mexiletine has been researched along with Chronic Disease in 28 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "we report on the first case of a woman affected by chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and recessive myotonia congenita (MC), treated with mexiletine." | 7.96 | Chronic inflammatory demyelinating polyradiculoneuropathy relapse after mexiletine withdrawal in a patient with concomitant myotonia congenita: A case report on a potential treatment option. ( Biasini, F; Bramanti, P; Calabrò, RS; Naro, A; Portaro, S, 2020) |
| "The antiarrhythmic efficacy of mexiletine hydrochloride (Mexitil) was evaluated in 100 patients with potentially lethal and drug-resistant ventricular arrhythmia." | 7.68 | Mexiletine. Long-term efficacy and side effects in patients with chronic drug-resistant potentially lethal ventricular arrhythmias. ( Aragon, E; Faitel, K; Frumin, H; Kerin, NZ; Marinescu, G; Rubenfire, M, 1990) |
| " The high incidence of side-effects was probably due to the high dosage used." | 6.65 | Evaluation of the antiarrhythmic efficacy of mexiletine in patients with chronic ventricular arrhythmias. ( Van Durme, JP, 1980) |
| "Static and dynamic allodynia occurred in a rat model of neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve." | 5.35 | Effect of mexiletine on dynamic allodynia induced by chronic constriction injury of the sciatic nerve in rats. ( Kurebayashi, Y; Nakazato-Imasato, E; Tanimoto-Mori, S, 2009) |
| "Mexiletine was well absorbed from the intestinal tract." | 5.27 | Pharmacokinetics and the antiarrhythmic effect of mexiletine in patients with chronic ventricular arrhythmias. ( Ebihara, A; Hashimoto, T; Hosoda, S; Kondo, K; Ohashi, K; Oka, T, 1984) |
| " The long therapeutic half-life of the drug allowed convenient dosage schedule and good compliance." | 5.26 | Mexiletine. Use in control of chronic drug-resistant ventricular arrhythmia. ( Abinader, EG; Cooper, M, 1979) |
| "we report on the first case of a woman affected by chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and recessive myotonia congenita (MC), treated with mexiletine." | 3.96 | Chronic inflammatory demyelinating polyradiculoneuropathy relapse after mexiletine withdrawal in a patient with concomitant myotonia congenita: A case report on a potential treatment option. ( Biasini, F; Bramanti, P; Calabrò, RS; Naro, A; Portaro, S, 2020) |
| "Mexiletine is thought to exert minimal negative inotropic actions, but its effects have not been evaluated in patients with severe congestive heart failure." | 3.68 | Cardiodepressant effects of mexiletine in patients with severe left ventricular dysfunction. ( Gottlieb, SS; Weinberg, M, 1992) |
| "The antiarrhythmic efficacy of mexiletine hydrochloride (Mexitil) was evaluated in 100 patients with potentially lethal and drug-resistant ventricular arrhythmia." | 3.68 | Mexiletine. Long-term efficacy and side effects in patients with chronic drug-resistant potentially lethal ventricular arrhythmias. ( Aragon, E; Faitel, K; Frumin, H; Kerin, NZ; Marinescu, G; Rubenfire, M, 1990) |
| "The efficacy of disopyramide (DP), mexiletine (MX), aprindine (AP) and cibenzoline (CZ) on ventricular arrhythmias was compared (single drug therapy)." | 3.67 | Therapeutic effectiveness and plasma levels of single or combination use of class I antiarrhythmic agents for ventricular arrhythmias. ( Furuya, H; Goto, Y; Tanabe, T; Yoshikawa, H, 1988) |
