mevalonic acid and Neoplasms

mevalonic acid has been researched along with Neoplasms in 71 studies

Research

Studies (71)

TimeframeStudies, this research(%)All Research%
pre-19904 (5.63)18.7374
1990's6 (8.45)18.2507
2000's17 (23.94)29.6817
2010's30 (42.25)24.3611
2020's14 (19.72)2.80

Authors

AuthorsStudies
Ai, YJ; Duan, KL; Guan, KL; Sun, SJ; Sun, YP; Xiong, Y; Yuan, HX; Zhang, C; Zhang, JY1
Irie, N; Oltvai, ZN; Sugiura, A; Tashiro, J; Warita, K; Warita, T; Zhou, Y1
Cuccioloni, M; Di Nicola, C; Eleuteri, AM; Fadaei-Tirani, F; Galindo, A; Gong, C; Marchetti, F; Nabissi, M; Pettinari, R; Romani, D1
Bensinger, SJ; Boland, BS; Chang, JT; Chi, H; Galletti, G; Goldrath, AW; Heeg, M; Hu, KH; Huang, H; Jain, M; Kennewick, K; Krummel, MF; Luna, V; Mathews, IT; Milner, JJ; Nguyen, Q; Reina-Campos, M; Santillano, N; Sharma, S; Vichaidit, A1
El Yousfi, Y; López-Rivas, A; Mora-Molina, R; Yerbes, R1
Ade, CP; Campbell, AD; Dankworth, B; Gay, DM; Kalogirou, C; Kaymak, I; Maier, CR; Marouf, H; McGregor, GH; Paauwe, M; Rosenfeldt, MT; Sansom, OJ; Schmitz, W; Schulze, A; Walz, S1
Göbel, A; Hofbauer, LC; Rachner, TD; Rauner, M1
Branchard, E; Elbaz, M; Longo, J; Penn, LZ; van Leeuwen, JE1
Rao, PS; Rao, US1
Fruman, DA; Juarez, D1
Cai, N; Cheng, K; Liang, H; Wen, J; Xiong, Y; Zhang, W; Zhang, Y; Zhu, J1
Chapman, NM; Chi, H; Dhungana, Y; Lim, SA; Long, L; Nguyen, TM; Palacios, G; Saravia, J; Shi, H; Su, W; Vogel, P; Wei, J1
Dong, Y; He, Z; Liang, Y; Wu, H; Yang, R; Zheng, K1
Bruzzese, F; Budillon, A; De Rienzo, S; Iannelli, F; Lombardi, R; Milone, MR; Pucci, B1
Ba-Alawi, W; Haibe-Kains, B; Longo, J; Mullen, PJ; Penn, LZ; van Leeuwen, JE; Yu, R1
Halašová, E; Škovierová, H; Sopková, J; Strnádel, J; Vidomanová, E1
Bi, F; Dai, X; Tang, Q; Xia, H; Zhou, S1
Barsotti, AM; Baslan, T; Culp-Hill, R; D'Alessandro, A; de Stanchina, E; Freed-Pastor, WA; Ho, YJ; Houlihan, SL; Huang, CH; Kastenhuber, ER; Li, X; Lowe, SW; Mayle, A; Moon, SH; Morris, JP; Prives, C; Regunath, K; Tong, DR; Tschaharganeh, DF; Xue, W; Zender, L1
Park, J; Tsantrizos, YS; Waller, DD1
Karolak, B; Murias, M; Regulska, K; Regulski, M; Stanisz, B1
Chu, X; Gao, J; Li, D; Liu, J; Qiao, Y; Qiu, Y1
Gruenbacher, G; Nussbaumer, O; Thurnher, M2
Morris, AJ; Onono, F; Spielmann, HP; Subramanian, KL; Subramanian, T; Sunkara, M1
Gruenbacher, G; Thurnher, M1
Ande, SR; Freed, DH; Ghavami, S; Hashemi, M; Moghadam, AR; Post, M; Sharma, P; Shojaei, S; Wiechec, E; Yeganeh, B; Zeki, AA1
Bifulco, M; Ciaglia, E; D'Alessandro, A; Picardi, P; Pisanti, S1
