mexiletine has been researched along with Coronary Disease in 45 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a controlled randomized cross-over trial, 21 patients with coronary artery disease and frequent ventricular arrhythmias were studied to test the efficacy and tolerance of mexiletine 200 mg t." | 9.06 | [Anti-arrhythmia effectiveness and tolerance of retard in comparison with standard mexiletine]. ( Geibel, A; Hohnloser, S; Hust, M; Just, H; Meinertz, T; Zehender, M, 1987) |
| "In 12 patients with coronary artery disease, 11 of them with previous myocardial infarction, the antiarrhythmic effects of orally administered flecainide (F." | 9.05 | [Antiarrhythmic efficacy of mexiletine, propafenone and flecainide in ventricular premature beats. A comparative study in patients after myocardial infarction (author's transl)]. ( Fabry, E; Klempt, HW; Nayebagha, A, 1982) |
| "The effects of lidocaine, tocainide and mexiletine were examined in 17 patients with coronary artery disease and chronic, recurrent, sustained ventricular tachycardia (VT) or ventricular fibrillation and inducible VT." | 7.67 | Efficacy of class Ib (lidocaine-like) antiarrhythmic agents for prevention of sustained ventricular tachycardia secondary to coronary artery disease. ( Easley, AR; Mann, DE; Reiter, MJ, 1987) |
| "The efficacy of combination therapy using a type IA agent (quinidine or procainamide) and a type IB agent (mexiletine) in suppressing inducible sustained ventricular tachyarrhythmias was studied in 23 patients undergoing serial drug testing with programmed stimulation." | 7.67 | Efficacy of combination therapy with mexiletine and a type IA agent for inducible ventricular tachyarrhythmias secondary to coronary artery disease. ( Greenspan, AM; Horowitz, LN; Rae, AP; Sokoloff, NM; Spielman, SR; Webb, CR, 1985) |
| "A review of studies of mexiletine, a class I antiarrhythmic drug, supports its use in patients with ventricular arrhythmias or in sinus rhythm." | 6.15 | Hemodynamic effects of mexiletine. ( Shanks, RG, 1984) |
| "Moricizine (moracizine) is a new class I antiarrythmic drug which is undergoing a large scale clinical trial at present." | 5.28 | The effect of pretreatment with moricizine on early arrhythmia resulting from myocardial ischemia in rats. ( Hashimoto, K; He, ZS; Komori, S; Tamura, K, 1992) |
| "In a controlled randomized cross-over trial, 21 patients with coronary artery disease and frequent ventricular arrhythmias were studied to test the efficacy and tolerance of mexiletine 200 mg t." | 5.06 | [Anti-arrhythmia effectiveness and tolerance of retard in comparison with standard mexiletine]. ( Geibel, A; Hohnloser, S; Hust, M; Just, H; Meinertz, T; Zehender, M, 1987) |
| "In 12 patients with coronary artery disease, 11 of them with previous myocardial infarction, the antiarrhythmic effects of orally administered flecainide (F." | 5.05 | [Antiarrhythmic efficacy of mexiletine, propafenone and flecainide in ventricular premature beats. A comparative study in patients after myocardial infarction (author's transl)]. ( Fabry, E; Klempt, HW; Nayebagha, A, 1982) |
