mexiletine has been researched along with Cramp in 5 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the safety and tolerability of mexiletine in a phase II double-blind randomized controlled trial of sporadic amyotrophic lateral sclerosis (SALS)." | 9.22 | A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression. ( Atassi, N; Barohn, RJ; Brown, RH; Cudkowicz, ME; Distad, JB; Graves, M; Greenblatt, DJ; Knox, AS; Macklin, EA; Parziale, N; Pestronk, A; Quinn, C; Salameh, JS; Shefner, JM; Simmons, Z; Swenson, A; Trivedi, J; Weiss, MD, 2016) |
| "Muscle cramps are often associated with lower motoneuron disorders, but features of cramps in Machado-Joseph disease patients have never been studied." | 5.32 | Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment. ( Arai, K; Hattori, T; Kanai, K; Kuwabara, S; Ogawara, K; Sung, JY, 2003) |
| "To determine the safety and tolerability of mexiletine in a phase II double-blind randomized controlled trial of sporadic amyotrophic lateral sclerosis (SALS)." | 5.22 | A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression. ( Atassi, N; Barohn, RJ; Brown, RH; Cudkowicz, ME; Distad, JB; Graves, M; Greenblatt, DJ; Knox, AS; Macklin, EA; Parziale, N; Pestronk, A; Quinn, C; Salameh, JS; Shefner, JM; Simmons, Z; Swenson, A; Trivedi, J; Weiss, MD, 2016) |
| "Threshold tracking was used to measure multiple excitability indices (strength-duration time constant, rheobase, refractoriness, supernormality, and threshold electrotonus) in median motor axons of 20 patients with neuropathic pain or muscle cramping, before and 3 months after treatment with oral 300 mg mexiletine per day." | 5.11 | The effects of mexiletine on excitability properties of human median motor axons. ( Hattori, T; Hiraga, A; Kanai, K; Kuwabara, S; Misawa, S; Nakata, M; Ogawara, K; Tamura, N, 2005) |
| "Muscle cramps are often associated with lower motoneuron disorders, but features of cramps in Machado-Joseph disease patients have never been studied." | 1.32 | Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment. ( Arai, K; Hattori, T; Kanai, K; Kuwabara, S; Ogawara, K; Sung, JY, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Katzberg, HD | 1 |
| Adiao, KJB | 1 |
| Espiritu, AI | 1 |
| Bagnas, MAC | 1 |
| Weiss, MD | 1 |
| Macklin, EA | 1 |
| Simmons, Z | 1 |
| Knox, AS | 1 |
| Greenblatt, DJ | 1 |
| Atassi, N | 1 |
| Graves, M | 1 |
| Parziale, N | 1 |
| Salameh, JS | 1 |
| Quinn, C | 1 |
| Brown, RH | 1 |
| Distad, JB | 1 |
| Trivedi, J | 1 |
| Shefner, JM | 1 |
| Barohn, RJ | 1 |
| Pestronk, A | 1 |
| Swenson, A | 1 |
| Cudkowicz, ME | 1 |
| Kanai, K | 2 |
| Kuwabara, S | 2 |
| Arai, K | 1 |
| Sung, JY | 1 |
| Ogawara, K | 2 |
| Hattori, T | 2 |
| Misawa, S | 1 |
| Tamura, N | 1 |
| Hiraga, A | 1 |
| Nakata, M | 1 |
2 reviews available for mexiletine and Cramp
| Article | Year |
|---|---|
Case Studies in Management of Muscle Cramps.
Topics: Adult; Disease Management; Female; Humans; Male; Mexiletine; Middle Aged; Muscle Cramp; Pregnancy; V | 2020 |
Efficacy and safety of mexiletine in amyotrophic lateral sclerosis: a systematic review of randomized controlled trials.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Female; Humans; Male; Mexiletine; Middle Aged; Muscle Cr | 2020 |
2 trials available for mexiletine and Cramp
| Article | Year |
|---|---|
A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression.
Topics: Amyotrophic Lateral Sclerosis; Disease Progression; Dose-Response Relationship, Drug; Female; Follow | 2016 |
The effects of mexiletine on excitability properties of human median motor axons.
Topics: Action Potentials; Administration, Oral; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Axons; | 2005 |
1 other study available for mexiletine and Cramp
| Article | Year |
|---|---|
Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment.
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Axons; Electromyography; Female; Humans; Machado-Joseph D | 2003 |