Page last updated: 2024-10-31

mexiletine and Chronic Disease

mexiletine has been researched along with Chronic Disease in 28 studies

Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.

Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).

Research Excerpts

ExcerptRelevanceReference
"we report on the first case of a woman affected by chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and recessive myotonia congenita (MC), treated with mexiletine."7.96Chronic inflammatory demyelinating polyradiculoneuropathy relapse after mexiletine withdrawal in a patient with concomitant myotonia congenita: A case report on a potential treatment option. ( Biasini, F; Bramanti, P; Calabrò, RS; Naro, A; Portaro, S, 2020)
"The antiarrhythmic efficacy of mexiletine hydrochloride (Mexitil) was evaluated in 100 patients with potentially lethal and drug-resistant ventricular arrhythmia."7.68Mexiletine. Long-term efficacy and side effects in patients with chronic drug-resistant potentially lethal ventricular arrhythmias. ( Aragon, E; Faitel, K; Frumin, H; Kerin, NZ; Marinescu, G; Rubenfire, M, 1990)
" The high incidence of side-effects was probably due to the high dosage used."6.65Evaluation of the antiarrhythmic efficacy of mexiletine in patients with chronic ventricular arrhythmias. ( Van Durme, JP, 1980)
"Static and dynamic allodynia occurred in a rat model of neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve."5.35Effect of mexiletine on dynamic allodynia induced by chronic constriction injury of the sciatic nerve in rats. ( Kurebayashi, Y; Nakazato-Imasato, E; Tanimoto-Mori, S, 2009)
"Mexiletine was well absorbed from the intestinal tract."5.27Pharmacokinetics and the antiarrhythmic effect of mexiletine in patients with chronic ventricular arrhythmias. ( Ebihara, A; Hashimoto, T; Hosoda, S; Kondo, K; Ohashi, K; Oka, T, 1984)
" The long therapeutic half-life of the drug allowed convenient dosage schedule and good compliance."5.26Mexiletine. Use in control of chronic drug-resistant ventricular arrhythmia. ( Abinader, EG; Cooper, M, 1979)
"we report on the first case of a woman affected by chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and recessive myotonia congenita (MC), treated with mexiletine."3.96Chronic inflammatory demyelinating polyradiculoneuropathy relapse after mexiletine withdrawal in a patient with concomitant myotonia congenita: A case report on a potential treatment option. ( Biasini, F; Bramanti, P; Calabrò, RS; Naro, A; Portaro, S, 2020)
"Mexiletine is thought to exert minimal negative inotropic actions, but its effects have not been evaluated in patients with severe congestive heart failure."3.68Cardiodepressant effects of mexiletine in patients with severe left ventricular dysfunction. ( Gottlieb, SS; Weinberg, M, 1992)
"The antiarrhythmic efficacy of mexiletine hydrochloride (Mexitil) was evaluated in 100 patients with potentially lethal and drug-resistant ventricular arrhythmia."3.68Mexiletine. Long-term efficacy and side effects in patients with chronic drug-resistant potentially lethal ventricular arrhythmias. ( Aragon, E; Faitel, K; Frumin, H; Kerin, NZ; Marinescu, G; Rubenfire, M, 1990)
"The efficacy of disopyramide (DP), mexiletine (MX), aprindine (AP) and cibenzoline (CZ) on ventricular arrhythmias was compared (single drug therapy)."3.67Therapeutic effectiveness and plasma levels of single or combination use of class I antiarrhythmic agents for ventricular arrhythmias. ( Furuya, H; Goto, Y; Tanabe, T; Yoshikawa, H, 1988)
"The clinical relevance of changes in pharmacokinetics of oral mexiletine (600 mg daily dose) was studied in 82 patients with ventricular arrhythmias and impaired liver, renal or heart function (control group n = 51, patients with liver cirrhosis n = 9, with renal insufficiency n = 14, or heart failure n = 8)."3.66Increase of mexiletine plasma levels due to delayed hepatic metabolism in patients with chronic liver disease. ( Lüderitz, B; Nitsch, J; Steinbeck, G, 1983)
" The high incidence of side-effects was probably due to the high dosage used."2.65Evaluation of the antiarrhythmic efficacy of mexiletine in patients with chronic ventricular arrhythmias. ( Van Durme, JP, 1980)
"neuropathic pain) is not very satisfactorily managed."2.44[Central and peripheral mechanisms in antinociception: current and future perspectives]. ( Fürst, Z, 2008)
"Mexiletine was used in an open-label study to evaluate its effectiveness in the treatment of this disorder."2.38Successful treatment for phantom pain. ( Davis, RW, 1993)
"Static and dynamic allodynia occurred in a rat model of neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve."1.35Effect of mexiletine on dynamic allodynia induced by chronic constriction injury of the sciatic nerve in rats. ( Kurebayashi, Y; Nakazato-Imasato, E; Tanimoto-Mori, S, 2009)
"Mexiletine was well absorbed from the intestinal tract."1.27Pharmacokinetics and the antiarrhythmic effect of mexiletine in patients with chronic ventricular arrhythmias. ( Ebihara, A; Hashimoto, T; Hosoda, S; Kondo, K; Ohashi, K; Oka, T, 1984)
" The long therapeutic half-life of the drug allowed convenient dosage schedule and good compliance."1.26Mexiletine. Use in control of chronic drug-resistant ventricular arrhythmia. ( Abinader, EG; Cooper, M, 1979)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199010 (35.71)18.7374
1990's8 (28.57)18.2507
2000's7 (25.00)29.6817
2010's2 (7.14)24.3611
2020's1 (3.57)2.80