| "The effects of lidocaine, tocainide and mexiletine were examined in 17 patients with coronary artery disease and chronic, recurrent, sustained ventricular tachycardia (VT) or ventricular fibrillation and inducible VT." | 3.67 | Efficacy of class Ib (lidocaine-like) antiarrhythmic agents for prevention of sustained ventricular tachycardia secondary to coronary artery disease. ( Easley, AR; Mann, DE; Reiter, MJ, 1987) |
| "The efficacy of combination therapy using a type IA agent (quinidine or procainamide) and a type IB agent (mexiletine) in suppressing inducible sustained ventricular tachyarrhythmias was studied in 23 patients undergoing serial drug testing with programmed stimulation." | 3.67 | Efficacy of combination therapy with mexiletine and a type IA agent for inducible ventricular tachyarrhythmias secondary to coronary artery disease. ( Greenspan, AM; Horowitz, LN; Rae, AP; Sokoloff, NM; Spielman, SR; Webb, CR, 1985) |
| "Forty-eight patients with ischaemic heart disease received oral mexiletine for the control or prevention of ventricular arrhythmias." | 3.66 | Long-term oral antiarrhythmic therapy with mexiletine. ( Adgey, AA; Campbell, NP; Pantridge, JF, 1978) |
| "Moricizine (moracizine) is a new class I antiarrythmic drug which is undergoing a large scale clinical trial at present." | 1.28 | The effect of pretreatment with moricizine on early arrhythmia resulting from myocardial ischemia in rats. ( Hashimoto, K; He, ZS; Komori, S; Tamura, K, 1992) |
| "Aggravation of ventricular arrhythmia is a serious, potentially lethal, side effect that can occur with all antiarrhythmic agents." | 1.27 | Clinical predictors of arrhythmia worsening by antiarrhythmic drugs. ( Lampert, S; Lown, B; Podrid, PJ; Slater, W, 1988) |
| "Protection from arrhythmias seems to be related to the combined presence of a noncompetitive adrenergic blockade associated with salutary effects on coronary circulation." | 1.27 | The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity. ( Schwartz, PJ; Vanoli, E; Zaza, A; Zuanetti, G, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (84.44) | 18.7374 |
| 1990's | 5 (11.11) | 18.2507 |
| 2000's | 2 (4.44) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mátyus, P | 1 |
| Varga, I | 1 |
| Rettegi, T | 1 |
| Simay, A | 1 |
| Kállay, N | 1 |
| Károlyházy, L | 1 |
| Kocsis, A | 1 |
| Varró, A | 1 |
| Pénzes, I | 1 |
| Papp, JG | 1 |
| Klempt, HW | 1 |
| Nayebagha, A | 1 |
| Fabry, E | 1 |
| Lüderitz, B | 2 |
| Shanks, RG | 2 |
| Hellestrand, KJ | 1 |
| Hoffmann, A | 1 |
| Schütz, E | 1 |
| White, R | 1 |
| Follath, F | 1 |
| Burckhardt, D | 1 |
| Wester, HA | 1 |
| Mouselimis, N | 1 |
| Duff, HJ | 2 |
| Roden, D | 1 |
| Primm, RK | 1 |
| Oates, JA | 1 |
| Woosley, RL | 1 |
| Santinelli, V | 2 |
| Chiariello, M | 3 |
| Stanislao, M | 1 |
| Condorelli, M | 3 |
| Ferro, G | 2 |
| Tari, MG | 2 |
| Vigorito, C | 1 |
| Ungaro, B | 1 |
| Fritz, KW | 1 |
| Riethmüller, H | 1 |
| Hempelmann, G | 1 |
| Winkle, RA | 1 |
| Perrenoud, JJ | 1 |
| Breithardt, G | 1 |
| Seipel, L | 1 |
| Abendroth, RR | 1 |
| Loogen, F | 1 |
| Meinertz, T | 2 |
| Kasper, W | 1 |
| Stengel, E | 1 |
| Waldecker, B | 1 |
| Löllgen, H | 1 |
| Jähnchen, E | 1 |
| Bechtold, H | 1 |
| Just, J | 1 |
| Pitt, B | 1 |
| Yoon, MS | 1 |
| Han, J | 1 |
| Logan, KR | 1 |
| McIlwaine, WJ | 1 |
| Adgey, AA | 2 |
| Pantridge, JF | 2 |
| Boyle, DM | 1 |
| Chapman, C | 1 |
| Kinney, C | 1 |
| McIlmoyle, EL | 1 |
| Salathia, K | 1 |
| Kána, A | 1 |
| Florcíková, L | 1 |
