mexiletine and Cardiovascular Stroke studies

Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.

Research Excerpts

Excerpt	Relevance	Reference
"Eighty two patients with ventricular extrasystole (VES) after myocardial infarction had been treated with antiarrhythmic drugs in the half (41 patients) with mexiletine (M) and in the half (41 patients) with other ones."	9.07	[Long-term mexiletine treatment of ventricular arrhythmia in patients after myocardial infarction]. ( Axenti, I; Drazkiewicz, U; Olszowy, Z; Petelenz, T, 1992)
"A double blind randomised study comparing the effects of oral mexiletine and placebo given to elderly patients (65 years and older) immediately following hospital admission with suspected myocardial infarction (MI) is described."	9.06	Prophylactic use of mexiletine in the elderly with acute myocardial infarction. ( Datta-Chaudhari, ML; O'Brien, TD, 1990)
"In a controlled randomized cross-over trial, 21 patients with coronary artery disease and frequent ventricular arrhythmias were studied to test the efficacy and tolerance of mexiletine 200 mg t."	9.06	[Anti-arrhythmia effectiveness and tolerance of retard in comparison with standard mexiletine]. ( Geibel, A; Hohnloser, S; Hust, M; Just, H; Meinertz, T; Zehender, M, 1987)
"The relationships between plasma mexiletine levels and the presence of ventricular arrhythmias and side effects were studied on patients from IMPACT (International Mexiletine and Placebo Antiarrhythmic Coronary Trial)."	9.06	Relationship between plasma mexiletine levels at steady-state. Presence of ventricular arrhythmias and side effects. ( Boissel, JP; Leizorovicz, A; Peyrieux, JC, 1987)
"In 12 patients with coronary artery disease, 11 of them with previous myocardial infarction, the antiarrhythmic effects of orally administered flecainide (F."	9.05	[Antiarrhythmic efficacy of mexiletine, propafenone and flecainide in ventricular premature beats. A comparative study in patients after myocardial infarction (author's transl)]. ( Fabry, E; Klempt, HW; Nayebagha, A, 1982)
"The antiarrhythmic effects of the sustained release form of mexiletine (Mexitil-Perlongets) were evaluated in a double-blind placebo trial in 630 patients with recent documented myocardial infarction."	9.05	International mexiletine and placebo antiarrhythmic coronary trial: I. Report on arrhythmia and other findings. Impact Research Group. ( , 1984)
"Intravenous and oral mexiletine prophylaxis was compared with lignocaine supplemented placebo in a single blind trial in 240 high-risk patients with acute myocardial infarction."	9.05	A trial of intravenous and oral mexiletine in acute myocardial infarction. ( Doar, JW; Head, CD; Leggett, RJ; Smyllie, HC, 1984)
"The antiarrhythmic efficacy of mexiletine in acute myocardial infarction (AMI) was studied in 99 patients randomized to mexiletine or placebo treatment."	9.05	Antiarrhythmic efficacy of combined intravenous and oral mexiletine in acute myocardial infarction. A double blind placebo-controlled study. ( Halinen, MO; Helin, MJ; Pentikäinen, PJ; Rehnberg, S, 1984)
"The incidence of ventricular arrhythmias after myocardial infarction has been compared in a controlled study of procainamide, mexiletine, and placebo."	9.04	Comparison of procainamide and mexiletine in prevention of ventricular arrhythmias after acute myocardial infarction. ( Campbell, RW; Dolder, MA; Julian, DG; Murray, A; Prescott, LF; Talbot, RG, 1975)
"The long-term effect of mexiletine on left ventricular (LV) contractility in patients with congestive heart failure is not clear."	7.69	Chronic effect of oral mexiletine administration on left ventricular contractility in patients with congestive heart failure: a study based on mitral regurgitant flow velocity measured by continuous-wave Doppler echocardiography. ( Hirabayashi, K; Matsuo, H; Morita, H; Nozaki, S; Ohmori, K; Yoshikawa, K, 1995)
"We describe a case of acute myocardial infarction complicated by atrial and ventricular arrhythmias in which it was possible to verify the effectiveness of lidocaine, mexiletine and propafenone."	7.67	Lidocaine, mexiletine and propafenone in the treatment of arrhythmias complicating myocardial infarction. A case report. ( Aguglia, F; De Marzio, P; Gnecchi, M, 1985)
"To study the effects of acute myocardial infarction on its pharmacokinetics a single oral dose of 400 mg mexiletine HCl was administered to seven patients."	7.66	Pharmacokinetics of oral mexiletine in patients with acute myocardial infarction. ( Halinen, MO; Helin, MJ; Pentikäinen, PJ, 1983)
"The anti-arrhythmic drug mexiletine caused an oesophageal ulcer, confirmed by endoscopy and biopsy, in a 72-year-old woman."	7.66	[Esophageal ulcer caused by mexiletine]. ( Rudolph, R; Seckfort, H; Seggewiss, H, 1983)
"Intravenous mexiletine (3 mg/Kg as bolus) was given to 7 patients with sustained ventricular tachycardia."	7.66	[Mexiletine in the treatment of lidocaine-resistant ventricular tachycardia. Preliminary results]. ( Chiariello, M; Clarizia, M; Condorelli, M; Santinelli, V; Stanislao, M; Turco, P, 1982)
" bolus of 250 mg of mexiletine was checked in cases of acute myocardial infarction with ventricular premature beats."	7.66	[Antiarrhythmic treatment with mexiletine in acute myocardial infarction (author's transl)]. ( Codecà, L; Gruppillo, P; Masoni, A; Masoni, C; Padovan, GC, 1981)
"Mexiletine is a new local anaesthetic antiarrhythmic agent whose chemical structure and electrophysiological properties closely resemble those of lignocaine although its anticonvulsant and pharmacokinetic properties differ from that drug."	6.36	Mexiletine: a review of its pharmacological properties and therapeutic efficacy in arrhythmias. ( Chew, CY; Collett, J; Singh, BN, 1979)