Authors

AuthorsStudies
Portaro, S1
Biasini, F1
Bramanti, P1
Naro, A1
Calabrò, RS1
Ermakov, S1
Hoffmayer, KS1
Gerstenfeld, EP1
Scheinman, MM1
Fürst, Z1
Nakazato-Imasato, E2
Tanimoto-Mori, S2
Kurebayashi, Y1
Morito, H1
Ogawa, K1
Kobayashi, N1
Fukumoto, T1
Asada, H1
Fassoulaki, A1
Patris, K1
Sarantopoulos, C1
Hogan, Q1
Ida, M1
Kuroiwa, Y1
Takada, Y1
Isobe, S1
Okada, M1
Ando, A1
Nonokawa, M1
Inden, Y1
Tomita, Y1
Suzuki, A1
Hirai, M1
Murohara, T1
Toide, K1
Kita, Y1
Carroll, IR1
Kaplan, KM1
Mackey, SC1
Ohashi, K1
Ebihara, A1
Hashimoto, T1
Hosoda, S1
Kondo, K1
Oka, T1
Nitsch, J2
Steinbeck, G2
Lüderitz, B2
Van Durme, JP1
Hedley, LR1
Martin, B1
Waterbury, LD1
Clarke, DE1
Hunter, JC1
Colclough, G1
Carter, A1
Ackerman, WE2
Davis, RW1
Golikov, AP1
Botolova, EN1
Rudnev, DV1
Lanchote, VL1
Cesarino, EJ1
Santos, VJ1
Mere Júnior, Y1
Santos, SR1
Abinader, EG1
Cooper, M1
Gottlieb, SS1
Weinberg, M1
Colclough, GW1
Juneja, MM1
Bellinger, K1
Kerin, NZ1
Aragon, E1
Marinescu, G1
Faitel, K1
Frumin, H1
Rubenfire, M1
Poggesi, L1
Scarti, L1
Ieri, A1
Lanzetta, T1
Grazzini, M1
Del Bene, P1
Masini, G1
Del Citerna, F1
Carnovali, M1
Masotti, G1
Haggman, DL1
Maloney, JD1
Morant, VA1
Castle, LW1
King-Rankine, M1
Goormastic, M1
Smetnev, AS1
Golitsyn, SP1
Levin, ER1
Sokolov, SF1
Koltunova, MI1
Priori, SG1
Bonazzi, O1
Facchini, M1
Varisco, T1
Schwartz, PJ1
Tanabe, T1
Yoshikawa, H1
Furuya, H1
Goto, Y1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy: a Prospective, Randomized Study.[NCT00954187]8 participants (Actual)Interventional2009-11-30Terminated (stopped due to PI left institution)
Comparative Evaluation of Osteopathy Treatment Efficacy in Pain Support After Breast Surgery in Oncology[NCT01403168]28 participants (Actual)Interventional2011-04-30Terminated (stopped due to Recruitment difficulties)
Management of Chronic Pain in Rehabilitation Project II Management of Chronic Pain in Persons With Amputation[NCT00006427]Phase 4125 participants Interventional1996-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for mexiletine and Chronic Disease

