mevalonic acid has been researched along with Multiple Myeloma in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 9 (50.00) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Ashihara, E; Hosogi, S; Kuwabara, N; Nakagawa, S; Sano, Y; Sato, S; Toda, Y | 1 |
| Andrews, DW; Branchard, E; Haibe-Kains, B; Keats, JJ; Li, Z; Licht, JD; Longo, J; Penn, LZ; Pugh, TJ; Smirnov, P; Trudel, S; van Leeuwen, JE | 1 |
| Arra, C; Bruzzese, F; Budillon, A; Caraglia, M; Chianese, MI; Ciardiello, C; Di Gennaro, E; Franco, R; Leone, A; Luciano, A; Milone, MR; Pucci, B; Rocco, M; Santini, D | 1 |
| Kalkat, M; Lang, KS; Li, Z; Minden, MD; Mullen, PJ; Pandyra, A; Penn, LZ; Pong, JT; Schimmer, AD; Trudel, S; Yu, R | 1 |
| Bloem, AC; Bogers-Boer, L; Lokhorst, HM; van de Donk, NW; van der Spek, E; van Kessel, B | 1 |
| van der Spek, E | 1 |
| Boutros, PC; Clendening, JW; Jurisica, I; Lehner, R; Li, Z; Martirosyan, A; Pandyra, A; Penn, LZ; Trudel, S | 1 |
| Boccadoro, M; Bosia, A; Canepari, ME; Castella, B; Coscia, M; Fiore, F; Foglietta, M; Massaia, M; Palumbo, A; Pantaleoni, F; Peola, S; Riganti, C | 1 |
| Iguchi, T; Ikeda, Y; Kizaki, M; Miyakawa, Y; Yamamoto, K | 1 |
| Belloni, D; Caligaris-Cappio, F; Ferrarini, M; Ferrero, E; Fortis, C; Girlanda, S; Groh, V; Sciorati, C; Spies, T; Ticozzi, P; Tresoldi, M; Vicari, A | 1 |
| Bloem, AC; Lokhorst, HM; van de Donk, NW; van der Spek, E | 1 |
| Baulch-Brown, C; Ma, D; Molloy, TJ; Spencer, A; Yeh, SL | 1 |
| Ashihara, E; Kawata, E; Kimura, S; Kiyono, Y; Kuroda, J; Maekawa, T; Okamoto, M; Sato, K; Shimazaki, C; Shimura, K; Takeuchi, M; Taniguchi, K; Taniwaki, M; Uchida, R | 1 |
| Ebetino, FH; Edwards, CM; Hulley, PA; Roelofs, AJ; Rogers, MJ; Russell, RG | 1 |
| Bergsagel, PL; Boutros, PC; Bros, C; Clendening, JW; Jurisica, I; Khosravi, F; Martirosyan, A; Penn, LZ; Stewart, AK; Wong, WW | 1 |
| Croucher, PI; Helfrich, MH; Rogers, MJ; Russell, RG; Shipman, CM | 1 |
| Croucher, PI; Graham, R; Rogers, MJ; Russell, G; Shipman, CM; Van Camp, B; Vanderkerken, K | 1 |
| Chang, WS; Chao, YJ; Li, JL; Li, YJ; Lin, LX; Ouyang, MH; Peng, YB | 1 |
1 review(s) available for mevalonic acid and Multiple Myeloma
| Article | Year |
|---|---|
New treatment strategies for multiple myeloma by targeting BCL-2 and the mevalonate pathway.
Topics: Animals; Apoptosis; Genes, bcl-2; Humans; Mevalonic Acid; Multiple Myeloma; Protein Prenylation; Signal Transduction | 2006 |
17 other study(ies) available for mevalonic acid and Multiple Myeloma
| Article | Year |
|---|---|
Hypoxia-adapted Multiple Myeloma Stem Cells Resist γδ-T-Cell-mediated Killing by Modulating the Mevalonate Pathway.
Topics: Humans; Hypoxia; Lymphocyte Activation; Mevalonic Acid; Multiple Myeloma; Receptors, Antigen, T-Cell, gamma-delta; Stem Cells | 2023 |
The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Bortezomib; Cell Proliferation; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 4; Female; Fluvastatin; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Mice; Mice, Inbred NOD; Mice, SCID; Multiple Myeloma; Polyisoprenyl Phosphates; Translocation, Genetic; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2021 |
Panobinostat synergizes with zoledronic acid in prostate cancer and multiple myeloma models by increasing ROS and modulating mevalonate and p38-MAPK pathways.