Beckwitt, CH; Oltvai, ZN; Schurdak, ME; Vazquez, A; Warita, K; Warita, T; Wells, A1
Gerner, C; Grunt, T; Haider, F; Karlic, H; Proestling, K; Thaler, R; Varga, F1
Brown, KR; Ericson, E; Gebbia, M; Giaever, G; Goard, CA; Hart, T; Kalkat, M; Lang, KS; Moffat, J; Mullen, PJ; Nislow, C; Pandyra, AA; Penn, LZ; Pong, JT; Sharma, P; Yu, R1
Chang, YN; Chen, T; Han, XH; Han, YW; Hong, W; Hu, ZM; Qi, HX; Shi, ZM; Zhang, K; Zhang, RX; Zhang, Z1
Ande, SR; Chen, QM; Hashemi, M; Hoshyar, R; Naderi, M; Solomon, C; Zuse, A1
Ashrafi, M; Azizian, M; Bathaie, SZ; Tamanoi, F1
Assaraf, YG; Bieńk, K; Cieślar-Pobuda, A; Dutta, C; Ghavami, S; Likus, W; Pakuła, M; Pathak, H; Shojaei, S; Siemianowicz, K; Wang, Q; Łos, MJ1
Archer, MC; Longo, J; Mullen, PJ; Penn, LZ; Yu, R1
Freed-Pastor, W; Prives, C1
Fryknäs, M; Gustafsson, MG; Jarvius, M; Kultima, K; Larsson, R; Lengqvist, J; Nygren, P; Rubin, J; Senkowski, W1
Bian, G; Deng, Z; Fang, C; Fu, S; Han, Y; Liu, T; Shi, X; Tao, H; Yuan, Y; Zhong, X1
Fildes, JE; Shaw, SM; Williams, SG; Yonan, N1
Kandefer-Szerszeń, M; Sławińska, A1
Herold, MJ; Herrmann, T; Kimmel, B; Kunzmann, V; Li, J; Müller, I; Rincon-Orozco, B1
Fritz, G1
Bouet, F; Cabillic, F; Catros, V; Desille, M; Fournié, JJ; Toutirais, O1
Boninsegna, A; Catalano, A; Colangelo, M; Lanza, P; Monego, G; Palozza, P; Ranelletti, FO; Simone, R1
Bil, J; Golab, J; Issat, T; Jakobisiak, M; Nowis, D; Winiarska, M1
Fernandez-Checa, JC; Garcia-Ruiz, C; Morales, A1
Smans, K; Swinnen, JV; Zaidi, N1
Angman, L; De Libero, G; Gober, HJ; Jenö, P; Kistowska, M; Mori, L1
GORE, IY; SCHROEPFER, GJ1
GORE, IY1
VAN DEN OORD, A1
Andela, VB; O'Keefe, RJ; Pirri, M; Puzas, EJ; Rosenblatt, JD; Rosier, RN; Schwarz, EM1
Archer, MC; Duncan, RE; El-Sohemy, A1
Elson, CE; Mo, H1
Abbruzzese, A; Budillon, A; Caponigro, F; Caraglia, M; Marra, M; Tagliaferri, P1
Giri, S; Rattan, R; Singh, AK; Singh, I1
Iwagaki, H; Nishibori, M; Takahashi, HK; Tanaka, N; Weitz-Schmidt, G; Yoshino, T1
Konstantinopoulos, PA; Papavassiliou, AG1
Bravo, L; Gupta, J; McAnally, JA; Mo, H; Sodhani, S1
Addeo, SR; Angeletti, S; Budillon, A; Caraglia, M; Dicuonzo, G; Gasparro, S; Grilli, C; La Cesa, A; Leoni, V; Santini, D; Schiavon, G; Tonini, G; Vincenzi, B; Virzí, V1
Siperstein, MD1
Elson, CE1
Elson, CE; Yu, SG1
Elson, CE; Hentosh, P; Mo, H; Peffley, DM1
McCarty, MF2
Benzaquen, M; Dimitroulakos, J; Freedman, MH; Kamel-Reid, S; Moore, MJ; Penn, LZ; Ye, LY; Yeger, H1
Buchwald, H1
Cox, AD; Der, CJ; Kato, K; Khosravi-Far, R1
Cox, AD; Der, CJ1

