mexiletine has been researched along with Atrial Fibrillation in 14 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experimental studies and clinical reports suggest antiarrhythmic properties of mexiletine in different arrhythmias." | 7.88 | Broad antiarrhythmic effect of mexiletine in different arrhythmia models. ( Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Garthmann, J; Köbe, J; Kochhäuser, S; Reinke, F; Wasmer, K, 2018) |
| "We describe a case of acute myocardial infarction complicated by atrial and ventricular arrhythmias in which it was possible to verify the effectiveness of lidocaine, mexiletine and propafenone." | 7.67 | Lidocaine, mexiletine and propafenone in the treatment of arrhythmias complicating myocardial infarction. A case report. ( Aguglia, F; De Marzio, P; Gnecchi, M, 1985) |
| "Disopyramide was first infused intravenously at 1 mg kg-1 for 5 min followed by a continuous infusion at 0." | 5.28 | Effects of a combination of disopyramide and mexiletine on the anterograde accessory pathway conduction in patients with Wolff-Parkinson-White syndrome. ( Aihara, N; Kamakura, S; Kurita, T; Matsuhisa, M; Ohe, T; Shimizu, W; Shimomura, K; Takaki, H, 1992) |
| "Experimental studies and clinical reports suggest antiarrhythmic properties of mexiletine in different arrhythmias." | 3.88 | Broad antiarrhythmic effect of mexiletine in different arrhythmia models. ( Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Garthmann, J; Köbe, J; Kochhäuser, S; Reinke, F; Wasmer, K, 2018) |
| "To investigate frequency dependent conduction slowing by mexiletine in the human atrium, we examined inter-atrial conduction time (IACT) at different stimulation frequencies (100/min to 220/min) in 13 patients with paroxysmal atrial fibrillation (Paf) and 7 patients without Paf." | 3.68 | [Frequency dependent prolongation of inter-atrial conduction time by mexiletine in human atrium]. ( Asayama, J; Inoue, D; Inoue, M; Ishibashi, K; Nakagawa, M; Omori, I; Sakai, R; Yamahara, Y, 1993) |
| "We describe a case of acute myocardial infarction complicated by atrial and ventricular arrhythmias in which it was possible to verify the effectiveness of lidocaine, mexiletine and propafenone." | 3.67 | Lidocaine, mexiletine and propafenone in the treatment of arrhythmias complicating myocardial infarction. A case report. ( Aguglia, F; De Marzio, P; Gnecchi, M, 1985) |
| "Mexiletine is a very well-known class IB antiarrhythmic drug, whose enantiomers differ in both pharmacodynamic and pharmacokinetic properties, the (R)-isomer being the eutomer on experimental arrhythmias and in binding studies on cardiac voltage-gated sodium channels." | 1.39 | Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers. ( Bruno, C; Budriesi, R; Carocci, A; Catalano, A; Cavalluzzi, MM; Defrenza, I; Di Mola, A; Franchini, C; Lentini, G; Micucci, M, 2013) |
| "Electrocardiography (ECG) showed ventricular tachycardia." | 1.35 | A case of myotonic dystrophy presenting with ventricular tachycardia and atrial fibrillation. ( Eroğlu, S; Müderrisoğlu, H; Ozbiçer, S; Ozin, B, 2009) |
| "Disopyramide was first infused intravenously at 1 mg kg-1 for 5 min followed by a continuous infusion at 0." | 1.28 | Effects of a combination of disopyramide and mexiletine on the anterograde accessory pathway conduction in patients with Wolff-Parkinson-White syndrome. ( Aihara, N; Kamakura, S; Kurita, T; Matsuhisa, M; Ohe, T; Shimizu, W; Shimomura, K; Takaki, H, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (28.57) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Catalano, A | 1 |
| Budriesi, R | 1 |
| Bruno, C | 1 |
| Di Mola, A | 1 |
| Defrenza, I | 1 |
| Cavalluzzi, MM | 1 |
| Micucci, M | 1 |
| Carocci, A | 1 |
| Franchini, C | 1 |
| Lentini, G | 1 |
| Dewal, RS | 1 |
| Greer-Short, A | 1 |
| Lane, C | 1 |
| Nirengi, S | 1 |
| Manzano, PA | 1 |
| Hernández-Saavedra, D | 1 |
| Wright, KR | 1 |