Topics: Animals; Antineoplastic Agents; Apoptosis; Diphosphonates; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; Humans; Hydroxamic Acids; Imidazoles; Indoles; Male; Mevalonic Acid; Mice; Mice, Nude; Models, Biological; Multiple Myeloma; p38 Mitogen-Activated Protein Kinases; Panobinostat; Prostatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Xenograft Model Antitumor Assays; Zoledronic Acid | 2013 |
Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Dipyridamole; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA Synthase; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Male; Mevalonic Acid; Mice; Multiple Myeloma; Sterol Regulatory Element Binding Protein 2 | 2014 |
Inhibition of the mevalonate pathway potentiates the effects of lenalidomide in myeloma.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Humans; Lenalidomide; Mevalonic Acid; Multiple Myeloma; Protein Prenylation; Simvastatin; STAT3 Transcription Factor; Thalidomide | 2009 |
Targeting the mevalonate pathway in multiple myeloma.
Topics: Animals; Humans; Mevalonic Acid; Multiple Myeloma; Signal Transduction | 2010 |
Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma.
Topics: Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoenzymes; Male; Mevalonic Acid; Multiple Myeloma | 2010 |
Immune modulation by zoledronic acid in human myeloma: an advantageous cross-talk between Vγ9Vδ2 T cells, αβ CD8+ T cells, regulatory T cells, and dendritic cells.
Topics: B7-1 Antigen; Bone Density Conservation Agents; CD8-Positive T-Lymphocytes; Cell Communication; Cell Proliferation; Dendritic Cells; Diphosphonates; Gene Expression Regulation; Hemiterpenes; Humans; Imidazoles; Lymphocyte Activation; Mevalonic Acid; Monocytes; Multiple Myeloma; Organophosphorus Compounds; Programmed Cell Death 1 Ligand 2 Protein; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; Zoledronic Acid | 2011 |
Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway.
Topics: Apoptosis; Cell Division; Cell Line, Tumor; Checkpoint Kinase 1; Diphosphonates; Diterpenes; Enzyme Inhibitors; Farnesol; Humans; Imidazoles; Interleukin-6; MAP Kinase Signaling System; Mevalonic Acid; Multiple Myeloma; Phosphorylation; Protein Kinases; S Phase; Signal Transduction; Stromal Cells | 2003 |
MICA expressed by multiple myeloma and monoclonal gammopathy of undetermined significance plasma cells Costimulates pamidronate-activated gammadelta lymphocytes.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Diphosphonates; Female; Histocompatibility Antigens Class I; Humans; Lymphocyte Activation; Male; Mevalonic Acid; Middle Aged; Multiple Myeloma; Pamidronate; Paraproteinemias; Plasma Cells; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes | 2005 |
Inhibitors of the mevalonate pathway as potential therapeutic agents in multiple myeloma.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diphosphonates; Drug Screening Assays, Antitumor; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Imidazoles; Indoles; Mevalonic Acid; Multiple Myeloma; Piperidines; Pyridines; Structure-Activity Relationship; Zoledronic Acid | 2007 |
Gamma delta T cells kill myeloma cells by sensing mevalonate metabolites and ICAM-1 molecules on cell surface.
Topics: Cell Line, Tumor; Cell Membrane; Cytotoxicity, Immunologic; Humans; Intercellular Adhesion Molecule-1; Membrane Proteins; Mevalonic Acid; Multiple Myeloma; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes | 2007 |
Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Diphosphonates; Down-Regulation; Drug Synergism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Multiple Myeloma; Phosphatidylcholines; Protein Prenylation | 2007 |
Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma.
Topics: Apoptosis; Disease Progression; GTP Phosphohydrolases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Multiple Myeloma | 2007 |
The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Diphosphonates; Diterpenes; Enzyme Inhibitors; Farnesol; Humans; Lovastatin; Mevalonic Acid; Multiple Myeloma; Protein Prenylation; Tumor Cells, Cultured | 1998 |
Bisphosphonates--mechanisms of action in multiple myeloma.
Topics: Animals; Diphosphonates; Disease Models, Animal; Humans; Mevalonic Acid; Mice; Multiple Myeloma; Osteolysis | 2000 |
Cholesterol requirement for growth of IR983F and P3X63-Ag8-U1 myeloma cells in serum-free medium.
Topics: Animals; Cell Division; Cholesterol; Culture Media, Serum-Free; Hybridomas; Kinetics; Mevalonic Acid; Mice; Multiple Myeloma; Rats; Tumor Cells, Cultured | 1991 |