Reviews

36 review(s) available for mevalonic acid and Neoplasms

ArticleYear
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide

2023
Cholesterol and beyond - The role of the mevalonate pathway in cancer biology.
    Biochimica et biophysica acta. Reviews on cancer, 2020, Volume: 1873, Issue:2

    Topics: Antineoplastic Agents; Cell Proliferation; Cell Transformation, Neoplastic; Cholesterol; Clinical Trials as Topic; Disease Progression; Geranyltranstransferase; Humans; Hydroxymethylglutaryl CoA Reductases; Metabolic Networks and Pathways; Mevalonic Acid; Neoplasms; Protein Processing, Post-Translational; rho GTP-Binding Proteins; Sterol Regulatory Element Binding Proteins; Treatment Outcome

2020
Statins as Anticancer Agents in the Era of Precision Medicine.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2020, 11-15, Volume: 26, Issue:22

    Topics: Antineoplastic Agents; Drug Repositioning; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metabolic Networks and Pathways; Mevalonic Acid; Neoplasms; Precision Medicine

2020
Targeting the Mevalonate Pathway in Cancer.
    Trends in cancer, 2021, Volume: 7, Issue:6

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Diterpenes; Farnesyltranstransferase; Feeding Behavior; Food-Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metabolic Networks and Pathways; Mevalonic Acid; Mice; Neoplasms; Pinocytosis; Polyisoprenyl Phosphates; Prenylation

2021
The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Acetaminophen; Antineoplastic Agents; Antioxidants; Apoptosis; Artemisinins; Auranofin; Cell Death; Cisplatin; Epigenesis, Genetic; Fatty Acids; Ferroptosis; Haloperidol; Humans; Indoles; Iron; Lapatinib; Mevalonic Acid; NADP; Neoplasms; Oxidation-Reduction; Oxidative Stress; Oxygen; Quinolines; Reactive Oxygen Species; Sorafenib; Spiro Compounds; Sulfasalazine; Trigonella

2020
Regulation of ferroptosis by bioactive phytochemicals: Implications for medical nutritional therapy.
    Pharmacological research, 2021, Volume: 168

    Topics: Dietary Supplements; Ferroptosis; Humans; Iron; Mevalonic Acid; Neoplasms; Oxidative Stress; Phospholipids; Phytochemicals; Plant Extracts

2021
Targeting Mevalonate Pathway in Cancer Treatment: Repurposing of Statins.
    Recent patents on anti-cancer drug discovery, 2018, Volume: 13, Issue:2

    Topics: Animals; Antineoplastic Agents; Drug Delivery Systems; Drug Repositioning; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Neoplasms; Signal Transduction

2018
The role of statins as therapeutic agents in cancer.
    General physiology and biophysics, 2017, Volume: 36, Issue:5

    Topics: Carcinogenesis; Cholesterol; Dose-Response Relationship, Drug; Evidence-Based Medicine; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mevalonic Acid; Models, Biological; Neoplasms; Treatment Outcome

2017
Inhibition of farnesyl pyrophosphate (FPP) and/or geranylgeranyl pyrophosphate (GGPP) biosynthesis and its implication in the treatment of cancers.
    Critical reviews in biochemistry and molecular biology, 2019, Volume: 54, Issue:1

    Topics: Animals; Antineoplastic Agents; Biosynthetic Pathways; Drug Discovery; Enzyme Inhibitors; Farnesyltranstransferase; Geranyltranstransferase; Humans; Mevalonic Acid; Models, Molecular; Neoplasms; Polyisoprenyl Phosphates; Protein Prenylation; Sesquiterpenes

2019
Can cardiovascular drugs support cancer treatment? The rationale for drug repurposing.
    Drug discovery today, 2019, Volume: 24, Issue:4

    Topics: Animals; Anticoagulants; Cardiac Glycosides; Cardiovascular Agents; Drug Repositioning; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Neoplasms; Renin-Angiotensin System; Sympathetic Nervous System

2019
Regulation of mevalonate metabolism in cancer and immune cells.
    Biochimica et biophysica acta, 2013, Volume: 1831, Issue:6

    Topics: Animals; Humans; Immunity, Innate; Mevalonic Acid; Neoplasms

2013
Mevalonate metabolism in cancer.
    Cancer letters, 2015, Jan-28, Volume: 356, Issue:2 Pt A

    Topics: Apoptosis; Cell Proliferation; Energy Metabolism; Glucose; Glycolysis; Humans; Mevalonic Acid; Neoplasms; Signal Transduction; T-Lymphocytes; Tumor Escape; Tumor Suppressor Protein p53

2015
Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.
    Pharmacology & therapeutics, 2014, Volume: 143, Issue:1

    Topics: Alkyl and Aryl Transferases; Animals; Cardiovascular Diseases; Farnesyltranstransferase; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung Diseases; Mevalonic Acid; Neoplasms; Pulmonary Disease, Chronic Obstructive; rho GTP-Binding Proteins; rho-Associated Kinases

2014
Novel prospects of statins as therapeutic agents in cancer.
    Pharmacological research, 2014, Volume: 88

    Topics: Animals; Antineoplastic Agents; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Neoplasms

