; Diabetic Neuropathies; Diagnosis, Differential; Enzyme Inhibito | 2002 |
[Symptomatic treatment of painful diabetic neuropathy].
Topics: Amines; Anti-Asthmatic Agents; Anticonvulsants; Antidepressive Agents; Antitussive Agents; Cyclohexa | 2005 |
Causes of neuropathic pain.
Topics: Animals; Blood Glucose; Diabetic Neuropathies; Humans; Leg; Lidocaine; Mexiletine; Pain; Regional Bl | 1993 |
Mexiletine. A review of its therapeutic use in painful diabetic neuropathy.
Topics: Diabetic Neuropathies; Humans; Mexiletine | 1998 |
6 trials available for mexiletine and Diabetic Neuropathies
| Article | Year |
|---|---|
A secondary analysis of PAIN-CONTRoLS: Pain's impact on sleep, fatigue, and activities of daily living.
Topics: Activities of Daily Living; Bayes Theorem; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hy | 2022 |
[Mexiletine in treatment of painful diabetic neuropathy].
Topics: Adult; Aged; Diabetic Neuropathies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Admi | 1994 |
A highly successful and novel model for treatment of chronic painful diabetic peripheral neuropathy.
Topics: Analgesics; Capsaicin; Diabetic Neuropathies; Exercise Therapy; Female; Glycated Hemoglobin; Humans; | 1993 |
Mexiletine in the symptomatic treatment of diabetic peripheral neuropathy.
Topics: Adult; Anti-Arrhythmia Agents; Diabetic Neuropathies; Double-Blind Method; Female; Humans; Male; Mex | 1997 |
Efficacy and safety of mexiletine in the treatment of painful diabetic neuropathy. The Mexiletine Study Group.
Topics: Anti-Arrhythmia Agents; Blood Pressure; Diabetic Neuropathies; Dose-Response Relationship, Drug; Dou | 1997 |
Mexiletine in the treatment of diabetic neuropathy.
Topics: Adult; Aged; Diabetic Neuropathies; Dose-Response Relationship, Drug; Double-Blind Method; Female; H | 1992 |
9 other studies available for mexiletine and Diabetic Neuropathies
| Article | Year |
|---|---|
Involvement of delta 1-opioid receptors in the antinociceptive effects of mexiletine in mice.
Topics: Animals; Diabetic Neuropathies; Male; Mexiletine; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antag | 1995 |
[Intravenous lidocaine in the treatment of post treatment neuropathy].
Topics: Administration, Oral; Aged; Diabetes Mellitus; Diabetic Neuropathies; Drug Therapy, Combination; Hum | 1994 |
[Antinociceptive effects of the enantiomorphs and its main metabolite in streptozotocin-induced diabetic mice].
Topics: Animals; Anti-Arrhythmia Agents; beta-Endorphin; Diabetes Mellitus, Experimental; Diabetic Neuropath | 2000 |
[Effect of mexiletine on spontaneous sensory afferent activity in spontaneous diabetic rats (WBN/Kob rats)].
Topics: Action Potentials; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Depression, Chemical; Diabet | 2000 |
[Treatment of pain in diabetic polyneuropathy].
Topics: Analgesics; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Carbamaze | 1991 |
The management of oral mexiletine and intravenous lidocaine to treat chronic painful symmetrical distal diabetic neuropathy.
Topics: Chronic Disease; Diabetic Neuropathies; Drug Therapy, Combination; Female; Humans; Infusions, Intrav | 1991 |
Relief of severe diabetic truncal pain with mexiletine.
Topics: Back Pain; Diabetic Neuropathies; Drug Administration Schedule; Humans; Male; Mexiletine; Middle Age | 1991 |
[Diabetic neuropathy--sensory abnormalities and treatment for painful neuropathy].
Topics: Alprostadil; Anticonvulsants; Antidepressive Agents, Tricyclic; Child; Diabetic Neuropathies; Female | 1991 |
[Diabetic neuropathies; new trends in physiopathology and treatment].
Topics: Diabetic Neuropathies; Evoked Potentials, Auditory; Humans; Mexiletine; Vitamin B 12 | 1989 |