"Eighty two patients with ventricular extrasystole (VES) after myocardial infarction had been treated with antiarrhythmic drugs in the half (41 patients) with mexiletine (M) and in the half (41 patients) with other ones."	5.07	[Long-term mexiletine treatment of ventricular arrhythmia in patients after myocardial infarction]. ( Axenti, I; Drazkiewicz, U; Olszowy, Z; Petelenz, T, 1992)
"9 years) included in the IMPACT study (multicenter, randomised, double-blind protocol, the main objective of which was to assess the antiarrhythmic effect of oral administration of delayed action mexiletine in patients with a recent myocardial infarction), answered a questionnaire of 85 items."	5.07	[Informed consent, what information is left after a therapeutic trial?]. ( Aupetit, JF; Chassoux, G; Gallet, M; Lestaevel, M; Lopez, M; Servan, E, 1994)
"A double blind randomised study comparing the effects of oral mexiletine and placebo given to elderly patients (65 years and older) immediately following hospital admission with suspected myocardial infarction (MI) is described."	5.06	Prophylactic use of mexiletine in the elderly with acute myocardial infarction. ( Datta-Chaudhari, ML; O'Brien, TD, 1990)
"In a controlled randomized cross-over trial, 21 patients with coronary artery disease and frequent ventricular arrhythmias were studied to test the efficacy and tolerance of mexiletine 200 mg t."	5.06	[Anti-arrhythmia effectiveness and tolerance of retard in comparison with standard mexiletine]. ( Geibel, A; Hohnloser, S; Hust, M; Just, H; Meinertz, T; Zehender, M, 1987)
"The relationships between plasma mexiletine levels and the presence of ventricular arrhythmias and side effects were studied on patients from IMPACT (International Mexiletine and Placebo Antiarrhythmic Coronary Trial)."	5.06	Relationship between plasma mexiletine levels at steady-state. Presence of ventricular arrhythmias and side effects. ( Boissel, JP; Leizorovicz, A; Peyrieux, JC, 1987)
"The antiarrhythmic effects of the sustained release form of mexiletine (Mexitil-Perlongets) were evaluated in a double-blind placebo trial in 630 patients with recent documented myocardial infarction."	5.05	International mexiletine and placebo antiarrhythmic coronary trial: I. Report on arrhythmia and other findings. Impact Research Group. ( , 1984)
"In 12 patients with coronary artery disease, 11 of them with previous myocardial infarction, the antiarrhythmic effects of orally administered flecainide (F."	5.05	[Antiarrhythmic efficacy of mexiletine, propafenone and flecainide in ventricular premature beats. A comparative study in patients after myocardial infarction (author's transl)]. ( Fabry, E; Klempt, HW; Nayebagha, A, 1982)
"The antiarrhythmic efficacy of mexiletine in acute myocardial infarction (AMI) was studied in 99 patients randomized to mexiletine or placebo treatment."	5.05	Antiarrhythmic efficacy of combined intravenous and oral mexiletine in acute myocardial infarction. A double blind placebo-controlled study. ( Halinen, MO; Helin, MJ; Pentikäinen, PJ; Rehnberg, S, 1984)
"Intravenous and oral mexiletine prophylaxis was compared with lignocaine supplemented placebo in a single blind trial in 240 high-risk patients with acute myocardial infarction."	5.05	A trial of intravenous and oral mexiletine in acute myocardial infarction. ( Doar, JW; Head, CD; Leggett, RJ; Smyllie, HC, 1984)
"In a controlled investigation on 84 patients with acute myocardial infarction, the effect of mexiletine on ectopic ventricular rhythms was tested with respect to mexiletine serum concentration."	5.05	[Mexiletin for treatment of ventricular ectopic rhythm in patients with acute myocardial infarction (author's transl)]. ( Brunner, H; Effert, S; Franken, G; Henning, B; Merx, W, 1980)
"A double blind randomised study was undertaken comparing the effects of oral mexiletine and placebo given by general practitioners at home in the early stages of suspected acute myocardial infarction, and continued for six weeks."	5.05	A trial of prophylactic mexiletine in home coronary care. ( Bell, JA; Holt, DW; Isaacson, JR; Snell, NJ; Thomas, JM, 1982)
"In a controlled study using mexiletine and placebo, the incidence of ventricular arrhythmias after acute myocardial infarction (AMI) has been compared."	5.04	[Frequency and prevention of ventricular arrhythmias after acute myocardial infarct]. ( Campbell, RW; Dolder, M; Julian, DG; Murray, A; Prescott, LE; Talbot, RG, 1976)
"The incidence of ventricular arrhythmias after myocardial infarction has been compared in a controlled study of procainamide, mexiletine, and placebo."	5.04	Comparison of procainamide and mexiletine in prevention of ventricular arrhythmias after acute myocardial infarction. ( Campbell, RW; Dolder, MA; Julian, DG; Murray, A; Prescott, LF; Talbot, RG, 1975)
"Quinidine and procainamide have the potential for major organ toxicity, whereas mexiletine has been reported to have little risk of organ toxicity, serious proarrhythmia or congestive heart failure, but a relatively high incidence of nuisance side effects."	4.78	Comparative cost-effectiveness analysis of quinidine, procainamide and mexiletine. ( Arnold, RJ; Beck, JR; Beshansky, JR; Frishman, WH; Kaniecki, DJ; Kowey, PR; Podrid, PJ, 1991)
"The long-term effect of mexiletine on left ventricular (LV) contractility in patients with congestive heart failure is not clear."	3.69	Chronic effect of oral mexiletine administration on left ventricular contractility in patients with congestive heart failure: a study based on mitral regurgitant flow velocity measured by continuous-wave Doppler echocardiography. ( Hirabayashi, K; Matsuo, H; Morita, H; Nozaki, S; Ohmori, K; Yoshikawa, K, 1995)
