mexiletine has been researched along with Brain Ischemia in 8 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The volume of cerebral infarction was measured in serial brain sections stained with triphenyltetrazolium chloride (TTC)." | 5.31 | Alteration of ischemic reperfusion injury in the rat neocortex by a potent antioxidant mexiletine. ( Chang, CZ; Howng, SL; Jeng, AY; Kung, SS; Kwan, AL; Loh, JK; Winardi, D, 2002) |
| "Furthermore, brain seizure activity recorded following 1 h MCAo and 72 h of recovery in injured rats was either completely blocked (30 min pre-MCAo treatment) or significantly reduced (30 min post-MCAo treatment) with RS100642 (1." | 5.31 | Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat. ( Tortella, FC; Williams, AJ, 2002) |
| " Pretreatment with Mex resulted in a significant infarct volume reduction when administered intraperitoneally, either at the dosage of 50 or 60 mg/kg, 1 hr before MCA occlusion (P < 0." | 5.30 | Mexiletine and magnesium independently, but not combined, protect against permanent focal cerebral ischemia in Wistar rats. ( Ayoub, IA; Harris, FB; Hassan, M; Lee, EJ; Maynard, KI; Ogilvy, CS, 1999) |
| "The development of hind paw mechanical allodynia was measured after BCAO using the von Frey test." | 1.43 | Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia. ( Harada, S; Matsuura, W; Tokuyama, S, 2016) |
| "Left middle cerebral artery occlusion following microcraniectomy and simultaneous bilateral carotid artery occlusion were performed." | 1.35 | The preventive effect of mexiletine on cerebral ischemic injury following experimental middle cerebral artery occlusion. ( Akar, A; Altinors, N; Caner, H; Cansever, T; Gulsen, S; Kabatas, S; Ozger, O; Yilmaz, C, 2009) |
| "Mexiletine pre-treatment reduced hippocampal damage by approximately half when compared to control animals receiving saline alone (45 vs." | 1.31 | The use-dependent sodium channel blocker mexiletine is neuroprotective against global ischemic injury. ( Hewitt, KE; Lesiuk, HJ; Stys, PK, 2001) |
| "The volume of cerebral infarction was measured in serial brain sections stained with triphenyltetrazolium chloride (TTC)." | 1.31 | Alteration of ischemic reperfusion injury in the rat neocortex by a potent antioxidant mexiletine. ( Chang, CZ; Howng, SL; Jeng, AY; Kung, SS; Kwan, AL; Loh, JK; Winardi, D, 2002) |
| "Furthermore, brain seizure activity recorded following 1 h MCAo and 72 h of recovery in injured rats was either completely blocked (30 min pre-MCAo treatment) or significantly reduced (30 min post-MCAo treatment) with RS100642 (1." | 1.31 | Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat. ( Tortella, FC; Williams, AJ, 2002) |
| " Pretreatment with Mex resulted in a significant infarct volume reduction when administered intraperitoneally, either at the dosage of 50 or 60 mg/kg, 1 hr before MCA occlusion (P < 0." | 1.30 | Mexiletine and magnesium independently, but not combined, protect against permanent focal cerebral ischemia in Wistar rats. ( Ayoub, IA; Harris, FB; Hassan, M; Lee, EJ; Maynard, KI; Ogilvy, CS, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matsuura, W | 1 |
| Harada, S | 1 |
| Tokuyama, S | 1 |
| Yilmaz, C | 1 |
| Ozger, O | 1 |
| Kabatas, S | 1 |
| Cansever, T | 1 |
| Akar, A | 1 |
| Gulsen, S | 1 |
| Altinors, N | 1 |
| Caner, H | 1 |
| Stys, PK | 2 |
| Lesiuk, H | 1 |
| Lee, EJ | 1 |
| Ayoub, IA | 1 |
| Harris, FB | 1 |
| Hassan, M | 1 |
| Ogilvy, CS | 1 |
| Maynard, KI | 1 |
| Hewitt, KE | 1 |
| Lesiuk, HJ | 1 |
| Chang, CZ | 1 |
| Winardi, D | 1 |
| Loh, JK | 1 |
| Kung, SS | 1 |
| Howng, SL | 1 |
| Jeng, AY | 1 |
| Kwan, AL | 1 |
| Williams, AJ | 1 |
| Tortella, FC | 1 |
| Dong, LP | 1 |
| Wang, TY | 1 |
| Zhang, L | 1 |
8 other studies available for mexiletine and Brain Ischemia
| Article | Year |
|---|---|
Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia.
Topics: Amines; Analgesics; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2016 |
The preventive effect of mexiletine on cerebral ischemic injury following experimental middle cerebral artery occlusion.
Topics: Animals; Anti-Arrhythmia Agents; Brain Ischemia; Calcium Channel Blockers; Disease Models, Animal; I | 2009 |
Correlation between electrophysiological effects of mexiletine and ischemic protection in central nervous system white matter.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Axons; Blood-Brain Barrier; Brain; Brain Ischemi | 1996 |
Mexiletine and magnesium independently, but not combined, protect against permanent focal cerebral ischemia in Wistar rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Drug Administration Schedule; Magnesium; Male; Mexilet | 1999 |
The use-dependent sodium channel blocker mexiletine is neuroprotective against global ischemic injury.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Body Temperature; Brain Ischemia; Hippocampus; Hypo | 2001 |
Alteration of ischemic reperfusion injury in the rat neocortex by a potent antioxidant mexiletine.
Topics: Animals; Anti-Arrhythmia Agents; Brain Edema; Brain Ischemia; Carotid Arteries; Cerebral Arteries; C | 2002 |
Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat.
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Dose-Response Relationship, Drug; Electroenceph | 2002 |
[Effect of mexiletine on energy metabolism of ischemic brain in mice].
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Dose-Response Relationship, Drug; Energy Metabolism | 1992 |