2014
YAP and TAZ Take Center Stage in Cancer.
    Biochemistry, 2015, Nov-03, Volume: 54, Issue:43

    Topics: Adaptor Proteins, Signal Transducing; Animals; Gene Expression Regulation; Hedgehog Proteins; Humans; Hypoxia; MAP Kinase Signaling System; Mevalonic Acid; MicroRNAs; Models, Biological; Neoplasms; Phosphatidylinositol 3-Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Receptors, Androgen; Receptors, G-Protein-Coupled; Receptors, Notch; RNA, Neoplasm; Signal Transduction; Smad Proteins; Transcription Factors; Wnt Signaling Pathway

2015
Mevalonate Cascade and its Regulation in Cholesterol Metabolism in Different Tissues in Health and Disease.
    Current molecular pharmacology, 2017, Volume: 10, Issue:1

    Topics: Acyl Coenzyme A; Animals; Cardiovascular Diseases; Cholesterol; GTP Phosphohydrolases; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infections; Mevalonic Acid; Neoplasms; Polyisoprenyl Phosphates; Sesquiterpenes; Signal Transduction

2017
Mevalonate Pathway and Human Cancers.
    Current molecular pharmacology, 2017, Volume: 10, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Metabolic Networks and Pathways; Mevalonic Acid; Mutation; Neoplasms; Protein Processing, Post-Translational

2017
Could drugs inhibiting the mevalonate pathway also target cancer stem cells?
    Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 2016, Volume: 25

    Topics: Animals; Antineoplastic Agents; Disease Progression; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplasms; Neoplastic Stem Cells; Proto-Oncogene Mas

2016
The interplay between cell signalling and the mevalonate pathway in cancer.
    Nature reviews. Cancer, 2016, Volume: 16, Issue:11

    Topics: Humans; Metabolic Networks and Pathways; Mevalonic Acid; Neoplasms; Signal Transduction

2016
Targeting mutant p53 through the mevalonate pathway.
    Nature cell biology, 2016, Oct-27, Volume: 18, Issue:11

    Topics: Animals; Apoptosis; Carcinogenesis; Humans; Mevalonic Acid; Mutation; Neoplasms; Tumor Suppressor Protein p53

2016
Potential immunologic effects of statins in cancer following transplantation.
    Cancer immunology, immunotherapy : CII, 2009, Volume: 58, Issue:3

    Topics: Animals; Cell Adhesion; Cell Proliferation; Chemotaxis; Graft Rejection; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immune System; Immunosuppressive Agents; Killer Cells, Natural; Mevalonic Acid; Models, Biological; Neoplasms; Organ Transplantation

2009
[The anticancer properties of statins].
    Postepy higieny i medycyny doswiadczalnej (Online), 2008, Aug-07, Volume: 62

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Neoplasms; Terpenes

2008
Targeting the mevalonate pathway for improved anticancer therapy.
    Current cancer drug targets, 2009, Volume: 9, Issue:5

    Topics: Animals; Antineoplastic Agents; Cell Death; Dimethylallyltranstransferase; Diphosphonates; Drug Delivery Systems; Drug Discovery; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Membrane Proteins; Mevalonic Acid; Models, Biological; Neoplasms; Protein Prenylation; ras Proteins; rho GTP-Binding Proteins; Signal Transduction

2009
[Tgammadelta lymphocytes in oncology: unconventional killer lymphocytes].
    Medecine sciences : M/S, 2010, Volume: 26, Issue:2

    Topics: Animals; Antigens, Neoplasm; Clinical Trials as Topic; Cytotoxicity, Immunologic; Dendritic Cells; Diphosphonates; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunity, Innate; Immunological Synapses; Immunotherapy; Immunotherapy, Adoptive; Lymphocyte Activation; Mevalonic Acid; Mice; Neoplasm Proteins; Neoplasms; Phosphoproteins; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocyte Subsets

2010
Statins and protein prenylation in cancer cell biology and therapy.
    Anti-cancer agents in medicinal chemistry, 2012, Volume: 12, Issue:4

    Topics: Animals; Antineoplastic Agents; Cholesterol; Hedgehog Proteins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Neoplasms; Protein Prenylation; Signal Transduction

2012
Novel aspects of mevalonate pathway inhibitors as antitumor agents.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Jul-01, Volume: 18, Issue:13

    Topics: Animals; Antineoplastic Agents; Diphosphonates; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunity, Innate; Immunologic Factors; Metabolic Networks and Pathways; Mevalonic Acid; Neoplasms; Prenylation; Protein Processing, Post-Translational