"In order to study the effects of treatment with class 1 antiarrhythmics on the metabolic, hemodynamic, and electrocardiographic responses to adrenaline, 12 healthy volunteers were infused on four occasions, after pretreatment with placebo, disopyramide, mexiletine, and flecainide, respectively, with adrenaline at a rate producing serum adrenaline concentrations comparable with those seen in acute myocardial infarction."	3.68	Metabolic, hemodynamic, and electrocardiographic responses to increased circulating adrenaline: effects of pretreatment with class 1 antiarrhythmics. ( Gullberg, B; Hansen, O; Johansson, BW, 1991)
"6 mg/min for 4-40 hrs), Propafenone (1-2 mg/Kg in 5 min + continuous infusion of 10-15 mcg/Kg/min for 24 hrs) and Mexiletine (250 mg in 15 min + 250 mg in 1 hr) have been evaluated in patients with acute myocardial infarction complicated by sinus tachycardia and hyperdynamic pattern, ventricular or supraventricular arrhythmias."	3.67	Hemodynamic effects of antiarrhythmic drugs in acute myocardial infarction. ( Ambrosini, F; Finzi, A; Lo Masto, M; Lotto, A; Massari, FM; Pagnoni, F; Valentini, R, 1984)
"We describe a case of acute myocardial infarction complicated by atrial and ventricular arrhythmias in which it was possible to verify the effectiveness of lidocaine, mexiletine and propafenone."	3.67	Lidocaine, mexiletine and propafenone in the treatment of arrhythmias complicating myocardial infarction. A case report. ( Aguglia, F; De Marzio, P; Gnecchi, M, 1985)
"Clinical safety and hemodynamic repercussions were studied after administration of six class I antiarrhythmics (xylocaine, ajmaline, mexiletine, lorcainide, indecainide and tocainide) to patients presenting acute myocardial infarction without complications."	3.67	[Hemodynamic repercussions and clinical tolerance of 6 class I anti-arrhythmia agents in acute myocardial infarction]. ( Bernard, R; de Hemptinne, J; Gillet, JM; Lewinson, H; Liebens, I; Renard, M; Shita, A; Waterschoot, P, 1986)
"18 patients with myocardial infarction complicated by severe ventricular arrhythmias (polymorphic VEBs or bigeminy = 5; VT = 11; VF = 2) were treated with antiarrhythmics which were stopped after 24 hours (intravenous infusion of mexiletine 0."	3.67	[Early interruption of antiarrhythmia treatment in the acute phase of infarction complicated by ventricular arrhythmia]. ( Farinotti, R; Gryman, R; Guérot, C; Khemache, A; Sebbah, J; Valère, PE, 1985)
"Hemodynamic effects of mexiletine were studied in 15 patients with normal sinus rhythm; most of them had a myocardial infarction."	3.66	Hemodynamic effects of an intravenous injection of mexiletine in patients hospitalised in intensive care units. ( Carlier, J; Henrard, L, 1980)
"To study the effects of acute myocardial infarction on its pharmacokinetics a single oral dose of 400 mg mexiletine HCl was administered to seven patients."	3.66	Pharmacokinetics of oral mexiletine in patients with acute myocardial infarction. ( Halinen, MO; Helin, MJ; Pentikäinen, PJ, 1983)
"The anti-arrhythmic drug mexiletine caused an oesophageal ulcer, confirmed by endoscopy and biopsy, in a 72-year-old woman."	3.66	[Esophageal ulcer caused by mexiletine]. ( Rudolph, R; Seckfort, H; Seggewiss, H, 1983)
" bolus of 250 mg of mexiletine was checked in cases of acute myocardial infarction with ventricular premature beats."	3.66	[Antiarrhythmic treatment with mexiletine in acute myocardial infarction (author's transl)]. ( Codecà, L; Gruppillo, P; Masoni, A; Masoni, C; Padovan, GC, 1981)
"Intravenous mexiletine (3 mg/Kg as bolus) was given to 7 patients with sustained ventricular tachycardia."	3.66	[Mexiletine in the treatment of lidocaine-resistant ventricular tachycardia. Preliminary results]. ( Chiariello, M; Clarizia, M; Condorelli, M; Santinelli, V; Stanislao, M; Turco, P, 1982)
"Forty-eight patients with ischaemic heart disease received oral mexiletine for the control or prevention of ventricular arrhythmias."	3.66	Long-term oral antiarrhythmic therapy with mexiletine. ( Adgey, AA; Campbell, NP; Pantridge, JF, 1978)
"It is effective against ventricular arrhythmias, both parenterally and orally, and has been used in acute myocardial infarction, in the convalescence following myocardial infarction and in ventricular arrhythmias of different aetiology."	2.65	Mexiletine in clinical practice. ( Boyle, DM, 1980)
"Mexiletine is a new local anaesthetic antiarrhythmic agent whose chemical structure and electrophysiological properties closely resemble those of lignocaine although its anticonvulsant and pharmacokinetic properties differ from that drug."	2.36	Mexiletine: a review of its pharmacological properties and therapeutic efficacy in arrhythmias. ( Chew, CY; Collett, J; Singh, BN, 1979)
"Mexiletine was recently shown to antagonize the effects of sotalol on repolarization of canine Purkinje fibers."	1.29	Antiarrhythmic effect of a sotalol-mexiletine combination on induced ventricular tachycardia in dogs. ( Cheymol, G; Chézalviel, F; Davy, JM; Guhennec, C; Jagueux, M; Poirier, JM; Simandoux, V; Vernhet, L; Weissenburger, J, 1993)
"75 to 2 micrograms ml-1) in all patients after a twice daily dosage regimen."	1.28	Simultaneous modelling of mexiletine and hydroxy-methyl-mexiletine data after single- and multiple-dose administration of a sustained-release mexiletine formulation. ( Bruno, R; Cano, JP; Djiane, P; Iliadis, A; Santoni, Y; Serradimigni, A, 1992)
"Mexiletine is a type 1B antiarrhythmic drug similar to lidocaine."	1.28	Prolongation of ventricular depolarization. ECG manifestation of mexiletine toxicity. ( Chandrasekaran, K; Hammill, SC; Nora, MO; Reeder, GS, 1989)
" Whether the existence of a compromised renal, hepatic or cardiac function alters dosage requirements is not clear."	1.26	Adaptation of the dose of mexiletine according to pharmacokinetic data. ( Bogaert, M, 1980)
"A combined intravenous and oral dosage regime for mexiletine has been evaluated in volunteer subjects."	1.26	A schedule for combined intravenous and oral dosing with mexiletine. ( Hampel, G; Holt, DW; Volans, GN, 1979)