| "The clinical relevance of changes in pharmacokinetics of oral mexiletine (600 mg daily dose) was studied in 82 patients with ventricular arrhythmias and impaired liver, renal or heart function (control group n = 51, patients with liver cirrhosis n = 9, with renal insufficiency n = 14, or heart failure n = 8)." | 3.66 | Increase of mexiletine plasma levels due to delayed hepatic metabolism in patients with chronic liver disease. ( Lüderitz, B; Nitsch, J; Steinbeck, G, 1983) |
| " The high incidence of side-effects was probably due to the high dosage used." | 2.65 | Evaluation of the antiarrhythmic efficacy of mexiletine in patients with chronic ventricular arrhythmias. ( Van Durme, JP, 1980) |
| "neuropathic pain) is not very satisfactorily managed." | 2.44 | [Central and peripheral mechanisms in antinociception: current and future perspectives]. ( Fürst, Z, 2008) |
| "Mexiletine was used in an open-label study to evaluate its effectiveness in the treatment of this disorder." | 2.38 | Successful treatment for phantom pain. ( Davis, RW, 1993) |
| "Static and dynamic allodynia occurred in a rat model of neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve." | 1.35 | Effect of mexiletine on dynamic allodynia induced by chronic constriction injury of the sciatic nerve in rats. ( Kurebayashi, Y; Nakazato-Imasato, E; Tanimoto-Mori, S, 2009) |
| "Mexiletine was well absorbed from the intestinal tract." | 1.27 | Pharmacokinetics and the antiarrhythmic effect of mexiletine in patients with chronic ventricular arrhythmias. ( Ebihara, A; Hashimoto, T; Hosoda, S; Kondo, K; Ohashi, K; Oka, T, 1984) |
| " The long therapeutic half-life of the drug allowed convenient dosage schedule and good compliance." | 1.26 | Mexiletine. Use in control of chronic drug-resistant ventricular arrhythmia. ( Abinader, EG; Cooper, M, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (35.71) | 18.7374 |
| 1990's | 8 (28.57) | 18.2507 |
| 2000's | 7 (25.00) | 29.6817 |
| 2010's | 2 (7.14) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Portaro, S | 1 |
| Biasini, F | 1 |
| Bramanti, P | 1 |
| Naro, A | 1 |
| Calabrò, RS | 1 |
| Ermakov, S | 1 |
| Hoffmayer, KS | 1 |
| Gerstenfeld, EP | 1 |
| Scheinman, MM | 1 |
| Fürst, Z | 1 |
| Nakazato-Imasato, E | 2 |
| Tanimoto-Mori, S | 2 |
| Kurebayashi, Y | 1 |
| Morito, H | 1 |
| Ogawa, K | 1 |
| Kobayashi, N | 1 |
| Fukumoto, T | 1 |
| Asada, H | 1 |
| Fassoulaki, A | 1 |
| Patris, K | 1 |
| Sarantopoulos, C | 1 |
| Hogan, Q | 1 |
| Ida, M | 1 |
| Kuroiwa, Y | 1 |
| Takada, Y | 1 |
| Isobe, S | 1 |
| Okada, M | 1 |
| Ando, A | 1 |
| Nonokawa, M | 1 |
| Inden, Y | 1 |
| Tomita, Y | 1 |
| Suzuki, A | 1 |
| Hirai, M | 1 |
| Murohara, T | 1 |
| Toide, K | 1 |
| Kita, Y | 1 |
| Carroll, IR | 1 |
| Kaplan, KM | 1 |
| Mackey, SC | 1 |
| Ohashi, K | 1 |
| Ebihara, A | 1 |
| Hashimoto, T | 1 |
| Hosoda, S | 1 |
| Kondo, K | 1 |
| Oka, T | 1 |
| Nitsch, J | 2 |
| Steinbeck, G | 2 |
| Lüderitz, B | 2 |
| Van Durme, JP | 1 |
| Hedley, LR | 1 |
| Martin, B | 1 |
| Waterbury, LD | 1 |
| Clarke, DE | 1 |
| Hunter, JC | 1 |
| Colclough, G | 1 |
| Carter, A | 1 |
| Ackerman, WE | 2 |
| Davis, RW | 1 |
| Golikov, AP | 1 |
| Botolova, EN | 1 |
| Rudnev, DV | 1 |
| Lanchote, VL | 1 |
| Cesarino, EJ | 1 |
| Santos, VJ | 1 |
| Mere Júnior, Y | 1 |
| Santos, SR | 1 |
| Abinader, EG | 1 |
| Cooper, M | 1 |
| Gottlieb, SS | 1 |
| Weinberg, M | 1 |
| Colclough, GW | 1 |
| Juneja, MM | 1 |
| Bellinger, K | 1 |
| Kerin, NZ | 1 |
| Aragon, E | 1 |
| Marinescu, G | 1 |
| Faitel, K | 1 |
| Frumin, H | 1 |
| Rubenfire, M | 1 |
| Poggesi, L | 1 |
| Scarti, L | 1 |
| Ieri, A | 1 |
| Lanzetta, T | 1 |
| Grazzini, M | 1 |
| Del Bene, P | 1 |
| Masini, G | 1 |