| Nassal, D | 1 |
| Baer, LA | 1 |
| Mohler, PJ | 1 |
| Hund, TJ | 1 |
| Stanford, KI | 1 |
| Frommeyer, G | 1 |
| Garthmann, J | 1 |
| Ellermann, C | 1 |
| Dechering, DG | 1 |
| Kochhäuser, S | 1 |
| Reinke, F | 1 |
| Köbe, J | 1 |
| Wasmer, K | 1 |
| Eckardt, L | 1 |
| Staudacher, I | 1 |
| Seehausen, S | 1 |
| Illg, C | 1 |
| Lugenbiel, P | 1 |
| Schweizer, PA | 1 |
| Katus, HA | 1 |
| Thomas, D | 1 |
| Eroğlu, S | 1 |
| Ozin, B | 1 |
| Ozbiçer, S | 1 |
| Müderrisoğlu, H | 1 |
| El Yaman, M | 1 |
| Perry, J | 1 |
| Makielski, JC | 1 |
| Ackerman, MJ | 1 |
| Cernusková, L | 1 |
| Benes, L | 1 |
| Csöllei, J | 1 |
| Tumová, I | 1 |
| Svec, P | 1 |
| Sakai, R | 1 |
| Inoue, D | 2 |
| Ishibashi, K | 1 |
| Inoue, M | 1 |
| Omori, I | 2 |
| Yamahara, Y | 1 |
| Asayama, J | 1 |
| Nakagawa, M | 2 |
| Henning, B | 1 |
| Merx, W | 1 |
| de Bakker, JM | 1 |
| Effert, S | 1 |
| Fomina, IG | 1 |
| Iankin, VV | 1 |
| Shimizu, W | 1 |
| Ohe, T | 1 |
| Kurita, T | 1 |
| Takaki, H | 1 |
| Aihara, N | 1 |
| Kamakura, S | 1 |
| Matsuhisa, M | 1 |
| Shimomura, K | 1 |
| Aguglia, F | 1 |
| Gnecchi, M | 1 |
| De Marzio, P | 1 |
| Shirayama, T | 1 |
| Katsume, H | 1 |
| Róna, G | 1 |
1 trial available for mexiletine and Atrial Fibrillation
| Article | Year |
|---|---|
[Prospective course of therapy arresting attacks of atrial fibrillation in patients with preexcitation syndromes].
Topics: Adult; Aged; Aged, 80 and over; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; D | 1992 |
13 other studies available for mexiletine and Atrial Fibrillation
| Article | Year |
|---|---|
Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Female; Guinea Pigs; Heart Atria; Mexiletine; | 2013 |
Phospho-ablation of cardiac sodium channel Na
Topics: Animals; Atrial Fibrillation; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Diet, High-Fat; Ge | 2021 |
Broad antiarrhythmic effect of mexiletine in different arrhythmia models.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Disea | 2018 |
Cardiac K
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrophysiological Phenomena; Gene Expressio | 2019 |
A case of myotonic dystrophy presenting with ventricular tachycardia and atrial fibrillation.
Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Defibrillators, Implantable | 2009 |
Suppression of atrial fibrillation with mexiletine pharmacotherapy in a young woman with type 1 long QT syndrome.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Child; Female; Humans; Long QT Syndrome; Mexiletine | 2008 |
Carbamate analogues of tocainide.
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Carbamates; C | 1994 |
[Frequency dependent prolongation of inter-atrial conduction time by mexiletine in human atrium].
Topics: Adolescent; Adult; Aged; Atrial Fibrillation; Electrophysiology; Female; Heart Atria; Heart Conducti | 1993 |
[The antifibrillatory effect of mexiletine (Kö 1173) in experimentally induced myocardial infarct].
Topics: Animals; Atrial Fibrillation; Disease Models, Animal; Dogs; Mexiletine; Myocardial Infarction; Propy | 1976 |
Effects of a combination of disopyramide and mexiletine on the anterograde accessory pathway conduction in patients with Wolff-Parkinson-White syndrome.
Topics: Adult; Atrial Fibrillation; Cardiac Pacing, Artificial; Disopyramide; Dose-Response Relationship, Dr | 1992 |
Lidocaine, mexiletine and propafenone in the treatment of arrhythmias complicating myocardial infarction. A case report.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Cardiac Complexes, Premature; Dru | 1985 |
Mexiletine for paroxysmal atrial fibrillation.
Topics: Adult; Aged; Atrial Fibrillation; Female; Humans; Male; Mexiletine; Middle Aged | 1988 |
[Treatment of atrial fibrillation with mexiletine in Wolff-Parkinson-White syndrome].
Topics: Adult; Aged; Atrial Fibrillation; Cardiac Pacing, Artificial; Combined Modality Therapy; Electrocard | 1986 |