Research

Studies (94)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Cardiovascular Hospitalizations

Timeframe	Studies, this research(%)	All Research%
pre-1990	73 (77.66)	18.7374
1990's	18 (19.15)	18.2507
2000's	2 (2.13)	29.6817
2010's	1 (1.06)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Odabasi, Z	1
Yapundich, R	1
Oh, SJ	1
Niwano, S	1
Inuo, K	1
Morohoshi, Y	1
Nakayama, S	1
Yuge, M	1
Imaki, R	1
Izumi, T	1
Sekiguchi, A	1
Kashiwagi, T	1
Ishida-Yamamoto, A	1
Takahashi, H	1
Hashimoto, Y	1
Kimura, H	1
Tohyama, M	1
Hashimoto, K	2
Iizuka, H	1
Oliver, MF	1
Gore, SM	1
Theisen, K	2
Jahrmärker, H	1
Rozenshtraukh, LV	1
Aniukhovskiĭ, EP	1
Beloshapko, GG	1
Dremin, SA	1
Kipshidze, NN	1
Chapidze, GE	1
Dzhandzhgava, ShM	1
Klempt, HW	1
Nayebagha, A	1
Fabry, E	1
Rudolph, R	1
Seggewiss, H	1
Seckfort, H	1
Smyllie, HC	1
Doar, JW	1
Head, CD	1
Leggett, RJ	1
Halinen, MO	2
Pentikäinen, PJ	2
Helin, MJ	2
Rehnberg, S	1
Hellestrand, KJ	1
Lotto, A	1
Finzi, A	1
Massari, FM	1
Pagnoni, F	1
Valentini, R	1
Ambrosini, F	1
Lo Masto, M	1
Hayakawa, H	1
Ino, T	1
Yanaga, T	1
Ichimaru, Y	1
Ueno, T	1
Hata, Y	1
Okamoto, K	1
Kodama, Y	1
Otsuka, K	1
Santinelli, V	3
Chiariello, M	3
Stanislao, M	2
Condorelli, M	3
Henrard, L	2
Carlier, J	2
Bogaert, M	1
Winkle, RA	1
Kulbertus, HE	1
Boyle, DM	2
Merx, W	2
Franken, G	1
Brunner, H	1
Effert, S	2
Henning, B	2
Pitt, B	1
Bell, JA	1
Thomas, JM	1
Isaacson, JR	1
Snell, NJ	1
Holt, DW	2
Mayrhofer, EF	1
Feilhauer, GD	1
Pilecky, I	1
Vockner, H	1
Kühn, P	1
Keltai, M	1
Kékány, P	1
Mádai, A	1
Turco, P	1
Clarizia, M	1
Codecà, L	1
Gruppillo, P	1
Padovan, GC	1
Masoni, C	1
Masoni, A	1
Logan, KR	1
McIlwaine, WJ	1
Adgey, AA	3
Pantridge, JF	2
Zaliunas, R	2
Zabiela, P	2
Slapikas, R	2
Vainoras, A	2
Pentiokiniene, D	2
Levisauskiene, R	2
Bechtold, H	2
Meyer, U	2
Morita, H	1
Hirabayashi, K	1
Nozaki, S	1
Ohmori, K	1
Yoshikawa, K	1
Matsuo, H	1
Chézalviel, F	1
Weissenburger, J	1
Guhennec, C	1
Jagueux, M	1
Davy, JM	1
Vernhet, L	1
Simandoux, V	1
Poirier, JM	1
Cheymol, G	1
Gallet, M	1
Aupetit, JF	1
Servan, E	1
Lestaevel, M	1
Lopez, M	1
Chassoux, G	1
Campbell, RW	7
Dolder, MA	2
Prescott, LF	3
Talbot, RG	5
Murray, A	5
Julian, DG	6
Loskot, F	1
Bauer, U	1
Ferro, G	1
Tari, MG	1
Achuff, SC	1
Pottage, A	2
Prescott, L	2
Dolder, M	3
Prescott, LE	2
Koch-Weser, J	1
Chew, CY	1
Collett, J	1
Singh, BN	1
Webb, SW	1
Hampel, G	1
Volans, GN	1
Dienstl, F	1
Koller, H	1
Prager, H	1
Sterz, H	1
Campbell, NP	1
Nimmo, J	1
Barber, JM	1
Ferguson, RW	1
Clements, JA	1
Kidner, PH	1
de Bakker, JM	1
Lellouche, D	1
Bougherbal, R	1
Drazkiewicz, U	1
Petelenz, T	1
Axenti, I	1
Olszowy, Z	1
Bach, P	1
Gonschior, P	1
Prinz, C	1
Kreuzer, E	1
Autenrieth, G	1
Steinbeck, G	1
Bruno, R	1
Santoni, Y	1
Iliadis, A	1
Djiane, P	1
Serradimigni, A	2
Cano, JP	2
He, ZS	1
Komori, S	1
Tamura, K	1
Tanabe, T	1
Takahashi, K	1
Yoshioka, K	1
Goto, Y	1
Hansen, O	1
Johansson, BW	1
Gullberg, B	1
Campbell, JK	1
Marshall, RJ	1
Winslow, E	1
Hashimoto, H	1
Satoh, N	1
Nakashima, M	1
Podrid, PJ	2
Kowey, PR	1
Frishman, WH	1
Arnold, RJ	1
Kaniecki, DJ	1
Beck, JR	1
Beshansky, JR	1
Shi, HM	1
Dai, RH	1
Wang, SY	1
Datta-Chaudhari, ML	1
O'Brien, TD	1
Conorev, EA	1
Rudnev, DV	2
Conorev, LA	1
Polumiskov, VY	1
Golikov, AP	2
Zacà, F	1
Ghinelli, M	1
Bombardini, T	1
De Collibus, C	1
Zaccaria, O	1
Steffanon, L	1
Azzolini, U	1
Valentini, P	1
Puddu, P	1
Roden, DM	1
Di Taranto, A	1
De Matteis, D	1
Zehender, M	1
Geibel, A	1
Hust, M	1
Hohnloser, S	1
Meinertz, T	1
Just, H	1
Duff, HJ	1
Cannon, NJ	1
Sheldon, RS	1
Aguglia, F	1
Gnecchi, M	1
De Marzio, P	1
Lévy-Prades, R	1
Philip, F	1
Danays, T	1
Anderson, JL	1
Han, J	1
Derhsam, GH	1
O'Connell, DP	1
Nora, MO	1
Chandrasekaran, K	1
Hammill, SC	1
Reeder, GS	1
Romanò, M	1
Spinelli, A	1
Muzio, L	1
Bernard, R	1
Renard, M	1
Shita, A	1
de Hemptinne, J	1
Gillet, JM	1
Lewinson, H	1
Liebens, I	1
Waterschoot, P	1
Denniss, AR	2
Ross, DL	2
Cody, DV	2
Russell, PA	2
Young, AA	2
Richards, DA	2
Uther, JB	2
Peyrieux, JC	1
Boissel, JP	1
Leizorovicz, A	1
Kasanuki, H	1
Onishi, S	1
Hirosawa, K	1
Sebbah, J	1
Khemache, A	1
Gryman, R	1
Farinotti, R	1
Guérot, C	1
Valère, PE	1
Forzoni, M	1
Lucioli, F	1
Burali, A	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Catheter Ablation for Ventricular Tachycardia in Patients With an Implantable Cardioverter Defibrillator (CALYPSO) PILOT TRIAL[NCT01576042]		27 participants (Actual)	Interventional	2012-05-31	Terminated (stopped due to Main objectives of the study were met; consensus among investigators that continuing the study would not add new information beyond that already learned.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Records participants hospitalized for VT during the study (NCT01576042)
Timeframe: Baseline, 6 months

Number of Participants Completed Month 3 Follow-Up

Intervention	participants (Number)
Catheter Ablation	5
Antiarrhythmic Medication	7

Records participants who completed Month 3 Follow-Up Visit (NCT01576042)
Timeframe: 3 months

Number of Participants Completed Month 6 Follow-Up

Intervention	participants (Number)
Catheter Ablation	11
Antiarrhythmic Medication	12

Records participants who completed Month 6 Follow-Up Visit (NCT01576042)
Timeframe: 6 Months

Number of Participants Had at Least One of the Efficacy Outcome Measurement

Intervention	participants (Number)
Catheter Ablation	7
Antiarrhythmic Medication	10

Records participants who had at least one of the efficacy outcome measurement (including death, hospitalization due to VT) (NCT01576042)
Timeframe: 6 Months

Number of Participants Received Treatment Assigned

Intervention	participants (Number)
Catheter Ablation	11
Antiarrhythmic Medication	14