| Del Citerna, F | 1 |
| Carnovali, M | 1 |
| Masotti, G | 1 |
| Haggman, DL | 1 |
| Maloney, JD | 1 |
| Morant, VA | 1 |
| Castle, LW | 1 |
| King-Rankine, M | 1 |
| Goormastic, M | 1 |
| Smetnev, AS | 1 |
| Golitsyn, SP | 1 |
| Levin, ER | 1 |
| Sokolov, SF | 1 |
| Koltunova, MI | 1 |
| Priori, SG | 1 |
| Bonazzi, O | 1 |
| Facchini, M | 1 |
| Varisco, T | 1 |
| Schwartz, PJ | 1 |
| Tanabe, T | 1 |
| Yoshikawa, H | 1 |
| Furuya, H | 1 |
| Goto, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy: a Prospective, Randomized Study.[NCT00954187] | 8 participants (Actual) | Interventional | 2009-11-30 | Terminated (stopped due to PI left institution) | |||
| Comparative Evaluation of Osteopathy Treatment Efficacy in Pain Support After Breast Surgery in Oncology[NCT01403168] | 28 participants (Actual) | Interventional | 2011-04-30 | Terminated (stopped due to Recruitment difficulties) | |||
| Management of Chronic Pain in Rehabilitation Project II Management of Chronic Pain in Persons With Amputation[NCT00006427] | Phase 4 | 125 participants | Interventional | 1996-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for mexiletine and Chronic Disease
| Article | Year |
|---|---|
[Central and peripheral mechanisms in antinociception: current and future perspectives].
Topics: Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocycl | 2008 |
[Diabetic neuropathy--concept, staging, diagnosis, treatment].
Topics: Aldehyde Reductase; Chronic Disease; Diabetic Neuropathies; Diagnosis, Differential; Enzyme Inhibito | 2002 |
Successful treatment for phantom pain.
Topics: Administration, Cutaneous; Aged; Chronic Disease; Clonidine; Drug Therapy, Combination; Female; Huma | 1993 |
7 trials available for mexiletine and Chronic Disease
| Article | Year |
|---|---|
The analgesic effect of gabapentin and mexiletine after breast surgery for cancer.
Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Antineoplastic Agents; Breast Neoplasms; Chr | 2002 |
The analgesic effect of gabapentin and mexiletine after breast surgery for cancer.
Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Antineoplastic Agents; Breast Neoplasms; Chr | 2002 |
The analgesic effect of gabapentin and mexiletine after breast surgery for cancer.
Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Antineoplastic Agents; Breast Neoplasms; Chr | 2002 |
The analgesic effect of gabapentin and mexiletine after breast surgery for cancer.
Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Antineoplastic Agents; Breast Neoplasms; Chr | 2002 |
Effects of antiarrhythmic agents on left ventricular function during exercise in patients with chronic left ventricular dysfunction.
Topics: Aged; Anti-Asthmatic Agents; Chronic Disease; Disopyramide; Exercise; Exercise Test; Female; Heart V | 2004 |
Evaluation of the antiarrhythmic efficacy of mexiletine in patients with chronic ventricular arrhythmias.
Topics: Arrhythmias, Cardiac; Atenolol; Chronic Disease; Clinical Trials as Topic; Disopyramide; Double-Blin | 1980 |
[Effect of kidney, liver or heart insufficiency on blood mexiletine levels].
Topics: Arrhythmias, Cardiac; Biological Availability; Chromatography, Gas; Chronic Disease; Heart Failure; | 1982 |
Enantioselectivity in the metabolism of mexiletine by conjugation in female patients with the arrhythmic form of chronic Chagas' heart disease.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Area Under Curve; Arrhythmias, Cardiac; Biotransformation; Chag | 1999 |
Efficacy of mexiletine in chronic ventricular arrhythmias: a multicentre double-blind medium-term trial.
Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Chronic Disease; | 1989 |
[Study of the comparative anti-arrhythmic effectiveness of allapinin, ethacizine and mexitil in patients with ventricular disorders of cardiac rhythm].
Topics: Aconitine; Aconitum; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Chronic Disease; Clinical Tria | 1988 |
18 other studies available for mexiletine and Chronic Disease
| Article | Year |
|---|---|
Chronic inflammatory demyelinating polyradiculoneuropathy relapse after mexiletine withdrawal in a patient with concomitant myotonia congenita: A case report on a potential treatment option.
Topics: Adult; Chronic Disease; Female; Follow-Up Studies; Humans; Mexiletine; Myotonia Congenita; Polyradic | 2020 |
Combination drug therapy for patients with intractable ventricular tachycardia associated with right ventricular cardiomyopathy.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmogenic Right Ventricular Dysplasia; Chronic Disease; Dr | 2014 |
Effect of mexiletine on dynamic allodynia induced by chronic constriction injury of the sciatic nerve in rats.
Topics: Analgesics; Animals; Chronic Disease; Constriction, Pathologic; Dose-Response Relationship, Drug; Hy | 2009 |
Drug-induced hypersensitivity syndrome followed by persistent arthritis.
Topics: Anti-Arrhythmia Agents; Arthralgia; Arthritis; Celecoxib; Chronic Disease; Cyclooxygenase 2 Inhibito | 2012 |
Pharmacologic investigation of the mechanism underlying cold allodynia using a new cold plate procedure in rats with chronic constriction injuries.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Calcium Channel Blockers; Chronic Disease; Cold Tempe | 2008 |
Mexiletine therapy for chronic pain: survival analysis identifies factors predicting clinical success.
Topics: Adolescent; Adult; Aged; Anesthetics, Local; Choice Behavior; Chronic Disease; Female; Humans; Kapla | 2008 |
Pharmacokinetics and the antiarrhythmic effect of mexiletine in patients with chronic ventricular arrhythmias.
Topics: Adult; Aged; Arrhythmias, Cardiac; Chronic Disease; Female; Humans; Kinetics; Male; Mexiletine; Midd | 1984 |
Increase of mexiletine plasma levels due to delayed hepatic metabolism in patients with chronic liver disease.
Topics: Arrhythmias, Cardiac; Chronic Disease; Heart Failure; Humans; Kidney Diseases; Kinetics; Liver; Live | 1983 |
A comparison of the action of mexiletine and morphine in rodent models of acute and chronic pain.
Topics: Acute Disease; Animals; Chronic Disease; Cold Temperature; Male; Mexiletine; Morphine; Pain; Pain Me | 1995 |
Mexiletine for chronic pain.
Topics: Aged; Chronic Disease; Humans; Male; Mexiletine; Pain | 1993 |
[Effectiveness of mexitil-depot in patients with chronic ventricular arrhythmia].
Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Chronic Disease; Delayed-Action Preparations; Elect | 1995 |
Mexiletine. Use in control of chronic drug-resistant ventricular arrhythmia.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chronic Disease; Drug Tolerance; Female; | 1979 |
Cardiodepressant effects of mexiletine in patients with severe left ventricular dysfunction.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Drug Evaluation; Female; Heart Failure; Hemodynamic | 1992 |
The management of oral mexiletine and intravenous lidocaine to treat chronic painful symmetrical distal diabetic neuropathy.
Topics: Chronic Disease; Diabetic Neuropathies; Drug Therapy, Combination; Female; Humans; Infusions, Intrav | 1991 |
Mexiletine. Long-term efficacy and side effects in patients with chronic drug-resistant potentially lethal ventricular arrhythmias.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; | 1990 |
Mexiletine therapy in patients with chronic drug-resistant malignant ventricular arrhythmias. Clinical efficacy, safety, and side effects.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Arrhythmias, Cardiac; Chronic Disease; Death, Sudden; Dizz | 1986 |
Antiarrhythmic efficacy of penticainide and comparison with disopyramide, flecainide, propafenone and mexiletine by acute oral drug testing.
Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chronic Disease; Di | 1987 |
Therapeutic effectiveness and plasma levels of single or combination use of class I antiarrhythmic agents for ventricular arrhythmias.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Chronic Disease; Disopyramide; | 1988 |