| Jurecková, A | 1 |
| Klabusay, L | 1 |
| Simícek, J | 1 |
| Tomecková, A | 1 |
| Komori, S | 4 |
| Sano, S | 1 |
| Li, BH | 1 |
| Matsumura, K | 1 |
| Naitoh, A | 1 |
| Mochizuki, S | 1 |
| Ishihara, T | 1 |
| Watanabe, A | 1 |
| Umetani, K | 1 |
| Ijiri, H | 1 |
| Sawanobori, T | 1 |
| Tamura, K | 2 |
| Kane, KA | 1 |
| Parratt, JR | 1 |
| Saitoh, M | 1 |
| Aye, NN | 1 |
| Nakazawa, T | 1 |
| Hashimoto, K | 2 |
| Merx, W | 1 |
| Henning, B | 1 |
| Brunner, H | 1 |
| De Bakker, JM | 1 |
| Härtel, H | 1 |
| Campbell, NP | 1 |
| McComish, M | 1 |
| Kitson, D | 1 |
| Robinson, C | 1 |
| Jewitt, DE | 1 |
| He, ZS | 1 |
| Fujimoto, Y | 1 |
| Fukuki, M | 1 |
| Hirokane, Y | 1 |
| Kotake, H | 1 |
| Mashiba, H | 1 |
| Nitsch, J | 1 |
| Leffler, J | 1 |
| Accettura, D | 1 |
| De Toma, L | 1 |
| Lagioia, R | 1 |
| Mastropasqua, F | 1 |
| Mangini, SG | 1 |
| Scrutinio, D | 1 |
| Rizzon, P | 1 |
| Zehender, M | 1 |
| Geibel, A | 1 |
| Hust, M | 1 |
| Hohnloser, S | 1 |
| Just, H | 1 |
| Cannon, NJ | 1 |
| Sheldon, RS | 1 |
| Tanabe, T | 1 |
| Yoshikawa, H | 1 |
| Tagawa, R | 1 |
| Furuya, H | 1 |
| Ide, M | 1 |
| Goto, Y | 1 |
| Liusov, VA | 1 |
| Dudaev, VA | 1 |
| Borodkin, VV | 1 |
| Rudakov, AV | 1 |
| Reiter, MJ | 1 |
| Easley, AR | 1 |
| Mann, DE | 1 |
| Slater, W | 1 |
| Lampert, S | 1 |
| Podrid, PJ | 1 |
| Lown, B | 1 |
| Fazio, S | 1 |
| Villari, B | 1 |
| Petitto, M | 1 |
| Santomauro, M | 1 |
| Iacono, C | 1 |
| Celentano, A | 1 |
| de Divitiis, O | 1 |
| Katz, A | 1 |
| Buskila, D | 1 |
| Sukenik, S | 1 |
| Horowitz, JD | 1 |
| Dynon, MK | 1 |
| Woodward, E | 1 |
| Sia, ST | 1 |
| Macdonald, PS | 1 |
| Morgan, DJ | 1 |
| Goble, AJ | 1 |
| Louis, WJ | 1 |
| Schwartz, PJ | 2 |
| Vanoli, E | 2 |
| Zaza, A | 1 |
| Zuanetti, G | 1 |
| Harron, DW | 1 |
| Brezina, M | 1 |
| Lillie, C | 1 |
| Kobinger, W | 1 |
| Greenspan, AM | 1 |
| Spielman, SR | 1 |
| Webb, CR | 1 |
| Sokoloff, NM | 1 |
| Rae, AP | 1 |
| Horowitz, LN | 1 |
5 reviews available for mexiletine and Coronary Disease
| Article | Year |
|---|---|
Novel antiarrhythmic compounds with combined class IB and class III mode of action.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Coronary Disease; Delayed Rectifier Potassium Ch | 2004 |
Hemodynamic effects of mexiletine.
Topics: Animals; Arrhythmias, Cardiac; Bradycardia; Coronary Disease; Hemodynamics; Humans; Male; Mexiletine | 1984 |
Comparison of the efficacy of newly developed antiarrhythmic drugs in the treatment of ventricular tachyarrhythmias.
Topics: Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Coronary Disease; Encaini | 1984 |
[Utilization of anti-arrhythmic drugs].
Topics: Action Potentials; Ajmaline; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Digital | 1980 |
Sudden cardiac death: role of left ventricular dysfunction.
Topics: Arrhythmias, Cardiac; Coronary Disease; Death, Sudden; Electrocardiography; Heart Ventricles; Humans | 1982 |
10 trials available for mexiletine and Coronary Disease
| Article | Year |
|---|---|
[Antiarrhythmic efficacy of mexiletine, propafenone and flecainide in ventricular premature beats. A comparative study in patients after myocardial infarction (author's transl)].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Coronary Disease; Electrocardiogr | 1982 |
Hemodynamic effects of mexiletine.