Records participants who received study randomized treatment during the study (NCT01576042)
Timeframe: 6 months

Number of Participants Remained on Randomized Treatment Assignment

Intervention	participants (Number)
Catheter Ablation	11
Antiarrhythmic Medication	14

Records participants who only received study treatment as randomized during the entire study (NCT01576042)
Timeframe: 6 month

Number of Participants Switched to Other Arm

Intervention	participants (Number)
Catheter Ablation	6
Antiarrhythmic Medication	13

Records participants who received study treatment as randomized and later switched to other treatment arm during the study (NCT01576042)
Timeframe: 6 months

Time to First Recurrent ICD Therapy for VT

Intervention	participants (Number)
Catheter Ablation	5
Antiarrhythmic Medication	1

Days from the date of the first study treatment to the date of first ICD recurrent therapy for VT. (NCT01576042)
Timeframe: Baseline, 6 months

Article	Year
[Medical treatment of extrasystole and tachycardia (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1980, Jan-18, Volume: 122, Issue:3 Topics: Action Potentials; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Bretylium Compounds; Calcium; Cardi	1980
Comparison of the efficacy of newly developed antiarrhythmic drugs in the treatment of ventricular tachyarrhythmias. European heart journal, 1984, Volume: 5 Suppl B Topics: Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Coronary Disease; Encaini	1984
Clinical antiarrhythmic efficacy of mexiletine: a review. Acta cardiologica. Supplementum, 1980, Issue:25 Topics: Administration, Oral; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Heart Con	1980
Sudden cardiac death: role of left ventricular dysfunction. Annals of the New York Academy of Sciences, 1982, Volume: 382 Topics: Arrhythmias, Cardiac; Coronary Disease; Death, Sudden; Electrocardiography; Heart Ventricles; Humans	1982
Prevention of sudden coronary death by chronic antiarrhythmic therapy. Advances in cardiology, 1978, Volume: 25 Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Bretylium Compounds; Clinical Trials as Topic; Death,	1978
Mexiletine: a review of its pharmacological properties and therapeutic efficacy in arrhythmias. Drugs, 1979, Volume: 17, Issue:3 Topics: Arrhythmias, Cardiac; Electrophysiology; Hemodynamics; Humans; Intestinal Absorption; Kinetics; Mexi	1979
[Ventricular tachycardia in anterior wall aneurysm after myocardial infarct]. Der Internist, 1992, Volume: 33, Issue:11 Topics: Aged; Amiodarone; Drug Therapy, Combination; Electrocardiography, Ambulatory; Heart Aneurysm; Heart	1992
Comparative cost-effectiveness analysis of quinidine, procainamide and mexiletine. The American journal of cardiology, 1991, Dec-15, Volume: 68, Issue:17 Topics: Ambulatory Care; Arrhythmias, Cardiac; Cost-Benefit Analysis; Costs and Cost Analysis; Decision Maki	1991
The role of antiarrhythmic drugs in prevention of sudden cardiac death. Cardiovascular clinics, 1985, Volume: 15, Issue:3 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Comple	1985
Rationale of combination antiarrhythmic drug therapy. Cardiovascular clinics, 1985, Volume: 16, Issue:1 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Bretylium Compounds; Digitalis Glyc	1985
Mexiletine. The New England journal of medicine, 1987, Jan-01, Volume: 316, Issue:1 Topics: Arrhythmias, Cardiac; Humans; Mexiletine; Myocardial Infarction	1987

