mexiletine has been researched along with Chronic Kidney Failure in 11 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We monitored the plasma levels of mexiletine in 20 dialysis patients with severe cardiac arrhythmias after repeated oral administration and the elimination by various dialysis procedures." | 3.67 | [Mexiletine in terminal renal failure and various dialysis procedures]. ( Aboudan, F; Evers, J; Finke, K; Messer, W, 1989) |
| "Mexiletine is a type 1B antiarrhythmic drug similar to lidocaine." | 1.28 | Prolongation of ventricular depolarization. ECG manifestation of mexiletine toxicity. ( Chandrasekaran, K; Hammill, SC; Nora, MO; Reeder, GS, 1989) |
| "Mexiletine is an investigational antiarrhythmic drug eliminated primarily by hepatic metabolism." | 1.27 | Pharmacokinetics and nondialyzability of mexiletine in renal failure. ( Stone, WJ; Wang, T; Woosley, RL; Wuellner, D, 1985) |
| "Mexiletine (Mexitil) is an effective antiarrhythmic drug for the treatment of ventricular dysrhythmias." | 1.26 | Pharmacokinetics of mexiletine in renal insufficiency. ( Baudinet, G; Carlier, J; de Landsheere, C; Dresse, A; El Allaf, D; Henrard, L; Quinaux, N, 1980) |
| "Although pharmacodynamic factors are very important in regard to the need for dose adaptation of mexiletine, pharmacokinetic factors also play a role." | 1.26 | Adaptation of the dose of mexiletine according to pharmacokinetic data. ( Bogaert, M, 1980) |
| "2 Mexiletine was administered orally three times daily for 10 days to 15 patients with chronic renal failure (creatinine clearance lower than 30 ml/min) and to 9 subjects with normal renal function." | 1.26 | Pharmacokinetics of mexiletine in renal insufficiency. ( Carlier, J; Crochelet, L; Delapierre, D; Dresse, A; El Allaf, D; Henrard, L, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (90.91) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, Y | 1 |
| Wei, J | 1 |
| Farid, NA | 1 |
| White, SM | 1 |
| Jones, TE | 1 |
| Reece, PA | 1 |
| Fisher, GC | 1 |
| Baudinet, G | 1 |
| Henrard, L | 2 |
| Quinaux, N | 1 |
| El Allaf, D | 2 |
| de Landsheere, C | 1 |
| Carlier, J | 2 |
| Dresse, A | 2 |
| Bogaert, M | 1 |
| Nitsch, J | 1 |
| Steinbeck, G | 1 |
| Lüderitz, B | 1 |
| Crochelet, L | 1 |
| Delapierre, D | 1 |
| Evers, J | 1 |
| Messer, W | 1 |
| Aboudan, F | 1 |
| Finke, K | 1 |
| Nora, MO | 1 |
| Chandrasekaran, K | 1 |
| Hammill, SC | 1 |
| Reeder, GS | 1 |
| Kuno, T | 1 |
| Takahashi, S | 1 |
| Hibiya, K | 1 |
| Shimada, A | 1 |
| Nagura, Y | 1 |
| Takeuchi, M | 1 |
| Hatano, M | 1 |
| Wang, T | 1 |
| Wuellner, D | 1 |
| Woosley, RL | 1 |
| Stone, WJ | 1 |
1 trial available for mexiletine and Chronic Kidney Failure
| Article | Year |
|---|---|
[Effect of kidney, liver or heart insufficiency on blood mexiletine levels].
Topics: Arrhythmias, Cardiac; Biological Availability; Chromatography, Gas; Chronic Disease; Heart Failure; | 1982 |
10 other studies available for mexiletine and Chronic Kidney Failure
| Article | Year |
|---|---|
Mexiletine Suppressed Recurrent Ventricular Tachycardia Triggered by Hemodialysis in an Old Patient with LQT2.
Topics: Anti-Arrhythmia Agents; Electrocardiography; Female; Follow-Up Studies; Humans; Kidney Failure, Chro | 2019 |
Determination of mexiletine and its metabolites in serum by liquid chromatography with fluorescence detection.
Topics: Chemical Phenomena; Chemistry; Chromatography, Liquid; Fluorescence; Humans; Kidney Failure, Chronic | 1983 |
Mexiletine removal by peritoneal dialysis.
Topics: Humans; Kidney Failure, Chronic; Male; Mexiletine; Middle Aged; Peritoneal Dialysis; Peritoneal Dial | 1983 |
Pharmacokinetics of mexiletine in renal insufficiency.
Topics: Administration, Oral; Half-Life; Humans; Injections, Intravenous; Intestinal Absorption; Kidney Fail | 1980 |
Adaptation of the dose of mexiletine according to pharmacokinetic data.
Topics: Administration, Oral; Humans; Injections, Intravenous; Kidney Failure, Chronic; Kinetics; Mexiletine | 1980 |
Pharmacokinetics of mexiletine in renal insufficiency.
Topics: Aged; Female; Half-Life; Humans; Kidney Failure, Chronic; Kinetics; Male; Mexiletine; Middle Aged; P | 1982 |
[Mexiletine in terminal renal failure and various dialysis procedures].
Topics: Adult; Aged; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Female; Heart Ventricles; Hemof | 1989 |
Prolongation of ventricular depolarization. ECG manifestation of mexiletine toxicity.
Topics: Aged; Arrhythmias, Cardiac; Electrocardiography; Female; Heart Conduction System; Humans; Kidney Fai | 1989 |
[The effects and pharmacokinetics of mexiletine in ventricular arrhythmia in maintenance hemodialysis patients].
Topics: Aged; Arrhythmias, Cardiac; Female; Humans; Kidney Failure, Chronic; Male; Mexiletine; Middle Aged; | 1987 |
Pharmacokinetics and nondialyzability of mexiletine in renal failure.
Topics: Administration, Oral; Adult; Creatinine; Humans; Hydrogen-Ion Concentration; Kidney Failure, Chronic | 1985 |