mexiletine has been researched along with Cerebral Infarction in 4 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The volume of cerebral infarction was measured in serial brain sections stained with triphenyltetrazolium chloride (TTC)." | 5.31 | Alteration of ischemic reperfusion injury in the rat neocortex by a potent antioxidant mexiletine. ( Chang, CZ; Howng, SL; Jeng, AY; Kung, SS; Kwan, AL; Loh, JK; Winardi, D, 2002) |
| "Furthermore, brain seizure activity recorded following 1 h MCAo and 72 h of recovery in injured rats was either completely blocked (30 min pre-MCAo treatment) or significantly reduced (30 min post-MCAo treatment) with RS100642 (1." | 5.31 | Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat. ( Tortella, FC; Williams, AJ, 2002) |
| " Pretreatment with Mex resulted in a significant infarct volume reduction when administered intraperitoneally, either at the dosage of 50 or 60 mg/kg, 1 hr before MCA occlusion (P < 0." | 5.30 | Mexiletine and magnesium independently, but not combined, protect against permanent focal cerebral ischemia in Wistar rats. ( Ayoub, IA; Harris, FB; Hassan, M; Lee, EJ; Maynard, KI; Ogilvy, CS, 1999) |
| "Mexiletine was generally well tolerated with only two patients experiencing transient nausea and dizziness." | 5.28 | Mexiletine for thalamic pain syndrome. ( Awerbuch, GI; Sandyk, R, 1990) |
| "The volume of cerebral infarction was measured in serial brain sections stained with triphenyltetrazolium chloride (TTC)." | 1.31 | Alteration of ischemic reperfusion injury in the rat neocortex by a potent antioxidant mexiletine. ( Chang, CZ; Howng, SL; Jeng, AY; Kung, SS; Kwan, AL; Loh, JK; Winardi, D, 2002) |
| "Furthermore, brain seizure activity recorded following 1 h MCAo and 72 h of recovery in injured rats was either completely blocked (30 min pre-MCAo treatment) or significantly reduced (30 min post-MCAo treatment) with RS100642 (1." | 1.31 | Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat. ( Tortella, FC; Williams, AJ, 2002) |
| " Pretreatment with Mex resulted in a significant infarct volume reduction when administered intraperitoneally, either at the dosage of 50 or 60 mg/kg, 1 hr before MCA occlusion (P < 0." | 1.30 | Mexiletine and magnesium independently, but not combined, protect against permanent focal cerebral ischemia in Wistar rats. ( Ayoub, IA; Harris, FB; Hassan, M; Lee, EJ; Maynard, KI; Ogilvy, CS, 1999) |
| "Mexiletine was generally well tolerated with only two patients experiencing transient nausea and dizziness." | 1.28 | Mexiletine for thalamic pain syndrome. ( Awerbuch, GI; Sandyk, R, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, EJ | 1 |
| Ayoub, IA | 1 |
| Harris, FB | 1 |
| Hassan, M | 1 |
| Ogilvy, CS | 1 |
| Maynard, KI | 1 |
| Chang, CZ | 1 |
| Winardi, D | 1 |
| Loh, JK | 1 |
| Kung, SS | 1 |
| Howng, SL | 1 |
| Jeng, AY | 1 |
| Kwan, AL | 1 |
| Williams, AJ | 1 |
| Tortella, FC | 1 |
| Awerbuch, GI | 1 |
| Sandyk, R | 1 |
4 other studies available for mexiletine and Cerebral Infarction
| Article | Year |
|---|---|
Mexiletine and magnesium independently, but not combined, protect against permanent focal cerebral ischemia in Wistar rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Drug Administration Schedule; Magnesium; Male; Mexilet | 1999 |
Alteration of ischemic reperfusion injury in the rat neocortex by a potent antioxidant mexiletine.
Topics: Animals; Anti-Arrhythmia Agents; Brain Edema; Brain Ischemia; Carotid Arteries; Cerebral Arteries; C | 2002 |
Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat.
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Dose-Response Relationship, Drug; Electroenceph | 2002 |
Mexiletine for thalamic pain syndrome.
Topics: Cerebral Hemorrhage; Cerebral Infarction; Female; Humans; Male; Mexiletine; Middle Aged; Multiple Sc | 1990 |