Article	Year
Oral mexiletine in high-risk patients after myocardial infarction. Lancet (London, England), 1981, Apr-04, Volume: 1, Issue:8223 Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Mexiletine; Myocardial Infarction; Propylamin	1981
[Clinical study of the anti-arrhythmia preparation, mexitil]. Kardiologiia, 1980, Volume: 20, Issue:10 Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Clinical Tr	1980
[Antiarrhythmic efficacy of mexiletine, propafenone and flecainide in ventricular premature beats. A comparative study in patients after myocardial infarction (author's transl)]. Zeitschrift fur Kardiologie, 1982, Volume: 71, Issue:5 Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Coronary Disease; Electrocardiogr	1982
International mexiletine and placebo antiarrhythmic coronary trial: I. Report on arrhythmia and other findings. Impact Research Group. Journal of the American College of Cardiology, 1984, Volume: 4, Issue:6 Topics: Adult; Aged; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Clinical Trials as Topic; Delayed-A	1984
A trial of intravenous and oral mexiletine in acute myocardial infarction. European journal of clinical pharmacology, 1984, Volume: 26, Issue:5 Topics: Administration, Oral; Arrhythmias, Cardiac; Clinical Trials as Topic; Humans; Infusions, Parenteral;	1984
Antiarrhythmic efficacy of combined intravenous and oral mexiletine in acute myocardial infarction. A double blind placebo-controlled study. European heart journal, 1984, Volume: 5, Issue:8 Topics: Adult; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Fem	1984
Clinical antiarrhythmic efficacy of mexiletine: a review. Acta cardiologica. Supplementum, 1980, Issue:25 Topics: Administration, Oral; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Heart Con	1980
Mexiletine in clinical practice. Acta cardiologica. Supplementum, 1980, Issue:25 Topics: Acute Disease; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Humans; Lidoc	1980
[Mexiletin for treatment of ventricular ectopic rhythm in patients with acute myocardial infarction (author's transl)]. Zeitschrift fur Kardiologie, 1980, Volume: 69, Issue:4 Topics: Acute Disease; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Female; Heart Ventricles; Human	1980
A trial of prophylactic mexiletine in home coronary care. British heart journal, 1982, Volume: 48, Issue:3 Topics: Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Fema	1982
[Hemodynamic effects of lidocaine and mexiletine in acute heart infarction]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1982, Aug-01, Volume: 37, Issue:15 Topics: Acute Disease; Female; Hemodynamics; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial In	1982
Signal-averaged ECG in prediction of the short-term suppression of ventricular premature beats by Mexiletine. International journal of cardiology, 1994, Volume: 46, Issue:3 Topics: Administration, Oral; Algorithms; Cardiac Complexes, Premature; Delayed-Action Preparations; Electro	1994
[Informed consent, what information is left after a therapeutic trial?]. Archives des maladies du coeur et des vaisseaux, 1994, Volume: 87, Issue:1 Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Informed Consent; Male;	1994
The effects of intravenous mexiletine on spectra of the signal-averaged ECG. Pacing and clinical electrophysiology : PACE, 1994, Volume: 17, Issue:11 Pt 2 Topics: Electrocardiography; Female; Humans; Infusions, Intravenous; Male; Mexiletine; Middle Aged; Myocardi	1994
Comparison of procainamide and mexiletine in prevention of ventricular arrhythmias after acute myocardial infarction. Lancet (London, England), 1975, Jun-07, Volume: 1, Issue:7919 Topics: Administration, Oral; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Drug Evaluation; Humans;	1975
[Treatment of ventricular extrasystole with mexiletine and Neo-gilurytmal in myocardial infarct patients]. Advances in clinical pharmacology, 1978, Volume: 16 Topics: Adult; Aged; Ajmaline; Cardiac Complexes, Premature; Clinical Trials as Topic; Electrocardiography;	1978
Ventricular arrhythmias after acute myocardial infarction treated with procainamide or mexiletine. Postgraduate medical journal, 1977, Volume: 53 Suppl 1 Topics: Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Humans; Male; Mexiletine; Myocardial Infarctio	1977
Mexiletine in the prevention of ventricular arrhythmias in acute myocardial infarction. Postgraduate medical journal, 1977, Volume: 53 Suppl 1 Topics: Administration, Oral; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Female; Humans; Male; Me	1977
[Treatment of ventricular arrhythmias after acute myocardial infarct with procaine amide and mexiletine]. Advances in clinical pharmacology, 1978, Volume: 16 Topics: Adult; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Hea	1978
Prevention of sudden coronary death by chronic antiarrhythmic therapy. Advances in cardiology, 1978, Volume: 25 Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Bretylium Compounds; Clinical Trials as Topic; Death,	1978
[Frequency and prevention of ventricular arrhythmias after acute myocardial infarct]. Schweizerische medizinische Wochenschrift, 1976, Nov-06, Volume: 106, Issue:45 Topics: Arrhythmias, Cardiac; Humans; Male; Mexiletine; Myocardial Infarction	1976
[Méxiletine. Action on heart rhythm disorders]. La Nouvelle presse medicale, 1975, Feb-01, Volume: 4, Issue:5 Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Clinical Trials as Topic; Drug E	1975
[Long-term mexiletine treatment of ventricular arrhythmia in patients after myocardial infarction]. Polskie Archiwum Medycyny Wewnetrznej, 1992, Volume: 87, Issue:3 Topics: Administration, Oral; Adult; Aged; Cardiac Complexes, Premature; Dose-Response Relationship, Drug; F	1992
Evaluation of disopyramide and mexiletine used alone and in combination for ventricular arrhythmias in patients with and without overt heart disease. International journal of cardiology, 1991, Volume: 32, Issue:3 Topics: Administration, Oral; Adult; Aged; Cardiac Complexes, Premature; Cardiomyopathy, Dilated; Cardiomyop	1991
Prophylactic use of mexiletine in the elderly with acute myocardial infarction. The Journal of the Association of Physicians of India, 1990, Volume: 38, Issue:2 Topics: Administration, Oral; Aged; Double-Blind Method; Drug Administration Schedule; Drug Evaluation; Elec	1990
The role of antiarrhythmic drugs in prevention of sudden cardiac death. Cardiovascular clinics, 1985, Volume: 15, Issue:3 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Comple	1985
[Anti-arrhythmia effectiveness and tolerance of retard in comparison with standard mexiletine]. Zeitschrift fur Kardiologie, 1987, Volume: 76, Issue:8 Topics: Adult; Aged; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Clinical Trials as Topic; Coronary	1987
Randomized controlled trial of prophylactic antiarrhythmic therapy in patients with inducible ventricular tachyarrhythmias after recent myocardial infarction. European heart journal, 1988, Volume: 9, Issue:7 Topics: Actuarial Analysis; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Electric Stimu	1988
International Mexiletine and Placebo Antiarrhythmic Coronary Trial (IMPACT): II. Results from 24-hour electrocardiograms. IMPACT Research Group. European heart journal, 1986, Volume: 7, Issue:9 Topics: Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Electrocardiograph	1986
Relationship between plasma mexiletine levels at steady-state. Presence of ventricular arrhythmias and side effects. Fundamental & clinical pharmacology, 1987, Volume: 1, Issue:1 Topics: Adult; Aged; Arrhythmias, Cardiac; Data Interpretation, Statistical; Female; Heart Ventricles; Human	1987