2012
ATP-citrate lyase: a key player in cancer metabolism.
    Cancer research, 2012, Aug-01, Volume: 72, Issue:15

    Topics: Animals; ATP Citrate (pro-S)-Lyase; Fatty Acids; Glucose; Glutamine; Humans; Metabolic Networks and Pathways; Mevalonic Acid; Models, Biological; Neoplasms

2012
The mevalonate synthesis pathway as a therapeutic target in cancer.
    Clinical orthopaedics and related research, 2003, Issue:415 Suppl

    Topics: Acute-Phase Proteins; Alendronate; Alkyl and Aryl Transferases; Animals; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Farnesyltranstransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Neoplasms; Polyisoprenyl Phosphates; Tumor Cells, Cultured

2003
Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention.
    Experimental biology and medicine (Maywood, N.J.), 2004, Volume: 229, Issue:7

    Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Cell Cycle; Cell Division; Clinical Trials as Topic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Neoplasms; Protein Processing, Post-Translational; Terpenes

2004
Isoprenylation of intracellular proteins as a new target for the therapy of human neoplasms: preclinical and clinical implications.
    Current drug targets, 2005, Volume: 6, Issue:3

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzodiazepines; Farnesyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Mevalonic Acid; Neoplasms; Phosphatidylinositol 3-Kinases; Piperidines; Protein Prenylation; Protein Processing, Post-Translational; Pyridines; Quinolones; ras Proteins

2005
Last generation of amino-bisphosphonates (N-BPs) and cancer angio-genesis: a new role for these drugs?
    Recent patents on anti-cancer drug discovery, 2006, Volume: 1, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Diphosphonates; Humans; Mevalonic Acid; Neoplasms; Osteoblasts; Osteoclasts; Patents as Topic; Regional Blood Flow; Signal Transduction; Structure-Activity Relationship

2006
Suppression of mevalonate pathway activities by dietary isoprenoids: protective roles in cancer and cardiovascular disease.
    The Journal of nutrition, 1995, Volume: 125, Issue:6 Suppl

    Topics: Animals; Cardiovascular Diseases; Diet; Humans; Hydroxymethylglutaryl-CoA Synthase; Mevalonic Acid; Neoplasms; Neoplasms, Experimental; Terpenes

1995
The chemoprevention of cancer by mevalonate-derived constituents of fruits and vegetables.
    The Journal of nutrition, 1994, Volume: 124, Issue:5

    Topics: Administration, Oral; Animals; Diet; Fruit; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Neoplasms; Neoplasms, Experimental; Terpenes; Vegetables

1994
Isoprenoid-mediated inhibition of mevalonate synthesis: potential application to cancer.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1999, Volume: 221, Issue:4

    Topics: Animals; Antineoplastic Agents, Phytogenic; Diet; Humans; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid; Mice; Neoplasms; Phytotherapy; Plants, Edible; Terpenes; Tumor Cells, Cultured

1999
Protein prenylation: key to ras function and cancer intervention?
    Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1992, Volume: 3, Issue:7

    Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Fungal Proteins; GTP-Binding Proteins; Humans; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Polyisoprenyl Phosphates; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); ras Proteins; Saccharomyces cerevisiae; Transferases

1992
The ras/cholesterol connection: implications for ras oncogenicity.
    Critical reviews in oncogenesis, 1992, Volume: 3, Issue:4

    Topics: Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Cholesterol; Dimethylallyltranstransferase; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Mevalonic Acid; Molecular Sequence Data; Neoplasms; Palmitic Acid; Palmitic Acids; Polyisoprenyl Phosphates; Protein Processing, Post-Translational; Sequence Homology

1992

Trials

1 trial(s) available for mevalonic acid and Neoplasms

ArticleYear
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide

2023

Other Studies

35 other study(ies) available for mevalonic acid and Neoplasms

ArticleYear
TET2 deficiency sensitizes tumor cells to statins by reducing HMGCS1 expression.
    Oncogene, 2022, Volume: 41, Issue:50

    Topics: Anticholesteremic Agents; Apoptosis; Dioxygenases; DNA-Binding Proteins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA Synthase; Mevalonic Acid; Neoplasms

2022
Alterations in the omics profiles in mevalonate pathway-inhibited cancer cells.
    Life sciences, 2023, Jan-01, Volume: 312

    Topics: Atorvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Neoplasms; Polyamines; Purines

2023
Multitarget-Directed Gallium(III) Tris(acyl-pyrazolonate) Complexes Induce Ferroptosis in Cancer Cells via Dysregulation of Cell Redox Homeostasis and Inhibition of the Mevalonate Pathway.
    Journal of medicinal chemistry, 2023, 03-09, Volume: 66, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Coordination Complexes; Ferroptosis; Gallium; Homeostasis; Humans; Mevalonic Acid; Neoplasms; Oxidation-Reduction; Reactive Oxygen Species