Topics: Animals; Arrhythmias, Cardiac; Bradycardia; Coronary Disease; Hemodynamics; Humans; Male; Mexiletine | 1984 |
[The effect of anti-arrhythmic drugs on myocardial function (author's transl)].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Coronary Disease; Depression, Chemical; Disopyramide; Echocardi | 1982 |
Serial electrophysiological testing of antiarrhythmic drug efficacy in patients with recurrent ventricular tachycardia.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Clinical Trials as Topic; Coronary | 1980 |
Comparison of the antiarrhythmic activity of mexiletine and lorcainide on ventricular arrhythmias.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Clinical Trials as Top | 1982 |
A comparison of mexiletine and a slow release formulation of mexiletine in patients admitted to a coronary care unit [proceedings].
Topics: Arrhythmias, Cardiac; Coronary Disease; Delayed-Action Preparations; Humans; Mexiletine; Propylamine | 1980 |
[Anti-arrhythmia action of mexiletine (KO 1173) on ventricular ectopic arrhythmias in dependence of its serum concentration].
Topics: Cardiac Complexes, Premature; Clinical Trials as Topic; Coronary Disease; Drug Evaluation; Female; H | 1977 |
[Comparison of mexiletine and dihydroquinidine in the treatment of ventricular asystolic arrhythmia].
Topics: Adult; Aged; Arrhythmias, Cardiac; Asthenia; Cardiac Complexes, Premature; Clinical Trials as Topic; | 1985 |
[Anti-arrhythmia effectiveness and tolerance of retard in comparison with standard mexiletine].
Topics: Adult; Aged; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Clinical Trials as Topic; Coronary | 1987 |
[Antiarrhythmic efficacy and tolerance of slow-release mexiletine in comparison with hydroquinidine retard].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Delayed-Action Preparat | 1987 |
31 other studies available for mexiletine and Coronary Disease
| Article | Year |
|---|---|
[Drug therapy of arrhythmia in coronary cardiopathy].
Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Cardiac Comp | 1983 |
Suppression of high-grade ventricular ectopic activity by antiarrhythmic drug treatment as a marker for survival in patients with chronic coronary artery disease.
Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Female; Hum | 1984 |
Mexiletine in the treatment of resistant ventricular arrhythmias: enhancement of efficacy and reduction of dose-related side effects by combination with quinidine.
Topics: Arrhythmias, Cardiac; Coronary Disease; Diarrhea; Dose-Response Relationship, Drug; Drug Therapy, Co | 1983 |
Mexiletine for treatment of sustained recurrent ventricular tachycardia.
Topics: Aged; Coronary Disease; Female; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Propylamine | 1983 |
Intropic effects of several antiarrhythmic drugs.
Topics: Ajmaline; Anti-Arrhythmia Agents; Aprindine; Blood Pressure; Bunaftine; Coronary Disease; Disopyrami | 1983 |
[Comparative haemodynamic studies with mexiletine and lidocaine in patients with coronary heart disease after aorto-coronary bypass (author's transl)].
Topics: Cardiac Output; Coronary Artery Bypass; Coronary Disease; Hemodynamics; Humans; Lidocaine; Mexiletin | 1981 |
Clinical efficacy of antiarrhythmic drugs in prevention of sudden coronary death.
Topics: Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Coronary Angiography; Coronary Artery Bypas | 1982 |
Electrophysiologic effects of mexiletine on normal and ischemic ventricles.
Topics: Animals; Coronary Disease; Diastole; Dogs; Electrocardiography; Electrophysiology; Heart Conduction | 1982 |
Recurrence of ventricular fibrillation in acute ischemic heart disease.
Topics: Acute Disease; Anti-Arrhythmia Agents; Coronary Disease; Female; Heart Arrest; Humans; Lidocaine; Ma | 1981 |
[Experience with mexiletin in the treatment of ventricular arrhythmias (author's transl)].
