mexiletine has been researched along with Death, Sudden in 13 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Death, Sudden: The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Many sudden deaths are presumed to be due to an arrhythmia, but the drugs best known for antiarrhythmic activity, the local anesthetic agents, have not been suitable prophylactic agents because of their toxicities and other undesirable pharmacologic characteristics." | 2.65 | Selection of an antiarrhythmic drug for a sudden-death-prevention trial. ( Duff, HJ; Oates, JA; Roden, DM; Woosley, RL, 1982) |
| " If side effects intervene that may cause continued therapy to be intolerable, changing the antiarrhythmic agent, as opposed to decreasing the dosage to an ineffective range, may be appropriate." | 1.27 | New directions in antiarrhythmic drug therapy. ( Somberg, JC, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gore, SM | 1 |
| Somberg, JC | 1 |
| Lüderitz, B | 1 |
| Manz, M | 1 |
| Steinbeck, G | 1 |
| Woosley, RL | 1 |
| Roden, DM | 2 |
| Duff, HJ | 1 |
| Oates, JA | 1 |
| Sgammini, HO | 1 |
| Evequoz, MC | 1 |
| Chuit, R | 1 |
| Atti, R | 1 |
| Santamarina, NO | 1 |
| Kuschnir, E | 1 |
| Winkle, RA | 1 |
| Pitt, B | 1 |
| Jequier, P | 1 |
| Jones, R | 1 |
| Mackintosh, A | 1 |
| Koch-Weser, J | 1 |
| Podrid, PJ | 1 |
| Haggman, DL | 1 |
| Maloney, JD | 1 |
| Morant, VA | 1 |
| Castle, LW | 1 |
| King-Rankine, M | 1 |
| Goormastic, M | 1 |
| Popławska, W | 1 |
| Chlewicka, I | 1 |
| Wójcik, E | 1 |
| Paczkowski, D | 1 |
| Walczak, F | 1 |
| Podleśny, J | 1 |
3 reviews available for mexiletine and Death, Sudden
| Article | Year |
|---|---|
Sudden cardiac death: role of left ventricular dysfunction.
Topics: Arrhythmias, Cardiac; Coronary Disease; Death, Sudden; Electrocardiography; Heart Ventricles; Humans | 1982 |
Prevention of sudden coronary death by chronic antiarrhythmic therapy.
Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Bretylium Compounds; Clinical Trials as Topic; Death, | 1978 |
The role of antiarrhythmic drugs in prevention of sudden cardiac death.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Comple | 1985 |
4 trials available for mexiletine and Death, Sudden
| Article | Year |
|---|---|
Selection of an antiarrhythmic drug for a sudden-death-prevention trial.
Topics: Acecainide; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneac | 1982 |
[Treatment of arrhythmias with high risk of sudden death in chronic Chagas' cardiopathy with oral mexiletine. Evaluation with 24-hour ambulatory electrocardiographic monitoring (Holter)].
Topics: Adult; Aged; Arrhythmias, Cardiac; Chagas Cardiomyopathy; Clinical Trials as Topic; Death, Sudden; E | 1983 |
Prevention of sudden coronary death by chronic antiarrhythmic therapy.
Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Bretylium Compounds; Clinical Trials as Topic; Death, | 1978 |
The role of antiarrhythmic drugs in prevention of sudden cardiac death.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Comple | 1985 |
8 other studies available for mexiletine and Death, Sudden
| Article | Year |
|---|---|
Mexiletine after myocardial infarction.
Topics: Death, Sudden; Humans; Mexiletine; Myocardial Infarction; Propylamines | 1981 |
New directions in antiarrhythmic drug therapy.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benz | 1984 |
[Sudden heart death in ventricular heart rhythm disorders: possibilities and limits of long-term therapy].
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Death, Sudden; Disopyramide; German | 1984 |
Clinical efficacy of antiarrhythmic drugs in prevention of sudden coronary death.
Topics: Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Coronary Angiography; Coronary Artery Bypas | 1982 |
Letter: Fatal mexiletine overdose.
Topics: Adult; Death, Sudden; Heart Block; Humans; Male; Mexiletine; Propylamines; Suicide | 1976 |
Antiarrhythmic drugs. Clinical pharmacology of the old and the new agents.
Topics: Acecainide; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death, Sudden; Delayed-Action | 1985 |
Mexiletine therapy in patients with chronic drug-resistant malignant ventricular arrhythmias. Clinical efficacy, safety, and side effects.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Arrhythmias, Cardiac; Chronic Disease; Death, Sudden; Dizz | 1986 |
[Remote results of the pharmacological treatment of patients with a high risk of sudden heart arrest in ventricular disorders of cardiac rhythm].
Topics: Adult; Aged; Amiodarone; Death, Sudden; Female; Heart Arrest; Humans; Male; Mexiletine; Middle Aged; | 1987 |