mexiletine has been researched along with Chagas Cardiomyopathy in 4 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Chagas Cardiomyopathy: A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amiodarone was the only one of the four drugs that caused a substantial reduction of ventricular premature complexes (logarithmic mean 97." | 1.27 | Comparative antiarrhythmic efficacy of verapamil, 17-monochloracetylajmaline, mexiletine and amiodarone in patients with severe chagasic myocarditis: relation with the underlying arrhythmogenic mechanisms. ( Bandieri, JD; Chiale, PA; Elizari, MV; Haedo, AH; Lázzari, JO; Rosenbaum, MB, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sgammini, H | 1 |
| Evequoz, C | 1 |
| Vera, T | 1 |
| Cengarle, S | 1 |
| Chuit, R | 2 |
| Kuschnir, E | 2 |
| Sgammini, HO | 1 |
| Evequoz, MC | 1 |
| Atti, R | 1 |
| Santamarina, NO | 1 |
| Lanchote, VL | 1 |
| Cesarino, EJ | 1 |
| Santos, VJ | 1 |
| Mere Júnior, Y | 1 |
| Santos, SR | 1 |
| Haedo, AH | 1 |
| Chiale, PA | 1 |
| Bandieri, JD | 1 |
| Lázzari, JO | 1 |
| Elizari, MV | 1 |
| Rosenbaum, MB | 1 |
2 trials available for mexiletine and Chagas Cardiomyopathy
| Article | Year |
|---|---|
[Treatment of arrhythmias with high risk of sudden death in chronic Chagas' cardiopathy with oral mexiletine. Evaluation with 24-hour ambulatory electrocardiographic monitoring (Holter)].
Topics: Adult; Aged; Arrhythmias, Cardiac; Chagas Cardiomyopathy; Clinical Trials as Topic; Death, Sudden; E | 1983 |
Enantioselectivity in the metabolism of mexiletine by conjugation in female patients with the arrhythmic form of chronic Chagas' heart disease.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Area Under Curve; Arrhythmias, Cardiac; Biotransformation; Chag | 1999 |
2 other studies available for mexiletine and Chagas Cardiomyopathy
| Article | Year |
|---|---|
[Prolonged treatment with oral mexiletine in severe ventricular extrasystole].
Topics: Adult; Aged; Cardiac Complexes, Premature; Chagas Cardiomyopathy; Female; Humans; Male; Mexiletine; | 1981 |
Comparative antiarrhythmic efficacy of verapamil, 17-monochloracetylajmaline, mexiletine and amiodarone in patients with severe chagasic myocarditis: relation with the underlying arrhythmogenic mechanisms.
Topics: Adult; Ajmaline; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Chagas Cardiomyopathy; Female; Human | 1986 |