2023
Metabolic programs of T cell tissue residency empower tumour immunity.
    Nature, 2023, Volume: 621, Issue:7977

    Topics: Animals; CD8-Positive T-Lymphocytes; Cell Respiration; Cholesterol; Humans; Immunologic Memory; Intestine, Small; Lymphocytes, Tumor-Infiltrating; Metabolomics; Mevalonic Acid; Mice; Mitochondria; Neoplasms; Ubiquinone; Virus Diseases; Viruses

2023
Role of the YAP/TAZ-TEAD Transcriptional Complex in the Metabolic Control of TRAIL Sensitivity by the Mevalonate Pathway in Cancer Cells.
    Cells, 2023, 09-27, Volume: 12, Issue:19

    Topics: Apoptosis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Ligands; Mevalonic Acid; Neoplasms; TEA Domain Transcription Factors; Trans-Activators; Transcription Factors; Transcriptional Coactivator with PDZ-Binding Motif Proteins; Tumor Necrosis Factors; YAP-Signaling Proteins

2023
Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress.
    Cancer research, 2020, 01-15, Volume: 80, Issue:2

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Citric Acid Cycle; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Mucosa; Mevalonic Acid; Mice; Mice, Transgenic; Neoplasms; Pyrimidines; Signal Transduction; Sterol Regulatory Element Binding Protein 2; Stress, Physiological; Tumor Microenvironment; Tumor Suppressor Protein p53; Ubiquinone; Xenograft Model Antitumor Assays

2020
Statins decrease the expression of c-Myc protein in cancer cell lines.
    Molecular and cellular biochemistry, 2021, Volume: 476, Issue:2

    Topics: Atorvastatin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Neoplasms; Proto-Oncogene Proteins c-myc; Simvastatin

2021
Lipid signalling enforces functional specialization of T
    Nature, 2021, Volume: 591, Issue:7849

    Topics: Animals; Cholesterol; Fatty Acid Synthases; Fatty Acids; Female; Gene Expression Regulation, Neoplastic; Intracellular Signaling Peptides and Proteins; Lipid Metabolism; Male; Membrane Proteins; Mevalonic Acid; Mice; Neoplasms; Phosphatidylinositol 3-Kinase; Programmed Cell Death 1 Receptor; Signal Transduction; Sterol Regulatory Element Binding Proteins; T-Lymphocytes, Regulatory; Up-Regulation

2021
Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins.
    Cancer research, 2018, 03-01, Volume: 78, Issue:5

    Topics: Apoptosis; Biomarkers, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Fluvastatin; Humans; Mevalonic Acid; Neoplasms; Polyisoprenyl Phosphates; Protein Prenylation; ras Proteins; Sesquiterpenes; Tumor Cells, Cultured; Zinc Finger E-box-Binding Homeobox 1

2018
Zoledronic acid enhances the efficacy of the MEK inhibitor trametinib in KRAS mutant cancers.
    Cancer letters, 2019, 02-01, Volume: 442

    Topics: A549 Cells; Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Female; HCT116 Cells; HT29 Cells; Humans; Mevalonic Acid; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Mutation; Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Protein Prenylation; Proto-Oncogene Proteins p21(ras); Pyridones; Pyrimidinones; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays; Zoledronic Acid

2019
p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression.
    Cell, 2019, 01-24, Volume: 176, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter 1; Cell Line; Cholesterol; Female; Genes, Tumor Suppressor; HCT116 Cells; Hepatocytes; Humans; Liver; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Neoplasms; Promoter Regions, Genetic; Sterol Regulatory Element Binding Protein 2; Terpenes; Tumor Suppressor Protein p53

2019
Multi-target-directed design, syntheses, and characterization of fluorescent bisphosphonate derivatives as multifunctional enzyme inhibitors in mevalonate pathway.
    Biochimica et biophysica acta, 2013, Volume: 1830, Issue:6

    Topics: Animals; Cell Proliferation; Cell Survival; Diphosphonates; Enzyme Inhibitors; Fluorescent Dyes; Hypercholesterolemia; Mevalonic Acid; Molecular Docking Simulation; Neoplasms; Rats

2013
Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway.
    The Journal of biological chemistry, 2013, Sep-20, Volume: 288, Issue:38

    Topics: Antineoplastic Agents; Cell Line, Tumor; Diterpenes; Farnesol; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Mutation; Neoplasms; Polyisoprenyl Phosphates; Protein Prenylation; Tumor Suppressor Protein p53

