mexicanolide has been researched along with Hyperglycemia* in 1 studies
1 other study(ies) available for mexicanolide and Hyperglycemia
| Article | Year |
|---|---|
Antihyperalgesic activity of a mexicanolide isolated from Swietenia humilis extract in nicotinamide-streptozotocin hyperglycemic mice.
Swietenia humilis Zucc. (Meliaceae) seeds are used in Mexico for the treatment of type 2 diabetes mellitus. Mexicanolides are the main hypoglycemic and antihyperglycemic compounds of the species. This study was conducted to investigate the antihyperalgesic effect of an aqueous extract of the seeds of Swietenia humilis (SHAE) and of mexicanolide 2-hydroxy-destigloyl-6-deoxyswietenine acetate (1), using the formalin test in mice. The antihyperalgesic actions of SHAE and mexicanolide 1, as well as its possible transductional activity, were assessed in nicotinamide-streptozotocin (NA-STZ) hyperglycemic mice. Local injection of SHAE (10-177μg) and mexicanolide 1 (0.5-3.5μg) exhibited concentration-dependent antihyperalgesic action in NA-STZ hyperglycemic mice. Ketanserin (6μg), a 5-HT Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Hyperalgesia; Hyperglycemia; Hypoglycemic Agents; Limonins; Male; Meliaceae; Mice; Mice, Inbred ICR; Niacinamide; Plant Extracts; Seeds; Streptozocin | 2017 |