mexiletine has been researched along with Alloxan Diabetes in 7 studies
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We examined the effect of mexiletine on the threshold for pain perception as determined by the application of mechanical noxious stimuli (tail-pinch) in diabetic mice." | 3.68 | Antinociceptive effect of mexiletine in diabetic mice. ( Aoki, T; Hitosugi, H; Kamei, J; Kasuya, Y; Kawashima, N; Ohhashi, Y, 1992) |
| " Animals in the control (n = 6 for each blood collection time), diabetic (single intravenous dosage of 45 mg·(kg body mass)(-1) of streptozotocin), and insulin-treated groups (diabetic rats treated daily with 2 IU insulin) received by gavage a single dose of 10 mg·(kg body mass)(-1) racemic MEX." | 1.40 | Influence of experimental diabetes and insulin treatment on the enantioselective pharmacokinetics of mexiletine and its metabolites. ( Barbosa Coelho, E; de Carvalho Leone, A; Lucia Lanchote, V; Marques, MP; Martinez, EZ; Pardo Campos Godoy, AL, 2014) |
| "Mexiletine (50 mg/kg) was injected intraperitoneally every day for six weeks." | 1.33 | Neuroprotective effect of mexiletine in the central nervous system of diabetic rats. ( Altinoz, E; Ates, O; Cayli, SR; Durak, A; Kocak, A; Tarim, O; Turkoz, Y; Yologlu, S; Yucel, N, 2006) |
| "pretreatment with mexiletine produced dose-dependent inhibition of fenvalerate-induced hyperalgesia and allodynia in mice, especially diabetic mice." | 1.32 | Effect of mexiletine on fenvalerate-induced nociceptive response in diabetic mice. ( Kamei, J; Saitoh, A; Tamura, N, 2004) |
| "), a selective protein kinase C inhibitor, significantly inhibited intrathecal fenvalerate-induced nociceptive behavior with a rightward shift of the dose-response curve for fenvalerate-induced nociceptive behavior to the level those observed in non-diabetic mice." | 1.31 | Modification of the fenvalerate-induced nociceptive response in mice by diabetes. ( Iguchi, E; Kamei, J; Morita, K; Sasaki, M; Tanaka, S; Zushida, K, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pardo Campos Godoy, AL | 1 |
| Martinez, EZ | 1 |
| Marques, MP | 1 |
| de Carvalho Leone, A | 1 |
| Barbosa Coelho, E | 1 |
| Lucia Lanchote, V | 1 |
| Kamei, J | 5 |
| Iguchi, E | 1 |
| Sasaki, M | 1 |
| Zushida, K | 1 |
| Morita, K | 1 |
| Tanaka, S | 1 |
| Saitoh, A | 1 |
| Tamura, N | 1 |
| Ates, O | 1 |
| Cayli, SR | 1 |
| Altinoz, E | 1 |
| Yucel, N | 1 |
| Kocak, A | 1 |
| Tarim, O | 1 |
| Durak, A | 1 |
| Turkoz, Y | 1 |
| Yologlu, S | 1 |
| Hitosugi, H | 2 |
| Kasuya, Y | 2 |
| Kawashima, N | 1 |
| Aoki, T | 1 |
| Ohhashi, Y | 1 |
7 other studies available for mexiletine and Alloxan Diabetes
| Article | Year |
|---|---|
Influence of experimental diabetes and insulin treatment on the enantioselective pharmacokinetics of mexiletine and its metabolites.
Topics: Animals; Area Under Curve; Diabetes Mellitus, Experimental; Insulin; Male; Mexiletine; Rats, Wistar; | 2014 |
Modification of the fenvalerate-induced nociceptive response in mice by diabetes.
Topics: Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Re | 2002 |
Effect of mexiletine on fenvalerate-induced nociceptive response in diabetic mice.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Male; Mexiletine; Mice; Mice, Inbred ICR; Nitr | 2004 |
Neuroprotective effect of mexiletine in the central nervous system of diabetic rats.
Topics: Animals; Blood Glucose; Brain Stem; Central Nervous System; Cerebellum; Cerebral Cortex; Diabetes Me | 2006 |
Effects of mexiletine on formalin-induced nociceptive responses in mice.
Topics: Animals; Diabetes Mellitus, Experimental; Formaldehyde; Injections, Intraperitoneal; Injections, Spi | 1993 |
[Antinociceptive effects of the enantiomorphs and its main metabolite in streptozotocin-induced diabetic mice].
Topics: Animals; Anti-Arrhythmia Agents; beta-Endorphin; Diabetes Mellitus, Experimental; Diabetic Neuropath | 2000 |
Antinociceptive effect of mexiletine in diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Male; Mexiletine; Mice; Mice, Inbred ICR; Nociceptors; Pai | 1992 |