2013
Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion.
    Scientific reports, 2014, Dec-23, Volume: 4

    Topics: Cadherins; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cholesterol; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Neoplasm Proteins; Neoplasms

2014
Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells.
    Cancer genetics, 2015, Volume: 208, Issue:5

    Topics: Antineoplastic Agents; Cell Line, Tumor; Diphosphonates; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Down-Regulation; Epigenesis, Genetic; Fatty Acids; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Ibandronic Acid; Lovastatin; Mevalonic Acid; MicroRNAs; NADP; Neoplasms; Protein Processing, Post-Translational; Simvastatin; Vitamin D

2015
Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.
    Oncotarget, 2015, Sep-29, Volume: 6, Issue:29

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dimethylallyltranstransferase; Farnesyltranstransferase; Fatty Acids, Monounsaturated; Female; Fluvastatin; Gene Expression Regulation, Neoplastic; Geranyltranstransferase; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Synthase; Indoles; Lung Neoplasms; Mevalonic Acid; Neoplasms; Real-Time Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Sterol Regulatory Element Binding Protein 2

2015
Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids.
    Cell chemical biology, 2016, Nov-17, Volume: 23, Issue:11

    Topics: Antineoplastic Agents; Cell Culture Techniques; Cell Line, Tumor; Drug Screening Assays, Antitumor; Gene Expression Profiling; High-Throughput Screening Assays; Humans; Mevalonic Acid; Neoplasms; Oxidative Phosphorylation; Signal Transduction; Spheroids, Cellular; Transcriptome; Tumor Cells, Cultured

2016
Production of taxadiene by engineering of mevalonate pathway in Escherichia coli and endophytic fungus Alternaria alternata TPF6.
    Biotechnology journal, 2017, Volume: 12, Issue:4

    Topics: Agrobacterium tumefaciens; Alkenes; Alternaria; Carbon-Carbon Double Bond Isomerases; Diterpenes; Endophytes; Escherichia coli; Gene Expression Regulation, Enzymologic; Hemiterpenes; HMGB1 Protein; Humans; Isomerases; Metabolic Engineering; Mevalonic Acid; Neoplasms; Transformation, Bacterial

2017
Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells.
    Journal of immunology (Baltimore, Md. : 1950), 2009, Jun-15, Volume: 182, Issue:12

    Topics: Cell Line; Dimethylallyltranstransferase; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Hematopoiesis; Humans; Lymphocyte Activation; Mevalonic Acid; Neoplasms; Receptors, Antigen, T-Cell, gamma-delta; Signal Transduction; T-Lymphocytes

2009
Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines.
    Carcinogenesis, 2010, Volume: 31, Issue:10

    Topics: Anticarcinogenic Agents; Apoptosis; Carotenoids; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lycopene; Male; Mevalonic Acid; Neoplasms; NF-kappa B; Protein Transport; ras Proteins; Reactive Oxygen Species; Signal Transduction

2010
Antitumor effects of the combination of cholesterol reducing drugs.
    Oncology reports, 2011, Volume: 26, Issue:1

    Topics: Animals; Anticholesteremic Agents; Antineoplastic Agents; Berberine; Cell Cycle; Cell Line, Tumor; Drug Therapy, Combination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms

2011
Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells.
    The Journal of experimental medicine, 2003, Jan-20, Volume: 197, Issue:2

    Topics: Breast Neoplasms; Cells, Cultured; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Immunotherapy; Lymphocyte Activation; Mevalonic Acid; Neoplasms; Phosphorylation; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocyte Subsets; Transfection; Tumor Cells, Cultured

2003
CHROMATOGRAPHIC SEPARATION OF ALLYLIC ALCOHOLS ON SILICIC ACID COLUMNS: ANALYSIS OF THE NONSAPONIFIABLE LIPIDS OF AN ASCITES TUMOR DERIVED FROM A BENZPYRENE-INDUCED SARCOMA.
    Journal of lipid research, 1963, Volume: 4

    Topics: Alcohols; Ascites; Benzopyrenes; Carbon Isotopes; Carcinogens; Chromatography; Lipids; Mevalonic Acid; Neoplasms; Neoplasms, Experimental; Oils; Propanols; Research; Sarcoma; Sarcoma, Experimental; Silicic Acid

1963
STEROLS IN NEOPLASTIC CELLS.
    Nature, 1964, May-23, Volume: 202

    Topics: Carbon Isotopes; Cholesterol; Electrons; Lipid Metabolism; Mevalonic Acid; Microscopy; Microscopy, Electron; Neoplasms; Radiography; Research; Sterols