Topics: Aged; Arrhythmias, Cardiac; Coronary Disease; Female; Heart Ventricles; Humans; Male; Mexiletine; Mi | 1980 |
Effects of bidisomide (SC-40230), a new class I antiarrhythmic agent, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats; comparison with mexiletine and disopyramide.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Complexes, Premature; Coronary Disease; Dis | 1995 |
Effects of NS-2, a new class 1 antiarrhythmic agent, and AFD-19, its active metabolite, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats: comparison with disopyramide and mexiletine.
Topics: Amino Alcohols; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Coronary Dise | 1994 |
Effects of HNS-32, a novel antiarrhythmic drug, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Coronary Disease; Dose-Response Relationship, Drug; | 2000 |
[Effects of mexiletine and lidocaine on myocardial performance in heart disease patients in various functional classes].
Topics: Adult; Arrhythmias, Cardiac; Cardiac Output; Coronary Disease; Heart Diseases; Heart Rate; Humans; L | 1978 |
Long-term oral antiarrhythmic therapy with mexiletine.
Topics: Administration, Oral; Arrhythmias, Cardiac; Coronary Disease; Female; Humans; Male; Mexiletine; Midd | 1978 |
Clinical electrophysiological effects of mexiletine.
Topics: Adolescent; Adult; Aged; Coronary Disease; Depression, Chemical; Female; Heart Conduction System; Hu | 1977 |
Haemodynamic effects of a new anti-arrhythmic agent, mexiletine (Kö 1173) in ischaemic heart disease.
Topics: Arrhythmias, Cardiac; Blood Pressure; Brachial Artery; Cardiac Output; Coronary Disease; Heart Rate; | 1975 |
The effect of pretreatment with moricizine on early arrhythmia resulting from myocardial ischemia in rats.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Disopyramide; Hemodynamics; Male; Mexiletine; Moric | 1992 |
Clinical study on coupling interval of ventricular premature contraction in patients with organic heart disease.
Topics: Cardiac Complexes, Premature; Coronary Disease; Disopyramide; Electrocardiography, Ambulatory; Femal | 1991 |
[Acute myocardial uptake of lidocaine, mexiletine and amiodarone].
Topics: Amiodarone; Anti-Arrhythmia Agents; Cardiac Catheterization; Coronary Disease; Humans; Injections, I | 1990 |
Mexiletine-quinidine in isolated hearts: an interaction involving the sodium channel.
Topics: Action Potentials; Animals; Coronary Disease; Drug Synergism; Drug Therapy, Combination; Heart; Hear | 1989 |
Evaluation of antiarrhythmic drug efficacy using holter electrocardiographic technique.
Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Complexes, | 1985 |
[Changes in thrombocyte-vascular hemostasis and cyclic nucleotide levels after anti-arrhythmia therapy in patients with ischemic heart disease].
Topics: Adult; Aged; Arrhythmias, Cardiac; Coronary Disease; Disopyramide; Female; Humans; Male; Mexiletine; | 1989 |
Efficacy of class Ib (lidocaine-like) antiarrhythmic agents for prevention of sustained ventricular tachycardia secondary to coronary artery disease.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Coronary Disease; Electrophysiology; Female; Heart Ventricles; | 1987 |
Clinical predictors of arrhythmia worsening by antiarrhythmic drugs.
Topics: Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Electrocardiography; Encai | 1988 |
Oral mexiletine-theophylline interaction.
Topics: Administration, Oral; Aged; Coronary Disease; Drug Interactions; Humans; Lung Diseases, Obstructive; | 1987 |
Short-term myocardial uptake of lidocaine and mexiletine in patients with ischemic heart disease.
Topics: Adult; Aged; Blood Flow Velocity; Cardiac Catheterization; Coronary Circulation; Coronary Disease; F | 1986 |
An experimental approach to the choice of antiarrhythmic therapy.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Diltiazem | 1986 |
The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Disease M | 1985 |
Antifibrillatory properties of alinidine after coronary artery occlusion in rats.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiovascular Agents; Clonidine; Coronary Di | 1985 |
Efficacy of combination therapy with mexiletine and a type IA agent for inducible ventricular tachyarrhythmias secondary to coronary artery disease.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Coronary Disease; Drug Therapy, Com | 1985 |