Article	Year
Polymyositis presenting with cardiac manifestations: Report of two cases and review of the literature. Clinical neurology and neurosurgery, 2010, Volume: 112, Issue:2 Topics: Adult; Anti-Arrhythmia Agents; Female; Heart Failure; Humans; Male; Mexiletine; Muscle, Skeletal; My	2010
Mexiletine protects myocardium during acute ischemia by opening sarcolemmal K-ATP channel: studies in closed-chest acute ischemia model in rabbits. Journal of cardiovascular pharmacology, 2004, Volume: 44, Issue:6 Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Disease Models, A	2004
Drug-induced hypersensitivity syndrome due to mexiletine associated with human herpes virus 6 and cytomegalovirus reactivation. The Journal of dermatology, 2005, Volume: 32, Issue:4 Topics: Aged; Anti-Arrhythmia Agents; Blood Chemical Analysis; Cytomegalovirus Infections; Diagnosis, Differ	2005
Mexiletine after myocardial infarction. Lancet (London, England), 1981, Apr-25, Volume: 1, Issue:8226 Topics: Death, Sudden; Humans; Mexiletine; Myocardial Infarction; Propylamines	1981
[Decrease in the fast sodium inflow current, a possible reason for the anti-arrhythmic action of etmozin and mexityl in the late stage of experimental myocardial infarct]. Kardiologiia, 1980, Volume: 20, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Dogs; Dose-Response Relationship, Dru	1980
[Esophageal ulcer caused by mexiletine]. Deutsche medizinische Wochenschrift (1946), 1983, Jul-01, Volume: 108, Issue:26 Topics: Aged; Cardiac Complexes, Premature; Esophageal Diseases; Female; Hemoptysis; Humans; Male; Mexiletin	1983
Hemodynamic effects of antiarrhythmic drugs in acute myocardial infarction. Giornale italiano di cardiologia, 1984, Volume: 14, Issue:10 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Central Ve	1984
Pharmacokinetics of oral mexiletine in patients with acute myocardial infarction. European journal of clinical pharmacology, 1983, Volume: 25, Issue:6 Topics: Absorption; Administration, Oral; Blood Proteins; Half-Life; Humans; Kinetics; Mexiletine; Middle Ag	1983
[Mexiletine, an anti-arrhythmia agent for acute stage of myocardial infarction]. Nihon rinsho. Japanese journal of clinical medicine, 1983, Volume: 41, Issue:12 Topics: Administration, Oral; Anti-Arrhythmia Agents; Half-Life; Humans; Infusions, Parenteral; Kinetics; Me	1983
The usefulness of Holter monitoring in the evaluation of antiarrhythmic drug efficacy for tachycardia. Japanese circulation journal, 1983, Volume: 47, Issue:1 Topics: Adult; Aged; Angina Pectoris, Variant; Anti-Arrhythmia Agents; Diltiazem; Disopyramide; Female; Hear	1983
Intravenous mexiletine in management of lidocaine-resistant ventricular tachycardia. American heart journal, 1983, Volume: 105, Issue:4 Topics: Adult; Drug Resistance; Female; Humans; Injections, Intravenous; Lidocaine; Male; Mexiletine; Middle	1983
Hemodynamic effects of an intravenous injection of mexiletine in patients hospitalised in intensive care units. Acta cardiologica. Supplementum, 1980, Issue:25 Topics: Adult; Aged; Female; Hemodynamics; Humans; Injections, Intravenous; Intensive Care Units; Male; Mexi	1980
Mexiletine in the treatment of ventricular arrhythmias. Acta cardiologica. Supplementum, 1980, Issue:25 Topics: Administration, Oral; Adult; Aged; Arrhythmias, Cardiac; Female; Heart Arrest; Heart Ventricles; Hum	1980
Adaptation of the dose of mexiletine according to pharmacokinetic data. Acta cardiologica. Supplementum, 1980, Issue:25 Topics: Administration, Oral; Humans; Injections, Intravenous; Kidney Failure, Chronic; Kinetics; Mexiletine	1980
Clinical efficacy of antiarrhythmic drugs in prevention of sudden coronary death. Annals of the New York Academy of Sciences, 1982, Volume: 382 Topics: Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Coronary Angiography; Coronary Artery Bypas	1982
[Sulfinpyrazone-associated renal failure (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1982, Jul-09, Volume: 107, Issue:27 Topics: Acute Kidney Injury; Adult; Aged; Blood Urea Nitrogen; Creatinine; Female; Humans; Indomethacin; Mal	1982
[Mexiletine in the treatment of lidocaine-resistant ventricular tachycardia. Preliminary results]. Giornale italiano di cardiologia, 1982, Volume: 12, Issue:6 Topics: Drug Resistance; Female; Humans; Lidocaine; Male; Mexiletine; Myocardial Infarction; Propylamines; T	1982
[Antiarrhythmic treatment with mexiletine in acute myocardial infarction (author's transl)]. Giornale italiano di cardiologia, 1981, Volume: 11, Issue:4 Topics: Aged; Arrhythmias, Cardiac; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Inf	1981
Recurrence of ventricular fibrillation in acute ischemic heart disease. Circulation, 1981, Volume: 64, Issue:6 Topics: Acute Disease; Anti-Arrhythmia Agents; Coronary Disease; Female; Heart Arrest; Humans; Lidocaine; Ma	1981
Chronic effect of oral mexiletine administration on left ventricular contractility in patients with congestive heart failure: a study based on mitral regurgitant flow velocity measured by continuous-wave Doppler echocardiography. Journal of clinical pharmacology, 1995, Volume: 35, Issue:5 Topics: Administration, Oral; Adult; Aged; Blood Flow Velocity; Cardiomyopathy, Dilated; Echocardiography, D	1995
Antiarrhythmic effect of a sotalol-mexiletine combination on induced ventricular tachycardia in dogs. Journal of cardiovascular pharmacology, 1993, Volume: 21, Issue:2 Topics: Animals; Coronary Vessels; Dogs; Drug Combinations; Electric Stimulation; Electrocardiography; Elect	1993
[Drug therapy of tachyarrhythmias (author's transl)]. Klinische Wochenschrift, 1978, Feb-15, Volume: 56, Issue:4 Topics: Action Potentials; Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Aprind	1978
[Effects of mexiletine and lidocaine on myocardial performance in heart disease patients in various functional classes]. Bollettino della Societa italiana di cardiologia, 1978, Volume: 23, Issue:6 Topics: Adult; Arrhythmias, Cardiac; Cardiac Output; Coronary Disease; Heart Diseases; Heart Rate; Humans; L	1978
The treatment of ventricular arrhythmias in acute myocardial infarction. British journal of hospital medicine, 1979, Volume: 21, Issue:4 Topics: Anti-Arrhythmia Agents; Electric Countershock; Electrocardiography; Humans; Lidocaine; Mexiletine; M	1979
A schedule for combined intravenous and oral dosing with mexiletine. The Journal of international medical research, 1979, Volume: 7, Issue:2 Topics: Administration, Oral; Adult; Female; Humans; Infusions, Parenteral; Male; Mexiletine; Myocardial Inf	1979
[Mexiletine in supraventricular arrhythmias]. Advances in clinical pharmacology, 1978, Volume: 16 Topics: Aged; Arrhythmias, Cardiac; Electrocardiography; Humans; Mexiletine; Myocardial Infarction; Propylam	1978
[Experience with mexiletine in the occurrence of ventricular arrhythmias in the acute phase of myocardial infarct]. Advances in clinical pharmacology, 1978, Volume: 16 Topics: Acute Disease; Aged; Arrhythmias, Cardiac; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged;	1978
Long-term oral antiarrhythmic therapy with mexiletine. British heart journal, 1978, Volume: 40, Issue:7 Topics: Administration, Oral; Arrhythmias, Cardiac; Coronary Disease; Female; Humans; Male; Mexiletine; Midd	1978
The development of mexiletine in the treatment of cardiac arrhythmias. Postgraduate medical journal, 1977, Volume: 53 Suppl 1 Topics: Arrhythmias, Cardiac; Humans; Mexiletine; Myocardial Infarction; Propylamines	1977
The use of mexiletine at the Ulster Hospital, Belfast. Postgraduate medical journal, 1977, Volume: 53 Suppl 1 Topics: Adult; Aged; Arrhythmias, Cardiac; Drug Tolerance; Female; Humans; Male; Mexiletine; Middle Aged; My	1977
