mexiletine has been researched along with Cardiac Failure in 15 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The goal of this study was to evaluate the influence of congestive heart failure (CHF) on the clearance of mexiletine." | 9.12 | Effect of congestive heart failure on mexiletine pharmacokinetics in a Japanese population. ( Fukumoto, K; Kobayashi, M; Ueno, K, 2006) |
| "The long-term effect of mexiletine on left ventricular (LV) contractility in patients with congestive heart failure is not clear." | 7.69 | Chronic effect of oral mexiletine administration on left ventricular contractility in patients with congestive heart failure: a study based on mitral regurgitant flow velocity measured by continuous-wave Doppler echocardiography. ( Hirabayashi, K; Matsuo, H; Morita, H; Nozaki, S; Ohmori, K; Yoshikawa, K, 1995) |
| "The goal of this study was to evaluate the influence of congestive heart failure (CHF) on the clearance of mexiletine." | 5.12 | Effect of congestive heart failure on mexiletine pharmacokinetics in a Japanese population. ( Fukumoto, K; Kobayashi, M; Ueno, K, 2006) |
| "Mexiletine and quinidine are often administered to patients with severe congestive heart failure, but their hemodynamic effects have not been adequately studied in these individuals." | 5.07 | Comparative hemodynamic effects of mexiletine and quinidine in patients with severe left ventricular dysfunction. ( Gottlieb, SS; Weinberg, M, 1991) |
| " In the present study, the chronic effects of clinical K-ATP channel openers, ie, nicorandil (Nic) and mexiletine (Mex), on cardiac function were evaluated in a rat model of experimental autoimmune myocarditis (EAM)." | 3.78 | Cardioprotective effects of sarcolemmal and mitochondrial K-ATP channel openers in an experimental model of autoimmune myocarditis. Role of the reduction in calcium overload during acute heart failure. ( Hirasawa, S; Izumi, T; Masuda, R; Masuda, T; Niwano, H; Niwano, S; Sasaki, S; Sato, K, 2012) |
| "The long-term effect of mexiletine on left ventricular (LV) contractility in patients with congestive heart failure is not clear." | 3.69 | Chronic effect of oral mexiletine administration on left ventricular contractility in patients with congestive heart failure: a study based on mitral regurgitant flow velocity measured by continuous-wave Doppler echocardiography. ( Hirabayashi, K; Matsuo, H; Morita, H; Nozaki, S; Ohmori, K; Yoshikawa, K, 1995) |
| "Mexiletine is thought to exert minimal negative inotropic actions, but its effects have not been evaluated in patients with severe congestive heart failure." | 3.68 | Cardiodepressant effects of mexiletine in patients with severe left ventricular dysfunction. ( Gottlieb, SS; Weinberg, M, 1992) |
| "The incidence of drug-induced congestive heart failure with several newer antiarrhythmic agents including encainide, ethmozine, lorcainide, mexiletine, propafenone and tocainide was determined in a group of 407 patients who underwent 1,133 drug tests." | 3.67 | Congestive heart failure induced by six of the newer antiarrhythmic drugs. ( Lampert, S; Lown, B; Podrid, PJ; Ravid, S, 1989) |
| "The clinical relevance of changes in pharmacokinetics of oral mexiletine (600 mg daily dose) was studied in 82 patients with ventricular arrhythmias and impaired liver, renal or heart function (control group n = 51, patients with liver cirrhosis n = 9, with renal insufficiency n = 14, or heart failure n = 8)." | 3.66 | Increase of mexiletine plasma levels due to delayed hepatic metabolism in patients with chronic liver disease. ( Lüderitz, B; Nitsch, J; Steinbeck, G, 1983) |
| "Mexiletine is a frequently used antiarrhythmic drug in patients with an implantable cardioverter defibrillator, usually thought of as producing no or minimal effects on the defibrillation threshold." | 1.31 | Mexiletine related chronic defibrillation threshold elevation: case report and review of the literature. ( Crystal, E; Ilia, R; Katz, A; Ovsyshcher, IE; Wagshal, AB, 2002) |
| "Mexiletine is a lidocaine analogue used in the treatment of symptomatic ventricular arrhythmias." | 1.28 | Mexiletine-associated left ventricular dysfunction: a case study. ( Ballas, SL; Baughman, KL; Griffith, LS; Veltri, EP, 1991) |
| "Antiarrhythmic drugs may induce congestive heart failure in patients with malignant ventricular arrhythmias and depressed left ventricular (LV) function." | 1.28 | Changes in cardiac output determined by continuous-wave Doppler echocardiography during propafenone or mexiletine drug testing. ( Lampert, S; Lange, H; Lown, B; Sutton, MS, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 6 (40.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bui, QM | 1 |