1964
THE ABSENCE OF CHOLESTEROL SYNTHESIS IN THE CRAB, CANCER PAGURUS L.
    Comparative biochemistry and physiology, 1964, Volume: 13

    Topics: Acetates; Animals; Anomura; Carbon Isotopes; Cholesterol; Crustacea; Lipid Metabolism; Mevalonic Acid; Neoplasms; Physiology, Comparative; Radiometry; Research; Squalene

1964
Mevalonate promotes the growth of tumors derived from human cancer cells in vivo and stimulates proliferation in vitro with enhanced cyclin-dependent kinase-2 activity.
    The Journal of biological chemistry, 2004, Aug-06, Volume: 279, Issue:32

    Topics: Animals; CDC2-CDC28 Kinases; Cell Division; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Flow Cytometry; G1 Phase; Gene Expression; Humans; Immunosorbent Techniques; Mevalonic Acid; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms; Phosphorylation; Protein Kinases; S Phase; Tumor Cells, Cultured

2004
Rho/ROCK pathway as a target of tumor therapy.
    Journal of neuroscience research, 2006, Feb-01, Volume: 83, Issue:2

    Topics: Amides; Animals; Antineoplastic Agents; Apoptosis; Blotting, Southern; Blotting, Western; Caspases; Cell Survival; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Flow Cytometry; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Lovastatin; Male; Mevalonic Acid; Mice; Neoplasms; Neoplasms, Experimental; Polyisoprenyl Phosphates; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Cells, Cultured

2006
Hypothesis: the antitumor activities of statins may be mediated by IL-18.
    Journal of leukocyte biology, 2006, Volume: 80, Issue:2

    Topics: Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-18; Lymphocyte Activation; Mevalonic Acid; Models, Biological; Neoplasms

2006
Multilevel modulation of the mevalonate and protein-prenylation circuitries as a novel strategy for anticancer therapy.
    Trends in pharmacological sciences, 2007, Volume: 28, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Drug Design; Enzyme Inhibitors; Humans; Mevalonic Acid; Neoplasms; Protein Prenylation

2007
Tocotrienols potentiate lovastatin-mediated growth suppression in vitro and in vivo.
    Experimental biology and medicine (Maywood, N.J.), 2007, Volume: 232, Issue:4

    Topics: Animals; Antioxidants; Cardiovascular Diseases; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Neoplasm Proteins; Neoplasms; Terpenes; Tocotrienols

2007
Feedback control of cholesterol synthesis in normal, malignant and premalignant tissues.
    Proceedings. Canadian Cancer Conference, 1967, Volume: 7

    Topics: Animals; Cholesterol; Feedback; Humans; Mevalonic Acid; Mice; Neoplasms; Rats; Salmonidae

1967
Suppression of dolichol synthesis with isoprenoids and statins may potentiate the cancer-retardant efficacy of IGF-I down-regulation.
    Medical hypotheses, 2001, Volume: 56, Issue:1

    Topics: Anticholesteremic Agents; Dolichols; Down-Regulation; Humans; Insulin-Like Growth Factor I; Mevalonic Acid; Neoplasms; Neovascularization, Pathologic; Sugar Phosphates

2001
Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:1

    Topics: Adult; Antineoplastic Agents; Apoptosis; Child; Chromatography, High Pressure Liquid; Female; Flow Cytometry; Formazans; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mass Spectrometry; Mevalonic Acid; Microscopy, Electron; Neoplasms; Tetrazolium Salts; Tumor Cells, Cultured

2001
Current prospects for controlling cancer growth with non-cytotoxic agents--nutrients, phytochemicals, herbal extracts, and available drugs.
    Medical hypotheses, 2001, Volume: 56, Issue:2

    Topics: Animals; Arachidonic Acid; Biological Factors; Cell Division; Down-Regulation; Flavonoids; Humans; Insulin-Like Growth Factor I; Linoleic Acid; Mevalonic Acid; Neoplasms; Neovascularization, Pathologic; Phenols; Phytotherapy; Plants; Polymers; Polyphenols; Receptors, Cytoplasmic and Nuclear; Selenium; Transcription Factors

2001
Cholesterol inhibition, cancer, and chemotherapy.
    Lancet (London, England), 1992, May-09, Volume: 339, Issue:8802

    Topics: Adjuvants, Pharmaceutic; Animals; Antineoplastic Agents; Cholesterol; Dogs; Drug Evaluation, Preclinical; Humans; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Lovastatin; Mevalonic Acid; Mice; Neoplasms; Neoplasms, Experimental; Rats

1992