Absorption, distribution and elimination of mexiletine. Postgraduate medical journal, 1977, Volume: 53 Suppl 1 Topics: Adult; Half-Life; Humans; Intestinal Absorption; Kinetics; Male; Mexiletine; Myocardial Infarction;	1977
Prevention of ventricular arrhythmias after myocardial infarction. Journal of the Royal College of Physicians of London, 1977, Volume: 11, Issue:4 Topics: Disopyramide; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Procainamide; Propranolol; Quini	1977
[The antifibrillatory effect of mexiletine (Kö 1173) in experimentally induced myocardial infarct]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1976, Volume: 82 Pt 2 Topics: Animals; Atrial Fibrillation; Disease Models, Animal; Dogs; Mexiletine; Myocardial Infarction; Propy	1976
Proceedings: Comparison of mexiletine and procainamide in prevention of recurrent ventricular arrhythmias after acute myocardial infarction. British heart journal, 1975, Volume: 37, Issue:7 Topics: Arrhythmias, Cardiac; Electrocardiography; Heart Ventricles; Humans; Male; Mexiletine; Myocardial In	1975
Simultaneous modelling of mexiletine and hydroxy-methyl-mexiletine data after single- and multiple-dose administration of a sustained-release mexiletine formulation. Biopharmaceutics & drug disposition, 1992, Volume: 13, Issue:7 Topics: Aged; Delayed-Action Preparations; Drug Administration Schedule; Humans; Male; Mexiletine; Middle Ag	1992
Inhibitory effect of moricizine on reperfusion induced tachyarrhythmias in rats--a comparison study with disopyramide and mexiletine. Japanese circulation journal, 1992, Volume: 56, Issue:8 Topics: Animals; Disopyramide; Heart; Hemodynamics; Male; Mexiletine; Moricizine; Myocardial Infarction; Rat	1992
Metabolic, hemodynamic, and electrocardiographic responses to increased circulating adrenaline: effects of pretreatment with class 1 antiarrhythmics. Angiology, 1991, Volume: 42, Issue:12 Topics: Adult; Analysis of Variance; Blood Pressure; Disopyramide; Electrocardiography; Epinephrine; Flecain	1991
Comparison of the electrophysiological effects of Org 7797, disopyramide, mexiletine and propafenone in anaesthetized dogs with myocardial infarcts. British journal of pharmacology, 1991, Volume: 104, Issue:2 Topics: Anesthetics; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disopyramide; Dogs; Electr	1991
Coupling interval-related effects of class I antiarrhythmic drugs, mexiletine, cibenzoline and disopyramide, on ventricular activation in canine myocardial infarction. Japanese journal of pharmacology, 1991, Volume: 57, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Disopyramide; Dogs; Electric Stimulation; E	1991
[Primary research on the clinical significance of ventricular late potentials (VLPs), and the impact of mexiletine, lidocaine and Astragalus membranaceus on VLPs]. Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine, 1991, Volume: 11, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Astragalus propinquus; Drugs, Chinese Herbal;	1991
Pharmacologic modifications of reperfusion arrhythmias in the dog in vivo: possible relation to limitation of the extent of infarction. International journal of cardiology, 1990, Volume: 28, Issue:3 Topics: Animals; Arrhythmias, Cardiac; Butylated Hydroxytoluene; Dogs; Drug Therapy, Combination; Electrocar	1990
[Mexiletine in patients with progressive infarction and reduced ventricular function: anti-arrhythmic efficacy and hemodynamic effects]. Giornale italiano di cardiologia, 1990, Volume: 20, Issue:6 Topics: Aged; Arrhythmias, Cardiac; Electrocardiography; Female; Heart Ventricles; Hemodynamics; Humans; Mal	1990
Antiarrhythmic drugs. Clinical pharmacology of the old and the new agents. Postgraduate medicine, 1985, Sep-15, Volume: 78, Issue:4 Topics: Acecainide; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death, Sudden; Delayed-Action	1985
[Evaluation of the efficiency of mexiletine in ventricular extrasystole in the post-infarct stage]. La Clinica terapeutica, 1987, Mar-31, Volume: 120, Issue:6 Topics: Adult; Aged; Cardiac Complexes, Premature; Drug Administration Schedule; Female; Humans; Male; Mexil	1987
Mexiletine-quinidine in isolated hearts: an interaction involving the sodium channel. Cardiovascular research, 1989, Volume: 23, Issue:7 Topics: Action Potentials; Animals; Coronary Disease; Drug Synergism; Drug Therapy, Combination; Heart; Hear	1989
Lidocaine, mexiletine and propafenone in the treatment of arrhythmias complicating myocardial infarction. A case report. International journal of cardiology, 1985, Volume: 7, Issue:3 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Cardiac Complexes, Premature; Dru	1985
[Reperfusion syndrome during thrombolytic therapy of myocardial infarct]. Kardiologiia, 1989, Volume: 29, Issue:11 Topics: Arrhythmias, Cardiac; Female; Fibrinolytic Agents; Hemodynamics; Humans; Male; Mexiletine; Middle Ag	1989
Mexiletine in acute myocardial infarction. Simulation of a theoretical protocol and validation in six patients. Arzneimittel-Forschung, 1989, Volume: 39, Issue:8 Topics: Acute Disease; Adult; Aged; Biological Availability; Electrocardiography; Female; Humans; Infusions,	1989
Arrhythmogenic effects of mexiletine in infarcted Purkinje tissues. Journal of electrocardiology, 1989, Volume: 22, Issue:1 Topics: Animals; Dogs; Dose-Response Relationship, Drug; Female; Heart Conduction System; Heart Ventricles;	1989
Prolongation of ventricular depolarization. ECG manifestation of mexiletine toxicity. Chest, 1989, Volume: 95, Issue:4 Topics: Aged; Arrhythmias, Cardiac; Electrocardiography; Female; Heart Conduction System; Humans; Kidney Fai	1989
[2 cases of lidocaine-resistant ventricular tachycardia treated with i.v. mexiletine during complicated acute myocardial infarct]. La Clinica terapeutica, 1987, Nov-30, Volume: 123, Issue:4 Topics: Aged; Aged, 80 and over; Drug Resistance; Electrocardiography; Female; Heart Ventricles; Humans; Inf	1987
[Hemodynamic repercussions and clinical tolerance of 6 class I anti-arrhythmia agents in acute myocardial infarction]. Annales de cardiologie et d'angeiologie, 1986, Volume: 35, Issue:4 Topics: Ajmaline; Anti-Arrhythmia Agents; Benzeneacetamides; Fluorenes; Hemodynamics; Lidocaine; Mexiletine;	1986
Effect of antiarrhythmic therapy on delayed potentials detected by the signal-averaged electrocardiogram in patients with ventricular tachycardia after acute myocardial infarction. The American journal of cardiology, 1986, Aug-01, Volume: 58, Issue:3 Topics: Action Potentials; Adult; Aged; Anti-Arrhythmia Agents; Electrocardiography; Heart Ventricles; Human	1986
The usefulness of electrophysiological-pharmacologic studies in the long-term therapy of paroxysmal tachycardias. Japanese circulation journal, 1985, Volume: 49, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Cardiomyopathies; Chromatogra	1985
[Early interruption of antiarrhythmia treatment in the acute phase of infarction complicated by ventricular arrhythmia]. Annales de cardiologie et d'angeiologie, 1985, Volume: 34, Issue:3 Topics: Arrhythmias, Cardiac; Drug Administration Schedule; Female; Humans; Male; Mexiletine; Middle Aged; M	1985
[Ventricular fibrillation caused by myocardial infarction refractory to electric shock and xylocaine. Positive response to intravenous mexiletine]. Minerva cardioangiologica, 1985, Volume: 33, Issue:3 Topics: Electric Countershock; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Infarction; Prop	1985

mexiletine and Cardiovascular Stroke