ArticleYear
[Central and peripheral mechanisms in antinociception: current and future perspectives].
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2008, Volume: 10, Issue:3

    Topics: Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocycl

2008
[Diabetic neuropathy--concept, staging, diagnosis, treatment].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 10

    Topics: Aldehyde Reductase; Chronic Disease; Diabetic Neuropathies; Diagnosis, Differential; Enzyme Inhibito

2002
Successful treatment for phantom pain.
    Orthopedics, 1993, Volume: 16, Issue:6

    Topics: Administration, Cutaneous; Aged; Chronic Disease; Clonidine; Drug Therapy, Combination; Female; Huma

1993

Trials

7 trials available for mexiletine and Chronic Disease

ArticleYear
The analgesic effect of gabapentin and mexiletine after breast surgery for cancer.
    Anesthesia and analgesia, 2002, Volume: 95, Issue:4

    Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Antineoplastic Agents; Breast Neoplasms; Chr

2002
The analgesic effect of gabapentin and mexiletine after breast surgery for cancer.
    Anesthesia and analgesia, 2002, Volume: 95, Issue:4

    Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Antineoplastic Agents; Breast Neoplasms; Chr

2002
The analgesic effect of gabapentin and mexiletine after breast surgery for cancer.
    Anesthesia and analgesia, 2002, Volume: 95, Issue:4

    Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Antineoplastic Agents; Breast Neoplasms; Chr

2002
The analgesic effect of gabapentin and mexiletine after breast surgery for cancer.
    Anesthesia and analgesia, 2002, Volume: 95, Issue:4

    Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Antineoplastic Agents; Breast Neoplasms; Chr

2002
Effects of antiarrhythmic agents on left ventricular function during exercise in patients with chronic left ventricular dysfunction.
    Annals of nuclear medicine, 2004, Volume: 18, Issue:3

    Topics: Aged; Anti-Asthmatic Agents; Chronic Disease; Disopyramide; Exercise; Exercise Test; Female; Heart V

2004
Evaluation of the antiarrhythmic efficacy of mexiletine in patients with chronic ventricular arrhythmias.
    Acta cardiologica. Supplementum, 1980, Issue:25

    Topics: Arrhythmias, Cardiac; Atenolol; Chronic Disease; Clinical Trials as Topic; Disopyramide; Double-Blin

1980
[Effect of kidney, liver or heart insufficiency on blood mexiletine levels].
    Der Internist, 1982, Volume: 23, Issue:5

    Topics: Arrhythmias, Cardiac; Biological Availability; Chromatography, Gas; Chronic Disease; Heart Failure;

1982
Enantioselectivity in the metabolism of mexiletine by conjugation in female patients with the arrhythmic form of chronic Chagas' heart disease.
    Chirality, 1999, Volume: 11, Issue:1

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Area Under Curve; Arrhythmias, Cardiac; Biotransformation; Chag

1999
Efficacy of mexiletine in chronic ventricular arrhythmias: a multicentre double-blind medium-term trial.
    International journal of clinical pharmacology research, 1989, Volume: 9, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Chronic Disease;

1989
[Study of the comparative anti-arrhythmic effectiveness of allapinin, ethacizine and mexitil in patients with ventricular disorders of cardiac rhythm].
    Terapevticheskii arkhiv, 1988, Volume: 60, Issue:8

    Topics: Aconitine; Aconitum; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Chronic Disease; Clinical Tria

1988

Other Studies

18 other studies available for mexiletine and Chronic Disease

ArticleYear
Chronic inflammatory demyelinating polyradiculoneuropathy relapse after mexiletine withdrawal in a patient with concomitant myotonia congenita: A case report on a potential treatment option.
    Medicine, 2020, Jul-10, Volume: 99, Issue:28

    Topics: Adult; Chronic Disease; Female; Follow-Up Studies; Humans; Mexiletine; Myotonia Congenita; Polyradic

2020
Combination drug therapy for patients with intractable ventricular tachycardia associated with right ventricular cardiomyopathy.
    Pacing and clinical electrophysiology : PACE, 2014, Volume: 37, Issue:1

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmogenic Right Ventricular Dysplasia; Chronic Disease; Dr

2014
Effect of mexiletine on dynamic allodynia induced by chronic constriction injury of the sciatic nerve in rats.
    The Journal of veterinary medical science, 2009, Volume: 71, Issue:7