| Allen, LA | 1 |
| Monte, AA | 1 |
| Page, RL | 1 |
| McIlvennan, CK | 1 |
| Odabasi, Z | 1 |
| Yapundich, R | 1 |
| Oh, SJ | 1 |
| Niwano, S | 1 |
| Hirasawa, S | 1 |
| Niwano, H | 1 |
| Sasaki, S | 1 |
| Masuda, R | 1 |
| Sato, K | 1 |
| Masuda, T | 1 |
| Izumi, T | 1 |
| Kobayashi, M | 1 |
| Fukumoto, K | 1 |
| Ueno, K | 1 |
| Nitsch, J | 2 |
| Steinbeck, G | 2 |
| Lüderitz, B | 2 |
| Meinertz, T | 1 |
| Kasper, W | 1 |
| Stengel, E | 1 |
| Waldecker, B | 1 |
| Löllgen, H | 1 |
| Jähnchen, E | 1 |
| Bechtold, H | 1 |
| Just, J | 1 |
| Morita, H | 1 |
| Hirabayashi, K | 1 |
| Nozaki, S | 1 |
| Ohmori, K | 1 |
| Yoshikawa, K | 1 |
| Matsuo, H | 1 |
| Crystal, E | 1 |
| Ovsyshcher, IE | 1 |
| Wagshal, AB | 1 |
| Katz, A | 1 |
| Ilia, R | 1 |
| Gottlieb, SS | 2 |
| Weinberg, M | 2 |
| Ellison, MJ | 1 |
| Lyman, DJ | 1 |
| San Miguel, E | 1 |
| Ballas, SL | 1 |
| Baughman, KL | 1 |
| Griffith, LS | 1 |
| Veltri, EP | 1 |
| Lange, H | 1 |
| Lampert, S | 2 |
| Sutton, MS | 1 |
| Lown, B | 2 |
| Ravid, S | 1 |
| Podrid, PJ | 1 |
4 trials available for mexiletine and Cardiac Failure
| Article | Year |
|---|---|
Effect of congestive heart failure on mexiletine pharmacokinetics in a Japanese population.
Topics: Administration, Oral; Anti-Arrhythmia Agents; Asian People; Biological Availability; Chromatography, | 2006 |
Comparison of the antiarrhythmic activity of mexiletine and lorcainide on ventricular arrhythmias.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Clinical Trials as Top | 1982 |
[Effect of kidney, liver or heart insufficiency on blood mexiletine levels].
Topics: Arrhythmias, Cardiac; Biological Availability; Chromatography, Gas; Chronic Disease; Heart Failure; | 1982 |
Comparative hemodynamic effects of mexiletine and quinidine in patients with severe left ventricular dysfunction.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Cardiac Catheterization; Drug Evaluation; Fema | 1991 |
11 other studies available for mexiletine and Cardiac Failure
| Article | Year |
|---|---|
Amphetamine-positive urine drug screens in the setting of mexiletine use: A case series.
Topics: Adult; Aged; Amphetamine; Biomarkers; Central Nervous System Stimulants; Chromatography, Gas; Drug M | 2016 |
Polymyositis presenting with cardiac manifestations: Report of two cases and review of the literature.
Topics: Adult; Anti-Arrhythmia Agents; Female; Heart Failure; Humans; Male; Mexiletine; Muscle, Skeletal; My | 2010 |
Cardioprotective effects of sarcolemmal and mitochondrial K-ATP channel openers in an experimental model of autoimmune myocarditis. Role of the reduction in calcium overload during acute heart failure.
Topics: Action Potentials; Acute Disease; Animals; Anti-Arrhythmia Agents; Autoimmune Diseases; Calcium; Ech | 2012 |
Increase of mexiletine plasma levels due to delayed hepatic metabolism in patients with chronic liver disease.
Topics: Arrhythmias, Cardiac; Chronic Disease; Heart Failure; Humans; Kidney Diseases; Kinetics; Liver; Live | 1983 |
Chronic effect of oral mexiletine administration on left ventricular contractility in patients with congestive heart failure: a study based on mitral regurgitant flow velocity measured by continuous-wave Doppler echocardiography.
Topics: Administration, Oral; Adult; Aged; Blood Flow Velocity; Cardiomyopathy, Dilated; Echocardiography, D | 1995 |
Mexiletine related chronic defibrillation threshold elevation: case report and review of the literature.
Topics: Adult; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Equipment Failure; Heart Failure; Humans; Ma | 2002 |
Cardiodepressant effects of mexiletine in patients with severe left ventricular dysfunction.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Drug Evaluation; Female; Heart Failure; Hemodynamic | 1992 |
Threefold increase in theophylline serum concentration after addition of mexiletine.
Topics: Drug Synergism; Drug Therapy, Combination; Heart Failure; Humans; Male; Mexiletine; Middle Aged; The | 1992 |
Mexiletine-associated left ventricular dysfunction: a case study.
Topics: Heart Failure; Humans; Male; Mexiletine; Middle Aged; Stroke Volume; Tachycardia | 1991 |
Changes in cardiac output determined by continuous-wave Doppler echocardiography during propafenone or mexiletine drug testing.
Topics: Cardiac Output; Depression, Chemical; Echocardiography, Doppler; Female; Heart Failure; Humans; Male | 1990 |
Congestive heart failure induced by six of the newer antiarrhythmic drugs.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Enc | 1989 |