    Topics: Analgesics; Animals; Chronic Disease; Constriction, Pathologic; Dose-Response Relationship, Drug; Hy

2009
Drug-induced hypersensitivity syndrome followed by persistent arthritis.
    The Journal of dermatology, 2012, Volume: 39, Issue:2

    Topics: Anti-Arrhythmia Agents; Arthralgia; Arthritis; Celecoxib; Chronic Disease; Cyclooxygenase 2 Inhibito

2012
Pharmacologic investigation of the mechanism underlying cold allodynia using a new cold plate procedure in rats with chronic constriction injuries.
    Behavioural pharmacology, 2008, Volume: 19, Issue:1

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Calcium Channel Blockers; Chronic Disease; Cold Tempe

2008
Mexiletine therapy for chronic pain: survival analysis identifies factors predicting clinical success.
    Journal of pain and symptom management, 2008, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Aged; Anesthetics, Local; Choice Behavior; Chronic Disease; Female; Humans; Kapla

2008
Pharmacokinetics and the antiarrhythmic effect of mexiletine in patients with chronic ventricular arrhythmias.
    Arzneimittel-Forschung, 1984, Volume: 34, Issue:4

    Topics: Adult; Aged; Arrhythmias, Cardiac; Chronic Disease; Female; Humans; Kinetics; Male; Mexiletine; Midd

1984
Increase of mexiletine plasma levels due to delayed hepatic metabolism in patients with chronic liver disease.
    European heart journal, 1983, Volume: 4, Issue:11

    Topics: Arrhythmias, Cardiac; Chronic Disease; Heart Failure; Humans; Kidney Diseases; Kinetics; Liver; Live

1983
A comparison of the action of mexiletine and morphine in rodent models of acute and chronic pain.
    Proceedings of the Western Pharmacology Society, 1995, Volume: 38

    Topics: Acute Disease; Animals; Chronic Disease; Cold Temperature; Male; Mexiletine; Morphine; Pain; Pain Me

1995
Mexiletine for chronic pain.
    Lancet (London, England), 1993, Dec-11, Volume: 342, Issue:8885

    Topics: Aged; Chronic Disease; Humans; Male; Mexiletine; Pain

1993
[Effectiveness of mexitil-depot in patients with chronic ventricular arrhythmia].
    Klinicheskaia meditsina, 1995, Volume: 73, Issue:6

    Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Chronic Disease; Delayed-Action Preparations; Elect

1995
Mexiletine. Use in control of chronic drug-resistant ventricular arrhythmia.
    JAMA, 1979, Jul-27, Volume: 242, Issue:4

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chronic Disease; Drug Tolerance; Female;

1979
Cardiodepressant effects of mexiletine in patients with severe left ventricular dysfunction.
    European heart journal, 1992, Volume: 13, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Drug Evaluation; Female; Heart Failure; Hemodynamic

1992
The management of oral mexiletine and intravenous lidocaine to treat chronic painful symmetrical distal diabetic neuropathy.
    The Journal of the Kentucky Medical Association, 1991, Volume: 89, Issue:10

    Topics: Chronic Disease; Diabetic Neuropathies; Drug Therapy, Combination; Female; Humans; Infusions, Intrav

1991
Mexiletine. Long-term efficacy and side effects in patients with chronic drug-resistant potentially lethal ventricular arrhythmias.
    Archives of internal medicine, 1990, Volume: 150, Issue:2

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Arrhythmias, Cardiac;

1990
Mexiletine therapy in patients with chronic drug-resistant malignant ventricular arrhythmias. Clinical efficacy, safety, and side effects.
    Cleveland Clinic quarterly, 1986,Summer, Volume: 53, Issue:2

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Arrhythmias, Cardiac; Chronic Disease; Death, Sudden; Dizz

1986
Antiarrhythmic efficacy of penticainide and comparison with disopyramide, flecainide, propafenone and mexiletine by acute oral drug testing.
    The American journal of cardiology, 1987, Nov-01, Volume: 60, Issue:13

    Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chronic Disease; Di

1987
Therapeutic effectiveness and plasma levels of single or combination use of class I antiarrhythmic agents for ventricular arrhythmias.
    Japanese circulation journal, 1988, Volume: 52, Issue:3

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Chronic Disease; Disopyramide;

1988